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Evidence of Interaction Between LSM3 and LSM7

The interaction score between LSM3 and LSM7 is 1.58E5.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between LSM3 and LSM7 = 0.80

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismLSM3 OrthologueLSM7 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YLR438C-A 1 YNL147W 1
  • Y2H
  • Other
  • AffinityCaptureMS

Get References From PubMed
worm Q9U1W8 1 Q23543 1
fly Q8IMX8 1 Q9VJI7 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in LSM3 and LSM7:
Domains in LSM3Domains in LSM7
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain
IPR001163 Small nuclear ribonucleoprotein (Sm protein)
IPR010920 Small nuclear-like ribonucleoprotein
IPR006649 snRNP domain

The Chi square scores for co-occurrence of domains that are present in LSM3 and LSM7 are listed below.

Domain 1Domain 2Chi Square
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR006649 snRNP domain 1325.87
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR001163 Small nuclear ribonucleoprotein (Sm protein) 1297.61
IPR006649 snRNP domain IPR006649 snRNP domain 1206.57
IPR010920 Small nuclear-like ribonucleoprotein IPR006649 snRNP domain 1168.89
IPR001163 Small nuclear ribonucleoprotein (Sm protein) IPR010920 Small nuclear-like ribonucleoprotein 1143.95
IPR010920 Small nuclear-like ribonucleoprotein IPR010920 Small nuclear-like ribonucleoprotein 355.236

The background colour of the table refers to:

  • Blue Domain is only present in LSM3
  • Yellow Domain is only present in LSM7
  • Green Domain is present in both LSM3 and LSM7

 0.265
Post-translational Modifications

Protein: LSM3

PTMResidueReference
N-acetylalanine 1 HPRD

Protein: LSM7

PTMResidueReference
Localisation

Protein: LSM3

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: LSM7

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between LSM3 and LSM7 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between LSM3 andLSM7. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , LSM3 has 321 interactors and LSM7 has 270 interactors of which there are 204 common interactors.

Common InteractorName of Common InteractorScore for LSM3-Interactor (?)Score for LSM7-Interactor (?)
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 2.74E3 3.51E3
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 778.00 3.51E3
LSM4 LSM4: U6 snRNA-associated Sm-like protein LSm4 323.00 1.64E3
LSM6 LSM6: U6 snRNA-associated Sm-like protein LSm6 323.00 323.00
LSM1 LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1 323.00 195.00
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 68.20 69.60
PRPF4 PRPF4, PRP4: U4/U6 small nuclear ribonucleoprotein Prp4 32.60 69.60
PRP19 PRPF19, NMP200, PRP19, SNEV: Pre-mRNA-processing factor 19 25.60 25.60
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 12.80 2.60
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 12.80 205.00
LSM8 LSM8: U6 snRNA-associated Sm-like protein LSm8 10.30 2.60
SNRPE SNRPE: Small nuclear ribonucleoprotein E 2.91 8.73
SNRPF SNRPF, PBSCF: Small nuclear ribonucleoprotein F 2.60 205.00
SNRPG SNRPG, PBSCG: Small nuclear ribonucleoprotein G 2.60 2.60
SNRPD2 SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2 2.60 691.00
PRPF8 PRPF8, PRPC8: Pre-mRNA-processing-splicing factor 8 1.84 3.05
SNRPB SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B' 1.36 2.91
DCP1A DCP1A, SMIF: mRNA-decapping enzyme 1A 1.20 0.364
PRPF31 PRPF31, PRP31: U4/U6 small nuclear ribonucleoprotein Prp31 1.10 3.89
PRPF6 PRPF6, C20orf14: Pre-mRNA-processing factor 6 0.890 1.82
SNRPEL1 RP11-390F4.1-001: Small nuclear ribonucleoprotein polypeptide E-like protein 1. 0.354 0.105
XRN1 XRN1, SEP1: 5'-3' exoribonuclease 1 0.354 0.354
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.293 0.293
DDX50 DDX50: ATP-dependent RNA helicase DDX50 0.293 0.293
DDX21 DDX21: Nucleolar RNA helicase 2 0.287 0.293
GNB2L1 Lung cancer oncogene 7 0.287 0.293
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.287 0.137
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.287 0.293
CNOT7 CNOT7, CAF1: CCR4-NOT transcription complex subunit 7 0.263 0.263
DDX1 DDX1: ATP-dependent RNA helicase DDX1 0.263 0.123
NUP37 NUP37: Nucleoporin Nup37 0.263 0.123
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.257 0.123
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.257 0.123
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.257 0.123
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.257 0.263
SND1 SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1 0.257 0.123
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.257 0.263
RBBP4 RBBP4, RBAP48: Histone-binding protein RBBP4 0.257 0.123
LSM11 LSM11: U7 snRNA-associated Sm-like protein LSm11 0.237 0.237
LSM10 LSM10: U7 snRNA-associated Sm-like protein LSm10 0.237 0.237
FLJ36874 N/A 0.218 0.593
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.174 0.137
DCP1B DCP1B: mRNA-decapping enzyme 1B 0.160 0.039
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.156 0.074
CDC20 CDC20: Cell division cycle protein 20 homolog 0.156 0.060
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.156 0.123
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.156 0.044
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.156 0.074
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.156 0.060
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.156 0.074
SEC31L1 N/A 0.156 0.074
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.156 0.123
SNRPN HCERN3, SNRPN, SMN: Small nuclear ribonucleoprotein-associated protein N 0.141 0.156
WDR1 N/A 0.140 0.067
GTF3C2 GTF3C2, KIAA0011: General transcription factor 3C polypeptide 2 0.137 0.293
SMARCAL1 SMARCAL1, HARP: SWI/SNF-related matrix-associated actin-dependent regulator of c 0.137 0.083
WDR41 N/A 0.137 0.293
COPB2 COPB2: Coatomer subunit beta' 0.126 0.060
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.126 0.074
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.126 0.074
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.126 0.044
COPA COPA: Coatomer subunit alpha 0.126 0.060
ERCC3 ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit 0.126 0.044
REXO2 REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor 0.126 0.044
DDX23 DDX23: Probable ATP-dependent RNA helicase DDX23 0.123 0.123
DDX18 DDX18: ATP-dependent RNA helicase DDX18 0.123 0.263
WDR3 WDR3: WD repeat-containing protein 3 0.123 0.123
DDX49 DDX49: Probable ATP-dependent RNA helicase DDX49 0.123 0.263
NUP43 N/A 0.123 0.263
DDX39 DDX39: ATP-dependent RNA helicase DDX39 0.123 0.123
EIF4A1 EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I 0.123 0.263
PPP2R2A PPP2R2A: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alp 0.123 0.123
TAF5 TAF5, TAF2D: Transcription initiation factor TFIID subunit 5 0.123 0.074
DDX47 E4-DBP: DEAD box protein 0.123 0.263
WDR68 WDR68, HAN11: WD repeat-containing protein 68 0.123 0.123
RBBP7 RBBP7, RBAP46: Histone-binding protein RBBP7 0.123 0.123
BAT1 N/A 0.123 0.263
LOC645472 hCG_23490: Uncharacterized protein ENSP00000329276 0.119 0.117
LOC197135 N/A 0.119 0.119
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.093 0.060
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.093 0.060
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.093 0.060
Nle NLE1, HUSSY-07: Notchless protein homolog 1 0.093 0.074
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.093 0.074
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.093 0.060
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.093 0.044
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.093 0.044
CORO1C CORO1C, CRNN4: Coronin-1C 0.093 0.044
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.093 0.060
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.093 0.074
SEC13L1 SEC13, D3S1231E, SEC13L1, SEC13R: Protein SEC13 homolog 0.083 0.137
FBXW2 FBXW2, FBW2, FWD2: F-box/WD repeat-containing protein 2 0.083 0.137
RECQL RECQL, RECQL1: ATP-dependent DNA helicase Q1 0.074 0.074
RAD54L RAD54L, RAD54A: DNA repair and recombination protein RAD54-like 0.074 0.060
STRAP STRAP, MAWD, UNRIP: Serine-threonine kinase receptor-associated protein 0.074 0.123
BOP1 BOP1, KIAA0124: Ribosome biogenesis protein BOP1 0.074 0.123
TSSC1 TSSC1: Protein TSSC1 0.074 0.123
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.074 0.074
WDR18 N/A 0.074 0.123
WDR12 WDR12: WD repeat-containing protein 12 0.074 0.074
LRBA LRBA, BGL, CDC4L, LBA: Lipopolysaccharide-responsive and beige-like anchor prote 0.074 0.074
DDX27 DDX27, RHLP, HSPC259, PP3241: Probable ATP-dependent RNA helicase DDX27 0.074 0.263
DDX48 EIF4A3, DDX48, KIAA0111: Eukaryotic initiation factor 4A-III 0.074 0.123
FLJ10439 WDR74, NSA1: WD repeat-containing protein 74 0.074 0.123
DDX54 DDX54: ATP-dependent RNA helicase DDX54 0.074 0.123
CDC40 CDC40, EHB3, PRP17, PRPF17: Pre-mRNA-processing factor 17 0.074 0.123
POLD1 POLD1, POLD: DNA polymerase delta catalytic subunit 0.074 0.123
KIAA0052 SKIV2L2, KIAA0052: Superkiller viralicidic activity 2-like 2 0.074 0.060
JMJD2C JMJD2C, GASC1, JHDM3C, KIAA0780: JmjC domain-containing histone demethylation pr 0.074 0.074
POLE POLE, POLE1: DNA polymerase epsilon catalytic subunit A 0.074 0.074
WDR57 WDR57, PRP8BP, SFP38: WD repeat-containing protein 57 0.074 0.074
WDR77 WDR77, HKMT1069, hCG_39991: Androgen receptor cofactor p44 0.074 0.123
DHX35 C20orf15, DHX35, DDX35: Probable ATP-dependent RNA helicase DHX35 0.074 0.060
DDX19A DDX19A, DDX19L: ATP-dependent RNA helicase DDX19A 0.074 0.123
DDX10 DDX10: Probable ATP-dependent RNA helicase DDX10 0.074 0.074
WDR8 WDR8: WD repeat-containing protein 8 0.067 0.083
RAD54B RAD54B: DNA repair and recombination protein RAD54B 0.067 0.050
PHF20 PHF20, C20orf104, GLEA2, HCA58, NZF, TZP: PHD finger protein 20 0.065 0.065
WDR67 WDR67: WD repeat-containing protein 67 0.060 0.044
WDR26 WDR26, CDW2, PRO0852, MIP2: WD repeat-containing protein 26 0.060 0.044
CORO7 CORO7: Coronin-7 0.060 0.074
WIPI2 WIPI2, CGI-50: WD repeat domain phosphoinositide-interacting protein 2 0.060 0.060
RAE1 RAE1, MRNP41: mRNA export factor 0.060 0.044
XPMC2H REXO4, PMC2, XPMC2H: RNA exonuclease 4 0.060 0.123
AAAS AAAS, ADRACALA, GL003: Aladin 0.060 0.044
HELLS HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase 0.060 0.060
POLA POLA1, POLA: DNA polymerase alpha catalytic subunit 0.060 0.060
PWP2H PWP2, PWP2H: Periodic tryptophan protein 2 homolog 0.060 0.123
DDX17 DDX17: Probable ATP-dependent RNA helicase DDX17 0.060 0.074
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.060 0.074
WDR39 CIAO1, WDR39: Protein CIAO1 0.060 0.123
RECQL4 RECQL4, RECQ4: ATP-dependent DNA helicase Q4 0.060 0.044
DHX38 DHX38, DDX38, KIAA0224, PRP16: Pre-mRNA-splicing factor ATP-dependent RNA helica 0.060 0.074
GRWD1 GRWD1, GRWD, WDR28: Glutamate-rich WD repeat-containing protein 1 0.060 0.074
IFIH1 IFIH1, MDA5, RH116: Interferon-induced helicase C domain-containing protein 1 0.060 0.074
DDX28 DDX28, MDDX28: Probable ATP-dependent RNA helicase DDX28 0.060 0.074
CNOT8 CNOT8, CALIF, POP2: CCR4-NOT transcription complex subunit 8 0.060 0.074
RNU3IP2 RRP9, RNU3IP2, U355K: U3 small nucleolar RNA-interacting protein 2 0.060 0.074
DYNC1I2 N/A 0.058 0.028
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.058 0.028
BRIP1 BRIP1, BACH1, FANCJ: Fanconi anemia group J protein 0.058 0.028
EML4 EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4 0.058 0.028
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.057 0.057
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.056 0.027
WDR54 N/A 0.056 0.027
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.056 0.027
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.054 0.049
DDB2 DDB2: DNA damage-binding protein 2 0.050 0.067
ISG20 ISG20, HEM45: Interferon-stimulated gene 20 kDa protein 0.050 0.067
GNB1L GNB1L, GY2, FKSG1, KIAA1645, WDR14: Guanine nucleotide-binding protein subunit b 0.050 0.050
NUTF2 NUTF2, NTF2: Nuclear transport factor 2 0.047 0.059
WDR48 WDR48, KIAA1449: WD repeat-containing protein 48 0.044 0.044
TTF2 TTF2: Transcription termination factor 2 0.044 0.044
EML3 EML3: Echinoderm microtubule-associated protein-like 3 0.044 0.074
DDX56 DDX56, DDX21, NOH61: Probable ATP-dependent RNA helicase DDX56 0.044 0.044
DDX52 DDX52, ROK1, HUSSY-19: Probable ATP-dependent RNA helicase DDX52 0.044 0.036
THRAP5 MED16, DRIP92, THRAP5: Mediator of RNA polymerase II transcription subunit 16 0.044 0.060
AAMP AAMP: Angio-associated migratory cell protein 0.044 0.074
LGP2 DHX58, D11LGP2E, LGP2: Probable ATP-dependent RNA helicase DHX58 0.044 0.044
CORO1A CORO1A, CORO1: Coronin-1A 0.044 0.060
REV3L REV3L, POLZ, REV3: DNA polymerase zeta catalytic subunit 0.041 0.041
ARPC1A ARPC1A, SOP2L: Actin-related protein 2/3 complex subunit 1A 0.036 0.044
DDX58 DDX58: Probable ATP-dependent RNA helicase DDX58 0.036 0.044
SETDB1 SETDB1, KIAA0067: Histone-lysine N-methyltransferase SETDB1 0.036 0.036
NBEAL2 N/A 0.036 0.060
WDR42A N/A 0.036 0.044
EIF4A2 EIF4A2, DDX2B, EIF4F: Eukaryotic initiation factor 4A-II 0.036 0.044
WDR37 N/A 0.036 0.044
CETN2 CETN2, CALT, CEN2: Centrin-2 0.036 0.028
WDR45L N/A 0.036 0.044
PARN PARN, DAN: Poly(A)-specific ribonuclease PARN 0.036 0.044
POLG POLG, MDP1, POLG1, POLGA: DNA polymerase subunit gamma-1 0.0331 0.055
RNASEH1 RNASEH1, RNH1: Ribonuclease H1 0.0331 0.055
WDR13 WDR13: WD repeat-containing protein 13 0.0308 0.050
TLE4 TLE4: TLE4 protein 0.028 0.036
KATNB1 KATNB1: Katanin p80 WD40-containing subunit B1 0.028 0.028
PEX7 PEX7, PTS2R: Peroxisomal targeting signal 2 receptor 0.028 0.028
ILF2 ILF2, NF45, PRO3063: Interleukin enhancer-binding factor 2 0.027 0.027
DKFZP586L0724 NOL11, L14: Nucleolar protein 11 0.027 0.027
NOL7 NOL7, C6orf90, NOP27: Nucleolar protein 7 0.027 0.027
XTP3TPA XTP3TPA, CDA03: XTP3-transactivated gene A protein 0.027 0.027
HNRPD N/A 0.027 0.027
BRWD2 BRWD2, WDR11, WDR15: Bromodomain and WD repeat-containing protein 2 0.027 0.0331
LBR LBR: Lamin-B receptor 0.027 0.027
WDR53 N/A 0.027 0.027
ERCC8 ERCC8, CKN1, CSA: DNA excision repair protein ERCC-8 0.027 0.027
DDX53 DDX53, CAGE: Probable ATP-dependent RNA helicase DDX53 0.027 0.027
WDR34 N/A 0.027 0.027
TLE6 TLE6: Transducin-like enhancer protein 6 0.027 0.027
TAF5L TAF5L, PAF65B: TAF5-like RNA polymerase II p300/CBP-associated factor-associated 0.027 0.027
FBXW8 FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6: F-box/WD repeat-containing protein 8 0.027 0.027
WDR72 N/A 0.027 0.027
REXO1L1 REXO1L1, GOR: Exonuclease GOR 0.027 0.027
FLJ12671 ISG20L2, HSD38, HSD-38: Interferon-stimulated 20 kDa exonuclease-like 2 0.027 0.027
BRWD1 N/A 0.027 0.027
PHF1 N/A 0.027 0.027
TREX1 TREX1: Three prime repair exonuclease 1 0.027 0.027
NEDD1 N/A 0.027 0.027
WDR17 N/A 0.027 0.027
RFWD2 RFWD2, COP1, RNF200: E3 ubiquitin-protein ligase RFWD2 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
TDRD4 TDRD4: Tudor domain-containing protein 4 0.027 0.027
KIF21A N/A 0.027 0.027
SNRPB N/A 0.0258 0.0258
0.572
Total Score 1.58E5