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Evidence of Interaction Between PSMA2 and PSMA4

The interaction score between PSMA2 and PSMA4 is 4.74E5.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PSMA2 and PSMA4 = 0.93

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.082
Orthology
OrganismPSMA2 OrthologuePSMA4 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YML092C 1 YGR135W 1
  • Y2H
  • Other
  • AffinityCaptureMS

Get References From PubMed
worm Q27488 1 Q9N599 1
fly P40301 1 P18053 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in PSMA2 and PSMA4:
Domains in PSMA2Domains in PSMA4
IPR001353 20S proteasome, A and B subunits
IPR000426 Proteasome alpha-subunit
IPR000243 Peptidase T1A, proteasome beta-subunit
IPR001353 20S proteasome, A and B subunits
IPR000426 Proteasome alpha-subunit

The Chi square scores for co-occurrence of domains that are present in PSMA2 and PSMA4 are listed below.

Domain 1Domain 2Chi Square
IPR001353 20S proteasome, A and B subunits IPR000426 Proteasome alpha-subunit 1084.67
IPR000426 Proteasome alpha-subunit IPR000243 Peptidase T1A, proteasome beta-subunit 998.751
IPR001353 20S proteasome, A and B subunits IPR001353 20S proteasome, A and B subunits 972.655
IPR001353 20S proteasome, A and B subunits IPR000243 Peptidase T1A, proteasome beta-subunit 960.483
IPR000426 Proteasome alpha-subunit IPR000426 Proteasome alpha-subunit 78.5459

The background colour of the table refers to:

  • Blue Domain is only present in PSMA2
  • Yellow Domain is only present in PSMA4
  • Green Domain is present in both PSMA2 and PSMA4

 0.265
Post-translational Modifications

Protein: PSMA2

PTMResidueReference
Phosphotyrosine 23 HPRD
Phosphotyrosine 97 HPRD

Protein: PSMA4

PTMResidueReference
Localisation

Protein: PSMA2

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: PSMA4

LocalisationReference
ER HPRD
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between PSMA2 and PSMA4 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PSMA2 andPSMA4. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PSMA2 has 927 interactors and PSMA4 has 196 interactors of which there are 165 common interactors.

Common InteractorName of Common InteractorScore for PSMA2-Interactor (?)Score for PSMA4-Interactor (?)
PSMA5 PSMA5: Proteasome subunit alpha type-5 1.02E4 2.07E3
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 3.41E3 691.00
PSMA7 PSMA7: Proteasome subunit alpha type-7 1.64E3 323.00
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 1.59E3 691.00
PSMB1 PSMB1, PSC5: Proteasome subunit beta type-1 precursor 691.00 691.00
PSMB2 PSMB2: Proteasome subunit beta type-2 691.00 691.00
PSMB6 PSMB6, LMPY: Proteasome subunit beta type-6 precursor 323.00 323.00
PSMA8 PSMA8, PSMA7L: Proteasome subunit alpha type-7-like 319.00 12.60
PSMA6 PSMA6, PROS27: Proteasome subunit alpha type-6 195.00 323.00
PSMB3 PSMB3: Proteasome subunit beta type-3 195.00 323.00
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 69.20 0.195
PSMB9 PSMB9, LMP2, RING12: Proteasome subunit beta type-9 precursor 31.70 31.70
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 10.50 1.01
PSMB8 PSMB8, DAQB-69D7.6-002, DASS-67H14.1-002, XXbac-BCX32M13.6-002, XXbac-BPG246D15. 5.60 0.221
PPP2CB PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 4.36 0.233
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 3.35 0.179
PSMB5 DKFZp686I0180: Putative uncharacterized protein DKFZp686I0180 (Fragment) 3.01 0.593
PSMA1 PSMA1, PROS30, PSC2: Proteasome subunit alpha type-1 2.91 2.91
PSMB4 N/A 1.82 1.82
PSMA1 N/A 1.79 0.354
CSNK2A1 CSNK2A1: CSNK2A1 protein 1.62 0.263
NULL RcPSMB3 (Fragment) 1.37 1.37
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.852 0.137
CDK4 CDK4: Cell division protein kinase 4 0.763 0.123
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.763 0.123
CDK7 CDK7, MO15: Cell division protein kinase 7 0.763 0.123
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.763 0.123
CTRL PSMB10, MECL1: Proteasome subunit beta type-10 precursor 0.666 0.666
PSMB4 PSMB4: Proteasome subunit beta type-4 precursor 0.617 0.0288
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.596 0.739
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.515 0.083
CDK2 CDK2: Cell division protein kinase 2 0.461 0.074
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.461 0.074
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.461 0.074
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.461 0.074
ROCK1 ROCK1: Rho-associated protein kinase 1 0.416 0.083
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.372 0.060
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.372 0.074
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.372 0.074
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.372 0.074
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.060
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.372 0.060
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.372 0.060
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.372 0.060
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.372 0.044
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.372 0.060
RPS6KB1 N/A 0.372 0.060
WEE1 WEE1: Wee1-like protein kinase 0.372 0.074
STK16 N/A 0.307 0.050
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.304 0.0968
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.275 0.044
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.275 0.044
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.275 0.044
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.275 0.044
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.044
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.275 0.036
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.044
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.275 0.060
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.275 0.060
PSMB5 PSMB5, LMPX: Proteasome subunit beta type-5 precursor 0.265 0.265
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.251 0.041
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.225 0.036
STK10 STK10: Uncharacterized protein STK10 0.225 0.044
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.225 0.044
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.225 0.028
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.225 0.036
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.225 0.036
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.225 0.036
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.225 0.044
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.225 0.044
PLK3 PLK3, CNK, FNK, PRK: Serine/threonine-protein kinase PLK3 0.225 0.225
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.191 0.041
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.191 0.041
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.191 0.0308
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.191 0.0308
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.191 0.041
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.191 0.0308
PLK2 PLK2, SNK: Serine/threonine-protein kinase PLK2 0.179 0.145
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.171 0.036
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.171 0.036
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.171 0.028
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.166 0.032
MAPKAPK5 N/A 0.165 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.165 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.165 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.165 0.027
MAPK15 N/A 0.165 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.165 0.027
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.165 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.165 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.165 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.165 0.027
PRKAA1 N/A 0.152 0.0308
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.152 0.0308
CDK6 CDK6: Cell division protein kinase 6 0.136 0.028
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.126 0.060
MELK MELK, KIAA0175: Maternal embryonic leucine zipper kinase 0.123 0.123
AURKB AURKB, AIK2, AIM1, ARK2, STK12: Serine/threonine-protein kinase 12 0.123 0.123
NULL N/A 0.119 0.119
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.103 0.067
VRK2 VRK2: Serine/threonine-protein kinase VRK2 0.0968 0.0968
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.093 0.044
LIMK2 LIMK2: LIM domain kinase 2 0.085 0.041
RIPK2 RIPK2, CARDIAK, UNQ277/PRO314/PRO34092, RICK, RIP2: Receptor-interacting serine/ 0.083 0.083
CSNK1G3 CSNK1G3: Casein kinase I isoform gamma-3 0.083 0.083
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.075 0.081
BUB1 0.074 0.074
BUB1B BUB1B, BUBR1, MAD3L: Mitotic checkpoint serine/threonine-protein kinase BUB1 bet 0.074 0.123
CSNK1A1 CSNK1A1: Casein kinase I isoform alpha 0.074 0.074
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.064 0.0308
RP6-213H19.1 MST4, MASK: Serine/threonine-protein kinase MST4 0.060 0.074
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.058 0.028
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.058 0.036
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.058 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.056 0.027
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.056 0.027
MAP2K5 N/A 0.056 0.027
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.056 0.027
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.053 0.027
CAMK2G Calcium/calmodulin-dependent protein kinase isoform A (Fragment) 0.050 0.050
TTK TTK, MPS1L1: Dual specificity protein kinase TTK 0.047 0.059
CLK3 CLK3: Dual specificity protein kinase CLK3 0.044 0.044
DYRK4 DYRK4: Dual specificity tyrosine-phosphorylation-regulated kinase 4 0.044 0.060
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.044 0.044
STK17A STK17A, DRAK1: Serine/threonine-protein kinase 17A 0.044 0.044
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.044 0.060
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.044 0.060
NEK2 NEK2, NLK1: Serine/threonine-protein kinase Nek2 0.044 0.044
CSNK1G2 CSNK1G2: Casein kinase I isoform gamma-2 0.044 0.060
MAP4K2 MAP4K2, GCK, RAB8IP: Mitogen-activated protein kinase kinase kinase kinase 2 0.044 0.044
EIF2AK1 N/A 0.041 0.041
DYRK2 DYRK2: Dual specificity tyrosine-phosphorylation-regulated kinase 2 0.041 0.041
ARAF ARAF, ARAF1, PKS, PKS2: A-Raf proto-oncogene serine/threonine-protein kinase 0.036 0.036
PRKX PRKX, PKX1: Serine/threonine-protein kinase PRKX 0.036 0.036
CSNK1D CSNK1D: Casein kinase I isoform delta 0.036 0.044
IRAK4 IRAK4: Interleukin-1 receptor-associated kinase 4 0.036 0.036
MAP4K5 MAP4K5: Mitogen-activated protein kinase kinase kinase kinase 5 0.036 0.044
ACVR2A ACVR2A, ACVR2: Activin receptor type-2A precursor 0.035 0.035
CDK9 CDK9, CDC2L4: Cell division protein kinase 9 0.035 0.047
ERN2 ERN2, IRE2: Serine/threonine-protein kinase/endoribonuclease IRE2 precursor 0.0331 0.027
VRK3 N/A 0.0308 0.041
PSMB8 PSMB8, LMP7, RING10, Y2: Proteasome subunit beta type-8 precursor 0.0288 0.0288
GAK GAK: Cyclin G-associated kinase 0.029 0.035
PCTK2 PCTK2: Serine/threonine-protein kinase PCTAIRE-2 0.028 0.036
WNK1 WNK1, KDP, KIAA0344, PRKWNK1: Serine/threonine-protein kinase WNK1 0.028 0.036
CSNK2A2 CSNK2A2, CK2A2: Casein kinase II subunit alpha' 0.028 0.036
PIM1 N/A 0.028 0.036
SERBP1 N/A 0.027 0.027
DGUOK N/A 0.027 0.027
MRPL22 MRPL22, HSPC158: 39S ribosomal protein L22, mitochondrial precursor 0.027 0.027
PTD004 N/A 0.027 0.027
BUB3 N/A 0.027 0.027
E2IG3 N/A 0.027 0.027
RTCD1 RTCD1, RPC, RPC1, RTC1: RNA 3'-terminal phosphate cyclase 0.027 0.027
HSPC185 CGI-117, HSPC111: UPF0384 protein CGI-117 0.027 0.027
EIF2AK3 EIF2AK3, PEK, PERK: Eukaryotic translation initiation factor 2-alpha kinase 3 pr 0.027 0.027
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
CDC2L2 N/A 0.027 0.027
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
0.572
Total Score 4.74E5