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Evidence of Interaction Between MCM7 and MCM2

The interaction score between MCM7 and MCM2 is 4.78E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MCM7 and MCM2 = 0.92

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.082
Orthology
OrganismMCM7 OrthologueMCM2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YBR202W 1 YBL023C 1
  • CoLocalization
  • CoPurification
  • CoFractionation

Get References From PubMed
worm O16297 1 Q9XXI9 1
fly Q9XYU0 1 P49735 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in MCM7 and MCM2:
Domains in MCM7Domains in MCM2
IPR003593 AAA ATPase
IPR001208 MCM
IPR008050 MCM protein 7
IPR008994 Nucleic acid-binding OB-fold
IPR001208 MCM
IPR008045 MCM protein 2

The Chi square scores for co-occurrence of domains that are present in MCM7 and MCM2 are listed below.

Domain 1Domain 2Chi Square
IPR001208 MCM IPR001208 MCM 364.867
IPR008050 MCM protein 7 IPR001208 MCM 315.618
IPR001208 MCM IPR008994 Nucleic acid-binding OB-fold 301.459
IPR008050 MCM protein 7 IPR008994 Nucleic acid-binding OB-fold 169.761
IPR003593 AAA ATPase IPR001208 MCM 127.202
IPR003593 AAA ATPase IPR008994 Nucleic acid-binding OB-fold 36.1462
IPR003593 AAA ATPase IPR008045 MCM protein 2 26.073

The background colour of the table refers to:

  • Blue Domain is only present in MCM7
  • Yellow Domain is only present in MCM2
  • Green Domain is present in both MCM7 and MCM2

 0.027
Post-translational Modifications

Protein: MCM7

PTMResidueReference

Protein: MCM2

PTMResidueReference
Phosphorylation 26 PubMed, HPRD
Phosphorylation 27 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 106 PubMed, HPRD
Phosphorylation 139 PubMed, HPRD
Phosphoserine 27 HPRD
Phosphoserine 41 HPRD
Phosphoserine 108 PubMed, HPRD
Phosphothreonine 106 HPRD
Localisation

Protein: MCM7

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD
Cytoplasm HPRD

Protein: MCM2

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD
Transitive Score

The common interactors between MCM7 and MCM2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MCM7 andMCM2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MCM7 has 165 interactors and MCM2 has 983 interactors of which there are 148 common interactors.

Common InteractorName of Common InteractorScore for MCM7-Interactor (?)Score for MCM2-Interactor (?)
MCM3 MCM3: DNA replication licensing factor MCM3 209.00 1.29E3
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 69.60 1.29E3
MCM5 MCM5, CDC46: DNA replication licensing factor MCM5 69.60 209.00
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 69.60 431.00
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 1.82 63.90
MCM6 MCM6: DNA replication licensing factor MCM6 0.789 69.60
PCNA PCNA: Proliferating cell nuclear antigen 0.789 0.827
MCM10 MCM10, PRO2249: Protein MCM10 homolog 0.593 0.593
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.293 0.852
CCNA2 CCNA2, CCN1, CCNA: Cyclin-A2 0.263 0.263
CCNB2 CCNB2: G2/mitotic-specific cyclin-B2 0.263 0.263
CCNB1 Cyclin B1 0.263 1.62
RFC4 RFC4: Replication factor C subunit 4 0.207 0.207
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.207 0.207
RFC5 RFC5: Replication factor C subunit 5 0.207 0.207
RFC3 RFC3: Replication factor C subunit 3 0.207 0.207
CDC45L CDC45L, CDC45L2, UNQ374/PRO710: CDC45-related protein 0.196 0.196
CCNF CCNF: G2/mitotic-specific cyclin-F 0.137 0.293
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.137 0.137
DNMT1 DNMT1, AIM, DNMT: DNA 0.137 0.515
ORC6L ORC6L: Origin recognition complex subunit 6 0.123 0.123
ORC2L ORC2L, ORC2: Origin recognition complex subunit 2 0.123 0.123
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.123 0.461
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.123 0.763
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 0.123 0.156
ABCE1 ABCE1, RLI, OK/SW-cl.40, RNASEL1, RNASELI, RNS4I: ATP-binding cassette sub-famil 0.123 0.123
RPA1 RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit 0.123 69.60
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.123 0.763
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.108 0.065
TAF9 AK6, AD-004, CGI-137: Adenylate kinase isoenzyme 6 0.108 0.108
PSMC3 PSMC3, TBP1: 26S protease regulatory subunit 6A 0.0968 0.0968
ATAD3A ATAD3A: ATPase family AAA domain-containing protein 3A 0.0968 0.0968
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.0968 0.503
POT1 POT1: Protection of telomeres protein 1 0.083 0.067
RB1 RB1: Retinoblastoma-associated protein 0.083 0.515
RFX5 RFX5: DNA-binding protein RFX5 0.083 0.067
C18orf56 N/A 0.082 0.082
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.074 0.461
CCNG1 CCNG1, CCNG, CYCG1: Cyclin-G1 0.074 0.060
XRCC3 XRCC3: DNA-repair protein XRCC3 0.074 0.074
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.074 0.372
MTA1 MTA1: Metastasis-associated protein MTA1 0.074 0.372
TFDP1 TFDP1, DP1: Transcription factor Dp-1 0.074 0.123
MRPS28 MRPS28, MRPS35, HSPC007: Mitochondrial 28S ribosomal protein S28 0.074 0.123
RP4-691N24.2 GINS1, KIAA0186, PSF1: DNA replication complex GINS protein PSF1 0.0739 0.0739
FEN1 FEN1, RAD2: Flap endonuclease 1 0.0739 0.144
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.067 0.515
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.067 0.307
POLR2G POLR2G: DNA-directed RNA polymerase II subunit RPB7 0.060 0.044
SCYE1 SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe 0.060 0.060
EIF1AX EIF1AX, EIF1A, EIF4C: Eukaryotic translation initiation factor 1A, X-chromosomal 0.060 0.060
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.060 0.372
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.060 0.074
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.060 0.372
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.060 0.372
RPS23 RPS23: 40S ribosomal protein S23 0.060 0.044
MDN1 MDN1, KIAA0301: Midasin 0.060 0.275
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.059 0.245
SRP54 SRP54: Signal recognition particle 54 kDa protein 0.059 0.059
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.059 0.304
RUVBL1 RUVBL1, NMP238, TIP49, TIP49A: RuvB-like 1 0.059 0.047
DARS DARS, PIG40: Aspartyl-tRNA synthetase, cytoplasmic 0.059 0.059
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.059 0.304
PSMC6 PSMC6, SUG2: 26S protease regulatory subunit S10B 0.059 0.059
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.059 0.304
SSBP1 SSBP1, SSBP: Single-stranded DNA-binding protein, mitochondrial precursor 0.055 0.0331
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.053 0.276
ADAR ADAR, ADAR1, DSRAD, G1P1, IFI4: Double-stranded RNA-specific adenosine deaminase 0.050 0.041
ELF1 ELF1: ETS-related transcription factor Elf-1 0.050 0.307
H1FX H1FX: Histone H1x 0.050 0.251
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.049 0.923
RUVBL2 RUVBL2, TIP48, CGI-46, TIP49B: RuvB-like 2 0.047 0.035
DVL2 DVL2: Segment polarity protein dishevelled homolog DVL-2 0.047 0.035
VCP VCP: Transitional endoplasmic reticulum ATPase 0.047 0.245
CCND3 CCND3: G1/S-specific cyclin-D3 0.044 0.036
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.044 0.275
CCNC CCNC: Cyclin-C 0.044 0.036
CUL2 CUL2: Cullin-2 0.044 0.126
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.044 0.275
E2F3 E2F3, KIAA0075: Transcription factor E2F3 0.044 0.044
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.044 0.225
GCLC GCLC, GLCL, GLCLC: Glutamate--cysteine ligase catalytic subunit 0.044 0.060
EIF1AY EIF1AY: Eukaryotic translation initiation factor 1A, Y-chromosomal 0.044 0.060
GTF2E2 GTF2E2, TF2E2: Transcription initiation factor IIE subunit beta 0.044 0.036
CSDA CSDA, DBPA: DNA-binding protein A 0.044 0.275
ERG ERG: Transcriptional regulator ERG 0.041 0.251
IRF3 IRF3: Interferon regulatory factor 3 0.041 0.191
OBFC1 OBFC1: Oligonucleotide/oligosaccharide-binding fold-containing protein 1 0.041 0.041
GTF2F2 N/A 0.041 0.251
IRF5 IRF5: Interferon regulatory factor 5 0.041 0.041
ELF4 ELF4, ELFR, MEF: ETS-related transcription factor Elf-4 0.041 0.0308
IRF4 IRF4, MUM1: Interferon regulatory factor 4 0.041 0.050
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.038 0.276
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.036 0.171
GABPA GABPA, E4TF1A: GA-binding protein alpha chain 0.036 0.036
DVL1 DVL1: Segment polarity protein dishevelled homolog DVL-1 0.036 0.028
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.036 0.225
H1F0 H1F0, H1FV: Histone H1.0 0.036 0.093
MYST3 MYST3, MOZ, RUNXBP2, ZNF220: Histone acetyltransferase MYST3 0.036 0.028
CCND2 CCND2: G1/S-specific cyclin-D2 0.036 0.044
NARS NARS, ASNS: Asparaginyl-tRNA synthetase, cytoplasmic 0.035 0.035
XAB1 XAB1, MBDIN, HUSSY-23: XPA-binding protein 1 0.0331 0.027
SRPR SRPR: Uncharacterized protein SRPR 0.032 0.166
IRF2 IRF2: Interferon regulatory factor 2 0.0308 0.0308
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.0308 0.251
ERF ERF: ETS domain-containing transcription factor ERF 0.0308 0.191
E2F2 E2F2: Transcription factor E2F2 0.0308 0.041
VPS4A VPS4A, VPS4: Vacuolar protein sorting-associating protein 4A 0.029 0.029
BCS1L BCS1L, BCS1: Mitochondrial chaperone BCS1 0.029 0.029
CCNH CCNH: Cyclin-H 0.028 0.171
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.028 0.275
CCNI CCNI: Cyclin-I 0.028 0.028
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.028 0.171
E2F5 E2F5: Transcription factor E2F5 0.028 0.028
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.028 0.171
PAX5 PAX5: Paired box protein Pax-5 0.028 0.028
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.028 0.171
DKFZp762E1312 FAKTS, FLEG1: 14-3-3-associated AKT substrate 0.027 0.027
GMNN GMNN: Geminin 0.027 0.053
TPX2 TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2 0.027 0.053
TACC3 TACC3, ERIC1: Transforming acidic coiled-coil-containing protein 3 0.027 0.053
RAD51AP1 N/A 0.027 0.027
HMMR HMMR: Hyaluronan-mediated motility receptor 0.027 0.027
DUT DUT: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor 0.027 0.027
GTSE1 GTSE1: G2 and S phase-expressed protein 1 0.027 0.053
KIAA0101 PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor 0.027 0.027
CDCA8 CDCA8, PESCRG3: Borealin 0.027 0.082
C22orf18 N/A 0.027 0.027
TMPO N/A 0.027 0.082
MCM10 N/A 0.027 0.027
SMC4L1 N/A 0.027 0.082
ZWINT N/A 0.027 0.082
ABCC4 ABCC4, MRP4: Multidrug resistance-associated protein 4 0.027 0.027
PRSS15 LONP1, PRSS15: Lon protease homolog, mitochondrial precursor 0.027 0.027
RPA3 RPA3, REPA3, RPA14: Replication protein A 14 kDa subunit 0.027 0.027
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.027 0.165
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.027 0.165
FOXQ1 FOXQ1, HFH1: Forkhead box protein Q1 0.027 0.027
HILS1 HILS1: Spermatid-specific linker histone H1-like protein 0.027 0.027
PAX3 PAX3, HUP2: Paired box protein Pax-3 0.027 0.027
C20orf116 C20orf116: Uncharacterized protein C20orf116 precursor 0.027 0.027
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.027 0.165
HSFY1 HSFY1, HSF2L, HSFY: Heat shock transcription factor, Y-linked 0.027 0.027
DNAH11 N/A 0.027 0.027
SPIC SPIC: Transcription factor Spi-C 0.027 0.027
ZCCHC17 ZCCHC17, PS1D, HSPC243, HSPC251, LDC4: Nucleolar protein of 40 kDa 0.027 0.027
ABCF2 ABCF2, HUSSY-18: ATP-binding cassette sub-family F member 2 0.027 0.027
IRF7 IRF7: Interferon regulatory factor 7 0.027 0.027
0.572
Total Score 4.78E4