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Evidence of Interaction Between DAZL and DND1

The interaction score between DAZL and DND1 is 0.043.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between DAZL and DND1 = 0.43

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 4.62E-3
Orthology N/A N/A
Domains Domains present in DAZL and DND1:
Domains in DAZLDomains in DND1
IPR000504 RNA-binding region RNP-1 (RNA recognition motif)
IPR012677 a_b_plait_nuc_bd.
IPR000504 RNA-binding region RNP-1 (RNA recognition motif)
IPR012677 a_b_plait_nuc_bd.

The Chi square scores for co-occurrence of domains that are present in DAZL and DND1 are listed below.

Domain 1Domain 2Chi Square
IPR000504 RNA-binding region RNP-1 (RNA recognition motif) IPR012677 a_b_plait_nuc_bd. 272.752
IPR012677 a_b_plait_nuc_bd. IPR012677 a_b_plait_nuc_bd. 261.323
IPR000504 RNA-binding region RNP-1 (RNA recognition motif) IPR000504 RNA-binding region RNP-1 (RNA recognition motif) 235.771

The background colour of the table refers to:

  • Blue Domain is only present in DAZL
  • Yellow Domain is only present in DND1
  • Green Domain is present in both DAZL and DND1

 0.027
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: DAZL

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: DND1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between DAZL and DND1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between DAZL andDND1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , DAZL has 74 interactors and DND1 has 197 interactors of which there are 48 common interactors.

Common InteractorName of Common InteractorScore for DAZL-Interactor (?)Score for DND1-Interactor (?)
ZCCHC14 ZCCHC14, KIAA0579: Zinc finger CCHC domain-containing protein 14 0.083 0.041
DAZ1 N/A 0.060 0.0308
DAZ1 DAZ2: Deleted in azoospermia protein 2 0.050 0.0308
GRLF1 N/A 0.050 0.041
NXF2 NXF2, TAPL2: Nuclear RNA export factor 2 0.047 0.039
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.041 0.067
IPO4 N/A 0.039 0.032
CSDA CSDA, DBPA: DNA-binding protein A 0.036 0.041
RANBP5 0.028 0.050
BRAP BRAP, RNF52: BRCA1-associated protein 0.028 0.067
SF3B4 SF3B4, SAP49: Splicing factor 3B subunit 4 0.028 0.067
BRPF1 BRPF1, BR140: Peregrin 0.028 0.067
LOC642558 FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1 0.027 0.027
SRrp35 SRRP35: 35 kDa SR repressor protein 0.027 0.027
ZGPAT N/A 0.027 0.027
PABPC5 PABPC5, PABP5: Polyadenylate-binding protein 5 0.027 0.027
MBD2 MBD2: Methyl-CpG-binding domain protein 2 0.027 0.027
U1SNRNPBP U1SNRNPBP: U1-snRNP binding protein homolog 0.027 0.027
ZCCHC5 ZCCHC5: Zinc finger CCHC domain-containing protein 5 0.027 0.027
ZCCHC17 ZCCHC17, PS1D, HSPC243, HSPC251, LDC4: Nucleolar protein of 40 kDa 0.027 0.027
ZCCHC7 ZCCHC7, HSPC086: Zinc finger CCHC domain-containing protein 7 0.027 0.027
RBMY1A1 RBMY1A1, RBM1, RBM2, YRRM1: RNA-binding motif protein, Y chromosome, family 1 me 0.027 0.027
DDX53 DDX53, CAGE: Probable ATP-dependent RNA helicase DDX53 0.027 0.027
BOLL BOLL, BOULE: Protein boule-like 0.027 0.027
POLDIP3 POLDIP3, KIAA1649, PDIP46: Polymerase delta-interacting protein 3 0.027 0.027
ACF ACF, ASP: APOBEC1 complementation factor 0.027 0.027
ZC3H8 ZC3H8, ZC3HDC8: Zinc finger CCCH domain-containing protein 8 0.027 0.027
UHMK1 UHMK1, KIS, KIST: Serine/threonine-protein kinase Kist 0.027 0.027
THOC4 THOC4, ALY, BEF: THO complex subunit 4 0.027 0.027
RBMY1H RBMY1C, YRRM: Y-chromosome RNA recognition motif protein (Fragment) 0.027 0.027
DUX4 FSHD, DUX4: Facioscapulohumeral muscular dystrophy 0.027 0.027
HNRPC HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2 0.027 0.027
KAT3 RBMXL1, DKFZp547N1117, RP4-531M19.2-001, hCG_23341: RNA-binding motif protein X- 0.027 0.027
SETBP1 N/A 0.027 0.027
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.027 0.027
RAVER1 RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1 0.027 0.027
ATXN2L ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein 0.027 0.027
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.027 0.027
MGC10433 MGC10433: Putative uncharacterized protein MGC10433 0.027 0.027
PTBP1 PTBP1, PTB: Polypyrimidine tract-binding protein 1 0.027 0.027
ZCCHC12 ZCCHC12: Zinc finger CCHC domain-containing protein 12 0.027 0.027
ZCCHC4 ZCCHC4: Zinc finger CCHC domain-containing protein 4 0.027 0.027
ZCCHC3 ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3 0.027 0.027
RALY RALY: RNA binding protein (Fragment) 0.027 0.027
ZC3HAV1 ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1 0.027 0.027
ZCCHC9 ZCCHC9: ZCCHC9 protein 0.027 0.027
RBPMS RBPMS: RNA-binding protein with multiple splicing 0.027 0.027
ZNF278 PATZ1, PATZ, RIAZ, ZBTB19, ZNF278, ZSG: POZ-, AT hook-, and zinc finger-containi 0.027 0.027
2.15E-3
Total Score 0.043