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Evidence of Interaction Between EPOR and SHC3

The interaction score between EPOR and SHC3 is 1.64.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPOR and SHC3 = -0.06

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology N/A N/A
Domains Domains present in EPOR and SHC3:
Domains in EPORDomains in SHC3
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR000980 SH2 motif
IPR006019 Phosphotyrosine interaction (PID or PI)
IPR006020 Phosphotyrosine interaction domain
IPR011993 PH_type.

The Chi square scores for co-occurrence of domains that are present in EPOR and SHC3 are listed below.

Domain 1Domain 2Chi Square
IPR002996 Cytkn_recept_B/G. IPR000980 SH2 motif 227.343
IPR003961 Fibronectin, type III IPR000980 SH2 motif 184.508
IPR003528 Long hematopoietin receptor, single chain IPR000980 SH2 motif 151.135
IPR009167 Erythropoietin receptor IPR000980 SH2 motif 38.4825
IPR003961 Fibronectin, type III IPR011993 PH_type. 3.27464
IPR003528 Long hematopoietin receptor, single chain IPR011993 PH_type. 0.89194
IPR002996 Cytkn_recept_B/G. IPR011993 PH_type. 0.141797

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in SHC3
  • Green Domain is present in both EPOR and SHC3

 0.021
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: SHC3

PTMResidueReference
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: SHC3

LocalisationReference
Cytoplasm HPRD
Transitive Score

The common interactors between EPOR and SHC3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andSHC3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and SHC3 has 346 interactors of which there are 148 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for SHC3-Interactor (?)
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.166 0.028
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.217
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 93.60
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.217
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.217
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.195
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.165 0.195
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.195
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 61.50
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 69.80
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 0.156
CRKL CRKL: Crk-like protein 0.126 7.56
GAB1 GAB1: GRB2-associated-binding protein 1 0.126 0.0308
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.145
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 207.00
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.123 0.115
INSR INSR: Insulin receptor precursor 0.123 61.50
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.128
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.039
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 0.145
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.027
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 0.265
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.027
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.027
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.126
NF2 NF2, SCH: Merlin 0.109 0.027
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.027
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.027
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 0.237
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 0.237
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.027
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 11.50
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.027
MAPK15 N/A 0.109 0.027
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 114.00
PSCD2 N/A 0.109 0.027
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 0.265
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.027
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.162
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.109 0.200
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.128
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.109 0.251
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 61.50
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.109 55.50
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.109 0.145
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.109 0.035
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 55.50
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 147.00
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.100 16.30
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 74.90
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 0.141
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 0.141
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.100 0.036
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.098 0.145
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.098 0.145
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.098 0.145
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 0.128
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.098 0.490
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.098 0.128
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.098 0.361
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.098 0.039
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 6.81
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 7.67
TLN2 TLN2: Uncharacterized protein TLN2 0.081 0.044
HCK N/A 0.081 67.50
SYK SYK: Tyrosine-protein kinase SYK 0.081 0.141
SPTAN1 N/A 0.0727 0.067
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 0.156
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 0.156
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.072 0.028
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 67.50
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 7.67
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.072 0.157
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.072 0.060
JAK1 0.072 0.141
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 0.197
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 6.81
ALK ALK: ALK tyrosine kinase receptor precursor 0.072 0.094
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 0.157
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.0308
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.0308
CSK CSK: Tyrosine-protein kinase CSK 0.072 0.141
PSD TYL: TYL protein 0.072 0.060
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.174
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.072 67.50
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 173.00
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 0.156
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 0.177
BMX N/A 0.072 0.244
LYN LYN: Tyrosine-protein kinase Lyn 0.072 0.141
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 9.04
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.067 0.156
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.028
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 7.56
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.044
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.065 0.028
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 0.197
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.065 0.036
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.065 0.044
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 0.197
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.036
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.065 0.036
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.062 0.032
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.056 0.028
FLT4 VEGFR3 long form 0.051 0.0258
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.0288
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.0288
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.0288
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.051 0.0258
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.0288
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.051 5.94
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.049 0.039
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.049 0.053
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.027
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.049 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 0.027
MAPKAPK5 N/A 0.049 0.027
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.027
MAP2K5 N/A 0.049 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.027
CNN2 CNN2: Calponin-2 0.049 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.049 0.027
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.046 0.032
SOS1 SOS1: Son of sevenless homolog 1 0.045 5.35
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.037 0.036
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.037 17.40
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.037 0.028
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.032 10.50
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.032 0.028
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.032 0.028
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.032 0.060
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.032 0.028
SH3GLB2 SH3GLB2, KIAA1848, PP578: SH3 domain GRB2-like protein B2 0.032 0.041
CDK5 CDK5: Cell division protein kinase 5 0.029 0.060
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.028
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.074
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.029 0.044
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.029 0.044
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.029 0.036
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 0.027 93.60
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
FGFR2 N/A 0.027 0.217
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.265
0.299
Total Score 1.64