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Evidence of Interaction Between EPOR and PIK3R2

The interaction score between EPOR and PIK3R2 is 7.40.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPOR and PIK3R2 = 0.07

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology N/A N/A
Domains Domains present in EPOR and PIK3R2:
Domains in EPORDomains in PIK3R2
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR008936 Rho GTPase activation protein
IPR001452 SH3
IPR000198 RhoGAP domain
IPR000980 SH2 motif
IPR001720 PI3 kinase, P85 regulatory subunit

The Chi square scores for co-occurrence of domains that are present in EPOR and PIK3R2 are listed below.

Domain 1Domain 2Chi Square
IPR002996 Cytkn_recept_B/G. IPR000980 SH2 motif 227.343
IPR003961 Fibronectin, type III IPR000980 SH2 motif 184.508
IPR003528 Long hematopoietin receptor, single chain IPR000980 SH2 motif 151.135
IPR009167 Erythropoietin receptor IPR000980 SH2 motif 38.4825
IPR003961 Fibronectin, type III IPR001452 SH3 15.104
IPR009167 Erythropoietin receptor IPR001452 SH3 4.09597
IPR003528 Long hematopoietin receptor, single chain IPR001452 SH3 3.64257
IPR002996 Cytkn_recept_B/G. IPR001452 SH3 0.0443172

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in PIK3R2
  • Green Domain is present in both EPOR and PIK3R2

 0.109
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: PIK3R2

PTMResidueReference
Phosphotyrosine 464 HPRD
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: PIK3R2

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between EPOR and PIK3R2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andPIK3R2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and PIK3R2 has 968 interactors of which there are 567 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for PIK3R2-Interactor (?)
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 3.59 0.152
CSH2 GH1: Somatotropin precursor 0.644 0.025
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.541 0.0416
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.340 0.049
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.253 0.043
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.251 0.033
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.210 0.026
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.072
CRLF3 N/A 0.191 0.029
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.166 0.111
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.166 0.088
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.166 0.088
CNTN1 CNTN1: Contactin-1 precursor 0.165 0.040
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.980
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.165 0.098
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.109
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.044
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.109
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.109
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.109
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.044
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 0.878
CNTN4 CNTN4: Contactin-4 precursor 0.165 0.040
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.044
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.109
FN1 N/A 0.165 0.109
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.109
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.980
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.109
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.109
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.980
BSG N/A 0.165 0.040
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.878
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.165 0.878
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.098
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.878
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.044
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.165 0.098
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.153 0.097
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.153 0.097
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 0.520
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 0.577
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.152 0.100
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.127 0.088
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 0.781
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.126 0.097
CD2AP CD2AP: CD2-associated protein 0.126 0.088
CRKL CRKL: Crk-like protein 0.126 0.097
RDX RDX: Radixin 0.126 0.136
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.126 0.033
GAB1 GAB1: GRB2-associated-binding protein 1 0.126 0.123
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.124 0.111
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.123 0.029
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.123 0.072
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.586
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 0.808
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.123 1.01
INSR INSR: Insulin receptor precursor 0.123 388.00
IL9R IL9R: Interleukin-9 receptor precursor 0.123 0.081
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.655
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.123 0.030
GHR GHR: Growth hormone receptor precursor 0.123 0.081
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.081
DCC DCC: Netrin receptor DCC precursor 0.123 0.030
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.123 0.067
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.123 0.0727
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.123 0.033
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 0.808
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.058
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.109 0.148
ELMO1 N/A 0.109 0.148
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.0688
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.109 0.148
ARHGEF7 N/A 0.109 0.148
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.165
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 1.30
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.148
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.165
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.109 0.148
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.109 0.148
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.165
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.483
NF2 NF2, SCH: Merlin 0.109 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.165
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.109 0.148
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.165
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 1.17
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 1.17
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.165
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.050
STAT3 0.109 0.148
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 0.148
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.165
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.109 0.148
MAPK15 N/A 0.109 0.165
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 1.17
PSCD2 N/A 0.109 0.165
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.109 0.148
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 1.05
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.050
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.109 0.148
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.109 0.148
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.109 0.148
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.109 0.148
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.148
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.109 0.148
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.165
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.109 0.148
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.731
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.109 0.731
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.577
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.065
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.109 0.065
ITGB4 N/A 0.109 0.029
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.109 0.902
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.0727
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 0.655
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.109 0.136
SORL1 SORL1: Sortilin-related receptor precursor 0.109 0.029
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.109 0.072
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.109 0.0407
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.109 0.030
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.109 0.100
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.065
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.109 0.520
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.109 0.808
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.109 0.046
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.109
PRLR PRLR: Prolactin receptor precursor 0.109 0.166
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.109 0.046
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 250.00
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.081
F3 F3: Tissue factor precursor 0.109 0.065
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.0727
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.109 0.090
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.109 0.073
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 315.00
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.105 0.081
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.110
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.100 0.088
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 1.07
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 0.770
STAM2 STAM2: Signal transducing adapter molecule 2 0.100 0.111
RPS6KB1 N/A 0.100 0.099
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 0.781
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.100 0.088
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.100 0.088
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.100 0.097
TLN1 TLN1: Uncharacterized protein TLN1 0.100 0.097
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.100 0.088
DOK1 DOK1: Docking protein 1 0.100 0.099
PLD2 PLD2: Phospholipase D2 0.100 0.097
NEO1 NEO1, NGN: Neogenin precursor 0.098 0.036
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.098 1.33
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.098 0.808
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.098 0.655
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 0.655
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.098 0.072
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.098 0.655
PTPRZ1 N/A 0.098 0.036
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.065
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.098 0.073
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.098 0.100
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.098 0.520
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.098 0.448
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.098 0.0407
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.096 0.030
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.091 0.033
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.091 0.099
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.091 0.123
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.091 0.111
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.087 0.029
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.148
KIR3DL1 N/A 0.083 0.109
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.083 0.040
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.083 0.098
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.083 0.044
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.109
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.083 0.109
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.044
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.083 0.109
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.081 0.088
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 0.099
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 0.099
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.109
TLN2 TLN2: Uncharacterized protein TLN2 0.081 0.225
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.191
RIN1 RIN1: Ras and Rab interactor 1 0.081 0.046
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.081 0.099
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.081 0.110
HCK N/A 0.081 0.694
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.081 0.088
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.081 0.111
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.081 0.099
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.081 0.097
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.081 0.078
DLG2 DLG2: Disks large homolog 2 0.081 0.057
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.081 0.033
SYK SYK: Tyrosine-protein kinase SYK 0.081 0.781
SORBS3 SORBS3, SCAM1: Vinexin 0.081 0.097
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.081 0.033
STK16 N/A 0.081 0.098
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.077 0.097
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.077 0.065
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.077 0.0727
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.075 0.136
CDK2 CDK2: Cell division protein kinase 2 0.075 0.111
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.075 0.111
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.075 0.088
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.075 0.033
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.075 0.099
WEE1 WEE1: Wee1-like protein kinase 0.075 0.111
SPTAN1 N/A 0.0727 0.152
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 0.781
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.072 0.111
MSN MSN: Moesin 0.072 0.078
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.072 0.099
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 0.694
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.072 0.093
FNBP1 N/A 0.072 0.099
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 0.694
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 0.099
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.072 0.088
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.072 0.872
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.072 0.225
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.072 0.111
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.072 0.110
JAK1 0.072 0.781
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 0.975
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.072 0.057
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.072 0.099
PLD1 PLD1: Phospholipase D1 0.072 0.136
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 0.099
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.191
ALK ALK: ALK tyrosine kinase receptor precursor 0.072 0.361
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 0.775
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.072 0.123
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.064
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.191
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.072 0.098
CSK CSK: Tyrosine-protein kinase CSK 0.072 0.781
PSD TYL: TYL protein 0.072 0.111
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.072 0.099
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.072 0.099
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.072 0.098
IRS1 IRS1: Insulin receptor substrate 1 0.072 0.109
CXorf9 N/A 0.072 0.088
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.072 0.109
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.072 0.191
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.072 0.088
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.072 0.136
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.975
PSCD4 PSCD4, CYT4: Cytohesin-4 0.072 0.099
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.072 0.099
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.072 0.781
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.072 0.098
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.072 0.033
TTN N/A 0.072 0.136
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 1.07
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.098
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 0.874
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 1.07
BMX N/A 0.072 2.42
LYN LYN: Tyrosine-protein kinase Lyn 0.072 0.781
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.072 0.098
VIL2 N/A 0.072 0.088
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.072 0.110
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.072 0.098
GAB2 N/A 0.072 0.109
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.0688 0.098
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.0688 0.098
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 0.098
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.067 0.177
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.171
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.065 0.111
APS SH2B2, APS: SH2B adapter protein 2 0.065 0.111
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 0.070
RASA3 RASA3: Ras GTPase-activating protein 3 0.065 0.097
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.171
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.065 0.097
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 1.98
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.065 0.098
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.065 0.171
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.065 0.111
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.065 0.088
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.065 0.098
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 1.20
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.171
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.065 0.099
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.065 0.111
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.058
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.062 0.0727
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.062 0.0453
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.0727
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.111
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.062 0.064
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.062 0.065
SELE SELE, ELAM1: E-selectin precursor 0.062 0.037
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.062 0.058
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.062 0.058
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.062 0.090
CD44 N/A 0.062 0.027
CDK4 CDK4: Cell division protein kinase 4 0.057 0.111
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.057 0.078
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.057 0.088
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.057 0.152
CDK6 CDK6: Cell division protein kinase 6 0.057 0.097
DYRK3 N/A 0.057 0.097
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.056 0.136
EGF EGF: Pro-epidermal growth factor precursor 0.055 0.029
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.055 0.029
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.055 0.0407
GPA33 GPA33: Cell surface A33 antigen precursor 0.055 0.033
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.055 0.065
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.026
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.055 0.072
MEP1B MEP1B: Meprin A subunit beta precursor 0.055 0.033
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.055 0.033
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.055 0.0727
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.055 0.0727
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.055 0.072
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.055 0.072
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.055 0.051
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.055 0.0407
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.058
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.055 0.037
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.055 0.051
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.055 0.065
LILRB1 N/A 0.055 0.065
CD7 CD7: T-cell antigen CD7 precursor 0.055 0.029
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.055 0.029
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.055 0.051
LDLR LDLR: Low-density lipoprotein receptor precursor 0.055 0.051
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.055 0.029
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.055 0.148
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.055 0.033
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.055 0.029
ITGB7 ITGB7: Integrin beta-7 precursor 0.055 0.029
PTPRA N/A 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.051 0.046
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.051 0.046
EPB41 EPB41, E41P: Protein 4.1 0.051 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.051 0.046
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.051 0.046
FLT4 VEGFR3 long form 0.051 1.37
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 1.53
CRK CRK: Proto-oncogene C-crk 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.051 0.046
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.051 0.046
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 1.53
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.617
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.051 0.553
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.617
GRB10 N/A 0.051 0.051
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.051 0.065
TP73 TP73, P73: Tumor protein p73 0.051 0.166
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.051 0.090
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.049 0.072
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.049 0.033
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.049 0.033
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.049 0.100
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.049 0.033
PVR PVR, PVS: Poliovirus receptor precursor 0.049 0.067
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.049 0.166
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.049 0.051
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.165
CDC2 CDC2: Cell division control protein 2 homolog 0.049 0.148
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.049 0.165
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.049 0.148
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 0.165
MAPKAPK5 N/A 0.049 0.165
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.052
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.049 0.047
PLAT PLAT: Tissue-type plasminogen activator precursor 0.049 0.030
EEF2K EEF2K: Elongation factor 2 kinase 0.049 0.148
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.056
ACTN4 ACTN4: Alpha-actinin-4 0.049 0.047
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.165
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.148
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.049 0.025
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.049 0.047
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.049 0.148
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.049 0.148
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.165
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.049 0.050
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.049 0.148
MAP2K5 N/A 0.049 0.056
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.049 0.148
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.165
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.049 0.148
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.165
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.049 0.148
CNN2 CNN2: Calponin-2 0.049 0.056
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.049 0.148
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.049 0.148
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.148
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.049 0.148
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.049 0.148
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.049 0.165
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.047 0.042
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.046 0.126
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.0453 0.088
FUBP1 N/A 0.0453 0.056
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.0453 0.099
DAB1 DAB1: Disabled homolog 1 0.0453 0.136
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.0453 0.088
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.037
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0453 0.099
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.0453 0.078
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.152
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0453 0.098
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.0453 0.058
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.045 0.081
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.045 0.0727
STAT2 STAT2: Signal transducer and activator of transcription 2 0.045 0.081
PLEK PLEK, P47: Pleckstrin 0.045 0.0727
SOS1 SOS1: Son of sevenless homolog 1 0.045 0.064
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.045 0.052
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.044 0.050
STAT4 STAT4: Signal transducer and activator of transcription 4 0.041 0.058
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.041 0.030
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.041 0.073
CENTA1 CENTA1: Centaurin-alpha 1 0.041 0.051
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.04 0.025
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.04 0.025
CDK7 CDK7, MO15: Cell division protein kinase 7 0.037 0.097
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.037 0.098
FLII FLII, FLIL: Protein flightless-1 homolog 0.037 0.031
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.037 0.031
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.037 0.097
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.037 0.111
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.037 0.099
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.037 0.097
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.037 0.191
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.037 0.111
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.088
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.037 0.099
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.037 0.056
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.037 0.225
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.037 0.097
NEDD4L NEDD4L, KIAA0439, NEDL3: E3 ubiquitin-protein ligase NEDD4-like protein 0.037 0.026
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.037 0.028
VASP VASP: Vasodilator-stimulated phosphoprotein 0.037 0.110
STK10 STK10: Uncharacterized protein STK10 0.037 0.078
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.037 0.078
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.037 0.033
F9 F9: Coagulation factor IX precursor 0.037 0.028
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.034
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.037 0.0296
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.037 0.098
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.037 0.045
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.037 0.111
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.037 0.111
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.037 0.111
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.036 0.026
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.0338 0.0273
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.034 0.098
PTGS1 PTGS1, COX1: Prostaglandin G/H synthase 1 precursor 0.034 0.034
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.034 0.098
CETN1 CETN1, CEN1, CETN: Centrin-1 0.034 0.036
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.034 0.098
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.033 0.037
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.032 0.035
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.032 0.035
C6 C6: Complement component C6 precursor 0.032 0.028
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.032 0.037
LCP1 LCP1, PLS2: Plastin-2 0.032 0.031
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.033
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.032 0.028
VWF VWF, F8VWF: von Willebrand factor precursor 0.032 0.037
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.032 0.037
FREQ FREQ, FLUP, NCS1: Neuronal calcium sensor 1 0.032 0.043
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.032 0.098
GRLF1 N/A 0.032 0.123
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.032 0.045
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.032 0.054
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.032 0.088
HPCA HPCA, BDR2: Neuron-specific calcium-binding protein hippocalcin 0.032 0.043
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.032 0.136
CHP CHP: Calcium-binding protein p22 0.032 0.035
C1S C1S: Complement C1s subcomponent precursor 0.032 0.025
S100A7 S100A7, PSOR1: Protein S100-A7 0.032 0.048
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.032 0.136
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.032 0.109
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.032 0.191
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.032 0.088
DAB2 DAB2, DOC2: Disabled homolog 2 0.032 0.111
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.032 0.097
PRKAA1 N/A 0.032 0.110
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.032 0.0296
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.032 0.099
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 0.099
PMP2 PMP2: Myelin P2 protein 0.032 0.056
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.098
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.032 0.171
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.032 0.111
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.032 0.086
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.032 0.037
ATM ATM: Serine-protein kinase ATM 0.032 0.099
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.032 0.111
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.035
GMIP GMIP: GEM-interacting protein 0.032 0.050
CDKL5 N/A 0.032 0.123
C1R C1R: Complement C1r subcomponent precursor 0.032 0.025
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.032 0.109
MYO3A MYO3A: Myosin IIIA 0.032 0.171
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.032 0.069
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.032 0.088
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.032 0.040
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.032 0.136
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.032 0.088
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.032 0.088
ACTN1 ACTN1: Alpha-actinin-1 0.032 0.031
DAPK2 DAPK2: Death-associated protein kinase 2 0.032 0.109
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.032 0.028
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.032 0.062
CDK5 CDK5: Cell division protein kinase 5 0.029 0.136
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.099
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.097
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.088
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.029 0.071
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.029 0.111
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.029 0.037
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.029 0.060
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.029 0.088
CNN3 CNN3: Calponin-3 0.029 0.109
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 0.171
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.029 0.111
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.111
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.029 0.094
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.029 0.136
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.088
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.029 0.136
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.029 0.111
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.029 0.037
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.028 0.044
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.028 0.098
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.028 0.044
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.028 0.109
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.028 0.109
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.109
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.028 0.098
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.109
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.028 0.109
ADCY6 ADCY6, KIAA0422: Adenylate cyclase type 6 0.028 0.044
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.028 0.044
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 0.027 0.195
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
FGFR2 N/A 0.027 0.217
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.265
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.025 0.026
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.025 0.058
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.025 0.081
ETS2 ETS2: Protein C-ets-2 0.025 0.065
0.228
Total Score 7.40