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Evidence of Interaction Between EPOR and STAM2

The interaction score between EPOR and STAM2 is 13.90.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPOR and STAM2 = 0.15

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.30E-3
Orthology N/A N/A
Domains Domains present in EPOR and STAM2:
Domains in EPORDomains in STAM2
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR001452 SH3
IPR000108 Neutrophil cytosol factor 2
IPR002014 VHS
IPR003903 Ubiquitin interacting motif
IPR003110 Phosphorylated immunoreceptor signaling ITAM

The Chi square scores for co-occurrence of domains that are present in EPOR and STAM2 are listed below.

Domain 1Domain 2Chi Square
IPR003961 Fibronectin, type III IPR001452 SH3 15.104
IPR003961 Fibronectin, type III IPR000108 Neutrophil cytosol factor 2 5.02275
IPR009167 Erythropoietin receptor IPR001452 SH3 4.09597
IPR003528 Long hematopoietin receptor, single chain IPR001452 SH3 3.64257
IPR003528 Long hematopoietin receptor, single chain IPR000108 Neutrophil cytosol factor 2 2.04175
IPR002996 Cytkn_recept_B/G. IPR000108 Neutrophil cytosol factor 2 0.332745
IPR002996 Cytkn_recept_B/G. IPR001452 SH3 0.0443172

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in STAM2
  • Green Domain is present in both EPOR and STAM2

 0.109
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: STAM2

PTMResidueReference
Phosphorylation 192 PubMed, HPRD
Phosphorylation 371 PubMed, HPRD
Phosphorylation 372 PubMed, HPRD
Phosphorylation 374 PubMed, HPRD
Phosphotyrosine 371 HPRD
Phosphotyrosine 374 HPRD
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: STAM2

LocalisationReference
Endosome HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between EPOR and STAM2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andSTAM2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and STAM2 has 1227 interactors of which there are 637 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for STAM2-Interactor (?)
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 3.59 0.152
PRL PRL: Prolactin precursor 0.644 0.051
CSH2 GH1: Somatotropin precursor 0.644 0.045
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.541 0.077
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.340 0.086
KEL KEL: Kell blood group glycoprotein 0.307 0.0453
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.253 0.035
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.251 0.100
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.210 0.166
HSP90AA1 Hsp89-alpha-delta-N 0.202 0.029
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.081
CRLF3 N/A 0.191 0.100
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.166 0.275
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.166 0.097
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.166 0.136
CNTN1 CNTN1: Contactin-1 precursor 0.165 0.098
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.109
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.165 0.044
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.109
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.109
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.109
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.044
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.109
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.109
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 0.098
CNTN4 CNTN4: Contactin-4 precursor 0.165 0.098
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.109
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.049
FN1 N/A 0.165 0.109
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.109
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.109
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.098
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.109
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.109
BSG N/A 0.165 0.098
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.098
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.165 0.098
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.098
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.098
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.109
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.165 0.098
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.153 0.086
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.153 0.069
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 0.073
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 0.064
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.152 0.081
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.127 0.069
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 82.20
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.126 0.171
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.126 0.045
CD2AP CD2AP: CD2-associated protein 0.126 0.136
CRKL CRKL: Crk-like protein 0.126 0.111
RDX RDX: Radixin 0.126 0.136
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.126 0.111
GAB1 GAB1: GRB2-associated-binding protein 1 0.126 0.191
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.124 0.029
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.124 0.086
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.123 0.072
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.123 0.126
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.064
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 0.064
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.123 0.073
INSR INSR: Insulin receptor precursor 0.123 0.073
IL9R IL9R: Interleukin-9 receptor precursor 0.123 0.072
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.064
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.123 0.090
GHR GHR: Growth hormone receptor precursor 0.123 0.100
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.081
DCC DCC: Netrin receptor DCC precursor 0.123 0.090
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.123 0.081
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.123 0.100
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.123 0.072
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 0.064
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.033
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.109 0.148
ELMO1 N/A 0.109 0.148
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.0688
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.109 0.075
ARHGEF7 N/A 0.109 0.148
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.165
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 0.165
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.148
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.165
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.109 0.148
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.109 0.148
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.165
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.062
NF2 NF2, SCH: Merlin 0.109 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.165
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.109 0.148
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.165
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 0.148
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 0.148
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.165
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.148
STAT3 0.109 0.148
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 0.148
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.165
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.109 0.148
MAPK15 N/A 0.109 0.165
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 0.148
PSCD2 N/A 0.109 0.165
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.109 0.148
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 0.165
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.148
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.109 0.148
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.109 0.148
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.109 0.148
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.109 0.148
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.148
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.109 0.148
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.165
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.109 0.075
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.081
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.109 0.072
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.073
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.065
TNC TNC, HXB: Tenascin precursor 0.109 0.064
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.109 0.072
ITGB4 N/A 0.109 0.072
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.109 0.081
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.0453
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 0.058
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.109 0.111
SORL1 SORL1: Sortilin-related receptor precursor 0.109 0.073
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.109 0.081
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.109 0.081
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.109 0.058
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.109 0.081
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.081
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.109 0.064
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.109 0.064
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.109 0.090
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.251
PRLR PRLR: Prolactin receptor precursor 0.109 0.100
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.109 0.058
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 0.090
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.100
F3 F3: Tissue factor precursor 0.109 0.032
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.057
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.109 0.064
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.109 0.090
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 0.064
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.105 0.065
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.109
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.100 0.111
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 0.136
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 0.171
RPS6KB1 N/A 0.100 0.171
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 0.136
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.100 0.136
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.100 0.171
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.100 0.097
TLN1 TLN1: Uncharacterized protein TLN1 0.100 0.136
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.100 0.139
DOK1 DOK1: Docking protein 1 0.100 0.171
PLD2 PLD2: Phospholipase D2 0.100 0.111
NEO1 NEO1, NGN: Neogenin precursor 0.098 0.073
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.098 0.064
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.098 0.064
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.098 0.064
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 0.073
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.098 0.100
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.098 0.064
PTPRZ1 N/A 0.098 0.058
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.065
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.098 0.073
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.098 0.081
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.098 0.073
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.098 0.058
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.098 0.0727
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.096 0.041
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.091 0.275
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.091 0.086
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.091 0.191
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.091 0.069
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.087 0.051
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.075
KIR3DL1 N/A 0.083 0.109
ATRN N/A 0.083 0.044
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.083 0.049
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.083 0.098
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.083 0.049
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.083 0.044
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.083 0.109
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.109
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.083 0.165
EDA N/A 0.083 0.049
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.109
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.083 0.109
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.081 0.111
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 0.088
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 0.171
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.152
TLN2 TLN2: Uncharacterized protein TLN2 0.081 0.088
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.152
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 0.0794
RIN1 RIN1: Ras and Rab interactor 1 0.081 0.111
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.081 0.136
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.081 0.123
HCK N/A 0.081 0.171
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.081 0.171
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.081 0.097
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.081 0.111
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.081 0.111
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.081 0.171
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.081 0.171
DLG2 DLG2: Disks large homolog 2 0.081 0.041
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.081 0.171
SYK SYK: Tyrosine-protein kinase SYK 0.081 0.136
SORBS3 SORBS3, SCAM1: Vinexin 0.081 0.171
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.081 0.191
STK16 N/A 0.081 0.191
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.077 0.139
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.077 0.081
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.077 0.100
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.077 0.037
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.075 0.086
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.075 0.029
CDK2 CDK2: Cell division protein kinase 2 0.075 0.069
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.075 0.086
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.075 0.086
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.075 0.114
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.075 0.086
WEE1 WEE1: Wee1-like protein kinase 0.075 0.114
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.074 0.032
SPTAN1 N/A 0.0727 0.110
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 0.097
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.072 0.099
MSN MSN: Moesin 0.072 0.136
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.072 0.171
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 0.111
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.072 0.111
FNBP1 N/A 0.072 0.136
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 0.171
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 0.136
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.072 0.111
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.072 0.098
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.072 0.111
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.072 0.088
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.072 0.191
JAK1 0.072 0.111
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 0.191
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.072 0.041
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.072 0.136
PLD1 PLD1: Phospholipase D1 0.072 0.136
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 0.136
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.097
ALK ALK: ALK tyrosine kinase receptor precursor 0.072 0.057
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 0.123
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.072 0.307
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.152
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.152
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.072 0.098
CSK CSK: Tyrosine-protein kinase CSK 0.072 0.136
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.072 0.041
PSD TYL: TYL protein 0.072 0.088
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.072 0.136
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.072 0.111
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.072 0.152
IRS1 IRS1: Insulin receptor substrate 1 0.072 0.152
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.072 0.045
CXorf9 N/A 0.072 0.136
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.072 0.191
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.072 0.152
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.072 0.152
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.072 0.111
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.123
PSCD4 PSCD4, CYT4: Cytohesin-4 0.072 0.136
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.072 0.111
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.072 0.097
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.072 0.152
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.072 0.046
TTN N/A 0.072 0.111
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.072 0.063
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 0.097
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.307
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 0.275
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 0.136
BMX N/A 0.072 0.123
LYN LYN: Tyrosine-protein kinase Lyn 0.072 0.171
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.072 0.191
VIL2 N/A 0.072 0.111
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.072 0.152
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.072 0.109
GAB2 N/A 0.072 0.109
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.0688 0.098
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.0688 0.044
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 0.098
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.067 0.036
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.088
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.065 0.136
APS SH2B2, APS: SH2B adapter protein 2 0.065 0.111
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 0.111
RASA3 RASA3: Ras GTPase-activating protein 3 0.065 0.111
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.088
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.065 0.097
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 0.152
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.065 0.307
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.065 0.088
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.065 0.088
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.065 0.111
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.065 0.123
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 0.191
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.088
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.065 0.097
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.065 0.088
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.073
MEP1A MEP1A: Meprin A subunit alpha precursor 0.062 0.029
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.062 0.100
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.100
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.044
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.062 0.029
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.062 0.126
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.062 0.113
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.062 0.033
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.062 0.033
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.062 0.029
CD44 N/A 0.062 0.046
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.061 0.113
CDK4 CDK4: Cell division protein kinase 4 0.057 0.069
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.057 0.069
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.057 0.086
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.057 0.077
CDK6 CDK6: Cell division protein kinase 6 0.057 0.086
DYRK3 N/A 0.057 0.233
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.056 0.049
EGF EGF: Pro-epidermal growth factor precursor 0.055 0.032
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.055 0.072
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.055 0.100
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.055 0.100
GPA33 GPA33: Cell surface A33 antigen precursor 0.055 0.081
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.055 0.100
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.081
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.055 0.100
MEP1B MEP1B: Meprin A subunit beta precursor 0.055 0.033
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.055 0.065
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.055 0.081
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.055 0.100
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.055 0.100
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.055 0.100
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.055 0.081
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.055 0.081
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.100
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.055 0.041
LILRB1 N/A 0.055 0.126
CD7 CD7: T-cell antigen CD7 precursor 0.055 0.072
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.055 0.100
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.055 0.126
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.055 0.100
LDLR LDLR: Low-density lipoprotein receptor precursor 0.055 0.033
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.055 0.100
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.055 0.029
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.055 0.033
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.055 0.100
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.055 0.100
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.051 0.046
RAPH1 N/A 0.051 0.051
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.051 0.046
C9orf88 N/A 0.051 0.051
EPB41 EPB41, E41P: Protein 4.1 0.051 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.051 0.046
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.051 0.046
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.051 0.046
FLT4 VEGFR3 long form 0.051 0.046
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 0.051 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.051 0.046
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.051 0.046
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
DLG1 DLG1: Disks large homolog 1 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 0.051 0.046
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.051
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.051 0.046
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.051
GRB10 N/A 0.051 0.051
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.051 0.046
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.051 0.046
NCAM1 N/A 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.051 0.041
TP73 TP73, P73: Tumor protein p73 0.051 0.081
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.051 0.148
ST8SIA4 ST8SIA4, PST, PST1, SIAT8D: CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransfe 0.051 0.032
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.0513 0.051
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.049 0.072
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.049 0.081
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.049 0.072
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.049 0.072
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.049 0.029
PVR PVR, PVS: Poliovirus receptor precursor 0.049 0.081
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.049 0.065
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.049 0.0727
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.083
CDC2 CDC2: Cell division control protein 2 homolog 0.049 0.075
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.049 0.052
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.083
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.049 0.075
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.049 0.075
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 0.083
MAPKAPK5 N/A 0.049 0.083
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.052
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.049 0.025
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.049 0.047
EEF2K EEF2K: Elongation factor 2 kinase 0.049 0.075
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.083
ACTN4 ACTN4: Alpha-actinin-4 0.049 0.047
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.165
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.148
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.049 0.062
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.049 0.025
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.049 0.148
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.049 0.075
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.049 0.075
PPEF1 N/A 0.049 0.052
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.083
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.049 0.075
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.049 0.075
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.049 0.0688
BMP1 N/A 0.049 0.030
MAP2K5 N/A 0.049 0.083
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.049 0.075
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.049 0.148
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.083
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.049 0.148
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.083
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.049 0.075
SNX3 N/A 0.049 0.075
CNN2 CNN2: Calponin-2 0.049 0.075
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.049 0.075
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.049 0.075
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.148
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.049 0.075
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.049 0.148
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.049 0.083
TNN TNN: Tenascin-N precursor 0.047 0.053
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.047 0.053
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.046 0.029
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.0453 0.111
FUBP1 N/A 0.0453 0.077
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.0453 0.056
DAB1 DAB1: Disabled homolog 1 0.0453 0.088
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.0453 0.069
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.077
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0453 0.111
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.0453 0.114
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.077
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0453 0.096
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.0453 0.029
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.0453 0.086
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.045 0.081
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.045 0.081
STAT2 STAT2: Signal transducer and activator of transcription 2 0.045 0.081
PLEK PLEK, P47: Pleckstrin 0.045 0.100
SOS1 SOS1: Son of sevenless homolog 1 0.045 0.090
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.045 0.073
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.0446 0.171
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.0446 0.114
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.0446 0.086
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.042 0.027
STAT4 STAT4: Signal transducer and activator of transcription 4 0.041 0.073
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.041 0.051
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.041 0.058
CENTA1 CENTA1: Centaurin-alpha 1 0.041 0.041
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.04 0.025
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.04 0.025
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.038 0.042
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.037 0.038
CDK7 CDK7, MO15: Cell division protein kinase 7 0.037 0.114
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.037 0.096
FLII FLII, FLIL: Protein flightless-1 homolog 0.037 0.054
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.037 0.060
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.037 0.111
CSPG2 N/A 0.037 0.0794
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.037 0.049
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.037 0.136
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.037 0.069
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.037 0.049
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.037 0.077
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.037 0.111
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.225
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.037 0.069
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.037 0.0308
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.037 0.069
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.037 0.056
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.037 0.056
NEDD4L NEDD4L, KIAA0439, NEDL3: E3 ubiquitin-protein ligase NEDD4-like protein 0.037 0.055
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.037 0.046
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.037 0.111
VASP VASP: Vasodilator-stimulated phosphoprotein 0.037 0.152
STK10 STK10: Uncharacterized protein STK10 0.037 0.069
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.037 0.086
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.037 0.096
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.048
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.037 0.056
C8A C8A: Complement component C8 alpha chain precursor 0.037 0.025
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.037 0.077
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.037 0.025
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.037 0.086
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.037 0.049
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.037 0.111
CSDA CSDA, DBPA: DNA-binding protein A 0.036 0.038
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.036 0.026
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0338 0.030
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.0338 0.030
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.034 0.044
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.034 0.044
LETM1 LETM1: Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial 0.034 0.047
CETN1 CETN1, CEN1, CETN: Centrin-1 0.034 0.036
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.034 0.098
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.033 0.0416
S100B S100B: Protein S100-B 0.032 0.031
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.032 0.0308
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.032 0.097
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.032 0.152
LCP1 LCP1, PLS2: Plastin-2 0.032 0.054
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.069
F12 F12: Coagulation factor XII precursor 0.032 0.051
VWF VWF, F8VWF: von Willebrand factor precursor 0.032 0.037
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.032 0.049
FREQ FREQ, FLUP, NCS1: Neuronal calcium sensor 1 0.032 0.028
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.032 0.152
MYL3 MYL3: Myosin light polypeptide 3 0.032 0.0308
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 0.032 0.0308
GRLF1 N/A 0.032 0.155
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.032 0.025
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.032 0.054
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.032 0.097
HPCA HPCA, BDR2: Neuron-specific calcium-binding protein hippocalcin 0.032 0.028
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.032 0.049
CHP CHP: Calcium-binding protein p22 0.032 0.035
S100A7 S100A7, PSOR1: Protein S100-A7 0.032 0.034
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.032 0.049
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.032 0.062
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.032 0.062
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.032 0.136
DAB2 DAB2, DOC2: Disabled homolog 2 0.032 0.097
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.032 0.069
PRKAA1 N/A 0.032 0.210
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.032 0.136
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.032 0.056
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 0.136
PMP2 PMP2: Myelin P2 protein 0.032 0.028
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.032 0.051
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.062
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.032 0.056
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.032 0.056
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.032 0.0308
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.032 0.044
ATM ATM: Serine-protein kinase ATM 0.032 0.056
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.032 0.056
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.048
GMIP GMIP: GEM-interacting protein 0.032 0.086
CDKL5 N/A 0.032 0.062
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.032 0.096
MYO3A MYO3A: Myosin IIIA 0.032 0.049
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.032 0.0308
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.032 0.069
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.032 0.069
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.032 0.069
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.032 0.056
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.032 0.056
ACTN1 ACTN1: Alpha-actinin-1 0.032 0.035
S100A3 S100A3, S100E: Protein S100-A3 0.032 0.039
DAPK2 DAPK2: Death-associated protein kinase 2 0.032 0.055
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.032 0.028
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.032 0.077
MTMR3 MTMR3, KIAA0371, ZFYVE10: Myotubularin-related protein 3 0.032 0.036
CDK5 CDK5: Cell division protein kinase 5 0.029 0.044
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.044
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.049
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.114
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.029 0.111
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.029 0.044
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.029 0.035
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.029 0.035
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.029 0.049
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.029 0.072
CNN3 CNN3: Calponin-3 0.029 0.049
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 0.056
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.029 0.056
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.088
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.029 0.037
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.029 0.097
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.029 0.043
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.069
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.029 0.088
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.029 0.049
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.028 0.044
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.028 0.098
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.028 0.044
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.028 0.044
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.028 0.049
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
ACE ACE, DCP, DCP1: Angiotensin-converting enzyme, somatic isoform precursor 0.028 0.044
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.028 0.049
SNAP23 SNAP23: Synaptosomal-associated protein 23 0.028 0.036
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.028 0.049
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.028 0.049
TMPRSS9 N/A 0.028 0.044
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.028 0.049
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.028 0.109
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.109
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.028 0.098
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.109
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.028 0.109
ADCY6 ADCY6, KIAA0422: Adenylate cyclase type 6 0.028 0.044
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.028 0.044
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.027 0.029
RACGAP1 RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1 0.027 0.038
THOC1 THOC1, HPR1: THO complex subunit 1 0.027 0.029
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.027 0.046
WWOX WWOX, FOR, WOX1: WW domain-containing oxidoreductase 0.0263 0.049
CIITA CIITA, MHC2TA: MHC class II transactivator 0.0263 0.026
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.025 0.090
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.025 0.041
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.025 0.0453
ETS2 ETS2: Protein C-ets-2 0.025 0.072
0.347
Total Score 13.90