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Evidence of Interaction Between EPOR and APS

The interaction score between EPOR and APS is 5.88.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPOR and APS = -0.13

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.48E-3
Orthology N/A N/A
Domains Domains present in EPOR and APS:
Domains in EPORDomains in APS
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR001849 Pleckstrin-like
IPR000980 SH2 motif
IPR011993 PH_type.

The Chi square scores for co-occurrence of domains that are present in EPOR and APS are listed below.

Domain 1Domain 2Chi Square
IPR002996 Cytkn_recept_B/G. IPR000980 SH2 motif 227.343
IPR003961 Fibronectin, type III IPR000980 SH2 motif 184.508
IPR003528 Long hematopoietin receptor, single chain IPR000980 SH2 motif 151.135
IPR009167 Erythropoietin receptor IPR000980 SH2 motif 38.4825
IPR003961 Fibronectin, type III IPR001849 Pleckstrin-like 7.30258
IPR003961 Fibronectin, type III IPR011993 PH_type. 3.27464
IPR003528 Long hematopoietin receptor, single chain IPR001849 Pleckstrin-like 2.94869
IPR003528 Long hematopoietin receptor, single chain IPR011993 PH_type. 0.89194
IPR002996 Cytkn_recept_B/G. IPR011993 PH_type. 0.141797
IPR002996 Cytkn_recept_B/G. IPR001849 Pleckstrin-like 0.0712315

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in APS
  • Green Domain is present in both EPOR and APS

 0.109
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: APS

PTMResidueReference
Phosphorylation 598 PubMed, HPRD
Phosphotyrosine 629 HPRD
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: APS

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between EPOR and APS that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andAPS. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and APS has 1316 interactors of which there are 670 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for APS-Interactor (?)
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 3.59 0.098
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.541 0.123
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.340 0.049
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.253 0.028
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.251 0.100
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.210 0.100
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.072
CRLF3 N/A 0.191 0.126
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.166 0.111
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.166 0.111
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.166 0.225
CNTN1 CNTN1: Contactin-1 precursor 0.165 0.098
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.980
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.165 0.098
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.109
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.109
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.109
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.109
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.109
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.109
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 0.878
CNTN4 CNTN4: Contactin-4 precursor 0.165 0.098
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.109
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.109
FN1 N/A 0.165 0.109
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.109
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.980
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.109
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.109
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.980
BSG N/A 0.165 0.098
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.878
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.165 0.878
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.098
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.878
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.109
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.165 0.098
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.153 0.111
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.153 0.111
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 0.577
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 0.577
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.152 0.081
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.127 0.225
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 0.874
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.126 0.136
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.126 0.045
CD2AP CD2AP: CD2-associated protein 0.126 0.171
CRKL CRKL: Crk-like protein 0.126 0.136
RDX RDX: Radixin 0.126 0.088
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.126 0.111
GAB1 GAB1: GRB2-associated-binding protein 1 0.126 0.191
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.124 0.029
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.124 0.111
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.123 0.072
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.123 0.072
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.655
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 0.655
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.123 0.577
INSR INSR: Insulin receptor precursor 0.123 0.577
IL9R IL9R: Interleukin-9 receptor precursor 0.123 0.126
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.808
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.123 0.064
GHR GHR: Growth hormone receptor precursor 0.123 0.100
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.100
DCC DCC: Netrin receptor DCC precursor 0.123 0.090
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.123 0.126
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.123 0.100
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.123 0.081
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 0.655
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.148
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.109 0.148
ELMO1 N/A 0.109 0.148
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.0688
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.109 0.148
ARHGEF7 N/A 0.109 0.148
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.165
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 1.30
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.165
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.165
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.109 0.148
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.109 0.148
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.165
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.483
NF2 NF2, SCH: Merlin 0.109 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.165
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.109 0.148
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.165
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 1.17
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 1.17
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.165
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.148
STAT3 0.109 0.165
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 0.148
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.165
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.109 0.148
MAPK15 N/A 0.109 0.165
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 1.17
PSCD2 N/A 0.109 0.165
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.109 0.148
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 1.30
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.165
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.109 0.148
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.109 0.148
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.109 0.148
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.109 0.148
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.148
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.109 0.148
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.165
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.109 0.148
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.731
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.109 0.581
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.902
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.072
TNC TNC, HXB: Tenascin precursor 0.109 0.058
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.109 0.072
ITGB4 N/A 0.109 0.072
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.109 0.581
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.081
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 0.520
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.109 0.136
SORL1 SORL1: Sortilin-related receptor precursor 0.109 0.100
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.109 0.100
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.109 0.100
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.109 0.058
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.109 0.126
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.100
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.109 0.655
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.109 0.808
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.109 0.064
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.191
PRLR PRLR: Prolactin receptor precursor 0.109 0.081
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.109 0.073
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 0.655
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.561
F3 F3: Tissue factor precursor 0.109 0.065
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.100
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.109 0.064
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.109 0.090
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 0.586
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.105 0.065
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.109
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.100 0.111
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 0.770
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 2.17
STAM2 STAM2: Signal transducing adapter molecule 2 0.100 0.111
RPS6KB1 N/A 0.100 0.136
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 1.35
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.100 0.111
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.100 0.225
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.100 0.225
TLN1 TLN1: Uncharacterized protein TLN1 0.100 0.171
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.100 0.225
DOK1 DOK1: Docking protein 1 0.100 0.136
PLD2 PLD2: Phospholipase D2 0.100 0.136
NEO1 NEO1, NGN: Neogenin precursor 0.098 0.090
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.098 0.808
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.098 0.808
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.098 1.13
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 0.655
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.098 0.072
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.098 0.655
PTPRZ1 N/A 0.098 0.073
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.072
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.098 0.064
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.098 0.561
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.098 0.577
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.098 0.655
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.098 0.081
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.096 0.064
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.091 0.111
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.091 0.136
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.091 0.123
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.091 0.171
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.087 0.026
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.148
KIR3DL1 N/A 0.083 0.109
CDH6 CDH6: Cadherin-6 precursor 0.083 0.049
DLK1 DLK1, DLK: Delta-like protein precursor 0.083 0.049
ATRN N/A 0.083 0.098
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.083 0.109
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.083 0.098
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.083 0.049
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.083 0.098
JAG2 JAG2: Jagged-2 precursor 0.083 0.044
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.083 0.109
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.109
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.083 0.109
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.049
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.083 0.109
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.081 0.171
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 0.097
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 0.171
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.109
TLN2 TLN2: Uncharacterized protein TLN2 0.081 0.111
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.191
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 0.063
RIN1 RIN1: Ras and Rab interactor 1 0.081 0.111
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.081 0.111
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.081 0.123
HCK N/A 0.081 0.874
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.081 0.225
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.081 0.111
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.081 0.026
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.081 0.171
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.081 0.111
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.081 0.111
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.081 0.136
DLG2 DLG2: Disks large homolog 2 0.081 0.046
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.081 0.171
SYK SYK: Tyrosine-protein kinase SYK 0.081 1.07
SORBS3 SORBS3, SCAM1: Vinexin 0.081 0.111
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.081 0.191
STK16 N/A 0.081 0.152
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.077 0.171
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.077 0.166
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.077 0.072
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.077 0.065
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.075 0.136
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.075 0.056
CDK2 CDK2: Cell division protein kinase 2 0.075 0.136
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.075 0.136
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.075 0.136
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.075 0.136
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.075 0.111
WEE1 WEE1: Wee1-like protein kinase 0.075 0.171
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.074 0.026
SPTAN1 N/A 0.0727 0.123
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 0.770
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.072 0.097
MSN MSN: Moesin 0.072 0.111
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.072 0.171
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 0.872
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.072 0.171
FNBP1 N/A 0.072 0.225
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 1.78
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 0.171
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.072 0.097
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.072 0.975
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.072 0.171
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.072 0.111
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.072 0.152
JAK1 0.072 0.874
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 1.50
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.072 0.046
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.072 0.171
PLD1 PLD1: Phospholipase D1 0.072 0.171
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 0.136
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.098
ALK ALK: ALK tyrosine kinase receptor precursor 0.072 0.445
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 0.975
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.072 0.123
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.152
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.251
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.072 0.123
CSK CSK: Tyrosine-protein kinase CSK 0.072 2.94
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.072 0.037
PSD TYL: TYL protein 0.072 0.111
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.072 0.097
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.072 0.171
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.072 0.515
IRS1 IRS1: Insulin receptor substrate 1 0.072 0.123
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.072 0.051
CXorf9 N/A 0.072 0.225
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.072 0.251
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.072 0.152
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.072 0.123
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.072 0.171
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.975
PSCD4 PSCD4, CYT4: Cytohesin-4 0.072 0.136
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.072 0.111
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.072 0.770
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.072 0.251
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.072 0.057
TTN N/A 0.072 0.111
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.072 0.051
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 0.770
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.072 0.037
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.072 0.037
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.251
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 0.874
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 1.78
BMX N/A 0.072 0.975
LYN LYN: Tyrosine-protein kinase Lyn 0.072 1.50
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.072 0.152
VIL2 N/A 0.072 0.171
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.072 0.123
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.072 0.123
GAB2 N/A 0.072 0.123
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.0688 0.098
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.0688 0.098
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 0.098
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.067 0.177
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.097
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.065 0.171
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 0.171
RASA3 RASA3: Ras GTPase-activating protein 3 0.065 0.111
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.097
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.065 0.088
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 1.20
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.065 0.109
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.065 0.111
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.065 0.111
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.065 0.171
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.065 0.307
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 1.50
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.111
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.065 0.111
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.065 0.111
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.090
MEP1A MEP1A: Meprin A subunit alpha precursor 0.062 0.033
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.062 0.081
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.062 0.032
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.126
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.062 0.037
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.111
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.062 0.029
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.062 0.090
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.062 0.081
SELE SELE, ELAM1: E-selectin precursor 0.062 0.032
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.062 0.051
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.062 0.072
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.062 0.065
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.062 0.090
CD44 N/A 0.062 0.032
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.061 0.041
CDK4 CDK4: Cell division protein kinase 4 0.057 0.136
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.057 0.136
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.057 0.136
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.057 0.152
CDK6 CDK6: Cell division protein kinase 6 0.057 0.097
DYRK3 N/A 0.057 0.088
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.056 0.136
F10 F10: Coagulation factor X precursor 0.055 0.029
EGF EGF: Pro-epidermal growth factor precursor 0.055 0.072
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.055 0.072
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.055 0.100
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.055 0.032
GPA33 GPA33: Cell surface A33 antigen precursor 0.055 0.081
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.055 0.166
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.126
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.055 0.274
ITGAE ITGAE: Integrin alpha-E precursor 0.055 0.091
MEP1B MEP1B: Meprin A subunit beta precursor 0.055 0.041
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.055 0.081
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.055 0.081
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.055 0.166
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.055 0.072
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.055 0.202
CDH5 CDH5: Cadherin-5 precursor 0.055 0.032
AREG AREG, SDGF: Amphiregulin precursor 0.055 0.032
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.055 0.072
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.055 0.100
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.055 0.0453
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.126
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.055 0.037
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.055 0.090
FAT2 FAT2, CDHF8, KIAA0811, MEGF1: Protocadherin Fat 2 precursor 0.055 0.033
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.055 0.073
LILRB1 N/A 0.055 0.100
UMOD UMOD: Uromodulin precursor 0.055 0.032
CD7 CD7: T-cell antigen CD7 precursor 0.055 0.072
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.055 0.126
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.055 0.100
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.055 0.274
CDH2 CDH2, CDHN, NCAD: Cadherin-2 precursor 0.055 0.029
LDLR LDLR: Low-density lipoprotein receptor precursor 0.055 0.033
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.055 0.202
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.055 0.064
NOTCH4 N/A 0.055 0.0453
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.055 0.041
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.055 0.026
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.055 0.075
ITGB7 ITGB7: Integrin beta-7 precursor 0.055 0.113
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.055 0.126
GNA12 GNA12: Guanine nucleotide-binding protein alpha-12 subunit 0.052 0.051
PTPRA N/A 0.051 0.051
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
PAPPA PAPPA: Pappalysin-1 precursor 0.051 0.051
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.051 0.046
RAPH1 N/A 0.051 0.051
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.051 0.046
C9orf88 N/A 0.051 0.051
EPB41 EPB41, E41P: Protein 4.1 0.051 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.051 0.046
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.051 0.046
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.051 0.046
FLT4 VEGFR3 long form 0.051 0.553
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 0.051 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.617
CRK CRK: Proto-oncogene C-crk 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.051 0.046
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.051 0.046
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
DLG1 DLG1: Disks large homolog 1 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.617
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 0.051 0.046
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.617
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.051 0.553
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.617
GRB10 N/A 0.051 0.051
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.051 0.046
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.051 0.046
NCAM1 N/A 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.051 0.073
TP73 TP73, P73: Tumor protein p73 0.051 0.081
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.051 0.073
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.0513 0.029
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.049 0.032
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.049 0.081
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.049 0.274
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.049 0.072
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.049 0.081
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.049 0.064
PVR PVR, PVS: Poliovirus receptor precursor 0.049 0.100
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.049 0.100
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.049 0.072
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.165
CDC2 CDC2: Cell division control protein 2 homolog 0.049 0.165
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.049 0.052
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.049 0.165
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.049 0.148
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 0.165
MAPKAPK5 N/A 0.049 0.165
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.052
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.049 0.025
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.049 0.047
PLAT PLAT: Tissue-type plasminogen activator precursor 0.049 0.030
EEF2K EEF2K: Elongation factor 2 kinase 0.049 0.165
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.165
ACTN4 ACTN4: Alpha-actinin-4 0.049 0.075
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.165
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.083
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.049 0.062
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.049 0.025
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.049 0.075
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.049 0.165
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.049 0.148
PPEF1 N/A 0.049 0.052
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.165
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.049 0.148
F7 F7: Coagulation factor VII precursor 0.049 0.030
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.049 0.148
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.049 0.0688
BMP1 N/A 0.049 0.030
MAP2K5 N/A 0.049 0.165
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.049 0.148
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.049 0.083
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.165
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.049 0.148
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.165
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.049 0.148
SNX3 N/A 0.049 0.047
CNN2 CNN2: Calponin-2 0.049 0.165
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.049 0.148
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.049 0.148
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.075
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.049 0.148
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.049 0.148
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.049 0.165
TSHR N/A 0.048 0.033
TNN TNN: Tenascin-N precursor 0.047 0.042
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.047 0.0338
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.046 0.065
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.0453 0.136
FUBP1 N/A 0.0453 0.096
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.0453 0.111
DAB1 DAB1: Disabled homolog 1 0.0453 0.111
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.0453 0.136
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.123
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0453 0.056
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.0453 0.111
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.152
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0453 0.191
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.0453 0.029
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.0453 0.111
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.045 0.072
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.045 0.072
STAT2 STAT2: Signal transducer and activator of transcription 2 0.045 0.126
PLEK PLEK, P47: Pleckstrin 0.045 0.166
SOS1 SOS1: Son of sevenless homolog 1 0.045 0.090
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.045 0.090
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.044 0.050
STAT4 STAT4: Signal transducer and activator of transcription 4 0.041 0.072
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.041 0.090
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.041 0.073
CENTA1 CENTA1: Centaurin-alpha 1 0.041 0.063
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.04 0.025
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.04 0.075
ITIH1 ITIH1, IGHEP1: Inter-alpha-trypsin inhibitor heavy chain H1 precursor 0.039 0.029
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.038 0.030
TBCE TBCE: Tubulin-specific chaperone E 0.037 0.029
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.037 0.038
CDK7 CDK7, MO15: Cell division protein kinase 7 0.037 0.136
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.037 0.123
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.037 0.039
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.037 0.111
CSPG2 N/A 0.037 0.045
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.037 0.0425
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.037 0.136
MUC2 MUC2, SMUC: Mucin-2 precursor 0.037 0.031
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.037 0.139
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.037 0.111
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.037 0.111
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.037 0.191
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.037 0.111
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.111
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.037 0.136
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.037 0.109
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.037 0.035
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.037 0.136
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.037 0.111
NEDD4L NEDD4L, KIAA0439, NEDL3: E3 ubiquitin-protein ligase NEDD4-like protein 0.037 0.060
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.037 0.041
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.037 0.114
VASP VASP: Vasodilator-stimulated phosphoprotein 0.037 0.152
STK10 STK10: Uncharacterized protein STK10 0.037 0.136
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.037 0.136
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.037 0.191
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.039
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.037 0.111
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.037 0.152
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.037 0.045
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.037 0.111
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.037 0.225
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.037 0.111
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.036 0.026
TK1 TK1: Thymidine kinase, cytosolic 0.036 0.026
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0338 0.0338
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.0338 0.053
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.034 0.098
PTGS1 PTGS1, COX1: Prostaglandin G/H synthase 1 precursor 0.034 0.034
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.034 0.098
LETM1 LETM1: Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial 0.034 0.036
CETN1 CETN1, CEN1, CETN: Centrin-1 0.034 0.036
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.034 0.098
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.033 0.0416
S100B S100B: Protein S100-B 0.032 0.034
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.032 0.035
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.032 0.050
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.032 0.307
LCP1 LCP1, PLS2: Plastin-2 0.032 0.086
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.171
VWF VWF, F8VWF: von Willebrand factor precursor 0.032 0.041
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.032 0.097
FREQ FREQ, FLUP, NCS1: Neuronal calcium sensor 1 0.032 0.0308
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.032 0.416
MYL3 MYL3: Myosin light polypeptide 3 0.032 0.0308
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 0.032 0.028
GRLF1 N/A 0.032 0.152
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.032 0.041
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.032 0.039
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.032 0.097
HPCA HPCA, BDR2: Neuron-specific calcium-binding protein hippocalcin 0.032 0.0308
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.032 0.191
CHP CHP: Calcium-binding protein p22 0.032 0.028
S100A7 S100A7, PSOR1: Protein S100-A7 0.032 0.039
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.032 0.097
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.032 0.109
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.032 0.152
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.032 0.111
DAB2 DAB2, DOC2: Disabled homolog 2 0.032 0.097
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.032 0.111
PRKAA1 N/A 0.032 0.109
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.032 0.136
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.032 0.171
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 0.171
PMP2 PMP2: Myelin P2 protein 0.032 0.097
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.032 0.046
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.191
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.032 0.225
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.032 0.111
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.032 0.097
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.032 0.136
ATM ATM: Serine-protein kinase ATM 0.032 0.111
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.032 0.097
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.034
GMIP GMIP: GEM-interacting protein 0.032 0.069
CDKL5 N/A 0.032 0.123
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.032 0.191
MYO3A MYO3A: Myosin IIIA 0.032 0.111
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.032 0.251
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.032 0.136
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.032 0.056
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.032 0.136
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.032 0.171
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.032 0.123
ACTN1 ACTN1: Alpha-actinin-1 0.032 0.044
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.032 0.046
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.032 0.041
S100A3 S100A3, S100E: Protein S100-A3 0.032 0.034
DAPK2 DAPK2: Death-associated protein kinase 2 0.032 0.152
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.032 0.035
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.032 0.060
CD82 CD82, KAI1, SAR2, ST6, TSPAN27: CD82 antigen 0.032 0.032
FRMD4A RP11-397C18.4, RP11-397C18.4-003: Novel protein 0.032 0.0308
SH3GLB2 SH3GLB2, KIAA1848, PP578: SH3 domain GRB2-like protein B2 0.032 0.0308
MDN1 MDN1, KIAA0301: Midasin 0.030 0.114
CDK5 CDK5: Cell division protein kinase 5 0.029 0.136
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.136
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.275
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.111
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.029 0.069
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.029 0.109
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.029 0.057
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.029 0.039
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.029 0.088
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.029 0.041
CNN3 CNN3: Calponin-3 0.029 0.098
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 0.275
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.029 0.136
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.111
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.029 0.057
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.029 0.041
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.029 0.109
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.029 0.041
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.029 0.028
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.136
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.029 0.111
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.029 0.136
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.029 0.037
PCDHA2 PCDHA2: Protocadherin alpha 2 precursor 0.028 0.049
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.028 0.044
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.028 0.044
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.028 0.036
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.028 0.044
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.028 0.049
APP APP, A4, AD1: Amyloid beta A4 protein precursor 0.028 0.098
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
DRD2 DRD2: D(2) dopamine receptor 0.028 0.049
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.028 0.049
TMPRSS9 N/A 0.028 0.049
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.028 0.049
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.028 0.109
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.028 0.109
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.109
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.028 0.044
MUCDHL MUPCDH, MUCDHL, UNQ2781/PRO7168: Mucin and cadherin-like protein precursor 0.028 0.049
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.109
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.028 0.109
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.028 0.098
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 0.027 0.195
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
FGFR2 N/A 0.027 0.217
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.265
CIITA CIITA, MHC2TA: MHC class II transactivator 0.0263 0.070
GNA15 GNA15, GNA16: Guanine nucleotide-binding protein alpha-15 subunit 0.026 0.0263
RHO RHO, OPN2: Rhodopsin 0.026 0.037
APLP2 APLP2, APPL2: Amyloid-like protein 2 precursor 0.026 0.064
FADD FADD, MORT1: Protein FADD 0.026 0.037
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.025 0.113
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.025 0.148
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.025 0.100
ETS2 ETS2: Protein C-ets-2 0.025 0.081
0.228
Total Score 5.88