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Evidence of Interaction Between EPOR and LCK

The interaction score between EPOR and LCK is 6.52.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPOR and LCK = -0.09

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology N/A N/A
Domains Domains present in EPOR and LCK:
Domains in EPORDomains in LCK
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR001452 SH3
IPR000980 SH2 motif

The Chi square scores for co-occurrence of domains that are present in EPOR and LCK are listed below.

Domain 1Domain 2Chi Square
IPR002996 Cytkn_recept_B/G. IPR000980 SH2 motif 227.343
IPR003961 Fibronectin, type III IPR000980 SH2 motif 184.508
IPR003528 Long hematopoietin receptor, single chain IPR000980 SH2 motif 151.135
IPR009167 Erythropoietin receptor IPR000980 SH2 motif 38.4825
IPR002996 Cytkn_recept_B/G. IPR008266 Tyrosine protein kinase, active site 29.0781
IPR003961 Fibronectin, type III IPR008266 Tyrosine protein kinase, active site 22.1621
IPR002996 Cytkn_recept_B/G. IPR001245 Tyrosine protein kinase 15.1473
IPR003961 Fibronectin, type III IPR001452 SH3 15.104
IPR003528 Long hematopoietin receptor, single chain IPR008266 Tyrosine protein kinase, active site 10.4494
IPR003961 Fibronectin, type III IPR001245 Tyrosine protein kinase 6.5864
IPR003528 Long hematopoietin receptor, single chain IPR001245 Tyrosine protein kinase 5.65936
IPR009167 Erythropoietin receptor IPR001452 SH3 4.09597
IPR003528 Long hematopoietin receptor, single chain IPR001452 SH3 3.64257
IPR009167 Erythropoietin receptor IPR008266 Tyrosine protein kinase, active site 1.98391
IPR003528 Long hematopoietin receptor, single chain IPR000719 Protein kinase 1.94307
IPR002996 Cytkn_recept_B/G. IPR000719 Protein kinase 1.43014
IPR009167 Erythropoietin receptor IPR000719 Protein kinase 0.93762
IPR009167 Erythropoietin receptor IPR001245 Tyrosine protein kinase 0.822994
IPR003961 Fibronectin, type III IPR000719 Protein kinase 0.712801
IPR002996 Cytkn_recept_B/G. IPR001452 SH3 0.0443172

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in LCK
  • Green Domain is present in both EPOR and LCK

 0.109
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: LCK

PTMResidueReference
Dephosphorylation 394 PubMed, HPRD
Dephosphorylation 505 PubMed, HPRD
Myristoylation 2 PubMed, HPRD
Palmitoylation 3 PubMed, HPRD
Palmitoylation 5 PubMed, HPRD
Phosphorylation 42 PubMed, HPRD
Phosphorylation 59 PubMed, HPRD
Phosphorylation 192 PubMed, HPRD
Phosphorylation 394 PubMed, HPRD
Phosphorylation 505 PubMed, HPRD
Phosphotyrosine 393 PubMed, HPRD
Phosphotyrosine 504 PubMed, HPRD
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: LCK

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between EPOR and LCK that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andLCK. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and LCK has 1670 interactors of which there are 677 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for LCK-Interactor (?)
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 3.59 0.109
SLC4A1 SLC4A1, AE1, DI, EPB3: Band 3 anion transport protein 0.923 0.0263
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.541 0.123
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.340 0.191
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.253 0.109
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.251 0.072
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.210 0.126
HSP90AA1 Hsp89-alpha-delta-N 0.202 0.077
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.0727
CRLF3 N/A 0.191 0.274
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.166 0.123
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.166 0.123
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.166 0.251
CNTN1 CNTN1: Contactin-1 precursor 0.165 0.109
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.980
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.165 0.109
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.109
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.109
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.109
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.109
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.109
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.109
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 0.980
CNTN4 CNTN4: Contactin-4 precursor 0.165 0.109
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.109
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.109
FN1 N/A 0.165 0.109
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.109
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.980
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.109
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.109
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.980
BSG N/A 0.165 0.109
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.980
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.165 0.980
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.109
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.980
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.109
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.165 0.109
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.153 0.152
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.153 0.152
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 0.644
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 0.644
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.152 0.065
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.127 0.191
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 1.20
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.126 0.191
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.126 0.041
CD2AP CD2AP: CD2-associated protein 0.126 0.191
CRKL CRKL: Crk-like protein 0.126 1.98
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.126 0.041
RDX RDX: Radixin 0.126 0.098
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.126 0.191
GAB1 GAB1: GRB2-associated-binding protein 1 0.126 0.098
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.125 0.032
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.124 0.026
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.124 0.123
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.123 0.065
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.123 0.0727
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.731
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 0.654
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.123 0.581
INSR INSR: Insulin receptor precursor 0.123 0.581
IL9R IL9R: Interleukin-9 receptor precursor 0.123 0.081
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.644
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.123 0.065
GHR GHR: Growth hormone receptor precursor 0.123 0.081
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.065
DCC DCC: Netrin receptor DCC precursor 0.123 0.065
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.123 0.065
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.123 0.081
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.123 0.072
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 0.654
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.166
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.109 0.165
ELMO1 N/A 0.109 0.165
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.0688
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.109 0.165
ARHGEF7 N/A 0.109 0.165
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.165
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 1.30
ANGPTL6 AGF, UNQ152/PRO178, ANGPTL6, ARP5: Angiopoietin-related protein 6 precursor 0.109 0.034
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.165
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 1.30
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.109 0.165
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.109 0.165
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 1.30
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.540
NF2 NF2, SCH: Merlin 0.109 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 1.30
FGG FGG, PRO2061: Fibrinogen gamma chain precursor 0.109 0.034
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.109 0.165
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.165
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 1.30
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 1.30
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.165
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.165
STAT3 0.109 1.30
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 1.30
FCN3 FCN3, FCNH, HAKA1: Ficolin-3 precursor 0.109 0.034
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.165
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.109 0.165
MAPK15 N/A 0.109 0.165
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 1.30
PSCD2 N/A 0.109 0.165
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.109 0.165
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 1.30
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.165
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.109 0.165
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.109 1.30
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.109 0.165
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.109 0.165
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.165
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.109 0.165
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.165
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.109 0.165
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.654
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.109 0.654
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.644
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 3.59
TNC TNC, HXB: Tenascin precursor 0.109 0.065
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.109 0.202
ITGB4 N/A 0.109 0.065
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.109 0.519
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.202
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 0.654
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.109 0.088
SORL1 SORL1: Sortilin-related receptor precursor 0.109 0.202
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.109 0.126
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.109 0.072
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.109 0.065
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.109 0.065
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.081
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.109 0.644
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.109 0.581
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.109 0.0727
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.123
PRLR PRLR: Prolactin receptor precursor 0.109 0.065
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.109 0.065
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 0.731
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.081
F3 F3: Tissue factor precursor 0.109 0.065
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.100
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.109 0.065
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.109 0.081
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 0.581
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.105 0.0727
CP CP: Ceruloplasmin precursor 0.100 0.046
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.307
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.100 2.42
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 0.775
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 0.975
STAM2 STAM2: Signal transducing adapter molecule 2 0.100 0.098
RPS6KB1 N/A 0.100 0.307
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 2.42
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.100 0.123
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.100 0.251
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.100 0.152
TLN1 TLN1: Uncharacterized protein TLN1 0.100 0.152
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.100 0.191
DOK1 DOK1: Docking protein 1 0.100 0.152
PLD2 PLD2: Phospholipase D2 0.100 0.109
NEO1 NEO1, NGN: Neogenin precursor 0.098 0.065
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.098 0.581
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.098 0.654
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.098 0.644
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 1.13
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.098 0.0727
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.098 0.644
PTPRZ1 N/A 0.098 0.065
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 1.19
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.098 0.0727
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.098 0.072
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.098 0.644
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.098 0.654
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.098 0.065
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.096 0.036
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.096 0.081
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.091 0.152
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.091 0.191
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.091 0.109
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.091 0.152
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.087 0.032
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.165
KIR3DL1 N/A 0.083 0.109
ATRN N/A 0.083 0.049
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.083 0.049
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.083 0.109
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.083 0.049
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.083 0.109
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.083 0.109
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.109
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.083 0.109
EDA N/A 0.083 0.049
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.109
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.083 0.109
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.081 0.191
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 14.30
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 1.98
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.098
TLN2 TLN2: Uncharacterized protein TLN2 0.081 0.110
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.859
F5 F5: Coagulation factor V precursor 0.081 0.041
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 0.051
RIN1 RIN1: Ras and Rab interactor 1 0.081 0.975
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.081 0.251
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.081 3.28
HCK N/A 0.081 0.975
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.081 0.251
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.081 0.152
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.081 0.077
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.081 0.191
FGL2 FGL2: Fibroleukin precursor 0.081 0.025
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.081 0.872
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.081 0.109
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.081 0.031
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.081 0.251
DLG2 DLG2: Disks large homolog 2 0.081 0.046
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.081 0.123
SYK SYK: Tyrosine-protein kinase SYK 0.081 1.20
SORBS3 SORBS3, SCAM1: Vinexin 0.081 0.098
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.081 0.152
STK16 N/A 0.081 0.191
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.077 0.152
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.077 0.274
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.077 0.100
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.077 0.037
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.075 0.123
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.075 0.096
CDK2 CDK2: Cell division protein kinase 2 0.075 0.191
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.075 0.152
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.075 0.251
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.075 0.152
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.075 0.251
WEE1 WEE1: Wee1-like protein kinase 0.075 0.123
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.074 0.0425
SPTAN1 N/A 0.0727 0.109
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 4.07
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.072 0.109
MSN MSN: Moesin 0.072 0.307
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.072 0.307
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 0.859
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.072 0.110
FNBP1 N/A 0.072 0.416
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 1.20
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 3.28
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.072 0.152
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.072 0.098
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.072 0.109
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.072 1.50
JAK1 0.072 3.28
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 0.859
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.072 0.041
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.072 0.307
PLD1 PLD1: Phospholipase D1 0.072 0.123
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 3.28
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.088
ALK ALK: ALK tyrosine kinase receptor precursor 0.072 0.355
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 0.975
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.072 0.098
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.098
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.098
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.072 3.28
CSK CSK: Tyrosine-protein kinase CSK 0.072 2.42
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.072 0.041
PSD TYL: TYL protein 0.072 0.109
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.072 0.191
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.072 0.852
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.072 0.123
IRS1 IRS1: Insulin receptor substrate 1 0.072 0.098
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.072 0.045
CXorf9 N/A 0.072 0.416
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.072 0.152
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.072 0.109
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.072 0.416
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.072 0.109
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.859
PSCD4 PSCD4, CYT4: Cytohesin-4 0.072 0.251
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.072 0.416
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.072 14.30
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.072 0.975
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.072 0.128
TTN N/A 0.072 0.109
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.072 0.041
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 0.693
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.072 0.041
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.072 0.041
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.191
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 0.859
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 0.859
BMX N/A 0.072 0.859
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.072 0.041
MFAP4 MFAP4: Microfibril-associated glycoprotein 4 precursor 0.072 0.025
LYN LYN: Tyrosine-protein kinase Lyn 0.072 1.20
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.072 0.152
VIL2 N/A 0.072 0.191
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.072 0.307
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.072 6.73
GAB2 N/A 0.072 0.109
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.0688 0.109
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.0688 0.109
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 0.980
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.067 0.197
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.110
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.065 0.109
APS SH2B2, APS: SH2B adapter protein 2 0.065 0.975
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 2.42
RASA3 RASA3: Ras GTPase-activating protein 3 0.065 0.416
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.110
F8 F8, F8C: Coagulation factor VIII precursor 0.065 0.041
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.065 0.098
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 0.859
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.065 0.191
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.065 0.098
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.065 0.123
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.065 0.191
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.065 0.123
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 0.975
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.110
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.065 0.307
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.065 0.098
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 2.46
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.062 0.202
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.062 0.072
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.274
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.515
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.062 0.065
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.062 0.126
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.062 0.072
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.062 0.126
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.062 0.033
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.062 0.126
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.062 0.072
CD44 N/A 0.062 0.057
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.061 0.057
CDK4 CDK4: Cell division protein kinase 4 0.057 0.152
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.057 0.416
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.057 0.251
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.057 0.123
CDK6 CDK6: Cell division protein kinase 6 0.057 0.109
DYRK3 N/A 0.057 0.098
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.056 0.123
EGF EGF: Pro-epidermal growth factor precursor 0.055 0.065
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.055 3.59
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.055 0.065
GPA33 GPA33: Cell surface A33 antigen precursor 0.055 0.126
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.055 0.081
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.274
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.055 0.036
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.055 0.081
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.055 0.202
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.055 0.100
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.055 0.081
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.055 0.072
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.055 0.202
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.055 0.065
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.055 0.072
CD69 CD69: Early activation antigen CD69 0.055 0.0446
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.274
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.055 0.065
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.055 0.032
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.055 0.166
LILRB1 N/A 0.055 0.081
CD7 CD7: T-cell antigen CD7 precursor 0.055 0.340
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.055 0.274
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.055 0.081
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.055 0.072
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.055 0.100
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.055 0.065
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.055 0.072
ITGB7 ITGB7: Integrin beta-7 precursor 0.055 0.153
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.055 0.274
PTPRA N/A 0.051 0.051
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.617
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.617
PAPPA PAPPA: Pappalysin-1 precursor 0.051 0.051
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.051 0.051
RAPH1 N/A 0.051 0.051
ITIH3 ITIH3: Inter-alpha-trypsin inhibitor heavy chain H3 precursor 0.051 0.051
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.051 0.051
C9orf88 N/A 0.051 0.051
EPB41 EPB41, E41P: Protein 4.1 0.051 0.051
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.051 0.617
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.051 0.051
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.051 0.051
FLT4 VEGFR3 long form 0.051 0.617
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 0.051 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.617
CRK CRK: Proto-oncogene C-crk 0.051 0.617
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.051 0.617
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.051 0.051
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
DLG1 DLG1: Disks large homolog 1 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.617
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 0.051 0.051
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.617
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.051 0.617
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.617
GRB10 N/A 0.051 0.617
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.051 0.051
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.051 0.051
NCAM1 N/A 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.051 0.100
TP73 TP73, P73: Tumor protein p73 0.051 0.072
ST3GAL1 ST3GAL1, SIAT4, SIAT4A: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sia 0.051 0.036
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.051 0.731
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.0513 0.166
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.049 0.340
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.049 0.072
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.049 0.065
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.049 0.065
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.049 0.029
PVR PVR, PVS: Poliovirus receptor precursor 0.049 0.0727
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.049 0.0727
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.049 0.0727
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.165
CDC2 CDC2: Cell division control protein 2 homolog 0.049 0.165
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.049 0.165
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.049 0.165
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.049 0.165
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 0.165
MAPKAPK5 N/A 0.049 0.165
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.165
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.049 0.028
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.049 0.165
EEF2K EEF2K: Elongation factor 2 kinase 0.049 0.165
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.165
ACTN4 ACTN4: Alpha-actinin-4 0.049 0.165
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.165
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.165
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.049 0.0688
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.049 0.028
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.049 0.165
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.049 0.165
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.049 0.165
PPEF1 N/A 0.049 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.165
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.049 0.165
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.049 0.165
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.049 0.0688
MAP2K5 N/A 0.049 0.165
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.049 0.165
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.049 0.165
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.165
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.049 0.165
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.165
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.049 0.165
SNX3 N/A 0.049 0.165
CNN2 CNN2: Calponin-2 0.049 0.165
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.049 0.165
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.049 0.165
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.165
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.049 0.165
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.049 0.165
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.049 0.165
TSHR N/A 0.048 0.032
TNN TNN: Tenascin-N precursor 0.047 0.038
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.047 0.030
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.046 0.058
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.0453 0.123
FUBP1 N/A 0.0453 0.260
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.0453 0.251
DAB1 DAB1: Disabled homolog 1 0.0453 0.109
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.0453 0.152
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.123
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0453 0.515
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.0453 0.191
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.109
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0453 0.123
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.0453 0.0425
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.0453 0.123
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.045 0.644
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.045 5.04
ST6GAL1 ST6GAL1, SIAT1: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltrans 0.045 0.027
STAT2 STAT2: Signal transducer and activator of transcription 2 0.045 1.13
PLEK PLEK, P47: Pleckstrin 0.045 0.126
SOS1 SOS1: Son of sevenless homolog 1 0.045 0.202
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.045 5.04
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.0446 0.0425
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.044 0.056
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.044 0.0688
STAT4 STAT4: Signal transducer and activator of transcription 4 0.041 5.04
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.041 0.100
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.041 0.072
CENTA1 CENTA1: Centaurin-alpha 1 0.041 0.051
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.04 0.028
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.04 0.083
CDC20 CDC20: Cell division cycle protein 20 homolog 0.039 0.0453
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.039 0.037
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.038 0.0338
TBCE TBCE: Tubulin-specific chaperone E 0.037 0.026
COPA COPA: Coatomer subunit alpha 0.037 0.032
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.037 0.032
CDK7 CDK7, MO15: Cell division protein kinase 7 0.037 0.152
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.037 0.191
FLII FLII, FLIL: Protein flightless-1 homolog 0.037 0.080
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.037 0.191
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.037 0.123
CSPG2 N/A 0.037 0.045
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.037 0.032
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.037 0.123
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.037 0.416
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.037 0.515
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.037 0.109
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.037 0.109
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.037 0.109
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.191
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.037 0.251
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.037 0.055
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.037 0.251
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.037 0.110
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.037 0.152
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.037 0.045
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.037 0.152
VASP VASP: Vasodilator-stimulated phosphoprotein 0.037 0.191
STK10 STK10: Uncharacterized protein STK10 0.037 0.515
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.037 0.251
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.037 0.251
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.109
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.037 0.123
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.037 0.515
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.037 0.045
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.037 0.109
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.037 0.251
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.037 0.098
RRM2 RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2 0.036 0.026
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.036 0.026
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0338 0.034
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.0338 0.0782
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.034 0.109
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.034 0.109
LETM1 LETM1: Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial 0.034 0.109
CETN1 CETN1, CEN1, CETN: Centrin-1 0.034 0.109
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.034 0.109
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.033 0.307
NDP NDP: Norrin precursor 0.033 0.036
S100B S100B: Protein S100-B 0.032 0.109
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.032 0.123
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.032 0.098
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.032 0.416
LCP1 LCP1, PLS2: Plastin-2 0.032 0.307
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.191
VWF VWF, F8VWF: von Willebrand factor precursor 0.032 0.045
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.032 0.109
FREQ FREQ, FLUP, NCS1: Neuronal calcium sensor 1 0.032 0.110
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.032 0.307
MYL3 MYL3: Myosin light polypeptide 3 0.032 0.109
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 0.032 0.098
GRLF1 N/A 0.032 0.109
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.032 0.041
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.032 0.109
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.032 0.109
HPCA HPCA, BDR2: Neuron-specific calcium-binding protein hippocalcin 0.032 0.098
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.032 0.098
CHP CHP: Calcium-binding protein p22 0.032 0.109
S100A7 S100A7, PSOR1: Protein S100-A7 0.032 0.109
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.032 0.110
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.032 0.123
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.032 0.123
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.032 0.251
DAB2 DAB2, DOC2: Disabled homolog 2 0.032 0.109
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.032 0.109
PRKAA1 N/A 0.032 0.251
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.032 0.109
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.032 0.191
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 0.307
PMP2 PMP2: Myelin P2 protein 0.032 0.049
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.032 0.041
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.152
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.032 0.098
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.032 0.123
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.032 0.049
SPARC SPARC, ON: SPARC precursor 0.032 0.041
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.032 0.098
ATM ATM: Serine-protein kinase ATM 0.032 0.852
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.032 0.098
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.123
GMIP GMIP: GEM-interacting protein 0.032 0.251
CDKL5 N/A 0.032 0.098
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.032 0.152
MYO3A MYO3A: Myosin IIIA 0.032 0.098
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.032 0.062
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.032 0.123
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.032 0.251
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.032 0.098
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.032 0.191
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.032 0.109
ACTN1 ACTN1: Alpha-actinin-1 0.032 0.123
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.032 0.041
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.032 0.041
FSTL1 FSTL1, FRP: Follistatin-related protein 1 precursor 0.032 0.041
S100A3 S100A3, S100E: Protein S100-A3 0.032 0.098
DAPK2 DAPK2: Death-associated protein kinase 2 0.032 0.098
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.032 0.123
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.032 0.096
CD82 CD82, KAI1, SAR2, ST6, TSPAN27: CD82 antigen 0.032 0.037
TP53 TP53, P53: Cellular tumor antigen p53 0.031 0.061
MDN1 MDN1, KIAA0301: Midasin 0.030 0.052
CDK5 CDK5: Cell division protein kinase 5 0.029 0.109
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.191
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.123
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.152
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.029 0.098
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.029 0.098
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.029 0.045
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.029 0.098
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.029 0.098
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.029 0.041
CNN3 CNN3: Calponin-3 0.029 0.098
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 0.098
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.029 0.110
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.098
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.029 0.046
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.029 0.041
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.029 0.110
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.029 0.041
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.029 0.191
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.416
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.029 0.098
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.029 0.098
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.029 0.037
AQP4 AQP4: Aquaporin-4 0.028 0.04
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.028 0.049
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.028 0.109
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.028 0.049
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.028 0.049
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.028 0.049
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.028 0.049
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.028 0.04
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.028 0.049
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.028 0.049
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.028 0.049
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.028 0.049
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.028 0.109
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.028 0.109
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.109
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.028 0.109
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.109
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.028 0.04
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.028 0.109
ADCY6 ADCY6, KIAA0422: Adenylate cyclase type 6 0.028 0.049
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.028 0.049
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 0.027 0.217
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
FGFR2 N/A 0.027 0.217
TJP1 TJP1, ZO1: Tight junction protein ZO-1 0.027 0.027
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.265
PIM1 N/A 0.027 0.0308
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.027 0.026
RACGAP1 RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1 0.027 0.026
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.027 0.052
THOC1 THOC1, HPR1: THO complex subunit 1 0.027 0.060
AQP1 AQP1, CHIP28: Aquaporin-1 0.027 0.031
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.027 0.026
RHO RHO, OPN2: Rhodopsin 0.026 0.029
FADD FADD, MORT1: Protein FADD 0.026 0.057
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.025 0.100
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.025 0.202
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.025 0.100
ETS2 ETS2: Protein C-ets-2 0.025 0.072
0.228
Total Score 6.52