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Evidence of Interaction Between EPOR and SPTA1

The interaction score between EPOR and SPTA1 is 3.11.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPOR and SPTA1 = 0.90

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.082
Orthology N/A N/A
Domains Domains present in EPOR and SPTA1:
Domains in EPORDomains in SPTA1
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR002048 Calcium-binding EF-hand
IPR001452 SH3
IPR000108 Neutrophil cytosol factor 2
IPR002017 Spectrin repeat
IPR011992 EF-Hand_type.
IPR013315 Spectrin_alpha.

The Chi square scores for co-occurrence of domains that are present in EPOR and SPTA1 are listed below.

Domain 1Domain 2Chi Square
IPR003961 Fibronectin, type III IPR001452 SH3 15.104
IPR002996 Cytkn_recept_B/G. IPR011992 EF-Hand_type. 9.08983
IPR003961 Fibronectin, type III IPR002048 Calcium-binding EF-hand 6.71206
IPR003961 Fibronectin, type III IPR000108 Neutrophil cytosol factor 2 5.02275
IPR009167 Erythropoietin receptor IPR001452 SH3 4.09597
IPR003528 Long hematopoietin receptor, single chain IPR001452 SH3 3.64257
IPR003528 Long hematopoietin receptor, single chain IPR000108 Neutrophil cytosol factor 2 2.04175
IPR003528 Long hematopoietin receptor, single chain IPR011992 EF-Hand_type. 0.995048
IPR002996 Cytkn_recept_B/G. IPR000108 Neutrophil cytosol factor 2 0.332745
IPR002996 Cytkn_recept_B/G. IPR001452 SH3 0.0443172
IPR003961 Fibronectin, type III IPR011992 EF-Hand_type. 0.00640738

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in SPTA1
  • Green Domain is present in both EPOR and SPTA1

 0.109
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: SPTA1

PTMResidueReference
Ubiquitination 1709 PubMed, HPRD
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: SPTA1

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD
Cytoskeleton HPRD
Transitive Score

The common interactors between EPOR and SPTA1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andSPTA1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and SPTA1 has 1294 interactors of which there are 644 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for SPTA1-Interactor (?)
SLC4A1 SLC4A1, AE1, DI, EPB3: Band 3 anion transport protein 0.923 0.472
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.541 0.923
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.340 0.260
TFRC TFRC: Transferrin receptor protein 1 0.307 0.074
KEL KEL: Kell blood group glycoprotein 0.307 0.125
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.253 0.430
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.251 0.126
OSBP2 C22:RP3-430N8.1-001: Oxysterol-binding protein 0.231 0.881
MPP1 MPP1, DXS552E, EMP55: 55 kDa erythrocyte membrane protein 0.231 0.270
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.210 0.082
HSP90AA1 Hsp89-alpha-delta-N 0.202 0.127
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.100
CRLF3 N/A 0.191 0.126
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.166 0.191
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.166 0.191
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.166 0.191
CNTN1 CNTN1: Contactin-1 precursor 0.165 0.044
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.109
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.165 0.049
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.109
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.044
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.109
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.049
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.109
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.044
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 0.109
CNTN4 CNTN4: Contactin-4 precursor 0.165 0.044
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.044
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.049
FN1 N/A 0.165 0.044
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.044
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.109
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.109
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.109
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.109
BSG N/A 0.165 0.044
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.109
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.165 0.109
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.109
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.109
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.044
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.165 0.109
GYPA GYPA, GPA: Glycophorin-A precursor 0.160 0.030
CAT CAT: Catalase 0.157 0.307
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.153 0.260
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.153 0.052
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 0.072
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 0.072
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.152 0.081
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.127 0.077
KLF1 KLF1, EKLF: Krueppel-like factor 1 0.126 0.472
TAL1 TAL1, SCL, TCL5: T-cell acute lymphocytic leukemia protein 1 0.126 1.32
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 0.191
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.126 0.152
CD2AP CD2AP: CD2-associated protein 0.126 0.077
CRKL CRKL: Crk-like protein 0.126 0.191
RDX RDX: Radixin 0.126 0.191
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.126 0.152
GAB1 GAB1: GRB2-associated-binding protein 1 0.126 0.191
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.125 0.036
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.125 0.052
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.124 0.0425
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.124 0.155
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.123 0.029
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.123 0.072
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.072
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 0.072
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.123 0.072
INSR INSR: Insulin receptor precursor 0.123 0.081
IL9R IL9R: Interleukin-9 receptor precursor 0.123 0.081
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.072
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.123 0.033
GHR GHR: Growth hormone receptor precursor 0.123 0.072
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.072
DCC DCC: Netrin receptor DCC precursor 0.123 0.081
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.123 0.033
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.123 0.072
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.123 0.081
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 0.081
UROD UROD: Uroporphyrinogen decarboxylase 0.111 0.923
CA1 CA1: Carbonic anhydrase 1 0.111 0.307
CA2 CA2: Carbonic anhydrase 2 0.111 0.161
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.029
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.109 0.165
ELMO1 N/A 0.109 0.165
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.109 0.083
ARHGEF7 N/A 0.109 0.165
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.165
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 0.165
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.165
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.056
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.109 0.165
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.109 0.165
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.165
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.0688
NF2 NF2, SCH: Merlin 0.109 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.165
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.109 0.165
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.165
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 0.165
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 0.165
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.165
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.165
STAT3 0.109 0.165
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 0.165
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.165
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.109 0.165
MAPK15 N/A 0.109 0.165
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 0.165
PSCD2 N/A 0.109 0.165
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.109 0.165
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 0.165
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.165
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.109 0.083
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.109 0.165
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.109 0.083
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.109 0.165
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.083
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.109 0.083
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.083
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.109 0.083
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.072
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.109 0.065
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.072
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.072
TNC TNC, HXB: Tenascin precursor 0.109 0.029
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.109 0.072
ITGB4 N/A 0.109 0.072
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.109 0.072
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.032
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 0.072
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.109 0.109
SORL1 SORL1: Sortilin-related receptor precursor 0.109 0.072
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.109 0.072
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.109 0.029
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.109 0.026
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.109 0.072
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.072
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.109 0.065
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.109 0.072
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.109 0.029
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.055
PRLR PRLR: Prolactin receptor precursor 0.109 0.072
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.109 0.029
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 0.072
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.072
F3 F3: Tissue factor precursor 0.109 0.032
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.029
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.109 0.072
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.109 0.072
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 0.065
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.105 0.166
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.123
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.100 0.123
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 0.152
FGB FGB: Fibrinogen beta chain precursor [Contains: Fibrinopeptide B] 0.100 0.025
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 0.123
STAM2 STAM2: Signal transducing adapter molecule 2 0.100 0.152
RPS6KB1 N/A 0.100 0.123
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 0.123
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.100 0.152
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.100 0.152
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.100 0.152
TLN1 TLN1: Uncharacterized protein TLN1 0.100 0.062
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.100 0.062
DOK1 DOK1: Docking protein 1 0.100 0.123
PLD2 PLD2: Phospholipase D2 0.100 0.123
NEO1 NEO1, NGN: Neogenin precursor 0.098 0.026
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.098 0.0727
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.098 0.065
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.098 0.065
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 0.065
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.098 0.065
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.098 0.065
PTPRZ1 N/A 0.098 0.029
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.072
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.098 0.065
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.098 0.072
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.098 0.065
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.098 0.072
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.098 0.026
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.096 0.057
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.091 0.307
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.091 0.127
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.091 0.307
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.091 0.096
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.087 0.124
SLC2A1 SLC2A1, GLUT1: Solute carrier family 2, facilitated glucose transporter member 1 0.087 0.037
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.083
KIR3DL1 N/A 0.083 0.109
ATRN N/A 0.083 0.049
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.083 0.044
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.083 0.109
JAG2 JAG2: Jagged-2 precursor 0.083 0.049
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.083 0.044
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.109
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.083 0.109
EDA N/A 0.083 0.049
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.109
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.083 0.109
GYPB GYPB, GPB: Glycophorin-B precursor 0.082 0.082
HBQ1 HBQ1: Hemoglobin subunit theta-1 0.082 0.082
ERAF AHSP, EDRF, ERAF: Alpha-hemoglobin-stabilizing protein 0.082 0.082
GLRX5 GLRX5, C14orf87: Glutaredoxin-related protein 5 0.082 0.082
ALAD ALAD: Delta-aminolevulinic acid dehydratase 0.082 0.082
TRAK2 TRAK2, ALS2CR3, KIAA0549: Trafficking kinesin-binding protein 2 0.082 0.082
XK XK, XKR1, XRG1: Membrane transport protein XK 0.082 0.082
HMBS HMBS, PBGD, UPS: Porphobilinogen deaminase 0.082 0.082
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.081 0.109
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 0.123
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 0.109
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.109
TLN2 TLN2: Uncharacterized protein TLN2 0.081 0.077
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.123
RIN1 RIN1: Ras and Rab interactor 1 0.081 0.109
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.081 0.109
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.081 0.037
HCK N/A 0.081 0.109
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.081 0.123
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.081 0.109
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.081 0.055
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.081 0.109
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.081 0.152
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.081 0.109
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.081 0.109
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.081 0.109
SYK SYK: Tyrosine-protein kinase SYK 0.081 0.109
SORBS3 SORBS3, SCAM1: Vinexin 0.081 0.062
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.081 0.055
STK16 N/A 0.081 0.0416
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.077 0.033
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.077 0.081
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.075 0.032
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.075 0.096
CDK2 CDK2: Cell division protein kinase 2 0.075 0.096
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.075 0.096
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.075 0.096
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.075 0.032
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.075 0.032
WEE1 WEE1: Wee1-like protein kinase 0.075 0.096
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.074 0.052
SPTAN1 N/A 0.0727 0.049
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 0.109
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.072 0.098
MSN MSN: Moesin 0.072 0.109
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.072 0.055
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 0.109
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.072 0.109
FNBP1 N/A 0.072 0.055
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 0.109
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 0.098
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.072 0.098
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.072 0.109
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.072 0.109
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.072 0.109
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.072 0.109
JAK1 0.072 0.109
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 0.109
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.072 0.055
PLD1 PLD1: Phospholipase D1 0.072 0.098
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 0.109
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.055
ALK ALK: ALK tyrosine kinase receptor precursor 0.072 0.045
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 0.098
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.072 0.109
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.109
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.123
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.072 0.109
CSK CSK: Tyrosine-protein kinase CSK 0.072 0.109
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.072 0.045
PSD TYL: TYL protein 0.072 0.109
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.072 0.109
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.072 0.109
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.072 0.055
IRS1 IRS1: Insulin receptor substrate 1 0.072 0.098
CXorf9 N/A 0.072 0.109
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.072 0.123
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.072 0.109
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.072 0.109
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.072 0.098
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.109
PSCD4 PSCD4, CYT4: Cytohesin-4 0.072 0.109
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.072 0.109
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.072 0.109
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.072 0.109
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.072 0.041
TTN N/A 0.072 0.109
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.072 0.045
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 0.109
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.109
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 0.109
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 0.109
BMX N/A 0.072 0.109
LYN LYN: Tyrosine-protein kinase Lyn 0.072 0.109
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.072 0.109
VIL2 N/A 0.072 0.109
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.072 0.055
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.072 0.109
GAB2 N/A 0.072 0.098
SLC7A5 SLC7A5, CD98LC, LAT1, MPE16: Large neutral amino acids transporter small subunit 0.070 0.0446
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.0688 0.109
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.0688 0.049
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 0.109
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.067 0.050
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.098
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.065 0.109
APS SH2B2, APS: SH2B adapter protein 2 0.065 0.098
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 0.098
RASA3 RASA3: Ras GTPase-activating protein 3 0.065 0.098
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.098
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.065 0.098
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 0.098
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.065 0.098
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.065 0.098
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.065 0.098
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.065 0.098
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.065 0.098
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 0.098
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.098
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.065 0.109
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.065 0.098
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.081
MEP1A MEP1A: Meprin A subunit alpha precursor 0.062 0.037
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.062 0.072
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.062 0.032
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.072
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.062 0.037
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.062 0.072
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.062 0.072
CD44 N/A 0.062 0.0263
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.061 0.057
H1F0 H1F0, H1FV: Histone H1.0 0.0594 0.111
EIF2AK1 N/A 0.057 0.049
CDK4 CDK4: Cell division protein kinase 4 0.057 0.077
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.057 0.077
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.057 0.077
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.057 0.026
CDK6 CDK6: Cell division protein kinase 6 0.057 0.062
DYRK3 N/A 0.057 0.096
EGF EGF: Pro-epidermal growth factor precursor 0.055 0.032
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.055 0.029
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.055 0.029
GPA33 GPA33: Cell surface A33 antigen precursor 0.055 0.029
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.055 0.029
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.029
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.055 0.072
ITGAE ITGAE: Integrin alpha-E precursor 0.055 0.0263
MEP1B MEP1B: Meprin A subunit beta precursor 0.055 0.032
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.055 0.029
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.055 0.029
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.055 0.029
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.055 0.072
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.055 0.072
CDH5 CDH5: Cadherin-5 precursor 0.055 0.032
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.055 0.026
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.055 0.029
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.072
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.055 0.032
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.055 0.032
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.055 0.032
LILRB1 N/A 0.055 0.072
CD7 CD7: T-cell antigen CD7 precursor 0.055 0.029
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.055 0.029
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.055 0.029
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.055 0.029
CDH2 CDH2, CDHN, NCAD: Cadherin-2 precursor 0.055 0.032
LDLR LDLR: Low-density lipoprotein receptor precursor 0.055 0.0263
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.055 0.029
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.055 0.072
NOTCH4 N/A 0.055 0.0263
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.055 0.0263
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.055 0.072
ITGB7 ITGB7: Integrin beta-7 precursor 0.055 0.032
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.055 0.029
TMCC2 TMCC2, KIAA0481, hucep-11: Transmembrane and coiled-coil domains protein 2 0.053 0.160
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.051 0.051
RAPH1 N/A 0.051 0.051
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.051 0.051
C9orf88 N/A 0.051 0.051
EPB41 EPB41, E41P: Protein 4.1 0.051 0.051
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.051 0.051
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.051 0.051
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.051 0.051
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 0.051 0.051
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.051
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.051 0.051
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.051
GRB10 N/A 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.051 0.037
TP73 TP73, P73: Tumor protein p73 0.051 0.081
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.051 0.072
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.0513 0.100
TPBG TPBG, 5T4: Trophoblast glycoprotein precursor 0.049 0.0263
SLITRK5 SLITRK5, KIAA0918, LRRC11: SLIT and NTRK-like protein 5 precursor 0.049 0.0263
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.049 0.072
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.049 0.029
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.049 0.026
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.049 0.072
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.049 0.029
PVR PVR, PVS: Poliovirus receptor precursor 0.049 0.026
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.049 0.072
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.049 0.026
RHCE RHCE, RHC, RHE: Blood group Rh(CE) polypeptide 0.049 0.027
BLVRB BLVRB, hCG_201414: Uncharacterized protein BLVRB 0.049 0.049
ERMAP ERMAP, RD, SC: Erythroid membrane-associated protein precursor 0.049 0.027
RHAG RHAG, RH50: Rhesus blood group-associated glycoprotein 0.049 0.027
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.028
CDC2 CDC2: Cell division control protein 2 homolog 0.049 0.083
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.049 0.165
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.028
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.049 0.028
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.049 0.028
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 0.028
MAPKAPK5 N/A 0.049 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.165
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.049 0.052
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.049 0.083
EEF2K EEF2K: Elongation factor 2 kinase 0.049 0.083
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.028
ACTN4 ACTN4: Alpha-actinin-4 0.049 0.165
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.165
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.056
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.049 0.0688
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.049 0.083
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.049 0.083
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.049 0.028
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.049 0.028
PPEF1 N/A 0.049 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.028
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.049 0.028
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.049 0.028
MAP2K5 N/A 0.049 0.083
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.049 0.028
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.049 0.083
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.028
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.049 0.165
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.083
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.049 0.028
SNX3 N/A 0.049 0.083
CNN2 CNN2: Calponin-2 0.049 0.165
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.049 0.028
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.049 0.083
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.165
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.049 0.028
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.049 0.165
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.049 0.028
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.047 0.047
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.046 0.033
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.0453 0.123
FUBP1 N/A 0.0453 0.062
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.0453 0.077
DAB1 DAB1: Disabled homolog 1 0.0453 0.152
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.123
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0453 0.152
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.077
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.0453 0.026
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.045 0.072
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.045 0.072
STAT2 STAT2: Signal transducer and activator of transcription 2 0.045 0.072
PLEK PLEK, P47: Pleckstrin 0.045 0.072
SOS1 SOS1: Son of sevenless homolog 1 0.045 0.065
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.045 0.072
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.0446 0.144
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.0446 0.070
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.0446 0.260
PRDX6 PRDX6, AOP2, KIAA0106: Peroxiredoxin-6 0.0446 0.070
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.044 0.083
HDGF HDGF, HMG1L2: Hepatoma-derived growth factor 0.042 0.157
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.042 0.472
PCAF PCAF: Histone acetyltransferase PCAF 0.042 0.157
TOP1 TOP1: DNA topoisomerase 1 0.042 0.042
STAT4 STAT4: Signal transducer and activator of transcription 4 0.041 0.072
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.041 0.029
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.041 0.029
CENTA1 CENTA1: Centaurin-alpha 1 0.041 0.041
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.04 0.028
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.04 0.052
CDC20 CDC20: Cell division cycle protein 20 homolog 0.039 0.027
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.038 0.038
COPA COPA: Coatomer subunit alpha 0.037 0.026
XPO7 XPO7, KIAA0745, RANBP16: Exportin-7 0.037 0.923
CDK7 CDK7, MO15: Cell division protein kinase 7 0.037 0.062
FLII FLII, FLIL: Protein flightless-1 homolog 0.037 0.034
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.037 0.109
CSPG2 N/A 0.037 0.045
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.037 0.055
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.037 0.062
MUC2 MUC2, SMUC: Mucin-2 precursor 0.037 0.025
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.037 0.055
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.037 0.055
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.037 0.055
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.037 0.062
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.037 0.109
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.109
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.037 0.034
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.037 0.055
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.037 0.062
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.037 0.055
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.037 0.045
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.037 0.055
VASP VASP: Vasodilator-stimulated phosphoprotein 0.037 0.109
STK10 STK10: Uncharacterized protein STK10 0.037 0.055
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.109
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.037 0.055
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.037 0.039
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.037 0.055
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.037 0.123
RRM2 RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2 0.036 0.052
CSDA CSDA, DBPA: DNA-binding protein A 0.036 0.070
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.036 0.070
TK1 TK1: Thymidine kinase, cytosolic 0.036 0.052
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.0338 0.0338
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.034 0.049
LETM1 LETM1: Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial 0.034 0.049
CETN1 CETN1, CEN1, CETN: Centrin-1 0.034 0.049
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.034 0.109
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.033 0.109
S100B S100B: Protein S100-B 0.032 0.109
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.032 0.055
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.032 0.055
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.032 0.109
LCP1 LCP1, PLS2: Plastin-2 0.032 0.109
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.109
VWF VWF, F8VWF: von Willebrand factor precursor 0.032 0.045
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.032 0.055
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.032 0.109
MYL3 MYL3: Myosin light polypeptide 3 0.032 0.055
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 0.032 0.055
GRLF1 N/A 0.032 0.055
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.032 0.055
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.032 0.098
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.032 0.055
S100A7 S100A7, PSOR1: Protein S100-A7 0.032 0.037
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.032 0.062
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.032 0.109
DAB2 DAB2, DOC2: Disabled homolog 2 0.032 0.109
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.032 0.055
PRKAA1 N/A 0.032 0.055
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.032 0.098
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.032 0.055
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 0.109
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.032 0.041
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.032 0.055
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.032 0.034
ATM ATM: Serine-protein kinase ATM 0.032 0.055
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.032 0.055
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.109
GMIP GMIP: GEM-interacting protein 0.032 0.055
CDKL5 N/A 0.032 0.055
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.032 0.055
MYO3A MYO3A: Myosin IIIA 0.032 0.109
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.032 0.034
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.032 0.049
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.032 0.109
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.032 0.049
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.032 0.055
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.032 0.055
ACTN1 ACTN1: Alpha-actinin-1 0.032 0.109
S100A3 S100A3, S100E: Protein S100-A3 0.032 0.098
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.032 0.077
FRMD4A RP11-397C18.4, RP11-397C18.4-003: Novel protein 0.032 0.050
MELK MELK, KIAA0175: Maternal embryonic leucine zipper kinase 0.032 0.0308
HBD HBD: Hemoglobin subunit delta 0.030 0.053
MDN1 MDN1, KIAA0301: Midasin 0.030 0.039
PLEK2 PLEK2: Pleckstrin-2 0.030 0.053
CDK5 CDK5: Cell division protein kinase 5 0.029 0.055
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.049
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.049
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.049
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.029 0.049
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.029 0.109
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.029 0.045
CNN3 CNN3: Calponin-3 0.029 0.098
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 0.049
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.029 0.049
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.109
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.029 0.041
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.029 0.098
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.029 0.098
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.055
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.029 0.109
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.029 0.049
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.029 0.049
PCDHA2 PCDHA2: Protocadherin alpha 2 precursor 0.028 0.049
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.028 0.049
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.028 0.109
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.028 0.049
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.028 0.049
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.028 0.044
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
ACE ACE, DCP, DCP1: Angiotensin-converting enzyme, somatic isoform precursor 0.028 0.049
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.028 0.049
SNAP23 SNAP23: Synaptosomal-associated protein 23 0.028 0.049
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.028 0.049
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.028 0.049
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.028 0.109
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.028 0.049
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.109
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.028 0.109
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.109
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.028 0.109
ADCY6 ADCY6, KIAA0422: Adenylate cyclase type 6 0.028 0.109
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.028 0.049
SLC6A8 SLC6A8: Sodium- and chloride-dependent creatine transporter 1 0.027 0.027
GYPE GYPE, GPE: Glycophorin-E precursor 0.027 0.082
RCL1 RCL1, RNAC, HSPC338, RPC2, RTC2: RNA 3'-terminal phosphate cyclase-like protein 0.027 0.027
LOC81558 N/A 0.027 0.027
ICAM4 N/A 0.027 0.027
ALAS2 RP5-884M20.1-007, ALAS2: Aminolevulinate, delta-, synthase 2 0.027 0.082
MARK3 N/A 0.027 0.027
RPIA RPIA, RPI: Ribose-5-phosphate isomerase 0.027 0.027
BZRPL1 BZRPL1: Peripheral-type benzodiazepine receptor-like protein 1 0.027 0.082
SLC30A1 SLC30A1, ZNT1: Zinc transporter 1 0.027 0.027
HBLD2 ISCA1, HBLD2, GK004: Iron-sulfur cluster assembly 1 homolog, mitochondrial precu 0.027 0.082
FBXO7 FBXO7, FBX7: F-box only protein 7 0.027 0.049
UBADC1 UBADC1, GBDR1, KPC2: Ubiquitin-associated domain-containing protein 1 0.027 0.293
CDC27 CDC27, D0S1430E, D17S978E: Cell division cycle protein 27 homolog 0.027 0.049
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.027 0.052
RACGAP1 RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1 0.027 0.0425
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.027 0.0425
THOC1 THOC1, HPR1: THO complex subunit 1 0.027 0.032
CA3 CA3: Carbonic anhydrase 3 0.027 0.0425
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.027 0.052
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.025 0.072
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.025 0.037
ETS2 ETS2: Protein C-ets-2 0.025 0.072
EPB49 EPB49, DMT: Dematin 0.025 0.053
2.15E-3
Total Score 3.11