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Evidence of Interaction Between EPOR and OSM

The interaction score between EPOR and OSM is 1.29.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPOR and OSM = 0.35

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 3.80E-3
Orthology N/A N/A
Domains Domains present in EPOR and OSM:
Domains in EPORDomains in OSM
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR009079 Four-helical cytokine
IPR003623 Oncostatin
IPR001581 LIF/OSM
IPR012351 Cytokine_4_hlx.

The Chi square scores for co-occurrence of domains that are present in EPOR and OSM are listed below.

Domain 1Domain 2Chi Square
IPR002996 Cytkn_recept_B/G. IPR012351 Cytokine_4_hlx. 606.856
IPR003961 Fibronectin, type III IPR012351 Cytokine_4_hlx. 192.256
IPR002996 Cytkn_recept_B/G. IPR009079 Four-helical cytokine 148.387
IPR002996 Cytkn_recept_B/G. IPR001581 LIF/OSM 97.6373
IPR003528 Long hematopoietin receptor, single chain IPR012351 Cytokine_4_hlx. 68.8366
IPR003961 Fibronectin, type III IPR009079 Four-helical cytokine 42.8476
IPR003961 Fibronectin, type III IPR001581 LIF/OSM 28.5335

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in OSM
  • Green Domain is present in both EPOR and OSM

 0.980
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: OSM

PTMResidueReference
Disulfide Bridge 152 PubMed, HPRD
Disulfide Bridge 192 PubMed, HPRD
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: OSM

LocalisationReference
Secreted HPRD
Transitive Score

The common interactors between EPOR and OSM that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andOSM. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and OSM has 553 interactors of which there are 299 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for OSM-Interactor (?)
IFNG IFNG: Interferon gamma precursor 0.980 0.028
KITLG KITLG, MGF, SCF: Kit ligand precursor 0.980 0.028
CSF3 CSF3, GCSF: Granulocyte colony-stimulating factor precursor 0.980 0.028
THPO THPO, MGDF: Thrombopoietin precursor 0.980 0.028
IL4 IL4: Interleukin-4 precursor 0.980 0.028
CSF2 CSF2, GMCSF: Granulocyte-macrophage colony-stimulating factor precursor 0.902 0.032
IL5 IL5: Interleukin-5 precursor 0.731 0.032
IL3 IL3: Interleukin-3 precursor 0.731 0.032
IL2 IL2: Interleukin 2 0.644 0.026
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.210 0.166
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.731
CRLF3 N/A 0.191 0.191
CNTN1 CNTN1: Contactin-1 precursor 0.165 0.165
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.109
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.980
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.109
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.165
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.980
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.109
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 0.04
CNTN4 CNTN4: Contactin-4 precursor 0.165 0.165
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.165
FN1 N/A 0.165 0.174
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.165
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.109
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.109
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 1.30
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.109
BSG N/A 0.165 0.109
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.109
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.109
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.109
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.165 0.109
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 0.081
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 0.166
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.152 1.81
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.127 0.046
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.126 0.109
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.126 0.032
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.125 0.0971
LGALS3 LGALS3, MAC2: Galectin-3 0.124 0.032
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.123 0.0727
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.123 0.072
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.072
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 0.123
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.123 0.081
INSR INSR: Insulin receptor precursor 0.123 0.081
IL9R IL9R: Interleukin-9 receptor precursor 0.123 1.13
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.081
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.123 0.072
GHR GHR: Growth hormone receptor precursor 0.123 0.644
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.100
DCC DCC: Netrin receptor DCC precursor 0.123 0.100
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.123 0.152
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.123 0.902
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.123 0.072
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 0.065
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 1.30
ANGPTL6 AGF, UNQ152/PRO178, ANGPTL6, ARP5: Angiopoietin-related protein 6 precursor 0.109 0.028
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.165
FGG FGG, PRO2061: Fibrinogen gamma chain precursor 0.109 0.028
FCN3 FCN3, FCNH, HAKA1: Ficolin-3 precursor 0.109 0.174
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.109 0.072
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.126
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.072
TNC TNC, HXB: Tenascin precursor 0.109 0.098
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.109 0.731
ITGB4 N/A 0.109 0.072
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.109 0.065
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.126
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 0.065
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.109 0.0263
SORL1 SORL1: Sortilin-related receptor precursor 0.109 0.100
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.109 0.902
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.109 0.072
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.109 0.0727
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.109 0.081
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.081
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.109 0.027
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.109 0.0727
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.109 0.081
PRLR PRLR: Prolactin receptor precursor 0.109 0.902
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.109 0.123
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 0.100
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.081
F3 F3: Tissue factor precursor 0.109 0.065
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.100
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.109 0.109
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 0.065
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.039
NEO1 NEO1, NGN: Neogenin precursor 0.098 0.0727
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.098 0.072
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.098 0.065
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 0.065
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.098 0.065
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.098 0.072
PTPRZ1 N/A 0.098 0.065
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.072
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.098 0.123
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.098 0.081
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.098 0.065
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.098 0.065
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.096 0.027
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.096 0.046
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.091 0.029
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.04
KIR3DL1 N/A 0.083 0.109
KLRD1 KLRD1, CD94: Natural killer cells antigen CD94 0.083 0.049
ATRN N/A 0.083 0.049
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.083 0.083
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.083 0.04
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.083 0.109
OPTC OPTC, OPT: Opticin precursor 0.083 0.083
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.083 0.083
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.083 0.109
EDA N/A 0.083 0.109
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.028
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.083 0.109
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 1.76
FGL2 FGL2: Fibroleukin precursor 0.081 0.032
ITGA2B ITGA2B, GP2B, ITGAB: Integrin alpha-IIb precursor 0.077 0.027
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.077 0.100
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.077 0.081
IL15RA IL15RA: Interleukin-15 receptor alpha chain precursor 0.075 0.032
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.072 0.109
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.072 0.109
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.072 0.109
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.072 0.039
TTN N/A 0.072 0.051
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.072 0.115
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.072 0.034
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.072 0.031
IFNB1 IFNB1, IFB, IFNB: Interferon beta precursor 0.072 0.026
TLR2 TLR2, TIL4: Toll-like receptor 2 precursor 0.062 0.057
GP1BA N/A 0.062 0.037
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.062 0.126
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.191
ASGR1 ASGR1: Asialoglycoprotein receptor 1 0.062 0.037
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.030
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.062 0.0263
ASGR2 ASGR2: Asialoglycoprotein receptor 2 0.062 0.037
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.062 0.166
SELE SELE, ELAM1: E-selectin precursor 0.062 0.037
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.062 0.037
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.061 0.0425
CDK6 CDK6: Cell division protein kinase 6 0.057 0.029
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.056 0.0263
F10 F10: Coagulation factor X precursor 0.055 0.137
EGF EGF: Pro-epidermal growth factor precursor 0.055 0.030
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.055 0.081
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.055 0.123
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.055 0.055
GPA33 GPA33: Cell surface A33 antigen precursor 0.055 0.100
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.055 0.191
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.126
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.055 0.100
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.055 0.098
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.055 0.081
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.055 0.191
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.055 0.072
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.055 0.081
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.055 0.072
GP1BB GP1BB: Platelet glycoprotein Ib beta chain precursor 0.055 0.0453
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.055 0.072
CD69 CD69: Early activation antigen CD69 0.055 0.0453
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.055 0.057
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.191
TLR4 TLR4: Toll-like receptor 4 precursor 0.055 0.057
LILRB1 N/A 0.055 0.126
CD7 CD7: T-cell antigen CD7 precursor 0.055 0.081
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.055 0.191
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.055 0.191
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.055 0.072
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.055 0.191
GP9 GP9: Platelet glycoprotein IX precursor 0.055 0.032
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.055 0.152
PAPPA PAPPA: Pappalysin-1 precursor 0.051 0.051
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.051 0.051
FLT4 VEGFR3 long form 0.051 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.027
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.051
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.051
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.051
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.051 0.051
NCAM1 N/A 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
TPBG TPBG, 5T4: Trophoblast glycoprotein precursor 0.049 0.029
SLITRK5 SLITRK5, KIAA0918, LRRC11: SLIT and NTRK-like protein 5 precursor 0.049 0.029
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.049 0.072
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.049 0.081
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.049 0.065
GP5 GP5: Platelet glycoprotein V precursor 0.049 0.0453
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.049 0.065
PVR PVR, PVS: Poliovirus receptor precursor 0.049 0.072
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.049 0.098
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.049 0.034
PLAT PLAT: Tissue-type plasminogen activator precursor 0.049 0.083
EEF2K EEF2K: Elongation factor 2 kinase 0.049 0.0688
LOC653509 SFTPA1, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A1 precursor 0.049 0.165
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.049 0.165
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.049 0.034
DCN DCN: Decorin precursor 0.049 0.083
CD46 N/A 0.049 0.028
F7 F7: Coagulation factor VII precursor 0.049 0.209
C4A C4A: Complement C4-A precursor 0.049 0.028
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.049 0.165
BMP1 N/A 0.049 0.028
CFHR1 CFHR1, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, HFL1, HFL2: Complement factor H-relate 0.049 0.028
TSHR N/A 0.048 0.0263
TNN TNN: Tenascin-N precursor 0.047 0.038
FUBP1 N/A 0.0453 0.0794
MBL2 MBL2, MBL: Mannose-binding protein C precursor 0.0453 0.115
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.0453 0.0513
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.063
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.0446 0.128
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.044 0.165
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.039 0.0453
CD14 CD14: Monocyte differentiation antigen CD14 precursor 0.039 0.060
C1QA C1QA: Complement C1q subcomponent subunit A precursor 0.037 0.103
C8B C8B: Complement component C8 beta chain precursor 0.037 0.090
PROZ PROZ: Vitamin K-dependent protein Z precursor 0.037 0.137
FLII FLII, FLIL: Protein flightless-1 homolog 0.037 0.039
CSPG2 N/A 0.037 0.191
PROS1 PROS1, PROS: Vitamin K-dependent protein S precursor 0.037 0.100
CFB CFB, BF, BFD: Complement factor B precursor 0.037 0.049
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.063
PROC PROC: Vitamin K-dependent protein C precursor 0.037 0.137
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.037 0.152
C2 C2: Complement C2 precursor 0.037 0.055
HP HP: Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta c 0.037 0.055
F9 F9: Coagulation factor IX precursor 0.037 0.156
C8A C8A: Complement component C8 alpha chain precursor 0.037 0.100
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.037 0.034
CFP CFP, PFC: Properdin precursor 0.037 0.176
PRG2 PRG2, MBP: Bone marrow proteoglycan precursor 0.037 0.055
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.034 0.032
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0338 0.030
COL4A1 N/A 0.032 0.859
ASPN ASPN: ASPN protein 0.032 0.055
C6 C6: Complement component C6 precursor 0.032 0.090
THBS1 THBS1, TSP, TSP1: Thrombospondin-1 precursor 0.032 0.100
COL15A1 COL15A1: Collagen alpha-1(XV) chain precursor [Contains: Endostatin 0.032 0.098
C7 C7: Complement component C7 precursor 0.032 0.090
F12 F12: Coagulation factor XII precursor 0.032 0.055
COL5A2 N/A 0.032 0.109
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.032 0.140
REG3A REG3A, HIP, PAP, PAP1: Regenerating islet-derived protein 3 alpha precursor 0.032 0.055
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.032 0.034
LUM LUM, LDC: Lumican precursor 0.032 0.049
SFTPA2 SFTPA2, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A2 precursor 0.032 0.109
C1S C1S: Complement C1s subcomponent precursor 0.032 0.049
KERA KERA: Keratocan precursor 0.032 0.062
SFTPD SFTPD, PSPD, SFTP4: Pulmonary surfactant-associated protein D precursor 0.032 0.109
COL17A1 COL17A1, BP180, BPAG2: Collagen alpha-1(XVII) chain 0.032 0.109
ADIPOQ ADIPOQ, ACDC, ACRP30, APM1, GBP28: Adiponectin precursor 0.032 0.115
COL5A1 N/A 0.032 0.115
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.032 0.109
C1R C1R: Complement C1r subcomponent precursor 0.032 0.049
REG1B REG1A, PSPS, REG: Lithostathine 1 alpha precursor 0.032 0.055
COL1A1 COL1A1: Collagen alpha-1(I) chain precursor 0.032 0.115
CLEC3B CLEC3B, TNA: Tetranectin precursor 0.032 0.055
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.032 0.025
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.032 0.031
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.032 0.031
IGFALS IGFALS, ALS: Insulin-like growth factor-binding protein complex acid labile chai 0.032 0.055
COL16A1 COL16A1: Collagen alpha-1(XVI) chain precursor 0.029 0.109
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.029 0.034
SPON1 SPON1, KIAA0762, VSGP: Spondin-1 precursor 0.029 0.090
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.029 0.034
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.029 0.034
SLIT2 SLIT2, SLIL3: Slit homolog 2 protein precursor 0.029 0.049
HGF HGF, HPTA: Hepatocyte growth factor precursor 0.028 0.083
ZP3 ZP3, ZP3A, ZP3B, ZPC: Zona pellucida sperm-binding protein 3 precursor 0.028 0.028
TMPRSS9 N/A 0.028 0.049
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.028 0.049
ROBO1 N/A 0.027 0.027
CRLF1 CRLF1, ZCYTOR5, UNQ288/PRO327: Cytokine receptor-like factor 1 precursor 0.027 0.265
KIRREL2 KIRREL2, NEPH3, UNQ5827/PRO19646: Kin of IRRE-like protein 2 precursor 0.027 0.027
IL5RA N/A 0.027 0.265
PSG6 PSG6, CGM3, PSGGB: Pregnancy-specific beta-1-glycoprotein 6 precursor 0.027 0.027
CSF3R CSF3R, GCSFR: Granulocyte colony-stimulating factor receptor precursor 0.027 0.217
CSF2RA CSF2RA, CSF2R, CSF2RY: Granulocyte-macrophage colony-stimulating factor receptor 0.027 0.217
NEGR1 NEGR1, UNQ2433/PRO4993: Neuronal growth regulator 1 precursor 0.027 0.027
CNTN6 CNTN6: Contactin-6 precursor 0.027 0.027
HAPLN4 HAPLN4, BRAL2, KIAA1926: Hyaluronan and proteoglycan link protein 4 precursor 0.027 0.027
IL22RA2 IL22RA2, UNQ5793/PRO19598/PRO19822: Interleukin-22 receptor alpha-2 chain precur 0.027 0.027
IL5RA IL5RA, IL5R: Interleukin-5 receptor alpha chain precursor 0.027 0.217
PSG11 PSG11, PSG13, PSG14: Pregnancy-specific beta-1-glycoprotein 11 precursor 0.027 0.027
TRIM42 TRIM42: Tripartite motif-containing protein 42 0.027 0.027
CNTN5 CNTN5: Contactin-5 precursor 0.027 0.027
PTPRT PTPRT, KIAA0283: Receptor-type tyrosine-protein phosphatase T precursor 0.027 0.027
THOC1 THOC1, HPR1: THO complex subunit 1 0.027 0.155
CXCL12 Stromal cell-derived factor 1 delta 0.027 0.026
CEACAM5 CEACAM5, CEA: Carcinoembryonic antigen-related cell adhesion molecule 5 precurso 0.026 0.033
FADD FADD, MORT1: Protein FADD 0.026 0.096
2.15E-3
Total Score 1.29