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Evidence of Interaction Between EPOR and CBL

The interaction score between EPOR and CBL is 4.67.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPOR and CBL = 0.00

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology N/A N/A
Domains Domains present in EPOR and CBL:
Domains in EPORDomains in CBL
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR001841 Zn-finger, RING
IPR000449 Ubiquitin-associated domain
IPR000980 SH2 motif
IPR000217 Tubulin
IPR003153 Adaptor protein Cbl, N-terminal
IPR011992 EF-Hand_type.
IPR013090 Phospholip_A2_AS.

The Chi square scores for co-occurrence of domains that are present in EPOR and CBL are listed below.

Domain 1Domain 2Chi Square
IPR002996 Cytkn_recept_B/G. IPR000980 SH2 motif 227.343
IPR003961 Fibronectin, type III IPR000980 SH2 motif 184.508
IPR003528 Long hematopoietin receptor, single chain IPR000980 SH2 motif 151.135
IPR009167 Erythropoietin receptor IPR000980 SH2 motif 38.4825
IPR002996 Cytkn_recept_B/G. IPR011992 EF-Hand_type. 9.08983
IPR003528 Long hematopoietin receptor, single chain IPR011992 EF-Hand_type. 0.995048
IPR003961 Fibronectin, type III IPR011992 EF-Hand_type. 0.00640738

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in CBL
  • Green Domain is present in both EPOR and CBL

 0.069
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: CBL

PTMResidueReference
Phosphorylation 371 PubMed, HPRD
Phosphorylation 619 PubMed, HPRD
Phosphorylation 623 PubMed, HPRD
Phosphorylation 639 PubMed, HPRD
Phosphorylation 642 PubMed, HPRD
Phosphorylation 667 PubMed, HPRD
Phosphorylation 669 PubMed, HPRD
Phosphorylation 674 PubMed, HPRD
Phosphorylation 675 PubMed, HPRD
Phosphorylation 700 PubMed, HPRD
Phosphorylation 731 PubMed, HPRD
Phosphorylation 774 PubMed, HPRD
Phosphoserine 669 HPRD
Phosphotyrosine 371 PubMed, HPRD
Phosphotyrosine 674 HPRD
Phosphotyrosine 700 HPRD
Phosphotyrosine 774 HPRD
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: CBL

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between EPOR and CBL that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andCBL. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and CBL has 1376 interactors of which there are 641 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for CBL-Interactor (?)
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 3.59 0.072
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.541 0.123
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.340 0.033
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.251 0.152
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.210 0.045
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.045
CRLF3 N/A 0.191 0.045
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.166 0.171
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.166 0.058
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.166 0.111
CNTN1 CNTN1: Contactin-1 precursor 0.165 0.062
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.540
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.165 0.062
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.0688
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.0688
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.0688
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.0688
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.0688
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.0688
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 0.483
CNTN4 CNTN4: Contactin-4 precursor 0.165 0.062
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.0688
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.0688
FN1 N/A 0.165 0.0688
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.0688
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.540
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.0688
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.0688
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.540
BSG N/A 0.165 0.062
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.483
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.165 0.483
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.062
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.483
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.0688
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.165 0.062
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.153 0.136
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.153 0.097
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 173.00
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 0.318
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.152 0.045
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.127 0.073
KLF1 KLF1, EKLF: Krueppel-like factor 1 0.126 0.049
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 0.655
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.126 0.136
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.126 0.045
CD2AP CD2AP: CD2-associated protein 0.126 0.090
CRKL CRKL: Crk-like protein 0.126 0.064
RDX RDX: Radixin 0.126 0.064
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.126 0.111
GAB1 GAB1: GRB2-associated-binding protein 1 0.126 0.109
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.125 0.049
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.124 0.033
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.124 0.136
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.123 0.063
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.123 0.063
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.318
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 214.00
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.123 0.361
INSR INSR: Insulin receptor precursor 0.123 0.318
IL9R IL9R: Interleukin-9 receptor precursor 0.123 0.051
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.318
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.123 0.041
GHR GHR: Growth hormone receptor precursor 0.123 0.051
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.045
DCC DCC: Netrin receptor DCC precursor 0.123 0.057
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.123 0.063
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.123 0.051
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.123 0.045
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 0.318
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.046
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.109 0.098
ELMO1 N/A 0.109 0.148
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.0688
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.109 0.148
ARHGEF7 N/A 0.109 0.098
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.109
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 0.980
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.148
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.109
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.109 0.098
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.109 0.098
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.109
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.483
NF2 NF2, SCH: Merlin 0.109 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.109
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.109 0.098
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.109
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 0.878
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 0.878
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.109
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.148
STAT3 0.109 0.098
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 8.34
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.109
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.109 0.148
MAPK15 N/A 0.109 0.165
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 0.878
PSCD2 N/A 0.109 0.109
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.109 0.148
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 0.980
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.148
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.109 0.098
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.109 0.098
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.109 0.098
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.109 0.148
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.098
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.109 0.098
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.109
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.109 0.148
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.403
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.109 0.320
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.445
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.051
TNC TNC, HXB: Tenascin precursor 0.109 0.037
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.109 0.045
ITGB4 N/A 0.109 0.051
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.109 0.403
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.051
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 0.286
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.109 0.073
SORL1 SORL1: Sortilin-related receptor precursor 0.109 0.051
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.109 0.051
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.109 0.051
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.109 0.041
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.109 0.051
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.051
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.109 0.318
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.109 0.445
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.109 0.057
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.100
PRLR PRLR: Prolactin receptor precursor 0.109 0.063
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.109 0.041
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 0.318
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.045
F3 F3: Tissue factor precursor 0.109 0.051
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.045
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.109 0.041
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.109 0.041
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 137.00
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.105 0.098
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.109
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.100 0.064
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 0.577
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 0.655
STAM2 STAM2: Signal transducing adapter molecule 2 0.100 0.148
RPS6KB1 N/A 0.100 0.097
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 0.655
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.100 0.064
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.100 0.111
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.100 0.064
TLN1 TLN1: Uncharacterized protein TLN1 0.100 0.064
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.100 0.111
DOK1 DOK1: Docking protein 1 0.100 0.111
PLD2 PLD2: Phospholipase D2 0.100 0.064
NEO1 NEO1, NGN: Neogenin precursor 0.098 0.057
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.098 0.361
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.098 0.286
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.098 0.361
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 0.445
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.098 0.063
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.098 0.361
PTPRZ1 N/A 0.098 0.037
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.051
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.098 0.041
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.098 0.045
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.098 0.445
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.098 0.318
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.098 0.041
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.096 0.046
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.091 0.171
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.091 0.111
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.091 0.123
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.091 0.111
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.098
KIR3DL1 N/A 0.083 0.0688
KLRD1 KLRD1, CD94: Natural killer cells antigen CD94 0.083 0.034
ATRN N/A 0.083 0.030
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.083 0.034
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.083 0.062
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.083 0.034
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.083 0.034
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.083 0.062
JAG2 JAG2: Jagged-2 precursor 0.083 0.030
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.083 0.0688
OPTC OPTC, OPT: Opticin precursor 0.083 0.034
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.083 0.034
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.0688
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.083 0.0688
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.034
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.083 0.0688
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.081 0.073
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 0.064
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 0.073
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.109
TLN2 TLN2: Uncharacterized protein TLN2 0.081 0.064
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.081
F5 F5: Coagulation factor V precursor 0.081 0.031
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 0.045
RIN1 RIN1: Ras and Rab interactor 1 0.081 0.097
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.081 0.097
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.081 0.072
HCK N/A 0.081 0.655
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.081 0.136
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.081 0.064
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.081 0.111
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.081 0.090
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.081 0.097
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.081 0.111
DLG2 DLG2: Disks large homolog 2 0.081 0.046
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.081 0.111
SYK SYK: Tyrosine-protein kinase SYK 0.081 0.808
SORBS3 SORBS3, SCAM1: Vinexin 0.081 43.20
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.081 0.081
STK16 N/A 0.081 0.152
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.077 0.073
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.077 0.051
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.077 0.051
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.075 0.136
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.075 0.033
CDK2 CDK2: Cell division protein kinase 2 0.075 0.111
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.075 0.111
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.075 0.111
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.075 0.090
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.075 0.097
WEE1 WEE1: Wee1-like protein kinase 0.075 0.136
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.074 0.037
SPTAN1 N/A 0.0727 0.072
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 0.577
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.072 0.097
MSN MSN: Moesin 0.072 0.064
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.072 0.090
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 0.577
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.072 0.136
FNBP1 N/A 0.072 0.111
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 0.655
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 0.073
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.072 0.097
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.072 0.731
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.072 0.064
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.072 0.064
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.072 0.081
JAK1 0.072 0.577
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 1.13
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.072 0.041
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.072 0.073
PLD1 PLD1: Phospholipase D1 0.072 0.073
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 0.073
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.065
ALK ALK: ALK tyrosine kinase receptor precursor 0.072 0.445
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 0.644
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.072 0.191
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.081
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.109
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.072 0.072
CSK CSK: Tyrosine-protein kinase CSK 0.072 0.655
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.072 0.041
PSD TYL: TYL protein 0.072 0.058
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.072 0.097
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.072 0.111
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.072 0.072
IRS1 IRS1: Insulin receptor substrate 1 0.072 0.152
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.072 0.045
CXorf9 N/A 0.072 0.111
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.072 0.152
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.072 0.081
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.072 0.123
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.072 0.073
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.731
PSCD4 PSCD4, CYT4: Cytohesin-4 0.072 0.090
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.072 0.064
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.072 277.00
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.072 0.100
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.072 0.046
TTN N/A 0.072 0.136
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.072 0.051
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 0.577
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.072 0.041
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.072 0.041
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.152
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 1.01
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 0.577
BMX N/A 0.072 0.644
LYN LYN: Tyrosine-protein kinase Lyn 0.072 0.655
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.072 0.123
VIL2 N/A 0.072 0.064
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.072 0.081
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.072 0.081
GAB2 N/A 0.072 0.109
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.0688 0.148
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.0688 0.148
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 0.148
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.067 0.145
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.058
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.065 0.090
APS SH2B2, APS: SH2B adapter protein 2 0.065 0.073
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 30.80
RASA3 RASA3: Ras GTPase-activating protein 3 0.065 0.073
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.097
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.065 0.064
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 0.902
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.065 0.152
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.065 0.064
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.065 0.097
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.065 0.058
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.065 0.123
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 1.20
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.088
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.065 0.111
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.065 0.064
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.097
MEP1A MEP1A: Meprin A subunit alpha precursor 0.062 0.037
GP1BA N/A 0.062 0.025
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.062 0.045
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.051
ASGR1 ASGR1: Asialoglycoprotein receptor 1 0.062 0.028
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.073
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.062 0.041
ASGR2 ASGR2: Asialoglycoprotein receptor 2 0.062 0.031
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.062 0.051
SELE SELE, ELAM1: E-selectin precursor 0.062 0.025
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.062 0.028
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.062 0.041
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.062 0.046
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.061 0.049
CDK4 CDK4: Cell division protein kinase 4 0.057 0.111
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.057 0.111
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.057 0.073
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.057 0.109
CDK6 CDK6: Cell division protein kinase 6 0.057 0.111
DYRK3 N/A 0.057 0.225
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.056 0.064
EGF EGF: Pro-epidermal growth factor precursor 0.055 0.051
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.055 0.051
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.055 0.051
GPA33 GPA33: Cell surface A33 antigen precursor 0.055 0.051
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.055 0.051
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.045
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.055 0.045
MEP1B MEP1B: Meprin A subunit beta precursor 0.055 0.057
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.055 0.051
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.055 0.063
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.055 0.051
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.055 0.051
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.055 0.051
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.055 0.051
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.055 0.045
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.055 0.025
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.051
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.055 0.046
LILRB1 N/A 0.055 0.063
CD7 CD7: T-cell antigen CD7 precursor 0.055 0.045
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.055 0.051
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.055 0.063
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.055 0.051
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.055 0.045
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.055 0.037
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.055 0.025
GP9 GP9: Platelet glycoprotein IX precursor 0.055 0.025
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.055 0.051
TMCC2 TMCC2, KIAA0481, hucep-11: Transmembrane and coiled-coil domains protein 2 0.053 0.030
PTPRA N/A 0.051 0.051
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
PAPPA PAPPA: Pappalysin-1 precursor 0.051 0.051
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.051 0.046
RAPH1 N/A 0.051 0.051
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.051 0.046
C9orf88 N/A 0.051 0.051
EPB41 EPB41, E41P: Protein 4.1 0.051 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.051 0.046
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.051 0.046
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.051 0.046
FLT4 VEGFR3 long form 0.051 0.553
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 0.051 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.617
CRK CRK: Proto-oncogene C-crk 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.051 0.046
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.051 0.046
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
DLG1 DLG1: Disks large homolog 1 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.617
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 0.051 0.046
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.617
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.051 0.553
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.617
GRB10 N/A 0.051 0.051
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.051 0.046
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.051 0.046
NCAM1 N/A 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.051 0.111
TP73 TP73, P73: Tumor protein p73 0.051 0.109
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.0513 0.136
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.049 0.063
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.049 0.051
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.049 0.045
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.049 0.045
PVR PVR, PVS: Poliovirus receptor precursor 0.049 0.051
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.049 0.045
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.049 0.041
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.109
CDC2 CDC2: Cell division control protein 2 homolog 0.049 0.148
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.049 0.049
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.049 0.165
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.049 0.148
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 0.165
MAPKAPK5 N/A 0.049 0.165
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.049
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.049 0.044
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.049 0.036
EEF2K EEF2K: Elongation factor 2 kinase 0.049 0.148
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.165
ACTN4 ACTN4: Alpha-actinin-4 0.049 0.098
LOC653509 SFTPA1, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A1 precursor 0.049 0.030
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.165
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.044
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.049 0.062
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.049 0.044
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.049 0.036
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.049 0.148
DCN DCN: Decorin precursor 0.049 0.034
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.049 0.148
PPEF1 N/A 0.049 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.109
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.049 0.148
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.049 0.148
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.049 0.0688
MAP2K5 N/A 0.049 0.109
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.049 0.148
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.049 0.036
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.165
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.049 0.148
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.165
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.049 0.148
CNN2 CNN2: Calponin-2 0.049 0.109
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.049 0.148
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.049 0.148
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.044
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.049 0.148
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.049 0.148
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.049 0.165
TSHR N/A 0.048 0.035
TNN TNN: Tenascin-N precursor 0.047 0.034
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.047 0.042
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.046 0.123
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.0453 0.073
FUBP1 N/A 0.0453 0.037
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.0453 0.097
MBL2 MBL2, MBL: Mannose-binding protein C precursor 0.0453 0.028
DAB1 DAB1: Disabled homolog 1 0.0453 0.097
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.0453 0.111
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.081
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0453 0.029
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.0453 0.136
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.152
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0453 0.109
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.0453 0.136
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.045 0.123
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.045 0.109
STAT2 STAT2: Signal transducer and activator of transcription 2 0.045 0.152
PLEK PLEK, P47: Pleckstrin 0.045 0.152
SOS1 SOS1: Son of sevenless homolog 1 0.045 0.136
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.045 0.097
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.0446 0.090
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.0446 0.027
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.0446 0.073
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.044 0.050
STAT4 STAT4: Signal transducer and activator of transcription 4 0.041 0.111
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.041 0.111
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.041 0.097
CENTA1 CENTA1: Centaurin-alpha 1 0.041 0.041
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.04 0.075
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.039 0.051
CD14 CD14: Monocyte differentiation antigen CD14 precursor 0.039 0.025
CDKN3 CDKN3, CDI1, CIP2, KAP: Cyclin-dependent kinase inhibitor 3 0.039 0.041
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.039 0.029
XRCC1 XRCC1: DNA-repair protein XRCC1 0.039 0.049
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.038 0.034
TBCE TBCE: Tubulin-specific chaperone E 0.037 0.033
CDK7 CDK7, MO15: Cell division protein kinase 7 0.037 0.136
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.037 0.152
FLII FLII, FLIL: Protein flightless-1 homolog 0.037 0.051
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.037 0.030
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.037 0.073
CSPG2 N/A 0.037 0.051
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.037 0.032
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.037 0.097
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.037 0.027
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.037 0.111
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.037 0.097
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.037 0.191
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.037 0.111
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.090
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.037 0.097
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.037 0.029
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.037 0.111
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.037 0.111
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.037 0.041
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.037 0.029
VASP VASP: Vasodilator-stimulated phosphoprotein 0.037 0.072
STK10 STK10: Uncharacterized protein STK10 0.037 0.111
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.037 0.111
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.037 0.109
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.037
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.037 0.111
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.037 0.152
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.037 0.045
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.037 0.111
PRG2 PRG2, MBP: Bone marrow proteoglycan precursor 0.037 0.025
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.037 0.111
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.037 0.097
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.036 0.037
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.034 0.051
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0338 0.0338
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.0338 0.034
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.034 0.148
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.034 0.148
CETN1 CETN1, CEN1, CETN: Centrin-1 0.034 0.047
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.034 0.025
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.034 0.148
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.033 0.029
S100B S100B: Protein S100-B 0.032 0.029
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.032 0.123
LCP1 LCP1, PLS2: Plastin-2 0.032 0.073
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.073
VWF VWF, F8VWF: von Willebrand factor precursor 0.032 0.041
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.032 0.097
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.032 0.123
GRLF1 N/A 0.032 0.127
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.032 0.045
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.032 0.035
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.032 0.097
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.032 0.097
S100A7 S100A7, PSOR1: Protein S100-A7 0.032 0.032
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.032 0.097
KERA KERA: Keratocan precursor 0.032 0.025
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.032 0.098
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.032 0.109
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.032 0.111
DAB2 DAB2, DOC2: Disabled homolog 2 0.032 0.097
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.032 0.111
PRKAA1 N/A 0.032 0.251
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.032 0.111
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.032 0.088
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 0.073
PMP2 PMP2: Myelin P2 protein 0.032 0.026
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.032 0.051
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.191
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.032 0.111
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.032 0.136
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.032 0.029
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.032 0.097
ATM ATM: Serine-protein kinase ATM 0.032 0.111
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.032 0.111
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.032
GMIP GMIP: GEM-interacting protein 0.032 0.033
CDKL5 N/A 0.032 0.109
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.032 0.123
MYO3A MYO3A: Myosin IIIA 0.032 0.097
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.032 0.033
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.032 0.090
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.032 0.073
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.032 0.111
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.032 0.097
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.032 0.064
ACTN1 ACTN1: Alpha-actinin-1 0.032 0.064
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.032 0.051
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.032 0.045
S100A3 S100A3, S100E: Protein S100-A3 0.032 0.037
IGFALS IGFALS, ALS: Insulin-like growth factor-binding protein complex acid labile chai 0.032 0.028
DAPK2 DAPK2: Death-associated protein kinase 2 0.032 0.123
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.032 0.030
TP53 TP53, P53: Cellular tumor antigen p53 0.031 0.056
CDK5 CDK5: Cell division protein kinase 5 0.029 0.097
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.088
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.111
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.090
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.029 0.041
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.029 0.088
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.029 0.071
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.029 0.0263
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.029 0.058
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.029 0.041
CNN3 CNN3: Calponin-3 0.029 0.065
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 0.111
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.029 0.111
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.064
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.029 0.046
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.029 0.037
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.029 0.136
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.029 0.045
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.029 0.029
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.111
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.029 0.088
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.029 0.111
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.029 0.037
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.028 0.030
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.028 0.062
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.028 0.030
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.028 0.034
DRD2 DRD2: D(2) dopamine receptor 0.028 0.034
SNAP23 SNAP23: Synaptosomal-associated protein 23 0.028 0.030
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.028 0.034
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.028 0.034
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.028 0.0688
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.028 0.0688
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.0688
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.028 0.062
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.0688
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.028 0.0688
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.028 0.0688
ADCY6 ADCY6, KIAA0422: Adenylate cyclase type 6 0.028 0.062
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.028 0.030
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 0.027 0.126
FGFR2 N/A 0.027 0.141
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.217
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.027 0.041
THOC1 THOC1, HPR1: THO complex subunit 1 0.027 0.073
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.027 0.029
CIITA CIITA, MHC2TA: MHC class II transactivator 0.0263 0.037
FADD FADD, MORT1: Protein FADD 0.026 0.045
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.025 0.136
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.025 0.111
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.025 0.109
NUP214 N/A 0.025 0.026
ETS2 ETS2: Protein C-ets-2 0.025 0.109
0.228
Total Score 4.67