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Evidence of Interaction Between EPOR and MAPK1

The interaction score between EPOR and MAPK1 is 5.41.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPOR and MAPK1 = 0.17

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.30E-3
Orthology N/A N/A
Domains Domains present in EPOR and MAPK1:
Domains in EPORDomains in MAPK1
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase

The Chi square scores for co-occurrence of domains that are present in EPOR and MAPK1 are listed below.

Domain 1Domain 2Chi Square
IPR003961 Fibronectin, type III IPR008271 Serine/threonine protein kinase, active site 30.5883
IPR003961 Fibronectin, type III IPR002290 Serine/threonine protein kinase 13.198
IPR003528 Long hematopoietin receptor, single chain IPR011009 Protein kinase-like 3.32619
IPR002996 Cytkn_recept_B/G. IPR002290 Serine/threonine protein kinase 2.93674
IPR003528 Long hematopoietin receptor, single chain IPR000719 Protein kinase 1.94307
IPR002996 Cytkn_recept_B/G. IPR011009 Protein kinase-like 1.93327
IPR003961 Fibronectin, type III IPR008349 ERK1/2 MAP kinase 1.72177
IPR002996 Cytkn_recept_B/G. IPR000719 Protein kinase 1.43014
IPR009167 Erythropoietin receptor IPR000719 Protein kinase 0.93762
IPR003961 Fibronectin, type III IPR000719 Protein kinase 0.712801
IPR003961 Fibronectin, type III IPR011009 Protein kinase-like 0.616354
IPR009167 Erythropoietin receptor IPR011009 Protein kinase-like 0.331462
IPR003961 Fibronectin, type III IPR003527 MAP kinase 0.246402

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in MAPK1
  • Green Domain is present in both EPOR and MAPK1

 0.049
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD
Transitive Score

The common interactors between EPOR and MAPK1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andMAPK1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and MAPK1 has 1694 interactors of which there are 535 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for MAPK1-Interactor (?)
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 3.59 0.077
SLC4A1 SLC4A1, AE1, DI, EPB3: Band 3 anion transport protein 0.923 0.033
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.541 0.127
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.340 0.372
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.251 0.062
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.210 0.036
HSP90AA1 Hsp89-alpha-delta-N 0.202 3.95
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.033
CRLF3 N/A 0.191 0.036
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.166 0.069
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.166 0.114
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.166 0.139
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.049
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.165 0.098
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.049
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.098
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.049
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.109
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.098
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.049
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.098
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.109
CAT CAT: Catalase 0.157 0.038
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.153 0.139
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.153 0.114
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 0.029
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 0.041
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.152 0.037
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.127 0.139
TAL1 TAL1, SCL, TCL5: T-cell acute lymphocytic leukemia protein 1 0.126 0.069
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 0.372
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.126 0.188
CD2AP CD2AP: CD2-associated protein 0.126 0.139
CRKL CRKL: Crk-like protein 0.126 0.461
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.126 0.046
RDX RDX: Radixin 0.126 0.136
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.126 0.114
GAB1 GAB1: GRB2-associated-binding protein 1 0.126 0.152
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.125 0.046
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.125 0.046
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.124 0.071
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.124 0.056
IL9R IL9R: Interleukin-9 receptor precursor 0.123 0.032
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.123 0.064
GHR GHR: Growth hormone receptor precursor 0.123 0.037
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.123 0.075
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 0.026
UROD UROD: Uroporphyrinogen decarboxylase 0.111 0.029
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.073
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.109 0.148
ELMO1 N/A 0.109 0.148
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.034
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.109 62.30
ARHGEF7 N/A 0.109 0.148
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.165
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 0.165
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.075
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.165
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.109 0.148
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.109 0.148
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.165
NF2 NF2, SCH: Merlin 0.109 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.165
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.109 0.148
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.083
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 0.148
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 0.075
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.165
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.075
STAT3 0.109 0.148
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 0.148
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.165
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.109 0.148
MAPK15 N/A 0.109 0.083
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 0.148
PSCD2 N/A 0.109 0.165
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.109 0.148
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 0.165
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.075
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.109 0.075
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.109 0.148
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.109 0.075
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.109 0.075
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.075
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.109 0.075
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.083
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.109 62.30
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.041
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.0453
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.109 0.153
ITGB4 N/A 0.109 0.032
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.124
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 0.029
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.109 0.078
SORL1 SORL1: Sortilin-related receptor precursor 0.109 0.032
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.109 0.057
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.109 0.072
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.109 0.058
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.037
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.077
PRLR PRLR: Prolactin receptor precursor 0.109 0.033
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 0.067
F3 F3: Tissue factor precursor 0.109 0.032
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.091
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.109 0.029
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.105 0.109
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.155
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.100 0.225
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 0.111
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 0.275
STAM2 STAM2: Signal transducing adapter molecule 2 0.100 0.056
RPS6KB1 N/A 0.100 0.188
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 0.461
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.100 0.086
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.100 0.233
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.100 0.372
TLN1 TLN1: Uncharacterized protein TLN1 0.100 0.038
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.100 2.17
DOK1 DOK1: Docking protein 1 0.100 0.275
PLD2 PLD2: Phospholipase D2 0.100 0.111
NEO1 NEO1, NGN: Neogenin precursor 0.098 0.029
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 0.026
PTPRZ1 N/A 0.098 0.090
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.037
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.098 0.058
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.096 0.0446
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.091 0.069
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.091 0.139
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.091 0.096
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.091 0.086
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.087 0.051
SLC2A1 SLC2A1, GLUT1: Solute carrier family 2, facilitated glucose transporter member 1 0.087 0.027
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.075
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.083 0.044
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.083 0.044
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.049
EDA N/A 0.083 0.049
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.049
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.083 0.049
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.081 0.225
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 0.225
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 0.372
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.251
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.123
F5 F5: Coagulation factor V precursor 0.081 0.025
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 0.025
RIN1 RIN1: Ras and Rab interactor 1 0.081 0.171
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.081 0.188
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.081 0.307
HCK N/A 0.081 0.275
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.081 0.275
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.081 0.275
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.081 0.127
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.081 0.275
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.081 0.099
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.081 0.069
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.081 0.056
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.081 0.461
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.081 0.139
SYK SYK: Tyrosine-protein kinase SYK 0.081 0.275
SORBS3 SORBS3, SCAM1: Vinexin 0.081 0.049
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.081 0.251
STK16 N/A 0.081 0.077
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.077 0.063
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.077 0.036
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.075 0.056
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.075 0.063
CDK2 CDK2: Cell division protein kinase 2 0.075 6.80
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.075 0.086
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.075 0.233
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.075 2.02
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.075 0.139
WEE1 WEE1: Wee1-like protein kinase 0.075 0.056
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.074 0.052
SPTAN1 N/A 0.0727 0.062
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 0.275
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.072 0.044
MSN MSN: Moesin 0.072 0.461
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.072 0.233
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 0.111
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.072 0.044
FNBP1 N/A 0.072 0.188
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 0.372
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 0.461
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.072 0.069
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.072 0.251
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.072 0.044
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.072 0.136
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.072 0.416
JAK1 0.072 0.461
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 0.152
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.072 0.233
PLD1 PLD1: Phospholipase D1 0.072 0.097
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 0.372
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.044
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 0.152
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.072 0.077
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.109
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.109
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.072 0.307
CSK CSK: Tyrosine-protein kinase CSK 0.072 0.372
PSD TYL: TYL protein 0.072 0.171
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.072 0.461
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.072 0.225
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.072 0.096
IRS1 IRS1: Insulin receptor substrate 1 0.072 0.098
CXorf9 N/A 0.072 0.188
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.072 0.127
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.072 0.123
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.072 0.210
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.072 0.111
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.098
PSCD4 PSCD4, CYT4: Cytohesin-4 0.072 0.372
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.072 0.372
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.072 0.372
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.072 0.191
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.072 0.056
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 0.056
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.307
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 0.097
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 0.088
BMX N/A 0.072 0.110
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.072 0.041
LYN LYN: Tyrosine-protein kinase Lyn 0.072 0.372
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.072 0.307
VIL2 N/A 0.072 0.136
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.072 0.260
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.072 0.152
GAB2 N/A 0.072 0.251
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.0688 0.075
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.0688 62.30
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 0.148
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.136
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.065 0.044
APS SH2B2, APS: SH2B adapter protein 2 0.065 0.111
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 0.171
RASA3 RASA3: Ras GTPase-activating protein 3 0.065 0.225
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.097
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.065 0.097
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 0.110
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.065 0.155
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.065 0.088
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.065 0.086
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.065 0.171
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.065 0.191
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 0.026
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.097
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.065 0.461
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.065 0.136
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.275
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.062 0.036
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.062 0.032
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.036
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.062 0.036
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.069
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.062 0.057
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.062 0.033
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.062 0.027
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.062 0.0818
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.062 0.051
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.062 0.026
CD44 N/A 0.062 0.091
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.061 4.15
CDK4 CDK4: Cell division protein kinase 4 0.057 0.069
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.057 0.188
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.057 0.372
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.057 0.062
CDK6 CDK6: Cell division protein kinase 6 0.057 0.069
DYRK3 N/A 0.057 0.049
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.056 0.086
EGF EGF: Pro-epidermal growth factor precursor 0.055 0.029
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.027
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.055 0.040
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.055 0.037
ITGAE ITGAE: Integrin alpha-E precursor 0.055 0.027
CD69 CD69: Early activation antigen CD69 0.055 0.027
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.055 0.036
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.036
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.055 0.032
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.055 0.040
LILRB1 N/A 0.055 0.027
CD7 CD7: T-cell antigen CD7 precursor 0.055 0.036
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.055 0.036
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.055 0.029
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.055 0.037
ITGB7 ITGB7: Integrin beta-7 precursor 0.055 0.040
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.055 0.036
PTPRA N/A 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
RAPH1 N/A 0.051 0.051
C9orf88 N/A 0.051 0.051
EPB41 EPB41, E41P: Protein 4.1 0.051 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.051 0.046
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.051 0.046
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.051 0.046
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.051 0.046
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
GRB10 N/A 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.051 0.046
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.051 115.00
TP73 TP73, P73: Tumor protein p73 0.051 0.055
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.051 0.097
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.0513 0.233
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.049 0.032
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.083
CDC2 CDC2: Cell division control protein 2 homolog 0.049 0.075
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.049 0.028
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.083
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.049 0.075
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.049 0.075
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 0.083
MAPKAPK5 N/A 0.049 0.083
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.028
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.049 0.025
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.049 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.049 0.148
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.083
ACTN4 ACTN4: Alpha-actinin-4 0.049 0.025
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.083
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.075
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.049 0.025
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.049 0.025
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.049 0.075
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.049 0.075
PPEF1 N/A 0.049 0.028
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.083
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.049 0.075
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.049 0.075
MAP2K5 N/A 0.049 0.165
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.049 0.075
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.049 0.025
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.083
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.049 0.075
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.083
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.049 0.075
SNX3 N/A 0.049 0.075
CNN2 CNN2: Calponin-2 0.049 0.075
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.049 0.075
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.049 0.075
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.075
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.049 0.075
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.049 0.075
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.049 0.083
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.047 0.034
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.046 0.975
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.0453 0.171
FUBP1 N/A 0.0453 0.052
DAB1 DAB1: Disabled homolog 1 0.0453 0.097
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.0453 0.139
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.077
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0453 0.139
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.0453 0.046
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.096
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0453 0.155
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.0453 0.063
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.0453 0.069
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.045 0.109
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.045 0.416
STAT2 STAT2: Signal transducer and activator of transcription 2 0.045 0.191
PLEK PLEK, P47: Pleckstrin 0.045 0.515
SOS1 SOS1: Son of sevenless homolog 1 0.045 0.225
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.045 0.372
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.0446 0.038
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.0446 0.046
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.0446 0.063
PRDX6 PRDX6, AOP2, KIAA0106: Peroxiredoxin-6 0.0446 0.029
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.044 0.050
HDGF HDGF, HMG1L2: Hepatoma-derived growth factor 0.042 0.038
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.042 0.054
PCAF PCAF: Histone acetyltransferase PCAF 0.042 0.046
STAT4 STAT4: Signal transducer and activator of transcription 4 0.041 0.225
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.041 94.70
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.041 0.136
CENTA1 CENTA1: Centaurin-alpha 1 0.041 0.128
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.04 0.025
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.04 0.075
CDC20 CDC20: Cell division cycle protein 20 homolog 0.039 0.069
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.039 0.057
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.039 0.038
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.039 0.029
XRCC1 XRCC1: DNA-repair protein XRCC1 0.039 0.0425
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.038 0.053
TBCE TBCE: Tubulin-specific chaperone E 0.037 0.046
COPA COPA: Coatomer subunit alpha 0.037 0.063
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.037 0.038
CDK7 CDK7, MO15: Cell division protein kinase 7 0.037 0.086
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.037 0.096
FLII FLII, FLIL: Protein flightless-1 homolog 0.037 0.046
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.037 0.026
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.037 0.111
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.037 0.032
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.037 0.139
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.037 0.063
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.037 0.233
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.037 153.00
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.037 0.077
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.037 0.114
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.171
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.037 0.385
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.037 0.188
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.037 0.050
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.037 0.114
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.037 0.063
VASP VASP: Vasodilator-stimulated phosphoprotein 0.037 0.307
STK10 STK10: Uncharacterized protein STK10 0.037 0.385
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.037 0.188
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.037 0.210
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.0425
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.037 0.188
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.037 0.077
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.037 0.069
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.037 0.086
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.037 0.044
RRM2 RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2 0.036 0.029
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.036 0.048
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.034 0.029
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.034 0.075
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.034 0.075
CETN1 CETN1, CEN1, CETN: Centrin-1 0.034 0.025
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.034 0.025
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.034 0.025
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.033 0.260
NDP NDP: Norrin precursor 0.033 0.041
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.032 0.063
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.032 0.210
LCP1 LCP1, PLS2: Plastin-2 0.032 0.078
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.114
VWF VWF, F8VWF: von Willebrand factor precursor 0.032 0.041
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.032 0.086
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.032 0.127
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 0.032 1.42
GRLF1 N/A 0.032 0.062
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.032 0.111
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.032 0.056
CHP CHP: Calcium-binding protein p22 0.032 0.038
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.032 0.040
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.032 0.096
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.032 0.055
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.032 0.233
DAB2 DAB2, DOC2: Disabled homolog 2 0.032 0.097
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.032 0.114
PRKAA1 N/A 0.032 0.077
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.032 0.069
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.032 0.114
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 0.461
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.127
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.032 0.044
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.032 0.069
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.032 0.069
ATM ATM: Serine-protein kinase ATM 0.032 0.139
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.032 0.069
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.032
GMIP GMIP: GEM-interacting protein 0.032 0.188
CDKL5 N/A 0.032 0.049
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.032 0.127
MYO3A MYO3A: Myosin IIIA 0.032 0.044
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.032 0.171
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.032 0.385
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.032 0.044
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.032 0.233
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.032 0.086
DAPK2 DAPK2: Death-associated protein kinase 2 0.032 0.049
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.032 0.029
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.032 0.026
MTMR3 MTMR3, KIAA0371, ZFYVE10: Myotubularin-related protein 3 0.032 0.036
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.031 0.038
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.031 0.046
TP53 TP53, P53: Cellular tumor antigen p53 0.031 0.086
DYNC1I2 N/A 0.030 0.038
MDN1 MDN1, KIAA0301: Midasin 0.030 0.038
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.030 0.029
CDK5 CDK5: Cell division protein kinase 5 0.029 0.114
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.086
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.114
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.056
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.029 0.044
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.029 0.026
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.029 0.050
CNN3 CNN3: Calponin-3 0.029 0.044
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 0.049
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.029 0.040
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.136
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.029 0.028
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.029 0.056
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.029 0.063
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.139
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.029 0.056
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.029 0.069
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.029 0.046
AQP4 AQP4: Aquaporin-4 0.028 0.044
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.028 0.044
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.028 0.044
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.028 0.044
TBXA2R TBXA2R: Thromboxane A2 receptor 0.028 0.04
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.028 0.049
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.028 0.04
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.028 0.683
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.028 0.049
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.028 0.049
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.028 0.049
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.028 0.049
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.028 0.049
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.028 0.044
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.049
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.028 0.098
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.049
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.028 0.049
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.028 0.049
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.028 0.044
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.027 0.078
THOC1 THOC1, HPR1: THO complex subunit 1 0.027 0.114
AQP1 AQP1, CHIP28: Aquaporin-1 0.027 0.049
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.027 0.038
WWOX WWOX, FOR, WOX1: WW domain-containing oxidoreductase 0.0263 0.029
CIITA CIITA, MHC2TA: MHC class II transactivator 0.0263 0.096
PLSCR1 PLSCR1: Phospholipid scramblase 1 0.026 0.032
RHO RHO, OPN2: Rhodopsin 0.026 0.033
FADD FADD, MORT1: Protein FADD 0.026 0.075
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 0.026 10.50
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.025 0.225
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.025 0.139
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.025 0.096
NUP214 N/A 0.025 0.0425
ETS2 ETS2: Protein C-ets-2 0.025 0.152
GNB2L1 Lung cancer oncogene 7 0.025 0.0425
0.299
Total Score 5.41