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Evidence of Interaction Between EPOR and DUSP6

The interaction score between EPOR and DUSP6 is 15.10.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology N/A N/A
Domains Domains present in EPOR and DUSP6:
Domains in EPORDomains in DUSP6
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase
IPR001763 Rhodanese-like
IPR000340 Dual specificity protein phosphatase
IPR008343 MAP kinase phosphatase

The Chi square scores for co-occurrence of domains that are present in EPOR and DUSP6 are listed below.

Domain 1Domain 2Chi Square
IPR003961 Fibronectin, type III IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 7.51945
IPR002996 Cytkn_recept_B/G. IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 4.82057

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in DUSP6
  • Green Domain is present in both EPOR and DUSP6

 0.109
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: DUSP6

PTMResidueReference
Phosphorylation 159 PubMed, HPRD
Phosphorylation 197 PubMed, HPRD
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: DUSP6

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between EPOR and DUSP6 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andDUSP6. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and DUSP6 has 1727 interactors of which there are 626 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for DUSP6-Interactor (?)
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 3.59 0.083
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.541 0.165
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.340 0.025
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.253 0.025
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.251 0.165
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.210 0.109
HSP90AA1 Hsp89-alpha-delta-N 0.202 0.025
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.109
CRLF3 N/A 0.191 0.109
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.166 0.148
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.166 0.075
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.166 0.148
CNTN1 CNTN1: Contactin-1 precursor 0.165 0.098
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.109
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.165 0.044
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.109
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.109
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.109
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.044
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.109
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.109
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 0.098
CNTN4 CNTN4: Contactin-4 precursor 0.165 0.098
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.109
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.049
FN1 N/A 0.165 0.109
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.109
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.109
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.098
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.109
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.109
BSG N/A 0.165 0.098
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.098
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.165 0.098
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.098
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.098
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.109
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.165 0.098
CAT CAT: Catalase 0.157 0.025
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.153 0.148
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.153 0.148
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 0.098
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 0.098
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.152 0.109
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.127 0.148
KLF1 KLF1, EKLF: Krueppel-like factor 1 0.126 0.025
TAL1 TAL1, SCL, TCL5: T-cell acute lymphocytic leukemia protein 1 0.126 0.025
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 0.148
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.126 0.148
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.126 0.0688
CD2AP CD2AP: CD2-associated protein 0.126 0.075
CRKL CRKL: Crk-like protein 0.126 0.148
RDX RDX: Radixin 0.126 0.148
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.126 0.148
GAB1 GAB1: GRB2-associated-binding protein 1 0.126 0.052
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.125 0.025
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.125 0.025
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.124 0.047
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.124 0.148
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.123 0.109
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.123 0.109
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.098
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 0.098
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.123 0.098
INSR INSR: Insulin receptor precursor 0.123 0.098
IL9R IL9R: Interleukin-9 receptor precursor 0.123 0.109
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.098
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.123 0.098
GHR GHR: Growth hormone receptor precursor 0.123 0.109
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.109
DCC DCC: Netrin receptor DCC precursor 0.123 0.098
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.123 0.109
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.123 0.109
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.123 0.109
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 0.098
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.044
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.109 0.148
ELMO1 N/A 0.109 0.047
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.0688
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.109 0.047
ARHGEF7 N/A 0.109 0.047
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.083
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 0.165
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.148
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.165
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.109 0.075
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.109 0.148
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.165
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.062
NF2 NF2, SCH: Merlin 0.109 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.165
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.109 0.075
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.083
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 0.148
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 0.148
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.052
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.148
STAT3 0.109 0.148
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 0.148
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.052
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.109 0.148
MAPK15 N/A 0.109 1.30
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 0.148
PSCD2 N/A 0.109 0.052
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.109 0.148
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 0.165
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.148
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.109 0.075
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.109 0.148
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.109 0.075
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.109 0.148
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.075
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.109 0.075
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.083
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.109
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.109 0.109
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.098
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.109
TNC TNC, HXB: Tenascin precursor 0.109 0.098
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.109 0.109
ITGB4 N/A 0.109 0.109
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.109 0.109
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.049
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 0.098
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.109 0.148
SORL1 SORL1: Sortilin-related receptor precursor 0.109 0.098
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.109 0.109
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.109 0.109
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.109 0.098
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.109 0.109
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.109
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.109 0.098
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.109 0.098
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.109 0.098
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.083
PRLR PRLR: Prolactin receptor precursor 0.109 0.109
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.109 0.098
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 0.098
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.109
F3 F3: Tissue factor precursor 0.109 0.049
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.049
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.109 0.098
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.109 0.098
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 0.098
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.105 0.052
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.165
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.100 0.148
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 0.148
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 0.148
STAM2 STAM2: Signal transducing adapter molecule 2 0.100 0.075
RPS6KB1 N/A 0.100 0.148
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 0.148
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.100 0.148
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.100 0.148
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.100 0.047
TLN1 TLN1: Uncharacterized protein TLN1 0.100 0.148
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.100 0.075
DOK1 DOK1: Docking protein 1 0.100 0.148
PLD2 PLD2: Phospholipase D2 0.100 0.047
NEO1 NEO1, NGN: Neogenin precursor 0.098 0.098
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.098 0.098
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.098 0.098
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.098 0.098
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 0.098
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.098 0.109
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.098 0.098
PTPRZ1 N/A 0.098 0.098
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.109
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.098 0.098
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.098 0.109
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.098 0.098
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.098 0.098
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.098 0.109
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.096 0.044
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.091 0.148
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.091 0.148
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.091 0.028
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.091 0.148
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.148
KIR3DL1 N/A 0.083 0.109
KLRD1 KLRD1, CD94: Natural killer cells antigen CD94 0.083 0.049
ATRN N/A 0.083 0.044
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.083 0.098
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.083 0.109
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.083 0.109
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.083 0.109
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.081 0.047
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 0.148
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 0.148
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.165
TLN2 TLN2: Uncharacterized protein TLN2 0.081 0.148
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.165
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 0.0688
RIN1 RIN1: Ras and Rab interactor 1 0.081 0.148
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.081 0.148
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.081 0.165
HCK N/A 0.081 0.148
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.081 0.148
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.081 0.148
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.081 0.028
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.081 0.148
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.081 0.148
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.081 0.148
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.081 0.047
DLG2 DLG2: Disks large homolog 2 0.081 0.030
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.081 0.148
SYK SYK: Tyrosine-protein kinase SYK 0.081 0.148
SORBS3 SORBS3, SCAM1: Vinexin 0.081 0.075
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.081 0.083
STK16 N/A 0.081 0.165
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.077 0.148
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.077 0.109
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.077 0.109
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.075 0.148
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.075 0.075
CDK2 CDK2: Cell division protein kinase 2 0.075 0.148
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.075 0.148
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.075 0.148
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.075 0.148
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.075 0.148
WEE1 WEE1: Wee1-like protein kinase 0.075 0.148
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.074 0.028
SPTAN1 N/A 0.0727 0.083
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 0.148
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.072 0.148
MSN MSN: Moesin 0.072 0.148
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.072 0.075
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 0.148
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.072 0.148
FNBP1 N/A 0.072 0.075
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 0.148
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 0.148
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.072 0.148
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.072 0.165
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.072 0.148
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.072 0.148
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.072 0.165
JAK1 0.072 0.148
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 0.165
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.072 0.062
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.072 0.075
PLD1 PLD1: Phospholipase D1 0.072 0.047
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 0.148
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.075
ALK ALK: ALK tyrosine kinase receptor precursor 0.072 0.062
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 0.165
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.072 0.165
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.052
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.052
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.072 0.165
CSK CSK: Tyrosine-protein kinase CSK 0.072 0.148
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.072 0.062
PSD TYL: TYL protein 0.072 0.047
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.072 0.075
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.072 0.148
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.072 0.083
IRS1 IRS1: Insulin receptor substrate 1 0.072 0.165
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.072 0.0688
CXorf9 N/A 0.072 0.148
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.072 0.165
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.072 0.165
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.072 0.165
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.072 0.148
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.165
PSCD4 PSCD4, CYT4: Cytohesin-4 0.072 0.047
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.072 0.075
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.072 0.148
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.072 0.165
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.072 0.062
TTN N/A 0.072 0.148
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.072 0.0688
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 0.148
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.072 0.030
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.072 0.030
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.165
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 0.148
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 0.148
BMX N/A 0.072 0.165
LYN LYN: Tyrosine-protein kinase Lyn 0.072 0.148
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.072 0.052
VIL2 N/A 0.072 0.148
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.072 0.083
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.072 0.165
GAB2 N/A 0.072 0.052
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.0688 0.148
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.0688 0.047
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 0.148
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.148
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.065 0.075
APS SH2B2, APS: SH2B adapter protein 2 0.065 0.148
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 0.148
RASA3 RASA3: Ras GTPase-activating protein 3 0.065 0.047
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.075
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.065 0.148
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 0.165
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.065 0.165
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.065 0.047
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.065 0.148
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.065 0.075
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.065 0.052
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 0.165
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.148
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.065 0.047
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.065 0.148
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.148
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.062 0.109
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.109
ASGR1 ASGR1: Asialoglycoprotein receptor 1 0.062 0.044
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.148
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.062 0.098
ASGR2 ASGR2: Asialoglycoprotein receptor 2 0.062 0.049
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.062 0.109
SELE SELE, ELAM1: E-selectin precursor 0.062 0.049
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.062 0.098
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.062 0.098
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.061 0.025
EIF2AK1 N/A 0.057 0.027
CDK4 CDK4: Cell division protein kinase 4 0.057 0.148
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.057 0.148
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.057 0.148
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.057 0.165
CDK6 CDK6: Cell division protein kinase 6 0.057 0.148
DYRK3 N/A 0.057 0.148
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.056 0.148
EGF EGF: Pro-epidermal growth factor precursor 0.055 0.049
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.055 0.109
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.055 0.109
GPA33 GPA33: Cell surface A33 antigen precursor 0.055 0.109
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.055 0.109
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.109
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.055 0.109
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.055 0.109
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.055 0.109
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.055 0.109
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.055 0.109
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.055 0.109
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.055 0.109
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.055 0.109
CD69 CD69: Early activation antigen CD69 0.055 0.049
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.055 0.049
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.109
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.055 0.044
LILRB1 N/A 0.055 0.109
CD7 CD7: T-cell antigen CD7 precursor 0.055 0.109
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.055 0.109
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.055 0.109
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.055 0.109
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.055 0.109
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.055 0.098
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.055 0.109
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.051 0.046
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.051 0.553
EPB41 EPB41, E41P: Protein 4.1 0.051 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.051 0.046
FLT4 VEGFR3 long form 0.051 0.046
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 0.051 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.051 0.046
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 0.051 0.046
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.051
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.051 0.046
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.051
GRB10 N/A 0.051 0.051
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.051 0.046
DOK2 DOK2: Docking protein 2 0.051 0.051
NCAM1 N/A 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.051 0.047
TP73 TP73, P73: Tumor protein p73 0.051 0.165
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.051 0.148
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.0513 0.025
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.049 0.109
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.049 0.109
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.049 0.109
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.049 0.109
PVR PVR, PVS: Poliovirus receptor precursor 0.049 0.109
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.049 0.109
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 1.30
CDC2 CDC2: Cell division control protein 2 homolog 0.049 0.148
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.049 0.028
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.049 0.148
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.049 0.148
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 1.30
MAPKAPK5 N/A 0.049 0.165
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.028
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.049 0.025
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.049 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.049 0.148
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.165
ACTN4 ACTN4: Alpha-actinin-4 0.049 0.075
LOC653509 SFTPA1, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A1 precursor 0.049 0.030
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.165
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.025
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.049 0.062
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.049 0.025
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.049 0.025
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.049 0.148
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.049 0.148
PPEF1 N/A 0.049 0.028
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 1.30
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.049 0.148
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.049 0.148
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.049 0.0688
MAP2K5 N/A 0.049 0.165
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.049 0.148
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.049 0.025
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.165
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.049 0.148
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.165
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.049 0.148
SNX3 N/A 0.049 0.025
CNN2 CNN2: Calponin-2 0.049 0.025
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.049 0.148
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.049 0.148
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.025
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.049 0.148
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.049 0.148
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.049 0.165
TNN TNN: Tenascin-N precursor 0.047 0.046
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.047 0.046
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.046 0.052
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.0453 0.025
FUBP1 N/A 0.0453 0.028
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.0453 62.30
MBL2 MBL2, MBL: Mannose-binding protein C precursor 0.0453 0.030
DAB1 DAB1: Disabled homolog 1 0.0453 0.025
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.0453 0.148
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.165
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0453 0.025
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.0453 0.148
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.165
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0453 0.165
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.0453 0.025
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.0453 0.148
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.045 0.165
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.045 0.165
STAT2 STAT2: Signal transducer and activator of transcription 2 0.045 0.165
PLEK PLEK, P47: Pleckstrin 0.045 0.052
SOS1 SOS1: Son of sevenless homolog 1 0.045 0.148
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.045 0.148
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.0446 0.025
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.0446 0.025
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.0446 0.025
PRDX6 PRDX6, AOP2, KIAA0106: Peroxiredoxin-6 0.0446 0.047
HDGF HDGF, HMG1L2: Hepatoma-derived growth factor 0.042 0.025
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.042 0.025
PCAF PCAF: Histone acetyltransferase PCAF 0.042 0.025
STAT4 STAT4: Signal transducer and activator of transcription 4 0.041 0.148
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.041 0.047
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.041 0.047
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.04 0.025
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.04 0.025
CDC20 CDC20: Cell division cycle protein 20 homolog 0.039 0.025
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.039 0.025
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.039 0.025
XRCC1 XRCC1: DNA-repair protein XRCC1 0.039 0.028
TBCE TBCE: Tubulin-specific chaperone E 0.037 0.025
COPA COPA: Coatomer subunit alpha 0.037 0.025
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.037 0.025
CDK7 CDK7, MO15: Cell division protein kinase 7 0.037 0.148
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.037 0.165
FLII FLII, FLIL: Protein flightless-1 homolog 0.037 0.025
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.037 0.028
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.037 0.025
CSPG2 N/A 0.037 0.0688
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.037 0.028
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.037 0.148
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.037 0.025
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.037 0.148
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.037 33.30
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.037 0.165
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.037 0.148
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.025
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.037 0.148
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.037 0.025
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.037 0.025
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.037 0.148
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.037 0.148
NEDD4L NEDD4L, KIAA0439, NEDL3: E3 ubiquitin-protein ligase NEDD4-like protein 0.037 0.028
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.037 0.062
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.037 0.025
VASP VASP: Vasodilator-stimulated phosphoprotein 0.037 0.028
STK10 STK10: Uncharacterized protein STK10 0.037 0.148
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.037 0.148
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.037 0.165
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.028
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.037 0.148
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.037 0.165
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.037 0.034
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.037 0.148
PRG2 PRG2, MBP: Bone marrow proteoglycan precursor 0.037 0.034
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.037 0.148
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.037 0.148
RRM2 RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2 0.036 0.025
CSDA CSDA, DBPA: DNA-binding protein A 0.036 0.025
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.036 0.028
TK1 TK1: Thymidine kinase, cytosolic 0.036 0.025
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0338 0.051
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.0338 0.046
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.034 0.148
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.034 0.148
CETN1 CETN1, CEN1, CETN: Centrin-1 0.034 0.025
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.034 0.025
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.034 0.148
S100B S100B: Protein S100-B 0.032 0.028
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.032 0.025
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.032 0.025
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.032 0.165
LCP1 LCP1, PLS2: Plastin-2 0.032 0.075
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.025
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.032 0.148
FREQ FREQ, FLUP, NCS1: Neuronal calcium sensor 1 0.032 0.025
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.032 0.165
MYL3 MYL3: Myosin light polypeptide 3 0.032 0.025
REG3A REG3A, HIP, PAP, PAP1: Regenerating islet-derived protein 3 alpha precursor 0.032 0.034
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 0.032 0.025
GRLF1 N/A 0.032 0.028
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.032 0.034
SFTPA2 SFTPA2, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A2 precursor 0.032 0.034
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.032 0.025
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.032 0.148
HPCA HPCA, BDR2: Neuron-specific calcium-binding protein hippocalcin 0.032 0.025
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.032 0.148
CHP CHP: Calcium-binding protein p22 0.032 0.025
S100A7 S100A7, PSOR1: Protein S100-A7 0.032 0.028
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.032 0.148
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.032 0.165
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.032 0.165
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.032 0.148
DAB2 DAB2, DOC2: Disabled homolog 2 0.032 0.025
PAEP PAEP: Glycodelin precursor 0.032 0.028
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.032 0.148
PRKAA1 N/A 0.032 0.165
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.032 0.148
SFTPD SFTPD, PSPD, SFTP4: Pulmonary surfactant-associated protein D precursor 0.032 0.030
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.032 0.148
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 0.025
PMP2 PMP2: Myelin P2 protein 0.032 0.025
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.032 0.0688
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.165
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.032 0.148
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.032 0.148
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.032 0.025
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.032 0.148
ATM ATM: Serine-protein kinase ATM 0.032 0.148
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.032 0.148
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.028
GMIP GMIP: GEM-interacting protein 0.032 0.025
CDKL5 N/A 0.032 0.165
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.032 0.165
MYO3A MYO3A: Myosin IIIA 0.032 0.148
REG1B REG1A, PSPS, REG: Lithostathine 1 alpha precursor 0.032 0.034
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.032 0.025
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.032 0.148
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.032 0.025
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.032 0.148
CLEC3B CLEC3B, TNA: Tetranectin precursor 0.032 0.034
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.032 0.148
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.032 0.148
ACTN1 ACTN1: Alpha-actinin-1 0.032 0.075
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.032 0.034
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.032 0.034
S100A3 S100A3, S100E: Protein S100-A3 0.032 0.028
DAPK2 DAPK2: Death-associated protein kinase 2 0.032 0.165
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.032 0.025
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.032 0.028
FRMD4A RP11-397C18.4, RP11-397C18.4-003: Novel protein 0.032 0.027
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.031 0.025
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.031 0.025
TP53 TP53, P53: Cellular tumor antigen p53 0.031 0.075
DYNC1I2 N/A 0.030 0.025
MDN1 MDN1, KIAA0301: Midasin 0.030 0.025
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.030 0.025
CDK5 CDK5: Cell division protein kinase 5 0.029 0.148
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.148
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.148
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 1.17
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.029 0.025
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.029 0.148
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.029 0.030
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.029 0.028
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.029 0.025
CNN3 CNN3: Calponin-3 0.029 0.025
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 1.17
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.029 0.148
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.025
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.029 0.062
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.029 0.148
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.029 0.034
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.029 0.025
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.148
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.029 0.148
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.029 0.148
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.028 0.044
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.028 0.049
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.027 0.025
RACGAP1 RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1 0.027 0.025
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.027 0.025
THOC1 THOC1, HPR1: THO complex subunit 1 0.027 0.025
CA3 CA3: Carbonic anhydrase 3 0.027 0.025
AQP1 AQP1, CHIP28: Aquaporin-1 0.027 0.025
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.027 0.025
WWOX WWOX, FOR, WOX1: WW domain-containing oxidoreductase 0.0263 0.025
CIITA CIITA, MHC2TA: MHC class II transactivator 0.0263 0.028
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.025 0.075
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.025 0.148
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.025 0.165
NUP214 N/A 0.025 0.028
ETS2 ETS2: Protein C-ets-2 0.025 0.083
GNB2L1 Lung cancer oncogene 7 0.025 0.028
0.347
Total Score 15.10