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Evidence of Interaction Between EPOR and STAT5A

The interaction score between EPOR and STAT5A is 22.90.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPOR and STAT5A = 0.14

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.30E-3
Orthology N/A N/A
Domains Domains present in EPOR and STAT5A:
Domains in EPORDomains in STAT5A
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR008967 p53-like transcription factor, DNA-binding
IPR000980 SH2 motif
IPR001217 STAT protein
IPR011992 EF-Hand_type.
IPR012345 STAT_DNA_bd.

The Chi square scores for co-occurrence of domains that are present in EPOR and STAT5A are listed below.

Domain 1Domain 2Chi Square
IPR002996 Cytkn_recept_B/G. IPR000980 SH2 motif 227.343
IPR003961 Fibronectin, type III IPR000980 SH2 motif 184.508
IPR003528 Long hematopoietin receptor, single chain IPR000980 SH2 motif 151.135
IPR002996 Cytkn_recept_B/G. IPR012345 STAT_DNA_bd. 83.5162
IPR002996 Cytkn_recept_B/G. IPR001217 STAT protein 83.5162
IPR009167 Erythropoietin receptor IPR000980 SH2 motif 38.4825
IPR003961 Fibronectin, type III IPR001217 STAT protein 30.8295
IPR003961 Fibronectin, type III IPR012345 STAT_DNA_bd. 30.8295
IPR003528 Long hematopoietin receptor, single chain IPR001217 STAT protein 17.2516
IPR003528 Long hematopoietin receptor, single chain IPR012345 STAT_DNA_bd. 17.2516
IPR002996 Cytkn_recept_B/G. IPR008967 p53-like transcription factor, DNA-binding 9.39809
IPR002996 Cytkn_recept_B/G. IPR011992 EF-Hand_type. 9.08983
IPR003528 Long hematopoietin receptor, single chain IPR008967 p53-like transcription factor, DNA-binding 5.43728
IPR003528 Long hematopoietin receptor, single chain IPR011992 EF-Hand_type. 0.995048
IPR003961 Fibronectin, type III IPR008967 p53-like transcription factor, DNA-binding 0.192388
IPR003961 Fibronectin, type III IPR011992 EF-Hand_type. 0.00640738

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in STAT5A
  • Green Domain is present in both EPOR and STAT5A

 0.109
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: STAT5A

PTMResidueReference
Dephosphorylation 694 PubMed, HPRD
Phosphorylation 694 PubMed, HPRD
Phosphorylation 726 PubMed, HPRD
Phosphorylation 780 PubMed, HPRD
Phosphotyrosine 694 PubMed, HPRD
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: STAT5A

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between EPOR and STAT5A that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andSTAT5A. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and STAT5A has 1739 interactors of which there are 679 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for STAT5A-Interactor (?)
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 3.59 0.123
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.541 0.191
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.340 0.139
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.253 0.035
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.251 0.126
MPP1 MPP1, DXS552E, EMP55: 55 kDa erythrocyte membrane protein 0.231 0.0308
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.210 0.202
HSP90AA1 Hsp89-alpha-delta-N 0.202 0.114
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.065
CRLF3 N/A 0.191 0.274
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.166 0.171
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.166 0.171
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.166 0.275
CNTN1 CNTN1: Contactin-1 precursor 0.165 0.098
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.980
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.165 112.00
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.109
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.109
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.109
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.109
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.109
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.109
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 0.878
CNTN4 CNTN4: Contactin-4 precursor 0.165 0.098
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.109
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.109
FN1 N/A 0.165 0.109
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.109
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.980
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.109
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.109
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.980
BSG N/A 0.165 0.098
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.878
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.165 0.878
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.098
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.878
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.109
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.165 0.098
CAT CAT: Catalase 0.157 0.038
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.153 0.171
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.153 0.275
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 0.655
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 487.00
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.152 0.081
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.127 0.275
KLF1 KLF1, EKLF: Krueppel-like factor 1 0.126 0.033
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 1.04E3
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.126 0.372
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.126 0.045
CD2AP CD2AP: CD2-associated protein 0.126 0.372
CRKL CRKL: Crk-like protein 0.126 430.00
RDX RDX: Radixin 0.126 0.111
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.126 0.225
GAB1 GAB1: GRB2-associated-binding protein 1 0.126 0.123
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.125 0.032
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.125 0.038
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.124 0.038
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.124 0.225
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.123 0.065
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.123 0.065
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.577
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 0.586
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.123 0.577
INSR INSR: Insulin receptor precursor 0.123 277.00
IL9R IL9R: Interleukin-9 receptor precursor 0.123 0.081
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.655
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.123 0.064
GHR GHR: Growth hormone receptor precursor 0.123 0.100
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.072
DCC DCC: Netrin receptor DCC precursor 0.123 0.064
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.123 0.072
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.123 0.166
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.123 0.072
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 0.586
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.113
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.109 0.148
ELMO1 N/A 0.109 0.148
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.0688
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.109 0.148
ARHGEF7 N/A 0.109 0.148
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.165
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 1.30
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.148
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.165
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.109 0.148
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.109 0.148
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.165
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.483
NF2 NF2, SCH: Merlin 0.109 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.165
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.109 0.148
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.165
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 1.17
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 1.17
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.165
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.148
STAT3 0.109 12.60
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 0.148
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.165
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.109 0.148
MAPK15 N/A 0.109 0.165
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 563.00
PSCD2 N/A 0.109 0.165
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.109 0.148
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 1.30
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.148
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.109 0.148
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.109 0.148
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.109 0.148
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.109 0.148
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.148
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.109 0.148
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.165
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.109 0.148
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.519
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.109 0.581
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 1.33
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.202
TNC TNC, HXB: Tenascin precursor 0.109 0.058
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.109 0.081
ITGB4 N/A 0.109 0.065
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.109 0.654
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.202
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 250.00
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.109 0.099
SORL1 SORL1: Sortilin-related receptor precursor 0.109 0.166
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.109 0.081
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.109 0.065
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.109 0.065
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.109 0.072
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.081
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.109 0.520
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.109 0.520
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.109 0.065
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.152
PRLR PRLR: Prolactin receptor precursor 0.109 0.065
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.109 0.058
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 1.16E3
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.081
F3 F3: Tissue factor precursor 0.109 0.065
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.166
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.109 0.064
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.109 0.073
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 600.00
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.105 0.0727
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.251
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 0.874
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 2.17
STAM2 STAM2: Signal transducing adapter molecule 2 0.100 0.111
RPS6KB1 N/A 0.100 0.372
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 3.64
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.100 0.171
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.100 0.275
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.100 0.136
TLN1 TLN1: Uncharacterized protein TLN1 0.100 0.225
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.100 0.275
DOK1 DOK1: Docking protein 1 0.100 0.372
PLD2 PLD2: Phospholipase D2 0.100 0.111
NEO1 NEO1, NGN: Neogenin precursor 0.098 0.052
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.098 0.586
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.098 0.586
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.098 0.520
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 0.577
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.098 0.0727
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.098 0.586
PTPRZ1 N/A 0.098 0.058
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.202
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.098 0.065
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.098 0.072
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.098 0.577
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.098 0.465
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.098 0.0727
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.096 0.074
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.096 0.090
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.091 0.136
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.091 0.275
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.091 0.123
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.091 0.275
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.087 0.051
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.148
KIR3DL1 N/A 0.083 0.109
ATRN N/A 0.083 0.044
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.083 0.049
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.083 0.098
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.083 0.049
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.083 0.098
JAG2 JAG2: Jagged-2 precursor 0.083 0.044
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.083 0.109
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.109
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.083 0.109
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.049
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.083 0.109
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.081 0.225
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 0.225
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 370.00
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.191
TLN2 TLN2: Uncharacterized protein TLN2 0.081 0.078
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.152
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 0.063
RIN1 RIN1: Ras and Rab interactor 1 0.081 0.111
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.081 0.171
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.081 0.307
HCK N/A 0.081 1.78
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.081 0.275
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.081 0.171
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.081 0.127
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.081 0.225
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.081 0.088
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.081 0.171
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.081 0.035
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.081 0.275
DLG2 DLG2: Disks large homolog 2 0.081 0.041
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.081 0.275
SYK SYK: Tyrosine-protein kinase SYK 0.081 2.17
SORBS3 SORBS3, SCAM1: Vinexin 0.081 0.097
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.081 0.251
STK16 N/A 0.081 0.152
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.077 0.171
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.077 0.340
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.077 0.126
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.077 0.075
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.075 0.225
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.075 0.275
CDK2 CDK2: Cell division protein kinase 2 0.075 0.275
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.075 0.275
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.075 0.461
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.075 0.275
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.075 0.275
WEE1 WEE1: Wee1-like protein kinase 0.075 0.171
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.074 0.0425
SPTAN1 N/A 0.0727 0.098
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 1.35
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.072 0.111
MSN MSN: Moesin 0.072 0.275
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.072 0.372
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 0.694
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.072 0.099
FNBP1 N/A 0.072 0.372
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 1.78
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 0.372
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.072 0.171
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.072 2.42
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.072 0.088
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.072 0.099
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.072 0.307
JAK1 0.072 1.78
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 1.20
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.072 0.037
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.072 0.372
PLD1 PLD1: Phospholipase D1 0.072 0.111
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 0.275
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.088
ALK ALK: ALK tyrosine kinase receptor precursor 0.072 0.318
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 1.50
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.072 0.123
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.098
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.109
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.072 0.152
CSK CSK: Tyrosine-protein kinase CSK 0.072 2.17
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.072 0.041
PSD TYL: TYL protein 0.072 0.097
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.072 0.136
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.072 0.275
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.072 0.191
IRS1 IRS1: Insulin receptor substrate 1 0.072 0.098
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.072 0.045
CXorf9 N/A 0.072 0.275
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.072 0.152
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.072 0.109
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.072 0.416
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.072 0.111
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.775
PSCD4 PSCD4, CYT4: Cytohesin-4 0.072 0.275
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.072 0.461
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.072 856.00
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.072 0.191
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.072 0.094
TTN N/A 0.072 0.097
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.072 0.046
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 375.00
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.072 0.037
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.072 0.037
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.251
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 0.770
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 0.874
BMX N/A 0.072 0.775
LYN LYN: Tyrosine-protein kinase Lyn 0.072 1.78
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.072 0.251
VIL2 N/A 0.072 0.171
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.072 0.307
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.072 0.251
GAB2 N/A 0.072 0.191
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.0688 0.098
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.0688 0.098
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 131.00
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.067 0.440
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.088
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.065 0.088
APS SH2B2, APS: SH2B adapter protein 2 0.065 0.111
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 0.171
RASA3 RASA3: Ras GTPase-activating protein 3 0.065 0.136
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.078
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.065 0.097
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 0.775
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.065 0.152
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.065 0.088
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.065 0.111
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.065 0.111
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.065 0.191
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 0.859
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.088
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.065 0.225
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.065 0.099
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 409.00
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.062 0.202
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.202
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.225
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.062 0.073
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.062 0.166
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.062 0.0818
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.062 0.033
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.062 0.113
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.062 0.064
CD44 N/A 0.062 0.061
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.061 0.032
CDK4 CDK4: Cell division protein kinase 4 0.057 0.275
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.057 0.461
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.057 0.461
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.057 0.109
CDK6 CDK6: Cell division protein kinase 6 0.057 0.225
DYRK3 N/A 0.057 0.097
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.056 0.097
EGF EGF: Pro-epidermal growth factor precursor 0.055 0.072
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.055 0.166
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.055 0.0727
GPA33 GPA33: Cell surface A33 antigen precursor 0.055 0.100
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.055 0.166
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.202
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.055 0.100
ITGAE ITGAE: Integrin alpha-E precursor 0.055 0.027
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.055 0.072
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.055 0.166
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.055 0.166
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.055 0.081
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.055 0.126
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.055 0.0727
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.055 0.072
CD69 CD69: Early activation antigen CD69 0.055 0.027
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.055 0.027
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.202
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.055 0.181
LILRB1 N/A 0.055 0.166
CD7 CD7: T-cell antigen CD7 precursor 0.055 0.126
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.055 0.202
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.055 0.126
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.055 0.065
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.055 0.166
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.055 0.064
NOTCH4 N/A 0.055 0.029
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.055 0.067
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.055 0.037
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.055 0.202
PTPRA N/A 0.051 0.051
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
PAPPA PAPPA: Pappalysin-1 precursor 0.051 0.051
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.051 0.046
RAPH1 N/A 0.051 0.051
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.051 0.046
C9orf88 N/A 0.051 0.051
EPB41 EPB41, E41P: Protein 4.1 0.051 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.051 0.046
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.051 0.046
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.051 0.046
FLT4 VEGFR3 long form 0.051 0.553
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 0.051 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.617
CRK CRK: Proto-oncogene C-crk 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.051 0.046
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.051 0.046
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
DLG1 DLG1: Disks large homolog 1 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.617
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 0.051 0.046
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.617
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.051 0.553
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.617
GRB10 N/A 0.051 0.051
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.051 0.046
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.051 0.046
NCAM1 N/A 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.051 0.148
TP73 TP73, P73: Tumor protein p73 0.051 0.072
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.051 0.064
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.0513 0.245
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.049 0.029
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.049 0.100
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.049 0.072
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.049 0.065
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.049 0.065
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.049 0.026
PVR PVR, PVS: Poliovirus receptor precursor 0.049 0.0727
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.049 0.058
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.049 0.0727
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.165
CDC2 CDC2: Cell division control protein 2 homolog 0.049 0.148
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.049 0.083
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.049 0.165
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.049 0.148
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 0.165
MAPKAPK5 N/A 0.049 0.165
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.083
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.049 0.025
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.049 0.047
EEF2K EEF2K: Elongation factor 2 kinase 0.049 0.148
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.165
ACTN4 ACTN4: Alpha-actinin-4 0.049 0.148
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.165
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.075
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.049 0.062
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.049 0.075
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.049 0.047
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.049 0.148
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.049 0.148
PPEF1 N/A 0.049 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.165
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.049 0.148
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.049 0.148
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.049 0.0688
MAP2K5 N/A 0.049 0.165
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.049 0.148
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.049 0.047
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.165
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.049 0.148
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.165
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.049 0.148
SNX3 N/A 0.049 0.025
CNN2 CNN2: Calponin-2 0.049 0.165
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.049 0.148
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.049 0.148
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.075
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.049 0.148
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.049 0.148
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.049 0.165
TSHR N/A 0.048 0.029
TNN TNN: Tenascin-N precursor 0.047 0.030
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.047 0.034
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.046 0.065
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.0453 0.225
FUBP1 N/A 0.0453 0.260
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.0453 0.225
DAB1 DAB1: Disabled homolog 1 0.0453 0.111
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.0453 0.372
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.152
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0453 0.139
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.0453 0.171
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.123
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0453 0.251
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.0453 0.046
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.0453 0.111
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.045 0.065
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.045 0.274
STAT2 STAT2: Signal transducer and activator of transcription 2 0.045 0.126
PLEK PLEK, P47: Pleckstrin 0.045 0.202
SOS1 SOS1: Son of sevenless homolog 1 0.045 0.148
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.045 0.148
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.0446 0.275
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.0446 0.046
PRDX6 PRDX6, AOP2, KIAA0106: Peroxiredoxin-6 0.0446 0.029
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.044 0.050
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.044 0.062
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.042 0.041
PCAF PCAF: Histone acetyltransferase PCAF 0.042 0.041
STAT4 STAT4: Signal transducer and activator of transcription 4 0.041 7.69
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.041 0.090
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.041 0.064
CENTA1 CENTA1: Centaurin-alpha 1 0.041 0.051
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.04 0.025
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.04 0.025
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.039 0.075
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.039 0.032
XRCC1 XRCC1: DNA-repair protein XRCC1 0.039 0.091
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.038 0.053
TBCE TBCE: Tubulin-specific chaperone E 0.037 0.046
COPA COPA: Coatomer subunit alpha 0.037 0.038
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.037 0.046
CDK7 CDK7, MO15: Cell division protein kinase 7 0.037 0.136
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.037 0.191
FLII FLII, FLIL: Protein flightless-1 homolog 0.037 0.046
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.037 0.060
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.037 0.097
CSPG2 N/A 0.037 0.0794
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.037 0.127
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.037 0.111
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.037 0.071
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.037 0.275
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.037 112.00
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.037 0.109
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.037 0.136
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.171
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.037 0.372
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.037 0.056
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.037 0.046
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.037 0.099
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.037 0.275
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.037 0.041
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.037 0.054
VASP VASP: Vasodilator-stimulated phosphoprotein 0.037 0.251
STK10 STK10: Uncharacterized protein STK10 0.037 0.275
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.037 0.275
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.037 0.307
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.096
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.037 0.225
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.037 0.251
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.037 0.045
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.037 0.097
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.037 0.171
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.037 0.097
RRM2 RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2 0.036 0.038
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.036 0.0425
TK1 TK1: Thymidine kinase, cytosolic 0.036 0.029
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.034 0.029
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0338 0.030
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.0338 0.053
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.034 0.098
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.034 0.098
LETM1 LETM1: Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial 0.034 0.036
CETN1 CETN1, CEN1, CETN: Centrin-1 0.034 0.036
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.034 0.098
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.033 0.251
S100B S100B: Protein S100-B 0.032 0.049
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.032 0.035
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.032 0.0308
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.032 0.307
LCP1 LCP1, PLS2: Plastin-2 0.032 0.372
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.225
VWF VWF, F8VWF: von Willebrand factor precursor 0.032 0.041
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.032 0.097
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.032 0.307
MYL3 MYL3: Myosin light polypeptide 3 0.032 0.035
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 0.032 0.0308
GRLF1 N/A 0.032 0.055
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.032 0.045
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.032 0.035
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.032 0.111
HPCA HPCA, BDR2: Neuron-specific calcium-binding protein hippocalcin 0.032 0.028
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.032 0.088
CHP CHP: Calcium-binding protein p22 0.032 0.054
S100A7 S100A7, PSOR1: Protein S100-A7 0.032 0.049
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.032 0.099
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.032 0.123
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.032 0.098
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.032 0.225
DAB2 DAB2, DOC2: Disabled homolog 2 0.032 0.097
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.032 0.171
PRKAA1 N/A 0.032 0.152
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.032 0.097
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.032 0.171
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 0.372
PMP2 PMP2: Myelin P2 protein 0.032 0.044
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.032 0.041
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.251
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.032 0.097
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.032 0.171
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.032 0.044
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.032 0.099
ATM ATM: Serine-protein kinase ATM 0.032 0.225
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.032 0.111
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.077
GMIP GMIP: GEM-interacting protein 0.032 0.139
CDKL5 N/A 0.032 0.098
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.032 0.191
MYO3A MYO3A: Myosin IIIA 0.032 0.088
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.032 0.056
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.032 0.136
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.032 0.225
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.032 0.088
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.032 0.171
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.032 0.171
ACTN1 ACTN1: Alpha-actinin-1 0.032 0.111
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.032 0.041
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.032 0.041
S100A3 S100A3, S100E: Protein S100-A3 0.032 0.049
DAPK2 DAPK2: Death-associated protein kinase 2 0.032 0.109
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.032 0.043
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.032 0.080
GPR23 LPA4, GPR23, P2RY9: Lysophosphatidic acid receptor 4 0.032 0.037
MELK MELK, KIAA0175: Maternal embryonic leucine zipper kinase 0.032 0.044
MTMR3 MTMR3, KIAA0371, ZFYVE10: Myotubularin-related protein 3 0.032 0.028
TP53 TP53, P53: Cellular tumor antigen p53 0.031 0.067
LRFN4 LRFN4: Leucine-rich repeat and fibronectin type-III domain-containing protein 4 0.0308 0.032
MDN1 MDN1, KIAA0301: Midasin 0.030 0.038
CDK5 CDK5: Cell division protein kinase 5 0.029 0.136
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.136
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.136
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.097
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.029 0.031
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.029 0.088
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.029 0.041
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.029 0.035
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.029 0.088
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.029 0.046
CNN3 CNN3: Calponin-3 0.029 0.098
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 0.088
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.029 47.50
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.099
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.029 0.041
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.029 0.041
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.029 0.099
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.029 0.046
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.029 0.086
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.171
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.029 0.088
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.029 0.097
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.029 0.037
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.028 0.044
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.028 0.098
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.028 0.036
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.028 0.044
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.028 0.049
TBXA2R TBXA2R: Thromboxane A2 receptor 0.028 0.049
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
DRD2 DRD2: D(2) dopamine receptor 0.028 0.049
EDNRB EDNRB, ETRB: Endothelin B receptor precursor 0.028 0.049
PTAFR PTAFR, PAFR: Platelet-activating factor receptor 0.028 0.049
SNAP23 SNAP23: Synaptosomal-associated protein 23 0.028 0.044
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.028 0.049
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.028 0.049
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.028 0.109
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.028 0.109
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.109
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.028 0.098
FGFR2 N/A 0.028 6.17
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.109
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.028 0.049
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.028 0.109
ADCY6 ADCY6, KIAA0422: Adenylate cyclase type 6 0.028 0.098
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.028 0.044
UBADC1 UBADC1, GBDR1, KPC2: Ubiquitin-associated domain-containing protein 1 0.027 0.028
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 0.027 0.195
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
FGFR2 N/A 0.027 0.217
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.265
RIOK3 RIOK3, SUDD: Serine/threonine-protein kinase RIO3 0.027 0.028
PIM1 N/A 0.027 0.028
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.027 0.188
RACGAP1 RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1 0.027 0.038
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.027 0.078
THOC1 THOC1, HPR1: THO complex subunit 1 0.027 0.188
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.027 0.071
CIITA CIITA, MHC2TA: MHC class II transactivator 0.0263 0.0425
F2RL3 F2RL3, PAR4: Proteinase-activated receptor 4 precursor 0.026 0.029
SSTR3 SSTR3: Somatostatin receptor type 3 0.026 0.033
GNA15 GNA15, GNA16: Guanine nucleotide-binding protein alpha-15 subunit 0.026 0.0446
RHO RHO, OPN2: Rhodopsin 0.026 0.029
FADD FADD, MORT1: Protein FADD 0.026 0.075
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 0.026 0.032
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.025 0.245
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.025 0.245
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.025 0.126
ETS2 ETS2: Protein C-ets-2 0.025 0.126
GNB2L1 Lung cancer oncogene 7 0.025 0.036
0.572
Total Score 22.90