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Evidence of Interaction Between EPOR and STAT5B

The interaction score between EPOR and STAT5B is 14.50.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPOR and STAT5B = 0.18

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.30E-3
Orthology N/A N/A
Domains Domains present in EPOR and STAT5B:
Domains in EPORDomains in STAT5B
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR008967 p53-like transcription factor, DNA-binding
IPR000980 SH2 motif
IPR001217 STAT protein
IPR011992 EF-Hand_type.
IPR012345 STAT_DNA_bd.

The Chi square scores for co-occurrence of domains that are present in EPOR and STAT5B are listed below.

Domain 1Domain 2Chi Square
IPR002996 Cytkn_recept_B/G. IPR000980 SH2 motif 227.343
IPR003961 Fibronectin, type III IPR000980 SH2 motif 184.508
IPR003528 Long hematopoietin receptor, single chain IPR000980 SH2 motif 151.135
IPR002996 Cytkn_recept_B/G. IPR012345 STAT_DNA_bd. 83.5162
IPR002996 Cytkn_recept_B/G. IPR001217 STAT protein 83.5162
IPR009167 Erythropoietin receptor IPR000980 SH2 motif 38.4825
IPR003961 Fibronectin, type III IPR001217 STAT protein 30.8295
IPR003961 Fibronectin, type III IPR012345 STAT_DNA_bd. 30.8295
IPR003528 Long hematopoietin receptor, single chain IPR001217 STAT protein 17.2516
IPR003528 Long hematopoietin receptor, single chain IPR012345 STAT_DNA_bd. 17.2516
IPR002996 Cytkn_recept_B/G. IPR008967 p53-like transcription factor, DNA-binding 9.39809
IPR002996 Cytkn_recept_B/G. IPR011992 EF-Hand_type. 9.08983
IPR003528 Long hematopoietin receptor, single chain IPR008967 p53-like transcription factor, DNA-binding 5.43728
IPR003528 Long hematopoietin receptor, single chain IPR011992 EF-Hand_type. 0.995048
IPR003961 Fibronectin, type III IPR008967 p53-like transcription factor, DNA-binding 0.192388
IPR003961 Fibronectin, type III IPR011992 EF-Hand_type. 0.00640738

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in STAT5B
  • Green Domain is present in both EPOR and STAT5B

 0.069
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: STAT5B

PTMResidueReference
Dephosphorylation 699 PubMed, HPRD
Phosphorylation 679 PubMed, HPRD
Phosphorylation 699 PubMed, HPRD
Phosphorylation 725 PubMed, HPRD
Phosphorylation 731 PubMed, HPRD
Phosphorylation 740 PubMed, HPRD
Phosphorylation 743 PubMed, HPRD
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: STAT5B

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between EPOR and STAT5B that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andSTAT5B. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and STAT5B has 1726 interactors of which there are 646 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for STAT5B-Interactor (?)
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 3.59 0.081
PRL PRL: Prolactin precursor 0.644 0.025
CSH2 GH1: Somatotropin precursor 0.644 0.031
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.541 0.191
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.340 0.067
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.253 0.033
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.251 0.152
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.210 0.128
HSP90AA1 Hsp89-alpha-delta-N 0.202 0.051
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.041
CRLF3 N/A 0.191 0.354
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.166 0.136
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.166 0.113
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.166 0.372
CNTN1 CNTN1: Contactin-1 precursor 0.165 0.062
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.540
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.165 0.062
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.0688
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.0688
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.0688
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.0688
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.0688
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.0688
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 0.483
CNTN4 CNTN4: Contactin-4 precursor 0.165 0.062
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.0688
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.0688
FN1 N/A 0.165 0.0688
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.0688
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.540
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.0688
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.0688
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.540
BSG N/A 0.165 0.062
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.483
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.165 0.483
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.062
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.483
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.0688
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.165 0.062
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.153 0.225
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.153 0.225
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 0.445
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 214.00
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.152 0.051
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.127 0.181
KLF1 KLF1, EKLF: Krueppel-like factor 1 0.126 0.043
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 784.00
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.126 0.225
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.126 0.045
CD2AP CD2AP: CD2-associated protein 0.126 0.181
CRKL CRKL: Crk-like protein 0.126 0.245
RDX RDX: Radixin 0.126 0.064
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.126 0.225
GAB1 GAB1: GRB2-associated-binding protein 1 0.126 0.152
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.125 0.063
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.125 0.038
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.124 0.136
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.123 0.041
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.123 0.046
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.361
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 0.286
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.123 0.361
INSR INSR: Insulin receptor precursor 0.123 173.00
IL9R IL9R: Interleukin-9 receptor precursor 0.123 0.063
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.361
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.123 0.037
GHR GHR: Growth hormone receptor precursor 0.123 0.045
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.051
DCC DCC: Netrin receptor DCC precursor 0.123 0.041
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.123 0.045
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.123 0.173
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.123 0.063
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 0.286
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.094
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.109 0.098
ELMO1 N/A 0.109 0.148
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.0688
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.109 0.148
ARHGEF7 N/A 0.109 0.098
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.109
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 0.980
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.148
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.109
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.109 0.098
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.109 0.098
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.109
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.483
NF2 NF2, SCH: Merlin 0.109 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.109
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.109 0.098
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.109
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 0.878
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 0.878
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.109
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.148
STAT3 0.109 8.34
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 0.098
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.109
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.109 0.148
MAPK15 N/A 0.109 0.165
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 422.00
PSCD2 N/A 0.109 0.109
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.109 0.148
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 0.980
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.148
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.109 0.098
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.109 0.098
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.109 0.098
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.109 0.148
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.098
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.109 0.098
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.109
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.109 0.148
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.360
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.109 0.320
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.445
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.128
TNC TNC, HXB: Tenascin precursor 0.109 0.041
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.109 0.0794
ITGB4 N/A 0.109 0.045
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.109 0.360
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.173
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 155.00
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.109 0.052
SORL1 SORL1: Sortilin-related receptor precursor 0.109 0.214
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.109 0.063
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.109 0.051
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.109 0.041
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.109 0.051
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.063
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.109 0.318
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.109 0.318
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.109 0.041
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.100
PRLR PRLR: Prolactin receptor precursor 0.109 0.045
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.109 0.037
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 353.00
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.051
F3 F3: Tissue factor precursor 0.109 0.041
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.128
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.109 0.041
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.109 0.037
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 372.00
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.105 0.098
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.515
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.100 409.00
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 0.577
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 1.33
STAM2 STAM2: Signal transducing adapter molecule 2 0.100 0.073
RPS6KB1 N/A 0.100 0.372
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 2.73
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.100 0.148
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.100 0.372
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.100 0.148
TLN1 TLN1: Uncharacterized protein TLN1 0.100 0.181
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.100 0.372
DOK1 DOK1: Docking protein 1 0.100 0.275
PLD2 PLD2: Phospholipase D2 0.100 0.090
NEO1 NEO1, NGN: Neogenin precursor 0.098 0.041
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.098 0.318
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.098 0.318
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.098 0.286
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 0.445
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.098 0.041
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.098 0.286
PTPRZ1 N/A 0.098 0.041
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.173
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.098 0.037
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.098 0.051
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.098 0.286
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.098 0.256
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.098 0.046
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.096 0.094
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.091 0.171
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.091 0.372
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.091 0.152
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.091 0.225
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.087 0.035
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.098
KIR3DL1 N/A 0.083 0.0688
ATRN N/A 0.083 0.030
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.083 0.034
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.083 0.062
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.083 0.034
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.083 0.062
JAG2 JAG2: Jagged-2 precursor 0.083 0.030
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.083 0.0688
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.0688
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.083 0.0688
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.034
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.083 0.0688
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.081 0.245
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 0.245
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 330.00
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.191
TLN2 TLN2: Uncharacterized protein TLN2 0.081 0.052
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.100
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 0.051
RIN1 RIN1: Ras and Rab interactor 1 0.081 0.111
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.081 0.275
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.081 0.340
HCK N/A 0.081 1.62
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.081 0.372
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.081 0.113
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.081 0.075
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.081 0.275
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.081 0.058
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.081 0.171
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.081 0.035
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.081 0.461
DLG2 DLG2: Disks large homolog 2 0.081 0.037
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.081 0.275
SYK SYK: Tyrosine-protein kinase SYK 0.081 1.33
SORBS3 SORBS3, SCAM1: Vinexin 0.081 0.064
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.081 0.274
STK16 N/A 0.081 0.191
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.077 0.181
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.077 0.173
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.077 0.105
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.077 0.0513
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.075 0.171
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.075 0.148
CDK2 CDK2: Cell division protein kinase 2 0.075 0.275
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.075 0.171
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.075 0.372
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.075 0.148
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.075 0.275
WEE1 WEE1: Wee1-like protein kinase 0.075 0.171
SPTAN1 N/A 0.0727 0.065
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 1.62
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.072 0.097
MSN MSN: Moesin 0.072 0.304
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.072 0.245
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 0.520
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.072 0.097
FNBP1 N/A 0.072 0.275
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 1.62
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 0.245
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.072 0.171
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.072 2.46
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.072 0.064
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.072 0.058
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.072 0.202
JAK1 0.072 1.62
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 0.902
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.072 0.041
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.072 0.304
PLD1 PLD1: Phospholipase D1 0.072 0.064
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 0.245
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.058
ALK ALK: ALK tyrosine kinase receptor precursor 0.072 0.361
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 0.902
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.072 0.123
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.065
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.109
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.072 0.166
CSK CSK: Tyrosine-protein kinase CSK 0.072 2.20
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.072 0.041
PSD TYL: TYL protein 0.072 0.064
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.072 0.225
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.072 0.461
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.072 0.202
IRS1 IRS1: Insulin receptor substrate 1 0.072 0.109
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.072 0.045
CXorf9 N/A 0.072 0.372
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.072 0.191
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.072 0.081
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.072 0.515
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.072 0.090
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.581
PSCD4 PSCD4, CYT4: Cytohesin-4 0.072 0.245
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.072 0.304
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.072 784.00
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.072 0.100
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.072 0.155
TTN N/A 0.072 0.097
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.072 0.041
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 281.00
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.072 0.037
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.072 0.037
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.307
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 0.577
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 0.808
BMX N/A 0.072 0.644
LYN LYN: Tyrosine-protein kinase Lyn 0.072 1.62
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.072 0.251
VIL2 N/A 0.072 0.148
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.072 0.274
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.072 0.202
GAB2 N/A 0.072 0.251
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.0688 0.148
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.0688 0.148
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 199.00
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.067 0.225
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.065
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.065 0.064
APS SH2B2, APS: SH2B adapter protein 2 0.065 0.090
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 0.181
RASA3 RASA3: Ras GTPase-activating protein 3 0.065 0.148
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.078
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.065 0.065
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 0.644
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.065 0.152
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.065 0.058
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.065 0.097
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.065 0.090
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.065 0.152
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 0.975
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.099
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.065 0.275
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.065 0.064
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.062 0.214
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.214
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.181
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.062 0.071
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.062 0.105
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.062 0.076
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.062 0.094
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.062 0.041
CD44 N/A 0.062 0.029
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.061 0.046
EIF2AK1 N/A 0.057 0.0308
CDK4 CDK4: Cell division protein kinase 4 0.057 0.225
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.057 0.461
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.057 0.503
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.057 0.123
CDK6 CDK6: Cell division protein kinase 6 0.057 0.225
DYRK3 N/A 0.057 0.097
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.056 0.064
EGF EGF: Pro-epidermal growth factor precursor 0.055 0.045
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.055 0.173
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.055 0.045
GPA33 GPA33: Cell surface A33 antigen precursor 0.055 0.063
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.055 0.0794
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.173
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.055 0.063
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.055 0.045
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.055 0.0794
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.055 0.0794
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.055 0.051
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.055 0.063
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.055 0.041
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.055 0.051
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.214
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.055 0.155
LILRB1 N/A 0.055 0.105
CD7 CD7: T-cell antigen CD7 precursor 0.055 0.105
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.055 0.214
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.055 0.105
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.055 0.045
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.055 0.105
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.055 0.037
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.055 0.056
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.055 0.039
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.055 0.214
PTPRA N/A 0.051 0.051
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
PAPPA PAPPA: Pappalysin-1 precursor 0.051 0.051
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.051 0.046
RAPH1 N/A 0.051 0.051
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.051 0.046
C9orf88 N/A 0.051 0.051
EPB41 EPB41, E41P: Protein 4.1 0.051 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.051 0.046
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.051 0.046
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.051 0.046
FLT4 VEGFR3 long form 0.051 0.553
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 0.051 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.617
CRK CRK: Proto-oncogene C-crk 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.051 0.046
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.051 0.046
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
DLG1 DLG1: Disks large homolog 1 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.617
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 0.051 0.046
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.617
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.051 0.553
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.617
GRB10 N/A 0.051 0.051
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.051 0.046
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.051 0.046
NCAM1 N/A 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.051 0.225
TP73 TP73, P73: Tumor protein p73 0.051 0.098
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.051 0.097
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.0513 0.461
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.049 0.128
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.049 0.051
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.049 0.046
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.049 0.041
PVR PVR, PVS: Poliovirus receptor precursor 0.049 0.041
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.049 0.036
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.049 0.036
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.109
CDC2 CDC2: Cell division control protein 2 homolog 0.049 0.148
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.049 0.049
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.049 0.165
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.049 0.148
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 0.165
MAPKAPK5 N/A 0.049 0.165
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.049
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.049 0.036
EEF2K EEF2K: Elongation factor 2 kinase 0.049 0.148
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.165
ACTN4 ACTN4: Alpha-actinin-4 0.049 0.098
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.165
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.044
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.049 0.062
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.049 0.044
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.049 0.036
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.049 0.148
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.049 0.148
PPEF1 N/A 0.049 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.109
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.049 0.148
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.049 0.148
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.049 0.0688
MAP2K5 N/A 0.049 0.109
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.049 0.148
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.049 0.036
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.165
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.049 0.148
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.165
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.049 0.148
CNN2 CNN2: Calponin-2 0.049 0.109
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.049 0.148
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.049 0.148
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.044
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.049 0.148
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.049 0.148
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.049 0.165
TNN TNN: Tenascin-N precursor 0.047 0.034
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.047 0.034
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.046 0.109
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.0453 0.148
FUBP1 N/A 0.0453 0.153
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.0453 0.275
DAB1 DAB1: Disabled homolog 1 0.0453 0.097
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.0453 0.275
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.166
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0453 0.111
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.0453 0.225
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.152
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0453 0.307
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.0453 0.046
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.0453 0.136
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.045 0.109
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.045 0.852
STAT2 STAT2: Signal transducer and activator of transcription 2 0.045 0.191
PLEK PLEK, P47: Pleckstrin 0.045 0.307
SOS1 SOS1: Son of sevenless homolog 1 0.045 0.372
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.045 0.372
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.0446 0.148
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.0446 0.032
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.044 0.050
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.044 0.062
HDGF HDGF, HMG1L2: Hepatoma-derived growth factor 0.042 0.029
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.042 0.069
PCAF PCAF: Histone acetyltransferase PCAF 0.042 0.086
STAT4 STAT4: Signal transducer and activator of transcription 4 0.041 23.50
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.041 0.225
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.041 0.111
CENTA1 CENTA1: Centaurin-alpha 1 0.041 0.063
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.04 0.025
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.039 0.063
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.039 0.046
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.039 0.029
XRCC1 XRCC1: DNA-repair protein XRCC1 0.039 0.155
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.038 0.053
COPA COPA: Coatomer subunit alpha 0.037 0.046
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.037 0.046
CDK7 CDK7, MO15: Cell division protein kinase 7 0.037 0.136
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.037 0.251
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.037 0.046
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.037 0.073
CSPG2 N/A 0.037 0.0794
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.037 0.057
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.037 0.111
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.037 0.112
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.037 0.461
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.037 53.10
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.037 0.152
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.037 0.171
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.148
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.037 0.372
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.037 0.026
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.037 0.088
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.037 0.275
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.037 0.041
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.037 0.041
VASP VASP: Vasodilator-stimulated phosphoprotein 0.037 0.274
STK10 STK10: Uncharacterized protein STK10 0.037 0.461
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.037 0.275
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.037 0.307
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.037 0.075
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.037 0.225
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.037 0.416
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.037 0.063
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.037 0.171
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.037 0.225
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.037 0.097
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0338 0.030
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.0338 0.070
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.034 0.148
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.034 0.148
CETN1 CETN1, CEN1, CETN: Centrin-1 0.034 0.047
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.034 0.025
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.034 0.148
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.033 0.274
S100B S100B: Protein S100-B 0.032 0.029
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.032 0.027
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.032 0.515
LCP1 LCP1, PLS2: Plastin-2 0.032 0.245
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.181
VWF VWF, F8VWF: von Willebrand factor precursor 0.032 0.041
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.032 0.097
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.032 0.251
GRLF1 N/A 0.032 0.062
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.032 0.063
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.032 0.043
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.032 0.136
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.032 0.097
CHP CHP: Calcium-binding protein p22 0.032 0.033
S100A7 S100A7, PSOR1: Protein S100-A7 0.032 0.029
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.032 0.078
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.032 0.123
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.032 0.109
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.032 0.225
DAB2 DAB2, DOC2: Disabled homolog 2 0.032 0.136
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.032 0.171
PRKAA1 N/A 0.032 0.191
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.032 0.097
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.032 0.275
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 0.245
PMP2 PMP2: Myelin P2 protein 0.032 0.026
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.032 0.041
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.251
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.032 0.111
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.032 0.136
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.032 0.026
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.032 0.088
ATM ATM: Serine-protein kinase ATM 0.032 0.372
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.032 0.097
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.075
GMIP GMIP: GEM-interacting protein 0.032 0.111
CDKL5 N/A 0.032 0.109
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.032 0.152
MYO3A MYO3A: Myosin IIIA 0.032 0.088
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.032 0.029
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.032 0.073
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.032 0.181
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.032 0.088
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.032 0.171
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.032 0.113
ACTN1 ACTN1: Alpha-actinin-1 0.032 0.090
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.032 0.041
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.032 0.041
S100A3 S100A3, S100E: Protein S100-A3 0.032 0.029
DAPK2 DAPK2: Death-associated protein kinase 2 0.032 0.123
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.032 0.041
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.032 0.046
GPR23 LPA4, GPR23, P2RY9: Lysophosphatidic acid receptor 4 0.032 0.025
MELK MELK, KIAA0175: Maternal embryonic leucine zipper kinase 0.032 0.028
MTMR3 MTMR3, KIAA0371, ZFYVE10: Myotubularin-related protein 3 0.032 0.035
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.031 0.038
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.031 0.063
TP53 TP53, P53: Cellular tumor antigen p53 0.031 0.114
MDN1 MDN1, KIAA0301: Midasin 0.030 0.046
CDK5 CDK5: Cell division protein kinase 5 0.029 0.097
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.171
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.136
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.090
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.029 0.097
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.029 0.046
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.029 0.027
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.029 0.058
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.029 0.041
CNN3 CNN3: Calponin-3 0.029 0.0727
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 0.097
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.029 47.50
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.065
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.029 0.037
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.029 0.037
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.029 0.099
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.029 0.046
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.029 0.067
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.275
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.029 0.099
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.029 0.097
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.029 0.046
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.028 0.030
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.028 0.062
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.028 0.030
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.028 0.034
TBXA2R TBXA2R: Thromboxane A2 receptor 0.028 0.034
DRD2 DRD2: D(2) dopamine receptor 0.028 0.034
EDNRB EDNRB, ETRB: Endothelin B receptor precursor 0.028 0.034
PTAFR PTAFR, PAFR: Platelet-activating factor receptor 0.028 0.034
SNAP23 SNAP23: Synaptosomal-associated protein 23 0.028 0.030
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.028 0.034
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.028 0.034
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.028 0.0688
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.028 0.0688
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.0688
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.028 0.062
FGFR2 N/A 0.028 1.64
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.0688
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.028 0.034
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.028 0.0688
ADCY6 ADCY6, KIAA0422: Adenylate cyclase type 6 0.028 0.062
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.028 0.030
UBADC1 UBADC1, GBDR1, KPC2: Ubiquitin-associated domain-containing protein 1 0.027 0.028
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 0.027 0.126
FGFR2 N/A 0.027 0.141
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.217
RIOK3 RIOK3, SUDD: Serine/threonine-protein kinase RIO3 0.027 0.036
PIM1 N/A 0.027 0.044
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.027 0.051
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.027 0.078
THOC1 THOC1, HPR1: THO complex subunit 1 0.027 0.0818
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.027 0.071
FADD FADD, MORT1: Protein FADD 0.026 0.085
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.025 0.275
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.025 0.372
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.025 0.152
NUP214 N/A 0.025 0.0425
ETS2 ETS2: Protein C-ets-2 0.025 0.191
GNB2L1 Lung cancer oncogene 7 0.025 0.070
0.572
Total Score 14.50