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Evidence of Interaction Between EPOR and SOS1

The interaction score between EPOR and SOS1 is 5.40.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPOR and SOS1 = -0.07

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology N/A N/A
Domains Domains present in EPOR and SOS1:
Domains in EPORDomains in SOS1
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR011009 Protein kinase-like
IPR007125 Histone core
IPR009072 Histone-fold
IPR000219 DH domain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24
IPR001849 Pleckstrin-like
IPR001895 Guanine-nucleotide dissociation stimulator CDC25
IPR008937 Ras guanine nucleotide exchange factor
IPR000651 Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
IPR007124 Histone-fold/TFIID-TAF/NF-Y
IPR011993 PH_type.

The Chi square scores for co-occurrence of domains that are present in EPOR and SOS1 are listed below.

Domain 1Domain 2Chi Square
IPR003961 Fibronectin, type III IPR001849 Pleckstrin-like 7.30258
IPR003961 Fibronectin, type III IPR000219 DH domain 5.96262
IPR003961 Fibronectin, type III IPR001331 Guanine-nucleotide dissociation stimulator, CDC24 5.42661
IPR003528 Long hematopoietin receptor, single chain IPR011009 Protein kinase-like 3.32619
IPR003961 Fibronectin, type III IPR011993 PH_type. 3.27464
IPR003528 Long hematopoietin receptor, single chain IPR001849 Pleckstrin-like 2.94869
IPR002996 Cytkn_recept_B/G. IPR011009 Protein kinase-like 1.93327
IPR002996 Cytkn_recept_B/G. IPR001331 Guanine-nucleotide dissociation stimulator, CDC24 1.11167
IPR003528 Long hematopoietin receptor, single chain IPR011993 PH_type. 0.89194
IPR002996 Cytkn_recept_B/G. IPR000219 DH domain 0.73635
IPR003961 Fibronectin, type III IPR011009 Protein kinase-like 0.616354
IPR009167 Erythropoietin receptor IPR011009 Protein kinase-like 0.331462
IPR002996 Cytkn_recept_B/G. IPR011993 PH_type. 0.141797
IPR002996 Cytkn_recept_B/G. IPR001849 Pleckstrin-like 0.0712315

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in SOS1
  • Green Domain is present in both EPOR and SOS1

 0.069
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: SOS1

PTMResidueReference
Phosphorylation 1082 PubMed, HPRD
Phosphorylation 1132 PubMed, HPRD
Phosphorylation 1167 PubMed, HPRD
Phosphorylation 1178 PubMed, HPRD
Phosphorylation 1193 PubMed, HPRD
Phosphorylation 1197 PubMed, HPRD
Phosphorylation 1210 PubMed, HPRD
Phosphoserine 1082 HPRD
Phosphoserine 1210 HPRD
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: SOS1

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between EPOR and SOS1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andSOS1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and SOS1 has 1621 interactors of which there are 589 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for SOS1-Interactor (?)
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 3.59 0.065
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.541 0.123
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.340 0.051
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.251 0.152
HSP90AA1 Hsp89-alpha-delta-N 0.202 0.051
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.041
CRLF3 N/A 0.191 0.128
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.166 0.111
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.166 0.090
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.166 0.225
CNTN1 CNTN1: Contactin-1 precursor 0.165 0.062
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.0688
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.165 0.062
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.0688
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.0688
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.034
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.0688
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.0688
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.034
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 0.062
CNTN4 CNTN4: Contactin-4 precursor 0.165 0.062
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.0688
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.0688
FN1 N/A 0.165 0.0688
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.034
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.0688
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.0688
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.0688
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.0688
BSG N/A 0.165 0.030
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.062
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.165 0.062
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.062
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.062
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.0688
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.165 0.062
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.153 0.136
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.153 0.171
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 0.046
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 0.094
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.152 0.051
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.127 0.148
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 0.148
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.126 0.225
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.126 0.041
CD2AP CD2AP: CD2-associated protein 0.126 0.181
CRKL CRKL: Crk-like protein 0.126 0.148
RDX RDX: Radixin 0.126 0.073
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.126 0.171
GAB1 GAB1: GRB2-associated-binding protein 1 0.126 0.123
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.125 0.038
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.125 0.171
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.124 0.097
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.123 0.025
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.046
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 0.037
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.123 0.041
INSR INSR: Insulin receptor precursor 0.123 0.037
IL9R IL9R: Interleukin-9 receptor precursor 0.123 0.045
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.041
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.123 0.057
GHR GHR: Growth hormone receptor precursor 0.123 0.063
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.051
DCC DCC: Netrin receptor DCC precursor 0.123 0.046
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.123 0.045
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.123 0.0794
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 0.041
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.094
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.109 0.098
ELMO1 N/A 0.109 0.148
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.0688
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.109 0.148
ARHGEF7 N/A 0.109 0.098
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.109
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 0.109
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.148
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.109
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.109 0.098
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.109 0.098
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.109
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.062
NF2 NF2, SCH: Merlin 0.109 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.109
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.109 0.098
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.109
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 0.098
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 0.098
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.109
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.148
STAT3 0.109 0.098
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 18.00
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.109
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.109 0.148
MAPK15 N/A 0.109 0.165
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 0.098
PSCD2 N/A 0.109 0.109
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.109 0.148
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 0.109
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.148
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.109 112.00
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.109 0.098
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.109 0.098
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.109 0.148
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.098
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.109 0.098
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.109
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.109 0.148
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.041
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.109 0.041
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.071
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.0513
TNC TNC, HXB: Tenascin precursor 0.109 0.046
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.109 0.105
ITGB4 N/A 0.109 0.045
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.109 0.041
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.063
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 0.046
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.109 0.058
SORL1 SORL1: Sortilin-related receptor precursor 0.109 0.128
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.109 0.0794
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.109 0.051
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.109 0.041
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.051
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.109 0.046
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.109 0.037
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.109 0.037
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.126
PRLR PRLR: Prolactin receptor precursor 0.109 0.045
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.109 0.041
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 0.046
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.031
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.0513
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.109 0.046
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.109 0.046
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 0.046
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.105 0.098
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.307
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.100 0.148
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 0.064
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 0.148
STAM2 STAM2: Signal transducing adapter molecule 2 0.100 0.090
RPS6KB1 N/A 0.100 0.372
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 0.245
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.100 0.073
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.100 0.225
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.100 0.113
TLN1 TLN1: Uncharacterized protein TLN1 0.100 0.051
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.100 0.275
DOK1 DOK1: Docking protein 1 0.100 0.171
PLD2 PLD2: Phospholipase D2 0.100 0.073
NEO1 NEO1, NGN: Neogenin precursor 0.098 0.041
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.098 0.041
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.098 0.037
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.098 0.041
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 0.057
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.098 0.041
PTPRZ1 N/A 0.098 0.041
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.0513
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.098 0.037
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.098 0.031
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.098 0.041
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.098 0.037
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.098 0.045
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.096 0.057
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.091 0.136
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.091 0.372
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.091 0.055
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.091 0.225
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.098
KIR3DL1 N/A 0.083 0.034
CDH6 CDH6: Cadherin-6 precursor 0.083 0.034
DLK1 DLK1, DLK: Delta-like protein precursor 0.083 0.034
ATRN N/A 0.083 0.062
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.083 0.0688
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.083 0.030
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.083 0.034
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.083 0.062
JAG2 JAG2: Jagged-2 precursor 0.083 0.030
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.0688
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.034
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.081 0.181
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 0.181
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 0.181
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.152
TLN2 TLN2: Uncharacterized protein TLN2 0.081 0.026
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.100
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 0.051
RIN1 RIN1: Ras and Rab interactor 1 0.081 0.111
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.081 0.275
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.081 0.166
HCK N/A 0.081 0.090
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.081 0.275
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.081 0.090
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.081 0.075
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.081 0.171
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.081 0.064
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.081 0.136
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.081 0.046
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.081 0.275
DLG2 DLG2: Disks large homolog 2 0.081 0.037
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.081 0.225
SYK SYK: Tyrosine-protein kinase SYK 0.081 0.148
SORBS3 SORBS3, SCAM1: Vinexin 0.081 30.80
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.081 0.100
STK16 N/A 0.081 0.152
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.077 0.181
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.077 0.0794
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.075 0.111
CDK2 CDK2: Cell division protein kinase 2 0.075 0.171
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.075 0.136
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.075 0.275
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.075 0.148
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.075 0.225
WEE1 WEE1: Wee1-like protein kinase 0.075 0.136
SPTAN1 N/A 0.0727 0.072
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 0.181
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.072 0.088
MSN MSN: Moesin 0.072 0.148
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.072 0.245
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 0.073
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.072 0.088
FNBP1 N/A 0.072 0.372
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 0.113
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 0.245
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.072 0.111
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.072 0.202
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.072 0.064
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.072 0.064
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.072 0.166
JAK1 0.072 0.304
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 0.100
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.072 0.041
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.072 0.181
PLD1 PLD1: Phospholipase D1 0.072 0.064
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 0.304
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.065
ALK ALK: ALK tyrosine kinase receptor precursor 0.072 0.046
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 0.100
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.072 0.152
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.081
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.152
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.072 0.126
CSK CSK: Tyrosine-protein kinase CSK 0.072 0.245
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.072 0.046
PSD TYL: TYL protein 0.072 0.064
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.072 0.225
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.072 0.372
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.072 0.126
IRS1 IRS1: Insulin receptor substrate 1 0.072 0.123
CXorf9 N/A 0.072 0.275
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.072 0.251
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.072 0.081
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.072 0.515
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.072 0.073
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.065
PSCD4 PSCD4, CYT4: Cytohesin-4 0.072 0.181
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.072 0.304
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.072 0.181
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.072 0.126
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.072 0.155
TTN N/A 0.072 0.049
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.072 0.041
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 0.064
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.072 0.046
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.072 0.046
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.307
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 0.113
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 0.064
BMX N/A 0.072 0.065
LYN LYN: Tyrosine-protein kinase Lyn 0.072 0.148
LAMA2 LAMA2: Uncharacterized protein LAMA2 0.072 0.028
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.072 0.251
VIL2 N/A 0.072 0.113
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.072 0.166
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.072 0.202
GAB2 N/A 0.072 0.152
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.0688 0.148
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.0688 0.148
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 0.148
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.064
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.065 0.073
APS SH2B2, APS: SH2B adapter protein 2 0.065 0.090
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 0.181
RASA3 RASA3: Ras GTPase-activating protein 3 0.065 0.181
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.088
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.065 0.064
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 0.081
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.065 0.251
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.065 0.058
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.065 0.111
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.065 0.181
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.065 0.251
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 0.191
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.111
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.065 0.275
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.065 0.058
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.372
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.062 0.105
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.062 0.025
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.062 0.0513
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.148
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.062 0.025
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.062 0.046
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.062 0.031
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.062 0.076
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.062 0.041
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.062 0.094
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.062 0.041
CD44 N/A 0.062 0.0513
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.061 0.114
CDK4 CDK4: Cell division protein kinase 4 0.057 0.171
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.057 0.461
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.057 0.181
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.057 0.152
CDK6 CDK6: Cell division protein kinase 6 0.057 0.136
DYRK3 N/A 0.057 0.097
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.056 0.113
EGF EGF: Pro-epidermal growth factor precursor 0.055 0.045
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.055 0.039
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.128
ITGAE ITGAE: Integrin alpha-E precursor 0.055 0.063
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.055 0.031
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.055 0.051
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.055 0.063
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.055 0.071
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.055 0.094
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.055 0.046
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.055 0.035
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.055 0.028
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.055 0.031
ITGB7 ITGB7: Integrin beta-7 precursor 0.055 0.155
GNA12 GNA12: Guanine nucleotide-binding protein alpha-12 subunit 0.052 0.057
PTPRA N/A 0.051 0.051
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
RAPH1 N/A 0.051 0.051
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.051 0.046
C9orf88 N/A 0.051 0.051
EPB41 EPB41, E41P: Protein 4.1 0.051 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.051 0.046
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.051 0.046
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.051 0.046
FLT4 VEGFR3 long form 0.051 0.046
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.051 0.046
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.051 0.046
DLG1 DLG1: Disks large homolog 1 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.051
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.051 0.046
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.051
GRB10 N/A 0.051 0.051
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.051 0.046
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.051 0.046
NCAM1 N/A 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.051 0.171
TP73 TP73, P73: Tumor protein p73 0.051 0.049
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.051 0.136
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.0513 0.139
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.049 0.031
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.049 0.041
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.109
CDC2 CDC2: Cell division control protein 2 homolog 0.049 0.148
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.049 0.165
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.049 0.148
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 0.165
MAPKAPK5 N/A 0.049 0.165
PLAT PLAT: Tissue-type plasminogen activator precursor 0.049 0.030
EEF2K EEF2K: Elongation factor 2 kinase 0.049 0.148
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.165
ACTN4 ACTN4: Alpha-actinin-4 0.049 0.044
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.165
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.044
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.049 0.030
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.049 0.044
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.049 0.148
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.049 0.148
PPEF1 N/A 0.049 0.028
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.109
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.049 0.148
F7 F7: Coagulation factor VII precursor 0.049 0.030
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.049 0.148
BMP1 N/A 0.049 0.030
MAP2K5 N/A 0.049 0.109
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.049 0.148
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.049 0.044
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.165
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.049 0.148
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.165
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.049 0.148
SNX3 N/A 0.049 0.098
CNN2 CNN2: Calponin-2 0.049 0.049
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.049 0.148
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.049 0.148
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.044
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.049 0.148
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.049 0.148
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.049 0.165
TNN TNN: Tenascin-N precursor 0.047 0.042
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.047 0.034
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.046 0.098
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.0453 0.090
FUBP1 N/A 0.0453 0.0446
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.0453 0.225
DAB1 DAB1: Disabled homolog 1 0.0453 0.088
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.0453 0.275
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.081
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0453 0.111
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.0453 0.225
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.152
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0453 0.251
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.0453 0.372
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.0453 0.171
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.045 0.109
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.045 0.416
STAT2 STAT2: Signal transducer and activator of transcription 2 0.045 0.251
PLEK PLEK, P47: Pleckstrin 0.045 0.307
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.045 0.461
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.0446 0.033
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.044 0.050
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.042 0.0308
PCAF PCAF: Histone acetyltransferase PCAF 0.042 0.069
STAT4 STAT4: Signal transducer and activator of transcription 4 0.041 0.372
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.041 0.171
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.041 0.097
CENTA1 CENTA1: Centaurin-alpha 1 0.041 0.051
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.04 0.148
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.04 0.044
CDC20 CDC20: Cell division cycle protein 20 homolog 0.039 0.111
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.039 0.031
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.039 0.275
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.039 0.136
XRCC1 XRCC1: DNA-repair protein XRCC1 0.039 0.127
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.038 0.034
COPA COPA: Coatomer subunit alpha 0.037 0.275
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.037 0.275
CDK7 CDK7, MO15: Cell division protein kinase 7 0.037 0.171
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.037 0.191
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.037 0.073
CSPG2 N/A 0.037 0.031
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.037 0.136
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.037 0.111
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.037 0.461
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.037 0.111
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.037 0.123
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.037 0.136
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.181
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.037 0.372
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.037 0.113
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.037 0.148
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.037 0.099
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.037 0.171
NEDD4L NEDD4L, KIAA0439, NEDL3: E3 ubiquitin-protein ligase NEDD4-like protein 0.037 0.031
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.037 0.067
VASP VASP: Vasodilator-stimulated phosphoprotein 0.037 0.100
STK10 STK10: Uncharacterized protein STK10 0.037 0.372
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.037 0.372
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.037 0.307
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.037 0.225
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.037 0.416
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.037 0.045
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.037 0.136
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.037 0.275
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.037 0.111
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.0338 0.086
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.034 0.148
PTGS1 PTGS1, COX1: Prostaglandin G/H synthase 1 precursor 0.034 0.034
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.034 0.148
CETN1 CETN1, CEN1, CETN: Centrin-1 0.034 0.025
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.034 0.148
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.034 0.075
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.033 0.082
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.032 0.029
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.032 0.416
LCP1 LCP1, PLS2: Plastin-2 0.032 0.0818
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.051
VWF VWF, F8VWF: von Willebrand factor precursor 0.032 0.037
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.032 0.097
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.032 0.307
GRLF1 N/A 0.032 0.152
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.032 0.045
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.032 0.111
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.032 0.088
C1S C1S: Complement C1s subcomponent precursor 0.032 0.025
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.032 0.088
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.032 0.152
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.032 0.123
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.032 0.225
DAB2 DAB2, DOC2: Disabled homolog 2 0.032 0.097
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.032 0.111
PRKAA1 N/A 0.032 0.251
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.032 0.136
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.032 0.225
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 0.181
PMP2 PMP2: Myelin P2 protein 0.032 0.064
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.251
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.032 0.088
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.032 0.171
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.032 0.058
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.032 0.097
ATM ATM: Serine-protein kinase ATM 0.032 0.461
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.032 0.111
GMIP GMIP: GEM-interacting protein 0.032 0.067
CDKL5 N/A 0.032 0.109
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.032 0.191
MYO3A MYO3A: Myosin IIIA 0.032 0.099
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.032 0.090
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.032 0.148
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.032 0.0818
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.032 0.097
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.032 0.171
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.032 0.090
ACTN1 ACTN1: Alpha-actinin-1 0.032 0.033
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.032 0.045
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.032 0.045
DAPK2 DAPK2: Death-associated protein kinase 2 0.032 0.109
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.031 0.225
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.031 0.171
TP53 TP53, P53: Cellular tumor antigen p53 0.031 0.054
DYNC1I2 N/A 0.030 0.136
MDN1 MDN1, KIAA0301: Midasin 0.030 0.188
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.030 0.111
CDK5 CDK5: Cell division protein kinase 5 0.029 0.111
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.136
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.171
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.090
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.029 0.026
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.029 0.088
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.029 0.057
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.029 0.029
CNN3 CNN3: Calponin-3 0.029 0.029
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 0.111
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.029 0.099
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.058
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.029 0.037
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.029 0.088
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.029 0.041
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.275
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.029 0.088
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.029 0.111
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.029 0.046
PCDHA2 PCDHA2: Protocadherin alpha 2 precursor 0.028 0.034
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.028 0.030
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.028 0.030
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.028 0.030
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.028 0.034
APP APP, A4, AD1: Amyloid beta A4 protein precursor 0.028 0.062
ACE ACE, DCP, DCP1: Angiotensin-converting enzyme, somatic isoform precursor 0.028 0.030
DRD2 DRD2: D(2) dopamine receptor 0.028 0.034
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.028 0.030
SNAP23 SNAP23: Synaptosomal-associated protein 23 0.028 0.030
TMPRSS9 N/A 0.028 0.030
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.028 0.034
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.028 0.034
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.034
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.028 0.030
MUCDHL MUPCDH, MUCDHL, UNQ2781/PRO7168: Mucin and cadherin-like protein precursor 0.028 0.034
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.034
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.028 0.034
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.028 0.062
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.027 0.033
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.027 0.063
THOC1 THOC1, HPR1: THO complex subunit 1 0.027 0.0818
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.027 0.038
GNA15 GNA15, GNA16: Guanine nucleotide-binding protein alpha-15 subunit 0.026 0.039
APLP2 APLP2, APPL2: Amyloid-like protein 2 precursor 0.026 0.057
FADD FADD, MORT1: Protein FADD 0.026 0.039
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 0.026 0.056
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.025 0.114
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.025 0.461
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.025 0.191
NUP214 N/A 0.025 0.152
ETS2 ETS2: Protein C-ets-2 0.025 0.077
GNB2L1 Lung cancer oncogene 7 0.025 0.307
0.299
Total Score 5.40