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Evidence of Interaction Between EPOR and GRAP

The interaction score between EPOR and GRAP is 2.17.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPOR and GRAP = 0.02

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology N/A N/A
Domains Domains present in EPOR and GRAP:
Domains in EPORDomains in GRAP
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR001452 SH3
IPR000108 Neutrophil cytosol factor 2
IPR000980 SH2 motif

The Chi square scores for co-occurrence of domains that are present in EPOR and GRAP are listed below.

Domain 1Domain 2Chi Square
IPR002996 Cytkn_recept_B/G. IPR000980 SH2 motif 227.343
IPR003961 Fibronectin, type III IPR000980 SH2 motif 184.508
IPR003528 Long hematopoietin receptor, single chain IPR000980 SH2 motif 151.135
IPR009167 Erythropoietin receptor IPR000980 SH2 motif 38.4825
IPR003961 Fibronectin, type III IPR001452 SH3 15.104
IPR003961 Fibronectin, type III IPR000108 Neutrophil cytosol factor 2 5.02275
IPR009167 Erythropoietin receptor IPR001452 SH3 4.09597
IPR003528 Long hematopoietin receptor, single chain IPR001452 SH3 3.64257
IPR003528 Long hematopoietin receptor, single chain IPR000108 Neutrophil cytosol factor 2 2.04175
IPR002996 Cytkn_recept_B/G. IPR000108 Neutrophil cytosol factor 2 0.332745
IPR002996 Cytkn_recept_B/G. IPR001452 SH3 0.0443172

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in GRAP
  • Green Domain is present in both EPOR and GRAP

 0.021
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: GRAP

PTMResidueReference
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: GRAP

LocalisationReference
Cytoplasm HPRD
Transitive Score

The common interactors between EPOR and GRAP that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andGRAP. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and GRAP has 466 interactors of which there are 204 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for GRAP-Interactor (?)
CRLF3 N/A 0.191 0.032
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.166 0.028
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.217
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 0.195
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.217
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.217
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.217
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.165 0.195
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.195
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 0.128
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 61.50
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 0.218
CD2AP CD2AP: CD2-associated protein 0.126 0.028
CRKL CRKL: Crk-like protein 0.126 0.028
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.115
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 147.00
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.123 0.145
INSR INSR: Insulin receptor precursor 0.123 61.50
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.179
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 61.50
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.039
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.027
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 0.265
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.027
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.027
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.126
NF2 NF2, SCH: Merlin 0.109 0.027
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.027
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.027
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 0.265
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 0.237
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.027
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.027
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 2.04
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.027
MAPK15 N/A 0.109 0.027
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 114.00
PSCD2 N/A 0.109 0.027
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 0.265
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.109 27.60
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.109 0.027
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.027
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.027
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.143
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.109 0.129
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.145
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.032
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.109 0.145
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 55.50
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.109 0.128
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.109 61.50
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.0308
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 61.50
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.032
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 133.00
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.0308
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.100 31.80
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 0.156
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 0.305
RPS6KB1 N/A 0.100 0.044
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 0.402
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.100 0.028
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.100 0.028
DOK1 DOK1: Docking protein 1 0.100 0.028
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.098 0.115
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.098 0.128
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.098 0.179
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 0.179
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.098 0.115
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.032
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.098 0.128
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.098 0.145
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.091 0.036
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.091 0.028
SLC2A1 SLC2A1, GLUT1: Solute carrier family 2, facilitated glucose transporter member 1 0.087 0.0294
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.083 9.04
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 0.036
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 13.20
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.0308
HCK N/A 0.081 0.156
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.081 0.036
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.081 0.028
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.081 0.028
SYK SYK: Tyrosine-protein kinase SYK 0.081 0.244
SORBS3 SORBS3, SCAM1: Vinexin 0.081 7.56
STK16 N/A 0.081 0.0308
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.077 0.032
CDK2 CDK2: Cell division protein kinase 2 0.075 0.028
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.075 0.028
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.075 0.036
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 0.402
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.072 0.036
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 0.141
FNBP1 N/A 0.072 1.93
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 0.218
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 0.036
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.072 0.402
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.072 0.0308
JAK1 0.072 0.305
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 0.244
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.072 7.31
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 0.028
CTTN CTTN, EMS1: Src substrate cortactin 0.072 0.674
ALK ALK: ALK tyrosine kinase receptor precursor 0.072 0.094
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 0.174
CSK CSK: Tyrosine-protein kinase CSK 0.072 0.440
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.072 0.044
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.072 0.0308
CXorf9 N/A 0.072 0.036
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.072 0.041
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.072 0.050
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.072 8.58
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.197
PSCD4 PSCD4, CYT4: Cytohesin-4 0.072 0.028
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.072 0.036
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.072 0.360
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.072 0.0308
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 76.00
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.0308
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 0.177
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 0.274
BMX N/A 0.072 0.197
LYN LYN: Tyrosine-protein kinase Lyn 0.072 0.218
VIL2 N/A 0.072 0.036
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.072 0.0308
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.072 0.050
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 9.04
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.067 0.244
APS SH2B2, APS: SH2B adapter protein 2 0.065 0.028
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 13.20
RASA3 RASA3: Ras GTPase-activating protein 3 0.065 0.028
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 0.244
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 0.244
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.029
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.032
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.036
CDK4 CDK4: Cell division protein kinase 4 0.057 0.028
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.057 0.036
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.057 0.028
CDK6 CDK6: Cell division protein kinase 6 0.057 0.0308
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.055 0.039
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.039
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.055 0.039
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.055 0.032
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.055 0.032
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.032
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.055 0.032
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.055 0.032
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.055 0.032
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.051 1.29
FLT4 VEGFR3 long form 0.051 0.0258
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.0288
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.0288
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.0288
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.051 0.0258
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.0288
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.051 2.13
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.049 0.032
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 0.027
MAPKAPK5 N/A 0.049 0.027
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.027
MAP2K5 N/A 0.049 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.049 0.027
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.0453 0.028
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0453 0.060
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.0308
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.045 0.032
SOS1 SOS1: Son of sevenless homolog 1 0.045 2.44
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.045 2.98
STAT4 STAT4: Signal transducer and activator of transcription 4 0.041 0.035
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.037 0.041
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.037 4.72
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.037 0.036
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.028
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.037 0.028
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.037 0.028
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.037 1.02
STK10 STK10: Uncharacterized protein STK10 0.037 0.036
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.037 0.041
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.037 0.041
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.037 0.050
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.037 0.036
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.032 0.050
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.032 0.050
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.032 1.21
PRKAA1 N/A 0.032 0.0308
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 7.31
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.0308
ATM ATM: Serine-protein kinase ATM 0.032 0.060
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.029 0.272
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.036
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 0.027 0.195
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
FGFR2 N/A 0.027 0.217
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.265
PIM1 N/A 0.027 0.028
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.025 0.029
0.347
Total Score 2.17