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Evidence of Interaction Between EPOR and CTTN

The interaction score between EPOR and CTTN is 6.52.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPOR and CTTN = -0.06

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology N/A N/A
Domains Domains present in EPOR and CTTN:
Domains in EPORDomains in CTTN
IPR003961 Fibronectin, type III
IPR003528 Long hematopoietin receptor, single chain
IPR009167 Erythropoietin receptor
IPR002996 Cytkn_recept_B/G.
IPR001452 SH3
IPR000108 Neutrophil cytosol factor 2
IPR003134 Hs1/Cortactin

The Chi square scores for co-occurrence of domains that are present in EPOR and CTTN are listed below.

Domain 1Domain 2Chi Square
IPR003961 Fibronectin, type III IPR001452 SH3 15.104
IPR003961 Fibronectin, type III IPR000108 Neutrophil cytosol factor 2 5.02275
IPR009167 Erythropoietin receptor IPR001452 SH3 4.09597
IPR003528 Long hematopoietin receptor, single chain IPR001452 SH3 3.64257
IPR003528 Long hematopoietin receptor, single chain IPR000108 Neutrophil cytosol factor 2 2.04175
IPR002996 Cytkn_recept_B/G. IPR000108 Neutrophil cytosol factor 2 0.332745
IPR002996 Cytkn_recept_B/G. IPR001452 SH3 0.0443172

The background colour of the table refers to:

  • Blue Domain is only present in EPOR
  • Yellow Domain is only present in CTTN
  • Green Domain is present in both EPOR and CTTN

 0.109
Post-translational Modifications

Protein: EPOR

PTMResidueReference
Phosphorylation 368 PubMed, HPRD
Phosphorylation 426 PubMed, HPRD
Phosphorylation 454 PubMed, HPRD
Phosphorylation 456 PubMed, HPRD
Phosphorylation 468 PubMed, HPRD
Phosphorylation 485 PubMed, HPRD
Phosphorylation 489 PubMed, HPRD
Phosphorylation 504 PubMed, HPRD

Protein: CTTN

PTMResidueReference
Phosphorylation 334 PubMed, HPRD
Phosphorylation 401 PubMed, HPRD
Phosphorylation 405 PubMed, HPRD
Phosphorylation 418 PubMed, HPRD
Phosphorylation 421 PubMed, HPRD
Phosphorylation 446 PubMed, HPRD
Phosphorylation 453 PubMed, HPRD
Phosphorylation 470 PubMed, HPRD
Phosphorylation 486 PubMed, HPRD
Phosphoserine 405 HPRD
Phosphoserine 418 HPRD
Phosphothreonine 401 HPRD
Phosphotyrosine 215 HPRD
Phosphotyrosine 421 HPRD
Phosphotyrosine 446 HPRD
Phosphotyrosine 453 HPRD
Localisation

Protein: EPOR

LocalisationReference
ER HPRD
Plasma membrane HPRD
Secreted HPRD

Protein: CTTN

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD
Cytoskeleton HPRD
Transitive Score

The common interactors between EPOR and CTTN that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPOR andCTTN. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPOR has 1024 interactors and CTTN has 1089 interactors of which there are 602 common interactors.

Common InteractorName of Common InteractorScore for EPOR-Interactor (?)Score for CTTN-Interactor (?)
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 3.59 0.055
PRL PRL: Prolactin precursor 0.644 0.025
CSH2 GH1: Somatotropin precursor 0.644 0.025
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.541 0.049
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.340 0.044
KEL KEL: Kell blood group glycoprotein 0.307 0.032
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.251 0.065
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.210 0.0727
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.191 0.100
CRLF3 N/A 0.191 0.052
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.166 0.109
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.166 0.136
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.166 0.088
CNTN1 CNTN1: Contactin-1 precursor 0.165 0.109
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.109
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.165 0.049
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.109
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.109
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.109
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.044
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.109
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.109
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.165 0.109
CNTN4 CNTN4: Contactin-4 precursor 0.165 0.109
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.109
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.049
FN1 N/A 0.165 0.109
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.109
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.109
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.098
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.109
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.109
BSG N/A 0.165 0.109
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.109
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.165 0.109
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.098
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.109
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.109
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.165 0.109
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.153 0.049
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.153 0.056
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 0.100
KIT KIT: Mast/stem cell growth factor receptor precursor 0.152 0.072
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.152 0.081
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.127 0.049
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.126 0.088
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.126 0.097
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.126 0.063
CD2AP CD2AP: CD2-associated protein 0.126 0.050
CRKL CRKL: Crk-like protein 0.126 2.77
RDX RDX: Radixin 0.126 0.307
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.126 0.097
GAB1 GAB1: GRB2-associated-binding protein 1 0.126 0.109
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.124 0.044
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.123 0.100
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.123 0.100
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.100
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.123 0.081
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.123 0.166
INSR INSR: Insulin receptor precursor 0.123 0.100
IL9R IL9R: Interleukin-9 receptor precursor 0.123 0.072
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.072
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.123 0.166
GHR GHR: Growth hormone receptor precursor 0.123 0.072
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.072
DCC DCC: Netrin receptor DCC precursor 0.123 0.081
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.123 0.081
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.123 0.0727
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.123 0.081
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.123 0.081
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.110 0.033
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.109 0.165
ELMO1 N/A 0.109 0.165
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.0688
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.109 0.075
ARHGEF7 N/A 0.109 0.165
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.165
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.109 0.165
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.109 0.165
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.109 0.165
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.109 0.165
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.109 0.165
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.109 0.165
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.0688
NF2 NF2, SCH: Merlin 0.109 0.165
LNK SH2B3, LNK: SH2B adapter protein 3 0.109 0.165
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.109 0.165
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.165
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.109 0.165
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 0.165
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.165
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.165
STAT3 0.109 0.165
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.109 4.22
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.165
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.109 0.165
MAPK15 N/A 0.109 0.165
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.109 4.22
PSCD2 N/A 0.109 0.165
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.109 0.148
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.109 0.165
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.109 0.165
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.109 0.075
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.109 0.165
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.109 0.083
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.109 0.148
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.083
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.109 0.083
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.083
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.109 0.075
MET MET: Hepatocyte growth factor receptor precursor 0.109 0.126
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.109 0.166
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.065
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.109 0.0727
TNC TNC, HXB: Tenascin precursor 0.109 0.166
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.109 0.065
ITGB4 N/A 0.109 0.126
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.109 0.081
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.109 0.026
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.109 0.274
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.109 0.191
SORL1 SORL1: Sortilin-related receptor precursor 0.109 0.052
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.109 0.065
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.109 0.072
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.109 0.148
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.109 0.072
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.109 0.065
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.109 0.126
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.109 0.081
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.109 0.100
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.109 0.049
PRLR PRLR: Prolactin receptor precursor 0.109 0.065
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.109 0.100
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.109 0.065
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.0727
F3 F3: Tissue factor precursor 0.109 0.075
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.109 0.029
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.109 0.100
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.109 0.100
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.109 0.126
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.105 0.166
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.100 0.110
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.100 0.088
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.100 2.77
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.100 0.088
STAM2 STAM2: Signal transducing adapter molecule 2 0.100 0.097
RPS6KB1 N/A 0.100 0.110
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.100 0.088
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.100 0.191
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.100 0.088
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.100 0.098
TLN1 TLN1: Uncharacterized protein TLN1 0.100 0.077
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.100 0.056
DOK1 DOK1: Docking protein 1 0.100 0.110
PLD2 PLD2: Phospholipase D2 0.100 0.136
NEO1 NEO1, NGN: Neogenin precursor 0.098 0.126
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.098 0.166
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.098 0.126
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.098 0.100
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.098 0.100
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.098 0.081
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.098 0.081
PTPRZ1 N/A 0.098 0.100
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.058
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.098 0.126
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.098 0.065
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.098 0.126
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.098 0.100
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.098 0.126
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.096 0.032
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.091 0.109
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.091 0.056
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.091 0.109
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.091 0.050
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.087 0.029
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.083 0.075
KIR3DL1 N/A 0.083 0.109
ATRN N/A 0.083 0.049
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.083 0.049
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.083 0.109
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.083 0.049
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.083 0.049
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.083 0.109
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.109
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.083 0.109
EDA N/A 0.083 0.049
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.109
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.083 0.109
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.081 0.097
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.081 2.81
STAT6 STAT6: Signal transducer and activator of transcription 6 0.081 0.088
IRS2 IRS2: Insulin receptor substrate 2 0.081 0.109
TLN2 TLN2: Uncharacterized protein TLN2 0.081 0.096
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.081 0.123
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 0.041
RIN1 RIN1: Ras and Rab interactor 1 0.081 0.152
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.081 0.152
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.081 0.088
HCK N/A 0.081 2.81
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.081 0.088
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.081 0.152
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.081 0.109
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.081 0.191
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.081 0.123
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.081 0.088
DLG2 DLG2: Disks large homolog 2 0.081 0.025
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.081 0.088
SYK SYK: Tyrosine-protein kinase SYK 0.081 0.088
SORBS3 SORBS3, SCAM1: Vinexin 0.081 0.114
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.081 0.056
STK16 N/A 0.081 0.109
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.077 0.049
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.077 0.058
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.077 0.081
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.077 0.0453
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.075 0.055
CDK2 CDK2: Cell division protein kinase 2 0.075 0.044
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.075 0.044
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.075 0.049
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.075 0.049
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.075 0.056
WEE1 WEE1: Wee1-like protein kinase 0.075 0.049
SPTAN1 N/A 0.0727 0.096
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.072 0.110
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.072 0.152
MSN MSN: Moesin 0.072 0.098
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.072 0.039
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.072 7.83
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.072 0.191
FNBP1 N/A 0.072 0.040
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.072 2.23
VAV1 VAV1, VAV: Proto-oncogene vav 0.072 1.99
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.072 0.109
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.072 0.088
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.072 0.191
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.072 0.109
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.072 0.088
JAK1 0.072 0.110
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.072 0.109
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.072 0.0794
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.072 0.035
PLD1 PLD1: Phospholipase D1 0.072 0.111
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.072 2.23
ALK ALK: ALK tyrosine kinase receptor precursor 0.072 0.045
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.072 0.251
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.072 0.123
MCF2 MCF2, DBL: Proto-oncogene DBL 0.072 0.123
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.072 0.152
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.072 0.110
CSK CSK: Tyrosine-protein kinase CSK 0.072 0.078
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.072 0.173
PSD TYL: TYL protein 0.072 0.123
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.072 0.109
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.072 0.110
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.072 0.056
IRS1 IRS1: Insulin receptor substrate 1 0.072 0.251
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.072 0.051
CXorf9 N/A 0.072 0.078
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.072 0.110
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.072 0.123
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.072 0.088
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.072 0.152
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.072 0.152
PSCD4 PSCD4, CYT4: Cytohesin-4 0.072 0.088
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.072 0.088
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.072 0.110
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.072 0.110
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.072 0.046
TTN N/A 0.072 0.109
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.072 0.105
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.072 0.307
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.072 0.049
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.072 0.049
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.110
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.072 0.152
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.072 0.109
BMX N/A 0.072 0.123
LYN LYN: Tyrosine-protein kinase Lyn 0.072 0.088
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.072 0.098
VIL2 N/A 0.072 0.098
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.072 0.044
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.072 0.098
GAB2 N/A 0.072 0.123
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.0688 0.109
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.0688 0.044
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.0688 0.109
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.251
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.065 0.191
APS SH2B2, APS: SH2B adapter protein 2 0.065 0.098
NCK2 NCK2: Cytoplasmic protein NCK2 0.065 2.50
RASA3 RASA3: Ras GTPase-activating protein 3 0.065 0.097
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.065 0.191
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.065 0.191
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.065 0.152
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.065 0.109
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.065 0.191
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.065 0.111
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.065 0.088
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.065 0.098
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.065 0.123
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.065 0.152
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.065 0.098
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.065 0.152
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.058
MEP1A MEP1A: Meprin A subunit alpha precursor 0.062 0.037
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.062 0.058
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.058
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.044
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.062 0.032
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.062 0.065
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.062 0.065
PLXNB1 PLXNB1, KIAA0407, PLXN5, SEP: Plexin-B1 precursor 0.062 0.057
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.062 0.057
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.062 0.041
CD44 N/A 0.062 0.0263
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.061 0.029
CDK4 CDK4: Cell division protein kinase 4 0.057 0.055
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.057 0.044
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.057 0.056
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.057 0.055
CDK6 CDK6: Cell division protein kinase 6 0.057 0.055
DYRK3 N/A 0.057 0.062
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.056 0.077
EGF EGF: Pro-epidermal growth factor precursor 0.055 0.030
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.055 0.058
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.055 0.081
GPA33 GPA33: Cell surface A33 antigen precursor 0.055 0.065
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.055 0.058
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.055 0.058
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.055 0.0727
MEP1B MEP1B: Meprin A subunit beta precursor 0.055 0.032
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.055 0.072
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.055 0.0727
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.055 0.058
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.055 0.274
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.055 0.0727
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.055 0.081
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.055 0.126
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.052
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.055 0.026
LILRB1 N/A 0.055 0.0727
CD7 CD7: T-cell antigen CD7 precursor 0.055 0.0727
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.055 0.058
ITGA3 ITGA3, MSK18: Integrin alpha-3 precursor 0.055 0.027
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.055 0.0727
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.055 0.072
CDH2 CDH2, CDHN, NCAD: Cadherin-2 precursor 0.055 0.0446
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.055 0.058
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.055 0.0453
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.055 0.081
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.055 0.058
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.051 0.051
RAPH1 N/A 0.051 0.051
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.051 0.046
C9orf88 N/A 0.051 0.051
EPB41 EPB41, E41P: Protein 4.1 0.051 0.051
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.051 0.046
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.051 0.051
FLT4 VEGFR3 long form 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 0.051 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.051 1.31
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.051 0.051
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 0.051 0.051
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.051
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.051 0.051
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.051
GRB10 N/A 0.051 0.051
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.051 0.051
NCAM1 N/A 0.051 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.051 0.029
TP73 TP73, P73: Tumor protein p73 0.051 0.072
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.051 0.065
TPBG TPBG, 5T4: Trophoblast glycoprotein precursor 0.049 0.0446
ITGAV ITGAV, MSK8, VNRA: Integrin alpha-V precursor 0.049 0.074
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.049 0.0727
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.049 0.072
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.049 0.340
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.049 0.100
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.049 0.091
PVR PVR, PVS: Poliovirus receptor precursor 0.049 0.202
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.049 0.126
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.049 0.126
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.083
CDC2 CDC2: Cell division control protein 2 homolog 0.049 0.083
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.049 0.028
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.049 0.083
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.049 0.075
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.049 0.083
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.049 0.083
MAPKAPK5 N/A 0.049 0.083
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.028
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.049 0.028
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.049 0.028
EEF2K EEF2K: Elongation factor 2 kinase 0.049 0.083
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.049 0.083
ACTN4 ACTN4: Alpha-actinin-4 0.049 0.028
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.165
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.049 0.148
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.049 0.0688
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.049 0.028
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.049 0.028
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.049 0.083
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.049 0.075
PPEF1 N/A 0.049 0.028
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.083
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.049 0.083
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.049 0.083
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.049 0.0688
BMP1 N/A 0.049 0.034
MAP2K5 N/A 0.049 0.083
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.049 0.083
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.049 0.028
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.049 0.083
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.049 0.165
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.083
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.049 0.075
SNX3 N/A 0.049 0.075
CNN2 CNN2: Calponin-2 0.049 2.13
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.049 0.083
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.049 0.083
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.049 0.148
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.049 0.083
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.049 0.165
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.049 0.083
TNN TNN: Tenascin-N precursor 0.047 0.038
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.047 0.047
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.046 0.075
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.0453 0.109
FUBP1 N/A 0.0453 0.056
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.0453 0.044
DAB1 DAB1: Disabled homolog 1 0.0453 0.109
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.0453 0.055
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.077
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0453 0.088
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.0453 0.055
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0453 0.077
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0453 0.049
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.0453 0.069
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.045 0.166
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.045 0.058
STAT2 STAT2: Signal transducer and activator of transcription 2 0.045 0.065
PLEK PLEK, P47: Pleckstrin 0.045 0.058
SOS1 SOS1: Son of sevenless homolog 1 0.045 0.065
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.045 0.058
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.0446 0.050
STAT4 STAT4: Signal transducer and activator of transcription 4 0.041 0.0727
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.041 0.041
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.041 0.081
CENTA1 CENTA1: Centaurin-alpha 1 0.041 0.051
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.04 0.025
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.04 0.025
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.038 0.0338
CDK7 CDK7, MO15: Cell division protein kinase 7 0.037 0.056
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.037 0.056
FLII FLII, FLIL: Protein flightless-1 homolog 0.037 0.031
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.037 0.099
CSPG2 N/A 0.037 0.045
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.037 0.077
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.037 0.040
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.037 0.086
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.037 0.062
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.037 0.123
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.037 0.109
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.037 0.044
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.037 0.048
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.037 0.044
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.037 0.077
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.037 0.049
NEDD4L NEDD4L, KIAA0439, NEDL3: E3 ubiquitin-protein ligase NEDD4-like protein 0.037 0.026
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.037 0.128
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.037 0.049
VASP VASP: Vasodilator-stimulated phosphoprotein 0.037 0.098
STK10 STK10: Uncharacterized protein STK10 0.037 0.044
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.037 0.056
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.037 0.044
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.037 0.050
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.037 0.044
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.037 0.050
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.037 0.050
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.037 0.191
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.0338 0.059
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.0338 0.034
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.034 0.044
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.034 0.044
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.034 0.109
S100B S100B: Protein S100-B 0.032 0.026
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.032 0.144
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.032 0.078
LCP1 LCP1, PLS2: Plastin-2 0.032 0.338
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 2.61
VWF VWF, F8VWF: von Willebrand factor precursor 0.032 0.046
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.032 0.049
FREQ FREQ, FLUP, NCS1: Neuronal calcium sensor 1 0.032 0.029
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.032 0.088
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 0.032 0.032
GRLF1 N/A 0.032 0.077
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.032 0.026
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.032 0.123
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.032 0.155
CHP CHP: Calcium-binding protein p22 0.032 0.0425
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.032 0.049
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.032 0.055
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.032 0.062
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.032 0.088
DAB2 DAB2, DOC2: Disabled homolog 2 0.032 0.191
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.032 0.056
PRKAA1 N/A 0.032 0.049
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.032 0.152
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.032 0.056
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.032 0.070
PMP2 PMP2: Myelin P2 protein 0.032 0.048
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.032 0.173
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.049
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.032 0.086
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.032 0.056
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.032 0.039
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.032 0.069
ATM ATM: Serine-protein kinase ATM 0.032 0.044
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.032 0.062
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.032
GMIP GMIP: GEM-interacting protein 0.032 0.040
CDKL5 N/A 0.032 0.062
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.032 0.062
MYO3A MYO3A: Myosin IIIA 0.032 0.062
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.032 0.039
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.032 0.096
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.032 0.050
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.032 0.056
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.032 0.049
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.032 0.049
ACTN1 ACTN1: Alpha-actinin-1 0.032 0.0425
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.032 0.029
S100A3 S100A3, S100E: Protein S100-A3 0.032 0.026
DAPK2 DAPK2: Death-associated protein kinase 2 0.032 0.077
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.032 0.062
DYNC1I2 N/A 0.030 0.052
BCDO2 PTS: 6-pyruvoyl tetrahydrobiopterin synthase 0.030 0.052
PLEK2 PLEK2: Pleckstrin-2 0.030 0.032
CDK5 CDK5: Cell division protein kinase 5 0.029 0.062
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.055
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 2.96
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.056
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.029 0.043
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.029 0.077
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.029 0.026
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.029 3.95
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.029 0.128
CNN3 CNN3: Calponin-3 0.029 3.23
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 0.049
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.029 0.056
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.152
RPS6KA6 RPS6KA6, RSK4: Ribosomal protein S6 kinase alpha-6 0.029 0.025
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.029 0.063
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.029 0.123
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.029 0.029
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.029 0.026
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.044
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.029 0.152
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.029 0.086
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.028 0.049
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.028 0.109
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.028 0.049
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.028 0.049
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.028 0.049
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
ACE ACE, DCP, DCP1: Angiotensin-converting enzyme, somatic isoform precursor 0.028 0.049
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.028 0.049
SNAP23 SNAP23: Synaptosomal-associated protein 23 0.028 0.036
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.028 0.049
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.028 0.049
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.028 0.049
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.028 0.109
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.028 0.109
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.028 0.109
LAT LAT: Linker for activation of T-cells family member 1 0.028 0.109
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.028 0.109
ADCY6 ADCY6, KIAA0422: Adenylate cyclase type 6 0.028 0.049
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.028 0.049
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.025 0.0727
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.025 0.033
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.025 0.032
ETS2 ETS2: Protein C-ets-2 0.025 0.072
0.228
Total Score 6.52