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Evidence of Interaction Between LIG1 and CHTF18

The interaction score between LIG1 and CHTF18 is 1.78.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismLIG1 OrthologueCHTF18 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YDL164C 1 YMR078C 1
worm Q27474 1 Q21350 1
fly Q960P4 1 Q8IQ05 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 0.014
Post-translational Modifications

Protein: LIG1

PTMResidueReference
Phosphorylation 66 PubMed, HPRD
Phosphorylation 76 PubMed, HPRD
Phosphorylation 141 PubMed, HPRD
Phosphorylation 195 PubMed, HPRD
Phosphorylation 911 PubMed, HPRD
Phosphoserine 66 HPRD
Phosphoserine 76 HPRD
Phosphoserine 141 HPRD
Phosphoserine 911 HPRD
Phosphothreonine 195 HPRD

Protein: CHTF18

PTMResidueReference
Phosphorylation 871 PubMed, HPRD
Localisation

Protein: LIG1

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD

Protein: CHTF18

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between LIG1 and CHTF18 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between LIG1 andCHTF18. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , LIG1 has 892 interactors and CHTF18 has 789 interactors of which there are 397 common interactors.

Common InteractorName of Common InteractorScore for LIG1-Interactor (?)Score for CHTF18-Interactor (?)
PCNA PCNA: Proliferating cell nuclear antigen 73.00 3.39
UBE2R2 UBE2R2, CDC34B, UBC3B: Ubiquitin-conjugating enzyme E2 R2 3.39 0.025
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 1.26 0.025
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.704 0.030
ESPL1 N/A 0.307 0.028
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.307 0.028
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.251 0.028
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.028
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.144 0.028
FANCA FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein 0.144 0.028
UBAP2 N/A 0.144 0.028
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.141 0.025
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.141 0.025
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.139 0.025
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.139 0.025
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.129 0.025
CDK4 CDK4: Cell division protein kinase 4 0.129 0.025
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.129 0.025
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.129 0.025
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.129 0.025
CDK2 CDK2: Cell division protein kinase 2 0.129 0.025
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.129 0.025
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.129 0.025
WEE1 WEE1: Wee1-like protein kinase 0.129 0.025
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.129 0.025
ROCK1 ROCK1: Rho-associated protein kinase 1 0.127 0.028
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.114 0.025
CD2AP CD2AP: CD2-associated protein 0.112 0.025
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.111 0.025
DAB1 DAB1: Disabled homolog 1 0.111 0.025
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.097 0.025
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.091 0.028
CSK CSK: Tyrosine-protein kinase CSK 0.090 0.025
CRKL CRKL: Crk-like protein 0.090 0.025
DAB2 DAB2, DOC2: Disabled homolog 2 0.088 0.025
ABCF1 N/A 0.087 0.028
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.087 0.028
TRRAP N/A 0.087 0.028
FNBP1 N/A 0.087 0.025
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.086 0.025
DOK1 DOK1: Docking protein 1 0.086 0.025
NF2 NF2, SCH: Merlin 0.083 0.028
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.078 0.025
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.078 0.025
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.078 0.025
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.078 0.025
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.078 0.025
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.078 0.025
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.078 0.025
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.078 0.025
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.078 0.025
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.078 0.025
MDN1 MDN1, KIAA0301: Midasin 0.078 0.025
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.078 0.025
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.078 0.025
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.077 0.028
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.075 0.028
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.075 0.028
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.075 0.025
ELMO1 N/A 0.075 0.025
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.075 0.025
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.074 0.028
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.074 0.028
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.074 0.028
FUBP1 N/A 0.074 0.028
CXorf9 N/A 0.071 0.025
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.070 0.028
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.070 0.028
CHUK N/A 0.070 0.028
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.070 0.028
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.028
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.070 0.028
API5 N/A 0.070 0.028
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.070 0.028
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.069 0.025
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.067 0.025
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.067 0.025
VIL2 N/A 0.067 0.025
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.067 0.025
VAV1 VAV1, VAV: Proto-oncogene vav 0.067 0.025
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.067 0.025
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.067 0.025
XPO1 XPO1, CRM1: Exportin-1 0.066 0.025
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.066 0.025
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 0.066 0.025
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.066 0.025
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.066 0.025
LAMR1 RPSA, LAMBR, LAMR1: 40S ribosomal protein SA 0.066 0.025
CCT8 CCT8: Uncharacterized protein CCT8 0.066 0.025
HSPD1 0.066 0.025
RACGAP1 RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1 0.066 0.025
CCT4 CCT4, CCTD, SRB: T-complex protein 1 subunit delta 0.066 0.025
TK1 TK1: Thymidine kinase, cytosolic 0.066 0.025
LDHB LDHB: L-lactate dehydrogenase B chain 0.066 0.025
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.066 0.025
RRM2 RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2 0.066 0.025
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.066 0.025
CTPS CTPS: CTP synthase 1 0.066 0.025
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.066 0.025
CDC23 CDC23: Cell division cycle protein 23 homolog 0.066 0.025
CCT6A CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta 0.066 0.025
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.063 0.025
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.063 0.025
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.063 0.025
USP34 USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34 0.063 0.025
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.063 0.025
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.063 0.025
NOC2L NOC2L: Nucleolar complex protein 2 homolog 0.063 0.025
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.063 0.025
SAPS3 N/A 0.063 0.025
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.063 0.025
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.062 0.028
GAB1 GAB1: GRB2-associated-binding protein 1 0.062 0.028
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.061 0.028
GAB2 N/A 0.055 0.028
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.054 0.025
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.054 0.025
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.052 0.028
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.052 0.028
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.052 0.028
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.051 0.025
APS SH2B2, APS: SH2B adapter protein 2 0.051 0.025
PLD1 PLD1: Phospholipase D1 0.051 0.025
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.051 0.025
MSN MSN: Moesin 0.051 0.025
IRS1 IRS1: Insulin receptor substrate 1 0.049 0.028
IRS2 IRS2: Insulin receptor substrate 2 0.049 0.028
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.049 0.028
DNM3 DNM3: Uncharacterized protein DNM3 0.049 0.028
LNK SH2B3, LNK: SH2B adapter protein 3 0.049 0.028
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.049 0.028
PDZD2 CDNA FLJ46853 fis, clone UTERU3009775, moderately similar to Rattus norvegicus P 0.049 0.028
PSCD2 N/A 0.049 0.028
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.049 0.025
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.047 0.025
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.046 0.025
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.046 0.025
SYMPK SYMPK, SPK: Symplekin 0.046 0.025
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.046 0.025
AIP AIP, XAP2: AH receptor-interacting protein 0.046 0.025
CDK7 CDK7, MO15: Cell division protein kinase 7 0.046 0.025
CSDA CSDA, DBPA: DNA-binding protein A 0.046 0.025
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.046 0.025
KIAA1012 KIAA1012: Protein TRS85 homolog 0.046 0.025
DIAPH1 Diaphanous 1 0.046 0.025
RPS6KB1 N/A 0.046 0.025
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.046 0.025
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.046 0.025
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.046 0.025
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.046 0.025
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.046 0.025
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.046 0.025
KLHDC4 N/A 0.046 0.025
FKBP4 FKBP4: FK506-binding protein 4 0.046 0.025
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.046 0.028
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.046 0.028
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.0453 0.028
VASP VASP: Vasodilator-stimulated phosphoprotein 0.0453 0.028
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.028
NME1 NME1, NDPKA, NM23: Nucleoside diphosphate kinase A 0.0446 0.028
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.0446 0.028
PHB2 PHB2, BAP, REA: Prohibitin-2 0.0446 0.028
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.0446 0.028
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.044 0.025
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.044 0.025
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.044 0.025
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.044 0.025
MYO18A 0.044 0.025
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.044 0.025
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.044 0.025
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.044 0.025
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.044 0.025
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.044 0.025
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.044 0.025
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.0425 0.028
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.0425 0.028
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.0425 0.028
STK16 N/A 0.0425 0.028
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.0425 0.028
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.041 0.025
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.041 0.025
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.041 0.025
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.041 0.025
PSCD4 PSCD4, CYT4: Cytohesin-4 0.041 0.025
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.041 0.025
PLD2 PLD2: Phospholipase D2 0.041 0.025
RDX RDX: Radixin 0.041 0.025
RASA3 RASA3: Ras GTPase-activating protein 3 0.041 0.025
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.04 0.028
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.04 0.028
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.04 0.028
AMPH AMPH, AMPH1: Amphiphysin 0.04 0.028
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.04 0.028
FRG1 FRG1: Protein FRG1 0.040 0.025
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.040 0.025
CASP3 CASP3, CPP32: Caspase-3 precursor 0.040 0.025
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.040 0.025
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 0.040 0.025
RPL8 RPL8: 60S ribosomal protein L8 0.040 0.025
EEF1G EEF1G, EF1G, PRO1608: Elongation factor 1-gamma 0.040 0.025
QARS QARS: Glutaminyl-tRNA synthetase 0.040 0.025
HNRPK N/A 0.040 0.025
PPIA PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A 0.040 0.025
ME2 ME2: NAD-dependent malic enzyme, mitochondrial precursor 0.040 0.025
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.040 0.025
RPS3 RPS3, OK/SW-cl.26: 40S ribosomal protein S3 0.040 0.025
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.040 0.025
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.040 0.025
RPL3 RPL3, OK/SW-cl.32: 60S ribosomal protein L3 0.040 0.025
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.040 0.025
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.040 0.025
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.040 0.025
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.040 0.025
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.040 0.025
HSP90AA1 Hsp89-alpha-delta-N 0.040 0.025
MTHFD1 MTHFD1, MTHFC, MTHFD: C-1-tetrahydrofolate synthase, cytoplasmic 0.040 0.025
THOC1 THOC1, HPR1: THO complex subunit 1 0.040 0.025
EEF1B2 EEF1B2, EEF1B, EF1B: Elongation factor 1-beta 0.040 0.025
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.040 0.025
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.040 0.025
GSR GSR, GLUR, GRD1: Glutathione reductase, mitochondrial precursor 0.040 0.025
EIF3S6 EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6 0.040 0.025
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.040 0.025
NME2 NME2, NM23B: Nucleoside diphosphate kinase B 0.040 0.025
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.038 0.025
BRPF1 BRPF1, BR140: Peregrin 0.038 0.025
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.038 0.025
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.038 0.025
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.038 0.025
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.038 0.025
COPA COPA: Coatomer subunit alpha 0.038 0.025
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.038 0.025
COPE COPE: Coatomer subunit epsilon 0.038 0.025
CDK6 CDK6: Cell division protein kinase 6 0.038 0.025
C20orf4 C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4 0.038 0.025
TSC1 TSC1, KIAA0243, TSC: Hamartin 0.038 0.025
SNRK SNRK, KIAA0096, SNFRK: SNF-related serine/threonine-protein kinase 0.038 0.025
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.038 0.025
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.038 0.025
ATM ATM: Serine-protein kinase ATM 0.038 0.025
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.037 0.028
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.037 0.028
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.037 0.028
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.037 0.028
PDLIM1 PDLIM1, CLIM1, CLP36: PDZ and LIM domain protein 1 0.037 0.028
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.037 0.028
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.037 0.028
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.036 0.028
YWHAQ YWHAQ: 14-3-3 protein theta 0.036 0.028
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.036 0.028
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.036 0.028
IPO7 IPO7: Uncharacterized protein IPO7 0.036 0.028
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.036 0.025
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.036 0.025
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.036 0.025
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.036 0.025
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.036 0.025
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.036 0.025
LYN LYN: Tyrosine-protein kinase Lyn 0.033 0.025
STAM2 STAM2: Signal transducing adapter molecule 2 0.033 0.025
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.033 0.025
NCK2 NCK2: Cytoplasmic protein NCK2 0.033 0.025
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.033 0.025
PARD3 N/A 0.033 0.025
NOS1 NOS1: Nitric-oxide synthase, brain 0.033 0.028
MCF2 MCF2, DBL: Proto-oncogene DBL 0.032 0.028
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.032 0.028
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.032 0.028
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.032 0.028
PRKAA1 N/A 0.032 0.028
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.032 0.028
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.032 0.028
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.032 0.028
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.032 0.028
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.032 0.028
CARS CARS: Cysteinyl-tRNA synthetase, cytoplasmic 0.032 0.025
HSPH1 HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa 0.032 0.025
TRAP1 TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor 0.032 0.025
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.032 0.025
RPS10 RPS10: 40S ribosomal protein S10 0.032 0.025
THOP1 THOP1: Thimet oligopeptidase 0.032 0.025
USP10 USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10 0.032 0.025
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.032 0.025
PPARBP N/A 0.032 0.025
TBCE TBCE: Tubulin-specific chaperone E 0.032 0.025
RARS RARS: Arginyl-tRNA synthetase, cytoplasmic 0.032 0.025
EEF1A1 EEF1A1: Elongation factor 1-alpha 0.032 0.025
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.032 0.025
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 0.032 0.025
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.032 0.025
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.032 0.025
KPNA2 KPNA2, RCH1, SRP1: Importin subunit alpha-2 0.032 0.025
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.032 0.025
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.032 0.025
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.032 0.025
VCP VCP: Transitional endoplasmic reticulum ATPase 0.032 0.025
EEF2 EEF2, EF2: Elongation factor 2 0.032 0.025
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.0308 0.025
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.0308 0.025
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.025
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.029 0.025
BMX N/A 0.029 0.028
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.029 0.025
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.029 0.025
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.029 0.025
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.029 0.025
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.029 0.025
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.025
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.029 0.025
STK10 STK10: Uncharacterized protein STK10 0.029 0.025
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.029 0.025
GSK3B N/A 0.029 0.025
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.029 0.025
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.029 0.025
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.029 0.025
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 0.025
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.029 0.025
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.029 0.025
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
PPEF1 N/A 0.028 0.028
MAPKAPK5 N/A 0.028 0.028
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.028 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.028 0.028
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
MAPK15 N/A 0.028 0.028
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.028
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.028 0.028
PHLDB2 N/A 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.028 0.025
SORBS3 SORBS3, SCAM1: Vinexin 0.027 0.025
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.027 0.025
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.027 0.025
USP21 USP21, USP23: Ubiquitin carboxyl-terminal hydrolase 21 0.027 0.028
HD HD, IT15: Huntingtin 0.027 0.028
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.0263 0.028
RIMS1 RIMS1, KIAA0340, Nbla00761, RAB3IP2, RIM1: Regulating synaptic membrane exocytos 0.026 0.025
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.026 0.025
PSD TYL: TYL protein 0.026 0.025
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.026 0.025
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.026 0.028
GRLF1 N/A 0.026 0.028
AANAT AANAT, SNAT: Serotonin N-acetyltransferase 0.026 0.028
FAM65A FAM65A, KIAA1930: Protein FAM65A 0.026 0.028
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.026 0.028
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.026 0.028
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.026 0.028
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.026 0.028
MARK2 N/A 0.026 0.028
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.025 0.025
MAP2K3 N/A 0.025 0.025
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.025 0.025
BCOR N/A 0.025 0.025
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.025 0.025
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.025 0.025
ADK ADK: Adenosine kinase 0.025 0.025
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.025 0.025
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.025 0.025
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.025 0.025
CAMKK1 N/A 0.025 0.025
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.025
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.025 0.025
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.025 0.025
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.025
CAMK2A N/A 0.025 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.025
NIPBL N/A 0.025 0.025
CDC2 CDC2: Cell division control protein 2 homolog 0.025 0.025
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
GRK6 N/A 0.025 0.025
CDC25C CDC25C: M-phase inducer phosphatase 3 0.025 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.025
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.025 0.025
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.025
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.025 0.025
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.025 0.025
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.025 0.025
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
GIT2 N/A 0.025 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.025 0.025
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.025
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.025 0.025
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.025 0.025
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.025 0.025
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.025 0.025
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.025 0.025
PRKCB1 N/A 0.025 0.025
0.347
Total Score 1.78