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Evidence of Interaction Between LIG1 and CCND1

The interaction score between LIG1 and CCND1 is 2.59.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between LIG1 and CCND1 = 0.01

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology
OrganismLIG1 OrthologueCCND1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm Q27474 1 Q9U2M5 0.518
fly Q960P4 1 Q24158 0.444

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 0.028
Post-translational Modifications

Protein: LIG1

PTMResidueReference
Phosphorylation 66 PubMed, HPRD
Phosphorylation 76 PubMed, HPRD
Phosphorylation 141 PubMed, HPRD
Phosphorylation 195 PubMed, HPRD
Phosphorylation 911 PubMed, HPRD
Phosphoserine 66 HPRD
Phosphoserine 76 HPRD
Phosphoserine 141 HPRD
Phosphoserine 911 HPRD
Phosphothreonine 195 HPRD

Protein: CCND1

PTMResidueReference
Phosphorylation 90 PubMed, HPRD
Phosphorylation 197 PubMed, HPRD
Phosphorylation 234 PubMed, HPRD
Phosphorylation 286 PubMed, HPRD
Localisation

Protein: LIG1

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD

Protein: CCND1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between LIG1 and CCND1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between LIG1 andCCND1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , LIG1 has 892 interactors and CCND1 has 702 interactors of which there are 446 common interactors.

Common InteractorName of Common InteractorScore for LIG1-Interactor (?)Score for CCND1-Interactor (?)
PCNA PCNA: Proliferating cell nuclear antigen 73.00 0.056
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.704 0.123
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.307 0.077
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.276 0.056
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.276 0.049
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.276 0.111
MCM3 MCM3: DNA replication licensing factor MCM3 0.276 0.097
CBX3 CBX3: Chromobox protein homolog 3 0.276 0.056
SUZ12 SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12 0.276 0.049
TCOF1 N/A 0.144 0.026
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.144 0.152
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.144 0.062
BAZ1B BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain 0.144 0.055
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.139 0.097
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.139 0.111
BRCA1 BRCA1, RNF53: Breast cancer type 1 susceptibility protein 0.129 0.111
MYBL2 MYBL2, BMYB: Myb-related protein B 0.129 0.049
CDK4 CDK4: Cell division protein kinase 4 0.129 53.10
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.129 0.049
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.129 0.111
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.129 0.136
CDK2 CDK2: Cell division protein kinase 2 0.129 0.111
TCF3 TCF3, E2A, ITF1: Transcription factor E2-alpha 0.129 0.0308
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.129 0.049
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.129 0.049
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.129 0.056
WEE1 WEE1: Wee1-like protein kinase 0.129 0.056
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.129 0.049
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.129 0.111
CCNB1 Cyclin B1 0.129 0.136
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.129 0.097
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.129 0.049
HDAC3 HDAC3: Histone deacetylase 3 0.129 0.044
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.129 0.049
ROCK1 ROCK1: Rho-associated protein kinase 1 0.127 0.109
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.114 0.171
SOS1 SOS1: Son of sevenless homolog 1 0.114 0.049
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.111 0.026
CSK CSK: Tyrosine-protein kinase CSK 0.090 0.026
MATR3 MATR3, KIAA0723: Matrin-3 0.087 0.049
NBN NBN, NBS, NBS1, P95: Nibrin 0.087 0.049
KIF23 N/A 0.087 0.032
RB1 RB1: Retinoblastoma-associated protein 0.087 0.152
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.087 0.096
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.087 0.055
TRRAP N/A 0.087 0.032
NF2 NF2, SCH: Merlin 0.083 0.028
BAZ2A BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A 0.078 0.049
MTA1 MTA1: Metastasis-associated protein MTA1 0.078 0.069
AKAP8 AKAP8, AKAP95: A-kinase anchor protein 8 0.078 0.097
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.078 0.097
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.078 0.049
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.078 0.097
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.078 0.031
SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 0.078 0.111
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.078 0.049
TP53 TP53, P53: Cellular tumor antigen p53 0.078 0.086
PHF10 N/A 0.078 0.049
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.078 0.097
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.078 0.049
HDAC2 HDAC2: Histone deacetylase 2 0.078 0.056
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.078 0.056
YY1 YY1: Transcriptional repressor protein YY1 0.078 0.056
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.078 0.171
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.078 0.097
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.078 0.088
MDN1 MDN1, KIAA0301: Midasin 0.078 0.044
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.078 0.069
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.078 0.097
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.075 0.148
ELMO1 N/A 0.075 0.025
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.075 0.148
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.074 0.0263
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.074 0.0453
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.070 0.109
ZNF318 ZNF318, HRIHFB2436: Zinc finger protein 318 0.070 0.049
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.070 0.098
ELF1 ELF1: ETS-related transcription factor Elf-1 0.070 0.109
MYBBP1A MYBBP1A, P160: Myb-binding protein 1A 0.070 0.032
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.070 0.062
IRF3 IRF3: Interferon regulatory factor 3 0.070 0.152
TERF2 TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2 0.070 0.055
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.070 0.026
PHF3 PHF3, KIAA0244: PHD finger protein 3 0.070 0.049
MYB MYB: Myb proto-oncogene protein 0.070 0.055
TGIF2 TGIF2: Homeobox protein TGIF2 0.070 0.039
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.066 0.029
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.063 0.049
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.049
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.063 0.056
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.063 0.111
NOC2L NOC2L: Nucleolar complex protein 2 homolog 0.063 0.029
NCOR1 NCOR1, KIAA1047: Nuclear receptor corepressor 1 0.063 0.049
AKAP8L AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like 0.063 0.097
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.063 0.097
MRE11A MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A 0.063 0.056
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.063 0.049
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.063 0.111
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.055 0.026
SNAPC4 SNAPC4, SNAP190: snRNA-activating protein complex subunit 4 0.052 0.062
HIVEP1 N/A 0.052 0.055
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.052 0.109
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.052 0.032
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.052 0.026
SP100 N/A 0.052 0.055
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.052 0.098
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.052 0.049
TP53BP1 TP53BP1: Tumor suppressor p53-binding protein 1 0.052 0.055
XRCC1 XRCC1: DNA-repair protein XRCC1 0.052 0.062
EMD EMD, EDMD, STA: Emerin 0.052 0.026
IRS1 IRS1: Insulin receptor substrate 1 0.049 0.032
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.047 0.148
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.046 0.086
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.046 0.111
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.046 0.088
COPB2 COPB2: Coatomer subunit beta' 0.046 0.029
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.046 0.111
CDK7 CDK7, MO15: Cell division protein kinase 7 0.046 0.111
SP3 SP3: Transcription factor Sp3 0.046 0.049
KLF1 KLF1, EKLF: Krueppel-like factor 1 0.046 0.049
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.046 0.097
RPS6KB1 N/A 0.046 0.097
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.046 0.097
ZNF24 ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24 0.046 0.044
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.046 0.069
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.046 0.097
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.046 0.049
TAL1 TAL1, SCL, TCL5: T-cell acute lymphocytic leukemia protein 1 0.046 0.049
ZBTB40 ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40 0.046 0.049
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.046 0.0453
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.037
PHB2 PHB2, BAP, REA: Prohibitin-2 0.0446 0.081
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.044 0.111
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.044 0.044
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.0425 0.098
GTF2F2 N/A 0.0425 0.152
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.0425 0.055
H1FX H1FX: Histone H1x 0.0425 0.123
TERF2IP TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1 0.0425 0.056
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.0425 0.049
TERF1 TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1 0.0425 0.049
ERG ERG: Transcriptional regulator ERG 0.0425 0.109
ZNF267 ZNF267: Zinc finger protein 267 0.0425 0.049
STK16 N/A 0.0425 0.251
ZNF148 ZNF148, ZBP89: Zinc finger protein 148 0.0425 0.055
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.0425 0.055
NFATC1 N/A 0.0425 0.055
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.04 0.049
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.04 0.04
CASP3 CASP3, CPP32: Caspase-3 precursor 0.040 0.041
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.040 0.033
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.040 0.029
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.040 0.073
BRPF1 BRPF1, BR140: Peregrin 0.038 0.049
MLL MLL, ALL1, HRX, HTRX, TRX1: Zinc finger protein HRX 0.038 0.049
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.038 0.097
SOX4 SOX4: Transcription factor SOX-4 0.038 0.049
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.038 0.097
ZNF551 N/A 0.038 0.049
ZNF335 ZNF335: Zinc finger protein 335 0.038 0.049
MAFG MAFG: Transcription factor MafG 0.038 0.056
RELA RELA, NFKB3: Transcription factor p65 0.038 0.069
JARID1A JARID1A, RBBP2, RBP2: Histone demethylase JARID1A 0.038 0.097
HDAC6 HDAC6, JM21: Histone deacetylase 6 0.038 0.0308
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.038 0.088
ZNF217 ZNF217, ZABC1: Zinc finger protein 217 0.038 0.049
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.038 0.097
KLF13 KLF13, BTEB3, NSLP1: Krueppel-like factor 13 0.038 0.049
CDK6 CDK6: Cell division protein kinase 6 0.038 0.097
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.038 0.111
SATB1 SATB1: DNA-binding protein SATB1 0.038 0.049
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.038 0.0308
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.038 0.088
ATM ATM: Serine-protein kinase ATM 0.038 0.049
ZNF224 ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27: Zinc finger protein 224 0.038 0.069
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.037 0.0263
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.036 0.0263
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.036 0.044
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.033 0.029
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.033 0.029
REST REST, NRSF, XBR: RE1-silencing transcription factor 0.032 0.049
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.032 0.055
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.032 0.123
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.032 0.049
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.032 0.109
PRKAA1 N/A 0.032 0.109
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.032 0.055
ID3 ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3 0.032 0.077
ZFX ZFX: Zinc finger X-chromosomal protein 0.032 0.055
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.032 0.062
POU2F1 POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1 0.032 0.031
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.032 0.109
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.032 0.098
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.032 0.033
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.032 0.041
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.032 0.029
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.032 0.026
VCP VCP: Transitional endoplasmic reticulum ATPase 0.032 0.051
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.0308 0.056
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.0308 0.049
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.029 0.064
BMX N/A 0.029 0.029
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.029 0.033
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.029 0.049
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.029 0.029
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.029 0.111
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.049
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.029 0.088
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.029 0.097
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.029 0.043
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.029 0.097
STK10 STK10: Uncharacterized protein STK10 0.029 0.097
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.029 0.097
MTF1 MTF1: Metal regulatory transcription factor 1 0.029 0.049
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.029 0.088
LEF1 LEF1: Lymphoid enhancer-binding factor 1 0.029 0.044
CCNH CCNH: Cyclin-H 0.029 0.097
ZBTB7A ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A 0.029 0.056
ESRRA ESRRA, ERR1, ESRL1, NR3B1: Steroid hormone receptor ERR1 0.029 0.056
ETS1 ETS1, EWSR2: Protein C-ets-1 0.029 0.111
NR5A1 NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1 0.029 0.044
ZNF76 ZNF76, D6S229E: Zinc finger protein 76 0.029 0.049
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.029 0.097
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 0.111
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.029 0.088
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.029 0.088
TCF20 TCF20, KIAA0292, SPBP: Transcription factor 20 0.028 0.083
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
ZC3HAV1 ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1 0.028 0.028
CABLES1 N/A 0.028 0.028
NSBP1 NSBP1: Nucleosome-binding protein 1 0.028 0.028
C20orf18 N/A 0.028 0.052
UHRF1 0.028 0.083
ZCCHC3 ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3 0.028 0.028
ZHX1 ZHX1: Zinc fingers and homeoboxes protein 1 0.028 0.083
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.028 0.165
CBFA2T2 CBFA2T2, EHT, MTGR1: Protein CBFA2T2 0.028 0.028
MITF MITF: Microphthalmia-associated transcription factor 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
DKFZp434K1815 DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815 0.028 0.028
LOC642558 FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1 0.028 0.028
NFIA NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A 0.028 0.028
C13orf8 N/A 0.028 0.028
PPEF1 N/A 0.028 0.083
ZNF295 ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295 0.028 0.083
POGZ POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain 0.028 0.083
MAPKAPK5 N/A 0.028 0.083
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.028 0.165
HNRPC HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2 0.028 0.028
ZNF265 N/A 0.028 0.028
AR AR, DHTR, NR3C4: Androgen receptor 0.028 0.028
HDAC8 N/A 0.028 0.083
ZNF644 ZNF644, KIAA1221, ZEP2: Zinc finger protein 644 0.028 0.083
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.028 0.083
FLJ21816 PALB2, FANCN: Partner and localizer of BRCA2 0.028 0.028
SNRPB N/A 0.028 0.028
ZFP91 ZFP91, FKSG11: Zinc finger protein 91 homolog 0.028 0.083
DSP DSP: Desmoplakin 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.028 0.083
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
WDR54 N/A 0.028 0.028
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.028 0.083
ARNT ARNT: Aryl hydrocarbon receptor nuclear translocator 0.028 0.083
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.028 0.165
KIAA1443 HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez 0.028 0.052
CORO6 N/A 0.028 0.028
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
IRF7 N/A 0.028 0.028
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.028 0.028
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.028 0.165
DUSP15 N/A 0.028 0.028
RAB4A N/A 0.028 0.028
TMPO TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha 0.028 0.028
BID BID: BH3-interacting domain death agonist 0.028 0.028
MAPK15 N/A 0.028 0.165
ATXN2L ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein 0.028 0.028
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.028 0.165
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.083
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.028 0.083
MLL2 MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2 0.028 0.083
CUTL1 CUTL1: Homeobox protein cut-like 1 0.028 0.052
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.028 0.165
PHLDB2 N/A 0.028 0.028
RAVER1 RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1 0.028 0.028
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.165
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.083
NIPA1 NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1 0.028 0.028
SYTL4 Endocrine transmitter regulatory protein 0.028 0.028
ZNF579 ZNF579: Zinc finger protein 579 0.028 0.083
HES6 HES6: Transcription cofactor HES-6 0.028 0.052
KIF1B N/A 0.028 0.028
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.028 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
ILF3 ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3 0.028 0.028
JDP2 jdp2, JDP2: Jun dimerization protein 2 0.028 0.028
PTBP1 PTBP1: Polypyrimidine tract binding protein 1 0.028 0.028
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.027 0.029
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.0263 0.091
ERF ERF: ETS domain-containing transcription factor ERF 0.026 0.191
PER2 PER2, KIAA0347: Period circadian protein homolog 2 0.026 0.055
PPARA PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha 0.026 0.055
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.026 0.055
DDIT3 DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3 0.026 0.055
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.026 0.109
MDM4 MDM4, MDMX: Mdm4 protein 0.026 0.031
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.026 0.109
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.026 0.098
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.025 0.148
FAF1 FAF1, CGI-03: FAS-associated factor 1 0.025 0.025
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.025 0.025
MAP2K3 N/A 0.025 0.025
FARSLA FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain 0.025 0.148
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.025 0.025
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.025 0.148
HEXIM2 HEXIM2, L3: Protein HEXIM2 0.025 0.025
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.025 0.075
PURB PURB: Transcriptional activator protein Pur-beta 0.025 0.025
HNRPA2B1 HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1 0.025 0.025
RBL1 RBL1: Retinoblastoma-like protein 1 0.025 0.148
RBBP6 RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6 0.025 0.025
TIA1 TIA1: Nucleolysin TIA-1 isoform p40 0.025 0.025
DDX20 DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20 0.025 0.025
SAP14 SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14 0.025 0.025
BCOR N/A 0.025 0.025
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.025 0.148
LMNA LMNA, LMN1: Lamin-A/C 0.025 0.025
MAX MAX: Protein max 0.025 0.047
GEMIN5 GEMIN5: Gem-associated protein 5 0.025 0.025
GATAD2B GATAD2B, KIAA1150: Transcriptional repressor p66 beta 0.025 0.025
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.025 0.047
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.025 0.148
RBM10 RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10 0.025 0.075
WWTR1 WWTR1, TAZ: WW domain-containing transcription regulator protein 1 0.025 0.025
TCEA1 N/A 0.025 0.025
MLXIPL MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein 0.025 0.047
ARID4A ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A 0.025 0.148
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.025 0.025
SMN2 SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein 0.025 0.025
CCNT2 CCNT2: Cyclin-T2 0.025 0.148
NCOA3 NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3 0.025 0.075
NUP98 N/A 0.025 0.025
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.025 0.148
ADK ADK: Adenosine kinase 0.025 0.025
RFFL RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin 0.025 0.047
PHF16 PHF16, JADE3, KIAA0215: Protein Jade-3 0.025 0.075
NEDD4 NEDD4: Uncharacterized protein NEDD4 0.025 0.025
SYAP1 SYAP1, PRO3113: Synapse-associated protein 1 0.025 0.025
KCTD1 0.025 0.025
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.025 0.148
ZFPM1 ZFPM1, FOG1: Zinc finger protein ZFPM1 0.025 0.075
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.025 0.025
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.025 0.075
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.025 0.148
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.025 0.148
CAMKK1 N/A 0.025 0.025
ZNF598 ZNF598: Zinc finger protein 598 0.025 0.025
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.148
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.025 0.148
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
SMARCA2 SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2 0.025 0.025
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.025 0.148
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
FLJ23436 N/A 0.025 0.025
HNRPD HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0 0.025 0.025
DHX8 DHX8, DDX8: ATP-dependent RNA helicase DHX8 0.025 0.075
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.148
ZNF174 ZNF174, ZSCAN8: Zinc finger protein 174 0.025 0.075
RNF113A RNF113A, RNF113, ZNF183: RING finger protein 113A 0.025 0.047
CAMK2A N/A 0.025 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.075
NIPBL N/A 0.025 0.025
CDC2 CDC2: Cell division control protein 2 homolog 0.025 0.148
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.075
MSL3L1 MSL3L1: Male-specific lethal 3-like 1 0.025 0.075
GRK6 N/A 0.025 0.025
CDC25C CDC25C: M-phase inducer phosphatase 3 0.025 0.148
IWS1 IWS1, IWS1L: IWS1 homolog 0.025 0.025
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.025
MKI67IP MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein 0.025 0.025
C20orf77 N/A 0.025 0.025
REXO1 REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog 0.025 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.148
NSUN2 NSUN2, SAKI, TRM4: tRNA 0.025 0.025
POLR1C POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1 0.025 0.025
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.025 0.075
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.025 0.075
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.025
PSIP1 PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein 0.025 0.025
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.025 0.148
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.025
HDAC7A N/A 0.025 0.047
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.025 0.148
OSR1 OSR1, ODD: Protein odd-skipped-related 1 0.025 0.075
DIDO1 N/A 0.025 0.075
TFAP4 TFAP4: Transcription factor AP-4 0.025 0.075
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.025 0.148
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.025
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.025 0.148
NFYA NFYA: Nuclear transcription factor Y subunit alpha 0.025 0.025
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.025 0.148
HNRPM HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M 0.025 0.025
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
NHN1 NHN1: Conserved nuclear protein NHN1 0.025 0.025
GIT2 N/A 0.025 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.025 0.075
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.025 0.025
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.025
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.025 0.075
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.025 0.025
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.025 0.148
EDF1 EDF1: Endothelial differentiation-related factor 1 0.025 0.025
HIST3H2A HIST3H2A: Histone H2A type 3 0.025 0.025
SOX8 SOX8: Transcription factor SOX-8 0.025 0.075
ATXN2L N/A 0.025 0.025
HTATIP N/A 0.025 0.025
CREB1 CREB1: cAMP response element-binding protein 0.025 0.075
HNRPUL1 HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1 0.025 0.025
PRDM2 PRDM2, RIZ: PR domain zinc finger protein 2 0.025 0.075
C14orf4 C14orf4, KIAA1865, My039: RING finger protein C14orf4 0.025 0.047
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.025 0.165
SETD3 SETD3, C14orf154: SET domain-containing protein 3 0.025 0.025
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.025 0.148
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.025 0.025
MAPK8IP3 N/A 0.025 0.025
SEC13L1 N/A 0.025 0.025
MLL4 WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7 0.025 0.075
TAL2 TAL2: T-cell acute lymphocytic leukemia protein 2 0.025 0.075
BUB3 BUB3: Mitotic checkpoint protein BUB3 0.025 0.025
DLX3 DLX3: Homeobox protein DLX-3 0.025 0.075
BRD4 N/A 0.025 0.025
MIER1 MIER1, KIAA1610: Mesoderm induction early response protein 1 0.025 0.075
FLJ40432 FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227 0.025 0.025
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.025 0.025
TRERF1 TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1 0.025 0.075
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
RNF20 0.025 0.047
SSBP4 SSBP4: Single-stranded DNA-binding protein 4 0.025 0.025
SFRS9 SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9 0.025 0.025
NES N/A 0.025 0.028
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.025 0.148
SON 0.025 0.025
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.025 0.148
PRKCB1 N/A 0.025 0.025
HOXA10 HOXA10, HOX1H: Homeobox protein Hox-A10 0.025 0.047
0.347
Total Score 2.59