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Evidence of Interaction Between LIG1 and POLD1

The interaction score between LIG1 and POLD1 is 2.03.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between LIG1 and POLD1 = 0.83

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.027
Orthology
OrganismLIG1 OrthologuePOLD1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YDL164C 1 YDL102W 1
worm Q27474 1 P90829 1
fly Q960P4 1 P54358 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3
Domains No domains were used in calculating likelihood of interaction 1.48E-3
Post-translational Modifications

Protein: LIG1

PTMResidueReference
Phosphorylation 66 PubMed, HPRD
Phosphorylation 76 PubMed, HPRD
Phosphorylation 141 PubMed, HPRD
Phosphorylation 195 PubMed, HPRD
Phosphorylation 911 PubMed, HPRD
Phosphoserine 66 HPRD
Phosphoserine 76 HPRD
Phosphoserine 141 HPRD
Phosphoserine 911 HPRD
Phosphothreonine 195 HPRD

Protein: POLD1

PTMResidueReference
Localisation

Protein: LIG1

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD

Protein: POLD1

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between LIG1 and POLD1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between LIG1 andPOLD1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , LIG1 has 892 interactors and POLD1 has 67 interactors of which there are 27 common interactors.

Common InteractorName of Common InteractorScore for LIG1-Interactor (?)Score for POLD1-Interactor (?)
PCNA PCNA: Proliferating cell nuclear antigen 73.00 0.263
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.704 0.038
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 0.276 0.263
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.129 0.123
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 0.129 0.263
CDK4 CDK4: Cell division protein kinase 4 0.129 0.081
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.129 0.081
BRCA1 BRCA1, RNF53: Breast cancer type 1 susceptibility protein 0.129 0.038
CDK2 CDK2: Cell division protein kinase 2 0.129 0.038
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.129 0.038
WEE1 WEE1: Wee1-like protein kinase 0.129 0.038
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.129 0.038
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.129 0.038
NBN NBN, NBS, NBS1, P95: Nibrin 0.087 0.0255
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.087 0.083
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.078 0.038
MDN1 MDN1, KIAA0301: Midasin 0.078 0.060
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.078 0.038
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.070 0.0255
HSPD1 0.066 0.301
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.063 0.060
ZWINT N/A 0.027 0.027
C18orf56 N/A 0.027 0.027
C22orf18 N/A 0.027 0.082
RAD51AP1 N/A 0.027 0.027
SMC4L1 N/A 0.027 0.027
GMNN GMNN: Geminin 0.025 0.027
0.347
Total Score 2.03