Home
Advanced Search
Help
Update History
Statistics
Downloads
The Barton Group
<<< Back to LIG1

Evidence of Interaction Between LIG1 and FEN1

The interaction score between LIG1 and FEN1 is 2.90E3.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between LIG1 and FEN1 = 0.82

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismLIG1 OrthologueFEN1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YDL164C 1 YKL113C 1
  • ReconstitutedComplex

Get References From PubMed
worm Q27474 1 Q9N3T2 1
fly Q960P4 1 O96830 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains No domains were used in calculating likelihood of interaction 4.85E-3
Post-translational Modifications

Protein: LIG1

PTMResidueReference
Phosphorylation 66 PubMed, HPRD
Phosphorylation 76 PubMed, HPRD
Phosphorylation 141 PubMed, HPRD
Phosphorylation 195 PubMed, HPRD
Phosphorylation 911 PubMed, HPRD
Phosphoserine 66 HPRD
Phosphoserine 76 HPRD
Phosphoserine 141 HPRD
Phosphoserine 911 HPRD
Phosphothreonine 195 HPRD

Protein: FEN1

PTMResidueReference
Acetylation 354 PubMed, HPRD
Acetylation 375 PubMed, HPRD
Acetylation 377 PubMed, HPRD
Acetylation 380 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Localisation

Protein: LIG1

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD

Protein: FEN1

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Transitive Score

The common interactors between LIG1 and FEN1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between LIG1 andFEN1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , LIG1 has 892 interactors and FEN1 has 145 interactors of which there are 82 common interactors.

Common InteractorName of Common InteractorScore for LIG1-Interactor (?)Score for FEN1-Interactor (?)
PCNA PCNA: Proliferating cell nuclear antigen 73.00 38.00
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.704 0.081
ESPL1 N/A 0.307 0.053
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.307 0.025
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.307 0.160
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.307 0.053
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.307 0.025
MSH6 MSH6, GTBP: DNA mismatch repair protein MSH6 0.276 0.0479
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.276 0.0479
KIF11 N/A 0.276 0.144
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.276 0.144
TIMELESS TIMELESS, TIM, TIM1, TIMELESS1: Protein timeless homolog 0.276 0.0479
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.276 0.144
MCM3 MCM3: DNA replication licensing factor MCM3 0.276 0.144
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 0.276 0.0479
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.276 0.0479
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 0.276 0.0479
CBX3 CBX3: Chromobox protein homolog 3 0.276 0.0479
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.144 0.053
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.144 0.025
MKI67 MKI67: Antigen KI-67 0.144 0.053
BAZ1B BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain 0.144 0.025
CENPA CENPA: Histone H3-like centromeric protein A 0.144 0.053
PTMA N/A 0.144 0.025
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.144 0.025
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.141 0.0479
MYBL2 MYBL2, BMYB: Myb-related protein B 0.129 0.0479
CDK4 CDK4: Cell division protein kinase 4 0.129 0.0479
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.129 0.0479
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.129 0.0479
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.129 0.0479
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.129 0.0479
CDK2 CDK2: Cell division protein kinase 2 0.129 0.0479
CSPG6 SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3 0.129 0.0479
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.129 0.144
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.129 0.0479
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.129 0.0479
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.129 0.144
CCNB1 Cyclin B1 0.129 0.0479
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.129 0.0479
H2AFX H2AFX, H2AX: Histone H2A.x 0.129 0.0479
CDC20 CDC20: Cell division cycle protein 20 homolog 0.129 0.0479
POLA2 POLA2: DNA polymerase subunit alpha B 0.129 0.0479
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.129 0.0479
NUP153 N/A 0.129 0.0479
KIF23 N/A 0.087 0.025
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.087 0.025
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.078 0.0479
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.074 0.053
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.074 0.025
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.066 0.0479
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.066 0.0479
RACGAP1 RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1 0.066 0.0479
TK1 TK1: Thymidine kinase, cytosolic 0.066 0.0479
RRM2 RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2 0.066 0.144
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.066 0.0479
CTPS CTPS: CTP synthase 1 0.066 0.0479
CCT6A CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta 0.066 0.0479
TPX2 TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2 0.053 0.053
EZH2 EZH2: Enhancer of zeste homolog 2 0.0479 0.0479
SLBP SLBP, HBP: Histone RNA hairpin-binding protein 0.0479 0.0479
KNTC2 KNTC2, HEC, HEC1: Kinetochore protein Hec1 0.0479 0.144
DKC1 DKC1, NOLA4: H/ACA ribonucleoprotein complex subunit 4 0.0479 0.0479
PA2G4 PA2G4, EBP1: Proliferation-associated protein 2G4 0.0479 0.0479
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.0446 0.025
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.036 0.025
RPS10 RPS10: 40S ribosomal protein S10 0.032 1.49
TMPO N/A 0.027 0.027
C18orf56 N/A 0.027 0.082
C22orf18 N/A 0.027 0.027
MCM10 N/A 0.027 0.027
RAD51AP1 N/A 0.027 0.027
SMC4L1 N/A 0.027 0.082
KIAA0101 PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor 0.027 0.082
ZWINT N/A 0.027 0.082
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.025 0.025
PTTG1 PTTG1, EAP1, PTTG, TUTR1: Securin 0.025 0.025
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.025 0.053
TACC3 TACC3, ERIC1: Transforming acidic coiled-coil-containing protein 3 0.025 0.025
GMNN GMNN: Geminin 0.025 0.160
GTSE1 GTSE1: G2 and S phase-expressed protein 1 0.025 0.053
DBF4 DBF4, ASK: Protein DBF4 homolog 0.025 0.025
0.572
Total Score 2.90E3