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Evidence of Interaction Between LIG1 and RFC5

The interaction score between LIG1 and RFC5 is 1.86.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between LIG1 and RFC5 = 0.86

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismLIG1 OrthologueRFC5 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YDL164C 1 YNL290W 1
worm Q27474 1 P34429 1
fly Q960P4 1 Q9VKW3 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 8.25E-4
Post-translational Modifications

Protein: LIG1

PTMResidueReference
Phosphorylation 66 PubMed, HPRD
Phosphorylation 76 PubMed, HPRD
Phosphorylation 141 PubMed, HPRD
Phosphorylation 195 PubMed, HPRD
Phosphorylation 911 PubMed, HPRD
Phosphoserine 66 HPRD
Phosphoserine 76 HPRD
Phosphoserine 141 HPRD
Phosphoserine 911 HPRD
Phosphothreonine 195 HPRD

Protein: RFC5

PTMResidueReference
Localisation

Protein: LIG1

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD

Protein: RFC5

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between LIG1 and RFC5 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between LIG1 andRFC5. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , LIG1 has 892 interactors and RFC5 has 116 interactors of which there are 37 common interactors.

Common InteractorName of Common InteractorScore for LIG1-Interactor (?)Score for RFC5-Interactor (?)
PCNA PCNA: Proliferating cell nuclear antigen 73.00 54.70
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.307 0.0278
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.276 0.207
MCM3 MCM3: DNA replication licensing factor MCM3 0.276 0.620
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.129 0.207
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.129 0.059
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.129 0.207
H2AFX H2AFX, H2AX: Histone H2A.x 0.129 1.01
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.129 0.207
POLA2 POLA2: DNA polymerase subunit alpha B 0.129 1.01
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.129 0.0968
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.129 0.123
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.087 0.067
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.078 0.059
MDN1 MDN1, KIAA0301: Midasin 0.078 0.060
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.070 0.083
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.066 0.123
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.063 0.044
TPX2 TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2 0.053 0.027
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.040 0.123
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.040 0.074
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.032 0.074
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.032 0.074
VCP VCP: Transitional endoplasmic reticulum ATPase 0.032 0.060
TMPO N/A 0.027 0.027
C18orf56 N/A 0.027 0.027
C22orf18 N/A 0.027 0.027
MCM10 N/A 0.027 0.027
RAD51AP1 N/A 0.027 0.027
ITGB3BP N/A 0.027 0.027
SMC4L1 N/A 0.027 0.027
KIAA0101 PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor 0.027 0.027
ZWINT N/A 0.027 0.027
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.025 0.039
HIST3H2A HIST3H2A: Histone H2A type 3 0.025 0.039
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.025 0.027
GMNN GMNN: Geminin 0.025 0.027
0.572
Total Score 1.86