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Evidence of Interaction Between LIG1 and WAS

The interaction score between LIG1 and WAS is 4.63.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between LIG1 and WAS = 0.27

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.88E-3
Orthology
OrganismLIG1 OrthologueWAS OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YDL164C 1 YOR181W 1
worm Q27474 1 Q8MQE6 0.304
fly Q960P4 1 Q9VAT0 0.191

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in LIG1 and WAS:
Domains in LIG1Domains in WAS
IPR000977 ATP-dependent DNA ligase
IPR012309 DNA_ligase_A_C.
IPR012310 DNA_ligase_A_M.
IPR012308 DNA_ligase_A_N.
IPR003124 Actin-binding WH2
IPR000095 PAK-box/P21-Rho-binding
IPR011026 Wiscott-Aldrich syndrome, C-terminal
IPR000697 EVH1
IPR011993 PH_type.

The Chi square scores for co-occurrence of domains that are present in LIG1 and WAS are listed below.

Domain 1Domain 2Chi Square
IPR000977 ATP-dependent DNA ligase IPR011993 PH_type. 4.28421

The background colour of the table refers to:

  • Blue Domain is only present in LIG1
  • Yellow Domain is only present in WAS
  • Green Domain is present in both LIG1 and WAS

 0.049
Post-translational Modifications

Protein: LIG1

PTMResidueReference
Phosphorylation 66 PubMed, HPRD
Phosphorylation 76 PubMed, HPRD
Phosphorylation 141 PubMed, HPRD
Phosphorylation 195 PubMed, HPRD
Phosphorylation 911 PubMed, HPRD
Phosphoserine 66 HPRD
Phosphoserine 76 HPRD
Phosphoserine 141 HPRD
Phosphoserine 911 HPRD
Phosphothreonine 195 HPRD

Protein: WAS

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 291 PubMed, HPRD
Phosphorylation 291 PubMed, HPRD
Phosphorylation 483 PubMed, HPRD
Phosphorylation 484 PubMed, HPRD
Phosphoserine 482 PubMed, HPRD
Phosphoserine 483 PubMed, HPRD
Phosphotyrosine 290 HPRD
Localisation

Protein: LIG1

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD

Protein: WAS

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD
Transitive Score

The common interactors between LIG1 and WAS that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between LIG1 andWAS. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , LIG1 has 892 interactors and WAS has 1502 interactors of which there are 536 common interactors.

Common InteractorName of Common InteractorScore for LIG1-Interactor (?)Score for WAS-Interactor (?)
UBE2R2 UBE2R2, CDC34B, UBC3B: Ubiquitin-conjugating enzyme E2 R2 3.39 0.025
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 1.26 0.029
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.704 0.045
ESPL1 N/A 0.307 0.026
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.307 0.027
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.307 0.036
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.307 0.032
SUZ12 SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12 0.276 0.032
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.251 0.080
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.096
TCOF1 N/A 0.144 0.027
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.144 0.052
SET SET: Protein SET 0.144 0.027
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.144 0.027
FANCA FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein 0.144 0.032
UBAP2 N/A 0.144 0.032
RBM14 RBM14, SIP: RNA-binding protein 14 0.144 0.036
PTMA N/A 0.144 0.0446
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.144 0.036
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.141 0.046
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.141 0.054
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.139 0.461
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.139 0.461
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.129 0.063
CDK4 CDK4: Cell division protein kinase 4 0.129 0.171
TIAL1 TIAL1: Nucleolysin TIAR 0.129 0.040
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.129 0.032
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.129 0.136
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.129 0.032
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.129 0.046
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.129 0.032
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.129 0.425
CDK2 CDK2: Cell division protein kinase 2 0.129 0.171
CSPG6 SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3 0.129 0.032
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.129 0.032
CPSF1 CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1 0.129 0.032
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.129 0.171
TDG TDG: G/T mismatch-specific thymine DNA glycosylase 0.129 0.032
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.129 0.136
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.129 0.032
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.129 0.032
WEE1 WEE1: Wee1-like protein kinase 0.129 0.111
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.129 0.032
APEX1 APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase 0.129 0.032
ZCCHC8 ZCCHC8: Zinc finger CCHC domain-containing protein 8 0.129 0.032
SFRS4 SFRS4, SRP75: Splicing factor, arginine/serine-rich 4 0.129 0.032
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.129 0.040
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.129 0.032
NUP153 N/A 0.129 0.032
HDAC3 HDAC3: Histone deacetylase 3 0.129 0.032
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.129 0.038
ROCK1 ROCK1: Rho-associated protein kinase 1 0.127 0.515
PLEK PLEK, P47: Pleckstrin 0.127 0.541
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.114 0.275
SOS1 SOS1: Son of sevenless homolog 1 0.114 0.181
CD2AP CD2AP: CD2-associated protein 0.112 72.80
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.111 0.461
DAB1 DAB1: Disabled homolog 1 0.111 0.044
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.097 0.056
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.091 0.152
CSK CSK: Tyrosine-protein kinase CSK 0.090 1.62
CRKL CRKL: Crk-like protein 0.090 14.60
DAB2 DAB2, DOC2: Disabled homolog 2 0.088 0.049
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.088 0.026
MATR3 MATR3, KIAA0723: Matrin-3 0.087 0.027
NBN NBN, NBS, NBS1, P95: Nibrin 0.087 0.0446
ABCF1 N/A 0.087 0.052
RB1 RB1: Retinoblastoma-associated protein 0.087 0.027
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.087 0.0446
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.087 0.032
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.087 0.036
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.087 0.027
DDX21 DDX21: Nucleolar RNA helicase 2 0.087 0.036
TRRAP N/A 0.087 0.032
FNBP4 FNBP4, FBP30, KIAA1014: Formin-binding protein 4 0.087 0.036
GNB2L1 Lung cancer oncogene 7 0.087 0.0446
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.087 0.027
TOP2B N/A 0.087 0.027
FNBP1 N/A 0.087 40.60
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.086 0.822
DOK1 DOK1: Docking protein 1 0.086 0.233
NF2 NF2, SCH: Merlin 0.083 0.083
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.078 0.078
BAZ2A BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A 0.078 0.032
SNRPB2 SNRPB2: U2 small nuclear ribonucleoprotein B'' 0.078 0.032
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.078 0.032
AKAP8 AKAP8, AKAP95: A-kinase anchor protein 8 0.078 0.040
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.078 0.078
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.078 0.461
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.078 0.066
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.078 0.461
PABPC1 PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1 0.078 0.066
WBSCR20A N/A 0.078 0.032
ZNF330 ZNF330, NOA36: Zinc finger protein 330 0.078 0.032
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.078 0.032
SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 0.078 0.040
SAFB SAFB, HAP, HET, SAFB1: Scaffold attachment factor B 0.078 0.032
PHF10 N/A 0.078 0.032
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.078 0.040
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.078 0.111
PPP1R8 N/A 0.078 0.040
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.078 0.063
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.078 0.040
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.078 0.111
PAPOLA PAPOLA, PAP: Poly(A) polymerase alpha 0.078 0.066
YY1 YY1: Transcriptional repressor protein YY1 0.078 0.040
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.078 0.111
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.078 0.275
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.078 0.461
MDN1 MDN1, KIAA0301: Midasin 0.078 0.086
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.078 0.372
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.078 0.245
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.078 16.60
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.077 0.049
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.075 0.032
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.075 0.152
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.075 0.148
ELMO1 N/A 0.075 0.075
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.075 0.148
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.074 0.307
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.074 0.026
FUBP1 N/A 0.074 0.070
CXorf9 N/A 0.071 1.62
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.070 0.052
IKBKG IKBKG, FIP3, NEMO: NF-kappa-B essential modulator 0.070 0.074
KIAA0853 N/A 0.070 0.036
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.070 0.191
CHUK N/A 0.070 0.052
ZNF318 ZNF318, HRIHFB2436: Zinc finger protein 318 0.070 0.036
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.070 0.416
ELF1 ELF1: ETS-related transcription factor Elf-1 0.070 0.157
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.210
RBM6 RBM6, DEF3: RNA-binding protein 6 0.070 0.027
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.070 0.027
ZNF638 ZNF638, NP220, ZFML: Zinc finger protein 638 0.070 0.027
ARFGAP1 N/A 0.070 0.091
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.070 0.026
API5 N/A 0.070 0.0425
IRF3 IRF3: Interferon regulatory factor 3 0.070 0.036
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.070 0.070
PHF3 PHF3, KIAA0244: PHD finger protein 3 0.070 0.0446
TGIF2 TGIF2: Homeobox protein TGIF2 0.070 0.036
TBC1D1 TBC1D1, KIAA1108: TBC1 domain family member 1 0.070 0.030
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.069 0.188
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.067 0.046
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.067 0.069
VIL2 N/A 0.067 0.139
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.067 0.139
VAV1 VAV1, VAV: Proto-oncogene vav 0.067 260.00
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.067 1.62
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.067 24.50
XPO1 XPO1, CRM1: Exportin-1 0.066 0.139
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 0.066 0.063
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.066 0.171
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.066 0.038
LAMR1 RPSA, LAMBR, LAMR1: 40S ribosomal protein SA 0.066 0.063
CCT8 CCT8: Uncharacterized protein CCT8 0.066 0.038
CCT4 CCT4, CCTD, SRB: T-complex protein 1 subunit delta 0.066 0.029
LDHB LDHB: L-lactate dehydrogenase B chain 0.066 0.038
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.066 0.029
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.066 0.171
CTPS CTPS: CTP synthase 1 0.066 0.029
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.066 0.046
CDC23 CDC23: Cell division cycle protein 23 homolog 0.066 0.038
CCT6A CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta 0.066 0.029
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.063 0.063
CUL5 CUL5, VACM1: Cullin-5 0.063 0.032
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.063 0.029
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.245
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.063 0.032
SFRS6 SFRS6, SRP55: Splicing factor, arginine/serine-rich 6 0.063 0.040
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.063 0.040
USP34 USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34 0.063 0.063
TAF10 TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10 0.063 0.040
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.063 0.038
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.063 0.111
NCOR1 NCOR1, KIAA1047: Nuclear receptor corepressor 1 0.063 0.040
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.063 0.032
TOPORS TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors 0.063 0.032
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.063 0.046
SF3B4 SF3B4, SAP49: Splicing factor 3B subunit 4 0.063 0.032
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.063 0.137
SPEN SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein 0.063 0.032
SAPS3 N/A 0.063 0.063
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.063 0.129
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.063 0.066
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.062 0.260
GAB1 GAB1: GRB2-associated-binding protein 1 0.062 0.062
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.061 0.109
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.055 0.058
GAB2 N/A 0.055 0.155
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.054 4.88
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.054 14.60
RFXDC2 RFXDC2: Regulatory factor X domain-containing protein 2. 0.052 0.027
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.052 0.152
NCOA3 N/A 0.052 0.0446
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.052 0.074
IFI16 N/A 0.052 0.157
SP100 N/A 0.052 0.0446
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.052 0.416
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.052 0.0446
XRCC1 XRCC1: DNA-repair protein XRCC1 0.052 0.027
JMJD1A JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr 0.052 0.036
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.051
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.051 0.763
APS SH2B2, APS: SH2B adapter protein 2 0.051 0.171
PLD1 PLD1: Phospholipase D1 0.051 0.056
MSN MSN: Moesin 0.051 0.822
IRS1 IRS1: Insulin receptor substrate 1 0.049 0.049
IRS2 IRS2: Insulin receptor substrate 2 0.049 0.155
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.049 0.165
DNM3 DNM3: Uncharacterized protein DNM3 0.049 0.083
LNK SH2B3, LNK: SH2B adapter protein 3 0.049 0.165
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.049 0.083
PDZD2 CDNA FLJ46853 fis, clone UTERU3009775, moderately similar to Rattus norvegicus P 0.049 0.028
PSCD2 N/A 0.049 0.083
ANAPC1 ANAPC1, TSG24: Anaphase-promoting complex subunit 1 0.0479 0.030
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.047 0.148
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.046 0.461
EIF3S4 EIF3S4: Eukaryotic translation initiation factor 3 subunit 4 0.046 0.066
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.046 0.385
SYMPK SYMPK, SPK: Symplekin 0.046 0.029
SFRS5 SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5 0.046 0.066
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.046 0.171
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.046 0.032
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.046 0.141
EP300 N/A 0.046 0.040
AIP AIP, XAP2: AH receptor-interacting protein 0.046 0.046
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.046 0.066
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.046 0.090
CDK7 CDK7, MO15: Cell division protein kinase 7 0.046 0.171
SP3 SP3: Transcription factor Sp3 0.046 0.040
CLTC CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1 0.046 2.53
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.046 0.171
KIAA1012 KIAA1012: Protein TRS85 homolog 0.046 0.129
DIAPH1 Diaphanous 1 0.046 0.276
RBM8A RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A 0.046 0.040
RPS6KB1 N/A 0.046 0.372
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.046 0.046
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.046 0.063
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.046 0.078
ZNF24 ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24 0.046 0.032
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 0.046 0.040
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.046 0.032
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.046 0.063
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.046 0.275
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.046 0.040
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.046 0.225
KLHDC4 N/A 0.046 0.078
CUL4B N/A 0.046 0.032
DAXX DAXX, BING2, DAP6: Death domain-associated protein 6 0.046 0.032
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.046 0.066
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.046 0.123
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.046 0.852
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.0453 0.087
VASP VASP: Vasodilator-stimulated phosphoprotein 0.0453 0.852
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.191
NME1 NME1, NDPKA, NM23: Nucleoside diphosphate kinase A 0.0446 0.026
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.0446 0.032
PHB2 PHB2, BAP, REA: Prohibitin-2 0.0446 0.0425
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.0446 0.032
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.044 0.099
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.044 0.073
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.044 0.075
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.044 0.025
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.044 0.075
MYO18A 0.044 0.025
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.044 0.148
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.044 0.075
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.044 0.025
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.044 0.148
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.044 0.075
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.044 0.148
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.0425 0.109
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.0425 0.087
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.0425 0.0446
H1FX H1FX: Histone H1x 0.0425 0.036
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.0425 1.81
ZNF267 ZNF267: Zinc finger protein 267 0.0425 0.036
STK16 N/A 0.0425 0.191
WDR1 N/A 0.0425 0.0446
ZNF148 ZNF148, ZBP89: Zinc finger protein 148 0.0425 0.0446
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.0425 0.251
NFATC1 N/A 0.0425 0.036
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.041 0.097
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.041 0.111
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.041 0.114
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.041 0.114
PSCD4 PSCD4, CYT4: Cytohesin-4 0.041 0.822
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.041 0.136
PLD2 PLD2: Phospholipase D2 0.041 0.056
RDX RDX: Radixin 0.041 0.044
RASA3 RASA3: Ras GTPase-activating protein 3 0.041 0.225
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.04 0.165
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.04 0.165
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.04 0.165
AMPH AMPH, AMPH1: Amphiphysin 0.04 0.165
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.04 0.165
FRG1 FRG1: Protein FRG1 0.040 0.078
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.040 0.046
CASP3 CASP3, CPP32: Caspase-3 precursor 0.040 0.029
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 0.040 0.046
RPL8 RPL8: 60S ribosomal protein L8 0.040 0.063
EEF1G EEF1G, EF1G, PRO1608: Elongation factor 1-gamma 0.040 0.078
QARS QARS: Glutaminyl-tRNA synthetase 0.040 0.078
HNRPK N/A 0.040 0.129
PPIA PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A 0.040 0.063
ME2 ME2: NAD-dependent malic enzyme, mitochondrial precursor 0.040 0.078
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.040 0.129
RPS3 RPS3, OK/SW-cl.26: 40S ribosomal protein S3 0.040 0.078
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.040 0.038
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.040 0.038
RPL3 RPL3, OK/SW-cl.32: 60S ribosomal protein L3 0.040 0.078
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.040 0.046
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.040 0.046
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.040 0.038
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.040 0.275
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.040 0.225
HSP90AA1 Hsp89-alpha-delta-N 0.040 0.029
THOC1 THOC1, HPR1: THO complex subunit 1 0.040 0.038
EEF1B2 EEF1B2, EEF1B, EF1B: Elongation factor 1-beta 0.040 0.078
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.040 0.046
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.040 0.038
GSR GSR, GLUR, GRD1: Glutathione reductase, mitochondrial precursor 0.040 0.063
EIF3S6 EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6 0.040 0.078
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.040 0.046
NME2 NME2, NM23B: Nucleoside diphosphate kinase B 0.040 0.038
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.038 0.029
BRPF1 BRPF1, BR140: Peregrin 0.038 0.046
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.038 0.040
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.038 0.461
MYH9 MYH9: Myosin-9 0.038 0.137
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.038 0.038
RANBP9 RANBP9, RANBPM: Ran-binding protein 9 0.038 0.073
JARID1A JARID1A, RBBP2, RBP2: Histone demethylase JARID1A 0.038 0.141
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.038 1.62
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.038 0.078
ZNF217 ZNF217, ZABC1: Zinc finger protein 217 0.038 0.040
COPA COPA: Coatomer subunit alpha 0.038 0.046
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.038 0.461
COPE COPE: Coatomer subunit epsilon 0.038 0.046
KLF13 KLF13, BTEB3, NSLP1: Krueppel-like factor 13 0.038 0.032
CDK6 CDK6: Cell division protein kinase 6 0.038 0.136
SIRT1 SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1 0.038 0.032
DUSP22 DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22 0.038 0.032
C20orf4 C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4 0.038 0.029
DDX51 DDX51: ATP-dependent RNA helicase DDX51 0.038 0.040
TSC1 TSC1, KIAA0243, TSC: Hamartin 0.038 0.136
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.038 0.245
SNRK SNRK, KIAA0096, SNFRK: SNF-related serine/threonine-protein kinase 0.038 0.029
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.038 0.129
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.038 0.066
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.038 0.066
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.038 0.763
ATM ATM: Serine-protein kinase ATM 0.038 0.275
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.037 0.515
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.037 1.81
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.037 1.81
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.037 0.191
PDLIM1 PDLIM1, CLIM1, CLP36: PDZ and LIM domain protein 1 0.037 0.123
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.037 1.81
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.037 0.062
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.036 0.0425
YWHAQ YWHAQ: 14-3-3 protein theta 0.036 0.060
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.036 0.0425
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.036 0.0425
IPO7 IPO7: Uncharacterized protein IPO7 0.036 0.077
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.036 0.148
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.036 0.148
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.036 7.88
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.036 0.148
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.036 7.88
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.036 39.20
LYN LYN: Tyrosine-protein kinase Lyn 0.033 1.62
STAM2 STAM2: Signal transducing adapter molecule 2 0.033 0.136
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.033 0.225
NCK2 NCK2: Cytoplasmic protein NCK2 0.033 14.60
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.033 0.111
NOS1 NOS1: Nitric-oxide synthase, brain 0.033 0.035
MCF2 MCF2, DBL: Proto-oncogene DBL 0.032 0.098
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.032 0.123
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.032 0.561
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.032 0.307
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.032 0.052
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.032 0.166
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.032 0.027
PRKAA1 N/A 0.032 0.191
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.032 0.852
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.032 0.087
GTF3C1 N/A 0.032 0.027
RGS14 N/A 0.032 0.0446
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.032 0.087
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.032 0.026
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.032 0.100
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.032 0.307
STAT2 STAT2: Signal transducer and activator of transcription 2 0.032 0.166
CARS CARS: Cysteinyl-tRNA synthetase, cytoplasmic 0.032 0.063
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.032 0.129
RPS10 RPS10: 40S ribosomal protein S10 0.032 0.078
THOP1 THOP1: Thimet oligopeptidase 0.032 0.029
USP10 USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10 0.032 0.129
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.032 0.078
PPARBP N/A 0.032 0.078
TBCE TBCE: Tubulin-specific chaperone E 0.032 0.038
RARS RARS: Arginyl-tRNA synthetase, cytoplasmic 0.032 0.046
EEF1A1 EEF1A1: Elongation factor 1-alpha 0.032 0.078
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.032 0.046
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 0.032 0.063
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.032 0.038
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.032 0.078
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.032 0.078
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.032 0.063
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.032 0.372
VCP VCP: Transitional endoplasmic reticulum ATPase 0.032 0.046
EEF2 EEF2, EF2: Elongation factor 2 0.032 0.275
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.0308 0.372
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.0308 0.099
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.050
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.029 0.078
BMX N/A 0.029 0.109
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.029 0.050
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.029 29.20
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.029 0.088
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.029 0.032
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.029 0.275
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.029 0.040
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.029 0.372
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.171
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.029 0.032
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.029 0.040
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.029 0.372
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.029 0.066
STK10 STK10: Uncharacterized protein STK10 0.029 1.62
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.029 7.50
MTF1 MTF1: Metal regulatory transcription factor 1 0.029 0.040
CORO1C CORO1C, CRNN4: Coronin-1C 0.029 0.032
GSK3B N/A 0.029 0.078
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.029 0.275
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.029 0.069
WDR44 WDR44: WD repeat-containing protein 44 0.029 0.032
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.029 1.62
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.029 0.111
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.029 0.040
CREBBP CREBBP, CBP: CREB-binding protein 0.029 0.112
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.029 0.171
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.029 0.461
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.028 0.165
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
PPEF1 N/A 0.028 0.083
MAPKAPK5 N/A 0.028 0.165
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.028 0.165
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.028 0.165
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.028 0.165
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
RAB4A N/A 0.028 0.109
MAPK15 N/A 0.028 0.165
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.165
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.028 0.165
PHLDB2 N/A 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.165
SYTL4 Endocrine transmitter regulatory protein 0.028 0.049
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.028 0.0333
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.028 0.088
SORBS3 SORBS3, SCAM1: Vinexin 0.027 4.67
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.027 86.60
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.027 0.099
USP21 USP21, USP23: Ubiquitin carboxyl-terminal hydrolase 21 0.027 0.026
HD HD, IT15: Huntingtin 0.027 0.070
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.0263 0.109
RIMS1 RIMS1, KIAA0340, Nbla00761, RAB3IP2, RIM1: Regulating synaptic membrane exocytos 0.026 0.049
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.026 0.044
PSD TYL: TYL protein 0.026 0.044
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.026 0.050
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.026 0.087
GRLF1 N/A 0.026 0.109
AANAT AANAT, SNAT: Serotonin N-acetyltransferase 0.026 0.026
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.026 0.307
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.026 0.416
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.026 0.416
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.026 0.123
MARK2 N/A 0.026 0.087
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.025 0.148
MAP2K3 N/A 0.025 0.025
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.025 0.148
BCOR N/A 0.025 0.025
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.025 0.148
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.025 0.098
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.025 0.030
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.025 0.148
ADK ADK: Adenosine kinase 0.025 0.025
NEDD4 NEDD4: Uncharacterized protein NEDD4 0.025 0.683
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.025 0.148
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.025 0.148
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.025 0.098
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.025 0.148
CAMKK1 N/A 0.025 0.025
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.025
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.025 0.025
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.025 0.025
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.025
CAMK2A N/A 0.025 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.025
NIPBL N/A 0.025 0.025
CDC2 CDC2: Cell division control protein 2 homolog 0.025 0.148
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
GRK6 N/A 0.025 0.025
CDC25C CDC25C: M-phase inducer phosphatase 3 0.025 0.025
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.044
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.025
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.025 0.148
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.148
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.025 0.098
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.025 0.098
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.025 0.148
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.025 0.148
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.025 0.148
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
GIT2 N/A 0.025 0.075
EEF2K EEF2K: Elongation factor 2 kinase 0.025 0.148
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.025 0.098
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.025
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.025 0.148
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.025 0.148
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.025 0.148
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.025 0.148
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.025 0.030
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.025 0.148
PRKCB1 N/A 0.025 0.025
0.228
Total Score 4.63