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Evidence of Interaction Between LIG1 and IDH2

The interaction score between LIG1 and IDH2 is 3.30.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between LIG1 and IDH2 = 0.47

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 4.62E-3
Orthology
OrganismLIG1 OrthologueIDH2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YDL164C 1 YDL066W 1
bakers yeast YDL164C 1 YLR174W 1
bakers yeast YDL164C 1 YNL009W 0.408
worm Q27474 1 O17643 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 0.014
Post-translational Modifications

Protein: LIG1

PTMResidueReference
Phosphorylation 66 PubMed, HPRD
Phosphorylation 76 PubMed, HPRD
Phosphorylation 141 PubMed, HPRD
Phosphorylation 195 PubMed, HPRD
Phosphorylation 911 PubMed, HPRD
Phosphoserine 66 HPRD
Phosphoserine 76 HPRD
Phosphoserine 141 HPRD
Phosphoserine 911 HPRD
Phosphothreonine 195 HPRD

Protein: IDH2

PTMResidueReference
Acetylation 173 PubMed, HPRD
Localisation

Protein: LIG1

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD

Protein: IDH2

LocalisationReference
Mitochondrion HPRD
Transitive Score

The common interactors between LIG1 and IDH2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between LIG1 andIDH2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , LIG1 has 892 interactors and IDH2 has 478 interactors of which there are 294 common interactors.

Common InteractorName of Common InteractorScore for LIG1-Interactor (?)Score for IDH2-Interactor (?)
PCNA PCNA: Proliferating cell nuclear antigen 73.00 0.032
UBE2R2 UBE2R2, CDC34B, UBC3B: Ubiquitin-conjugating enzyme E2 R2 3.39 0.025
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 1.26 0.046
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.704 0.034
ESPL1 N/A 0.307 0.052
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.307 0.027
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.307 0.036
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.307 0.027
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.307 0.0425
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.276 0.032
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.276 0.032
MCM3 MCM3: DNA replication licensing factor MCM3 0.276 0.032
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.251 0.026
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.144 0.027
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.144 0.0425
KIF22 KIF22, KID, KNSL4: Kinesin-like protein KIF22 0.144 0.0446
MKI67 MKI67: Antigen KI-67 0.144 0.036
FANCA FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein 0.144 0.032
UBAP2 N/A 0.144 0.0425
CENPA CENPA: Histone H3-like centromeric protein A 0.144 0.036
PTMA N/A 0.144 0.027
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.144 0.027
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.141 0.038
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.139 0.038
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.129 0.038
MYBL2 MYBL2, BMYB: Myb-related protein B 0.129 0.036
CDK4 CDK4: Cell division protein kinase 4 0.129 0.070
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.129 0.038
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.129 0.0425
CDK2 CDK2: Cell division protein kinase 2 0.129 0.046
TCF3 TCF3, E2A, ITF1: Transcription factor E2-alpha 0.129 0.027
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.129 0.046
TDG TDG: G/T mismatch-specific thymine DNA glycosylase 0.129 0.027
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.129 0.038
WEE1 WEE1: Wee1-like protein kinase 0.129 0.032
ZCCHC8 ZCCHC8: Zinc finger CCHC domain-containing protein 8 0.129 0.027
H2AFX H2AFX, H2AX: Histone H2A.x 0.129 0.032
CDC20 CDC20: Cell division cycle protein 20 homolog 0.129 0.027
UNG N/A 0.129 0.038
HDAC3 HDAC3: Histone deacetylase 3 0.129 0.027
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.114 0.046
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.111 0.026
CSK CSK: Tyrosine-protein kinase CSK 0.090 0.029
CRKL CRKL: Crk-like protein 0.090 0.038
ABCF1 N/A 0.087 0.0425
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.087 0.032
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.087 0.027
AOF2 AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1 0.087 0.0425
TRRAP N/A 0.087 0.032
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.087 0.027
FNBP1 N/A 0.087 0.029
DOK1 DOK1: Docking protein 1 0.086 0.032
NF2 NF2, SCH: Merlin 0.083 0.028
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.078 0.038
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.078 0.038
HDGF HDGF, HMG1L2: Hepatoma-derived growth factor 0.078 0.036
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.078 0.032
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.078 0.029
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.078 0.029
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.078 0.038
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.078 0.046
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.078 0.046
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.078 0.029
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.078 0.046
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.078 0.029
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.075 0.032
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.075 0.025
ELMO1 N/A 0.075 0.025
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.075 0.025
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.074 0.032
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.074 0.052
FUBP1 N/A 0.074 0.032
CXorf9 N/A 0.071 0.032
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.070 0.032
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.070 0.026
CHUK N/A 0.070 0.032
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.070 0.032
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.032
ARFGAP1 N/A 0.070 0.027
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.070 0.0425
API5 N/A 0.070 0.026
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.070 0.026
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.067 0.029
XPO1 XPO1, CRM1: Exportin-1 0.066 0.038
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.066 0.046
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 0.066 0.038
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.066 0.046
HSPD1 0.066 0.029
RACGAP1 RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1 0.066 0.046
CCT4 CCT4, CCTD, SRB: T-complex protein 1 subunit delta 0.066 0.038
TK1 TK1: Thymidine kinase, cytosolic 0.066 0.038
RRM2 RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2 0.066 0.063
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.066 0.038
CTPS CTPS: CTP synthase 1 0.066 0.038
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.066 0.038
CDC23 CDC23: Cell division cycle protein 23 homolog 0.066 0.038
CCT6A CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta 0.066 0.038
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.063 0.038
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.063 0.029
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.063 0.029
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.063 0.046
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.063 0.032
NOC2L NOC2L: Nucleolar complex protein 2 homolog 0.063 0.029
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.063 0.046
SAPS3 N/A 0.063 0.029
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.061 0.0425
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.052 0.026
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.052 0.027
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.052 0.0425
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.052 0.026
EMD EMD, EDMD, STA: Emerin 0.052 0.036
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.049 0.028
DNM3 DNM3: Uncharacterized protein DNM3 0.049 0.028
LNK SH2B3, LNK: SH2B adapter protein 3 0.049 0.028
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.049 0.028
PSCD2 N/A 0.049 0.028
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.047 0.028
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.046 0.0425
SYMPK SYMPK, SPK: Symplekin 0.046 0.038
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.046 0.046
AIP AIP, XAP2: AH receptor-interacting protein 0.046 0.038
CSDA CSDA, DBPA: DNA-binding protein A 0.046 0.046
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.046 0.046
DIAPH1 Diaphanous 1 0.046 0.029
RPS6KB1 N/A 0.046 0.029
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.046 0.063
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.046 0.038
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.046 0.029
KLHDC4 N/A 0.046 0.029
FKBP4 FKBP4: FK506-binding protein 4 0.046 0.038
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.046 0.026
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.046 0.026
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.0453 0.032
LIMK2 LIMK2: LIM domain kinase 2 0.0453 0.026
NME1 NME1, NDPKA, NM23: Nucleoside diphosphate kinase A 0.0446 0.032
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.0446 0.052
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.0446 0.032
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.044 0.025
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.044 0.025
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.044 0.025
MYO18A 0.044 0.028
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.044 0.028
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.044 0.025
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.044 0.028
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.044 0.025
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.044 0.025
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.044 0.028
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.0425 0.026
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.0425 0.026
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.0425 0.052
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.041 0.026
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.04 0.028
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.04 0.028
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.04 0.028
AMPH AMPH, AMPH1: Amphiphysin 0.04 0.028
FRG1 FRG1: Protein FRG1 0.040 0.029
CASP3 CASP3, CPP32: Caspase-3 precursor 0.040 0.0425
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 0.040 0.038
EEF1G EEF1G, EF1G, PRO1608: Elongation factor 1-gamma 0.040 0.038
HNRPK N/A 0.040 0.038
PPIA PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A 0.040 0.029
ME2 ME2: NAD-dependent malic enzyme, mitochondrial precursor 0.040 0.029
RPS3 RPS3, OK/SW-cl.26: 40S ribosomal protein S3 0.040 0.038
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.040 0.029
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.040 0.046
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.040 0.038
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.040 0.029
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.040 0.046
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.040 0.029
HSP90AA1 Hsp89-alpha-delta-N 0.040 0.029
MTHFD1 MTHFD1, MTHFC, MTHFD: C-1-tetrahydrofolate synthase, cytoplasmic 0.040 0.046
THOC1 THOC1, HPR1: THO complex subunit 1 0.040 0.029
EEF1B2 EEF1B2, EEF1B, EF1B: Elongation factor 1-beta 0.040 0.029
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.040 0.038
GSR GSR, GLUR, GRD1: Glutathione reductase, mitochondrial precursor 0.040 0.038
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.040 12.30
NME2 NME2, NM23B: Nucleoside diphosphate kinase B 0.040 0.029
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.038 0.029
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.038 0.029
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.038 0.029
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.038 0.026
COPA COPA: Coatomer subunit alpha 0.038 0.029
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.038 0.046
COPE COPE: Coatomer subunit epsilon 0.038 0.046
C20orf4 C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4 0.038 0.038
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.038 0.032
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.037 0.026
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.037 0.032
PDLIM1 PDLIM1, CLIM1, CLP36: PDZ and LIM domain protein 1 0.037 0.0425
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.037 0.026
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.036 0.032
YWHAQ YWHAQ: 14-3-3 protein theta 0.036 0.032
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.036 0.032
IPO7 IPO7: Uncharacterized protein IPO7 0.036 0.026
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.036 0.025
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.036 0.025
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.036 0.028
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.036 0.025
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.036 0.025
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.032 0.026
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.032 0.026
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.032 0.026
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.032 0.032
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.032 0.026
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.032 0.0425
HSPH1 HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa 0.032 0.029
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.032 0.038
RPS10 RPS10: 40S ribosomal protein S10 0.032 0.038
THOP1 THOP1: Thimet oligopeptidase 0.032 0.038
USP10 USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10 0.032 10.00
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.032 0.046
PPARBP N/A 0.032 0.032
TBCE TBCE: Tubulin-specific chaperone E 0.032 0.029
RARS RARS: Arginyl-tRNA synthetase, cytoplasmic 0.032 0.029
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.032 0.029
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 0.032 0.046
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.032 0.038
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.032 0.038
KPNA2 KPNA2, RCH1, SRP1: Importin subunit alpha-2 0.032 0.026
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.032 0.038
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.032 0.029
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.032 0.046
VCP VCP: Transitional endoplasmic reticulum ATPase 0.032 0.038
EEF2 EEF2, EF2: Elongation factor 2 0.032 0.038
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.0308 0.026
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.029 0.032
ESRRA ESRRA, ERR1, ESRL1, NR3B1: Steroid hormone receptor ERR1 0.029 0.027
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.029 0.029
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
PPEF1 N/A 0.028 0.028
MAPKAPK5 N/A 0.028 0.028
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.028 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.028 0.028
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
MAPK15 N/A 0.028 0.028
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.028
PHLDB2 N/A 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
HD HD, IT15: Huntingtin 0.027 0.032
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.026 0.038
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.026 0.032
AANAT AANAT, SNAT: Serotonin N-acetyltransferase 0.026 0.026
FAM65A FAM65A, KIAA1930: Protein FAM65A 0.026 0.0425
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.026 0.026
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.026 0.032
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.026 0.026
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.025 0.025
MAP2K3 N/A 0.025 0.025
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.025 0.025
BCOR N/A 0.025 0.025
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.025 0.025
NUP98 N/A 0.025 3.39
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.025 0.025
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.025 0.025
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.025 0.025
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.025 0.025
CAMKK1 N/A 0.025 0.025
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.025
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.025 0.025
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.025 0.025
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.025
CAMK2A N/A 0.025 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.028
NIPBL N/A 0.025 0.025
CDC2 CDC2: Cell division control protein 2 homolog 0.025 0.025
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
GRK6 N/A 0.025 0.025
CDC25C CDC25C: M-phase inducer phosphatase 3 0.025 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.025
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.025 0.025
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.025 0.025
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.025 0.025
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.025 0.025
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.025 0.025
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.028
GIT2 N/A 0.025 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.025 0.025
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.025
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.025 0.025
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.025 0.025
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.025 0.025
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.025 0.025
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.025 0.025
PRKCB1 N/A 0.025 0.025
0.347
Total Score 3.30