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Evidence of Interaction Between LIG1 and FXR2

The interaction score between LIG1 and FXR2 is 2.19.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between LIG1 and FXR2 = 0.01

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology
OrganismLIG1 OrthologueFXR2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
fly Q960P4 1 Q9NFU0 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 0.014
Post-translational Modifications

Protein: LIG1

PTMResidueReference
Phosphorylation 66 PubMed, HPRD
Phosphorylation 76 PubMed, HPRD
Phosphorylation 141 PubMed, HPRD
Phosphorylation 195 PubMed, HPRD
Phosphorylation 911 PubMed, HPRD
Phosphoserine 66 HPRD
Phosphoserine 76 HPRD
Phosphoserine 141 HPRD
Phosphoserine 911 HPRD
Phosphothreonine 195 HPRD

Protein: FXR2

PTMResidueReference
Phosphorylation 601 PubMed, HPRD
Phosphorylation 603 PubMed, HPRD
Phosphotyrosine 519 HPRD
Localisation

Protein: LIG1

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD

Protein: FXR2

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Cytoplasm HPRD
Ribosome HPRD
Transitive Score

The common interactors between LIG1 and FXR2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between LIG1 andFXR2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , LIG1 has 892 interactors and FXR2 has 695 interactors of which there are 353 common interactors.

Common InteractorName of Common InteractorScore for LIG1-Interactor (?)Score for FXR2-Interactor (?)
UBE2R2 UBE2R2, CDC34B, UBC3B: Ubiquitin-conjugating enzyme E2 R2 3.39 0.025
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 1.26 0.029
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.704 0.027
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.307 0.0453
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.307 0.081
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.276 0.064
MCM3 MCM3: DNA replication licensing factor MCM3 0.276 0.073
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 0.276 0.090
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.251 0.0425
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.026
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.144 0.037
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.144 0.032
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.144 0.057
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.144 0.057
UBAP2 N/A 0.144 0.026
RBM14 RBM14, SIP: RNA-binding protein 14 0.144 0.100
SSB SSB: Lupus La protein 0.129 0.090
TIAL1 TIAL1: Nucleolysin TIAR 0.129 0.073
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.129 0.073
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.129 0.064
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.129 0.144
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.129 0.064
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.129 0.033
EIF2S2 EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2 0.129 0.090
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.129 0.073
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.129 0.064
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.129 0.090
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.129 0.073
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.129 0.073
CCNB1 Cyclin B1 0.129 0.033
SFRS4 SFRS4, SRP75: Splicing factor, arginine/serine-rich 4 0.129 0.073
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.129 0.073
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.129 0.064
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.129 0.073
PABPC4 PABPC4, APP1, PABP4: Polyadenylate-binding protein 4 0.129 0.073
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.129 0.097
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.114 0.029
CD2AP CD2AP: CD2-associated protein 0.112 0.049
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.111 0.056
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.091 0.062
CSK CSK: Tyrosine-protein kinase CSK 0.090 0.069
CRKL CRKL: Crk-like protein 0.090 0.086
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.088 0.032
MATR3 MATR3, KIAA0723: Matrin-3 0.087 0.126
ABCF1 N/A 0.087 0.026
RB1 RB1: Retinoblastoma-associated protein 0.087 0.030
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.087 0.037
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.087 0.123
DDX21 DDX21: Nucleolar RNA helicase 2 0.087 0.037
TRRAP N/A 0.087 0.026
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.087 0.166
FNBP1 N/A 0.087 0.069
NF2 NF2, SCH: Merlin 0.083 0.028
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.078 0.139
SNRPB2 SNRPB2: U2 small nuclear ribonucleoprotein B'' 0.078 0.073
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.078 0.033
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.078 0.056
PABPC1 PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1 0.078 0.064
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.078 0.037
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.078 0.113
SAFB SAFB, HAP, HET, SAFB1: Scaffold attachment factor B 0.078 0.113
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.078 0.033
TP53 TP53, P53: Cellular tumor antigen p53 0.078 0.027
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.078 0.073
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.078 0.113
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.078 0.073
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.078 0.051
MDN1 MDN1, KIAA0301: Midasin 0.078 0.136
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.078 0.064
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.077 0.077
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.075 0.032
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.075 0.062
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.075 0.025
ELMO1 N/A 0.075 0.025
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.075 0.025
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.074 0.055
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.074 0.032
FUBP1 N/A 0.074 0.123
CXorf9 N/A 0.071 0.056
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.070 0.100
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.070 0.026
ELF1 ELF1: ETS-related transcription factor Elf-1 0.070 0.037
RBM6 RBM6, DEF3: RNA-binding protein 6 0.070 0.081
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.070 0.100
ZNF638 ZNF638, NP220, ZFML: Zinc finger protein 638 0.070 0.100
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.070 0.110
API5 N/A 0.070 0.026
IRF3 IRF3: Interferon regulatory factor 3 0.070 0.0453
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.069 0.038
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.067 0.097
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.067 0.056
VAV1 VAV1, VAV: Proto-oncogene vav 0.067 0.056
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.067 0.056
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.067 0.049
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.066 0.109
ACIN1 ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus 0.063 0.090
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.063 0.029
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.063 0.111
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.033
SNRP70 SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa 0.063 0.090
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.063 0.029
WBSCR1 EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H 0.063 0.148
SFRS6 SFRS6, SRP55: Splicing factor, arginine/serine-rich 6 0.063 0.064
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.063 0.033
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.063 0.041
NOC2L NOC2L: Nucleolar complex protein 2 homolog 0.063 0.029
CSTF2T CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant 0.063 0.113
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.063 0.029
SF3B4 SF3B4, SAP49: Splicing factor 3B subunit 4 0.063 0.090
SPEN SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein 0.063 0.113
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.063 0.041
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.061 0.055
GAB2 N/A 0.055 0.032
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.054 0.056
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.054 0.049
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.052 0.032
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.052 0.081
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.052 0.026
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.051 0.056
APS SH2B2, APS: SH2B adapter protein 2 0.051 0.069
IRS2 IRS2: Insulin receptor substrate 2 0.049 0.026
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.049 0.083
DNM3 DNM3: Uncharacterized protein DNM3 0.049 0.028
LNK SH2B3, LNK: SH2B adapter protein 3 0.049 0.083
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.049 0.028
PDZD2 CDNA FLJ46853 fis, clone UTERU3009775, moderately similar to Rattus norvegicus P 0.049 0.028
PSCD2 N/A 0.049 0.028
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.049 0.052
SNRPA SNRPA: U1 small nuclear ribonucleoprotein A 0.048 0.0407
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.047 0.075
RBMX2 RBMX2, CGI-79: RNA-binding motif protein, X-linked 2 0.046 0.113
EIF3S4 EIF3S4: Eukaryotic translation initiation factor 3 subunit 4 0.046 0.090
SYMPK SYMPK, SPK: Symplekin 0.046 0.029
ERCC3 ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit 0.046 0.051
SFRS5 SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5 0.046 0.073
POLR2A POLR2A: Uncharacterized protein POLR2A 0.046 0.051
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.046 0.038
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.046 0.033
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.046 0.037
AIP AIP, XAP2: AH receptor-interacting protein 0.046 0.029
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.046 0.033
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.046 0.033
CSDA CSDA, DBPA: DNA-binding protein A 0.046 46.80
RBM8A RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A 0.046 0.113
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.046 0.029
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.046 0.136
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.046 0.029
RBM7 0.046 0.073
FKBP4 FKBP4: FK506-binding protein 4 0.046 0.038
HTATSF1 HTATSF1: HIV Tat-specific factor 1 0.046 0.113
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.046 0.062
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.046 0.062
NME1 NME1, NDPKA, NM23: Nucleoside diphosphate kinase A 0.0446 0.032
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.0446 0.0425
PHB2 PHB2, BAP, REA: Prohibitin-2 0.0446 0.026
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.0446 0.032
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.044 0.025
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.044 0.028
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.044 0.025
MYO18A 0.044 0.025
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.044 0.075
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.044 0.025
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.044 0.025
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.044 0.075
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.044 0.025
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.044 0.075
GTF2F2 N/A 0.0425 0.0453
SFRS15 SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15 0.0425 0.065
H1FX H1FX: Histone H1x 0.0425 0.037
ERG ERG: Transcriptional regulator ERG 0.0425 0.029
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.041 0.049
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.041 0.086
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.041 0.063
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.041 0.056
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.04 0.083
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.04 0.083
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.04 0.083
AMPH AMPH, AMPH1: Amphiphysin 0.04 0.083
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.04 0.083
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.040 0.029
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.040 0.111
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 0.040 0.029
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.040 127.00
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.040 0.097
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.040 0.029
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.038 0.038
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.038 0.033
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.038 0.041
COPE COPE: Coatomer subunit epsilon 0.038 0.029
TSC1 TSC1, KIAA0243, TSC: Hamartin 0.038 0.046
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.038 0.041
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.038 0.029
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.038 0.026
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.038 0.029
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.037 0.062
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.037 0.055
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.037 0.055
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.037 0.077
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.037 0.055
YWHAQ YWHAQ: 14-3-3 protein theta 0.036 0.032
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.036 0.026
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.036 0.032
IPO7 IPO7: Uncharacterized protein IPO7 0.036 0.026
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.036 0.075
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.036 0.075
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.036 0.075
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.036 0.075
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.036 0.075
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.036 0.075
LYN LYN: Tyrosine-protein kinase Lyn 0.033 0.062
STAM2 STAM2: Signal transducing adapter molecule 2 0.033 0.049
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.033 0.049
NCK2 NCK2: Cytoplasmic protein NCK2 0.033 0.069
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.033 0.056
MCF2 MCF2, DBL: Proto-oncogene DBL 0.032 0.032
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.032 0.0425
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.032 0.032
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.032 0.032
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.032 0.026
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.032 0.026
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.032 0.026
STAT2 STAT2: Signal transducer and activator of transcription 2 0.032 0.0453
CARS CARS: Cysteinyl-tRNA synthetase, cytoplasmic 0.032 0.029
HSPH1 HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa 0.032 0.029
TRAP1 TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor 0.032 0.038
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.032 0.111
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.032 0.111
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.032 0.136
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.032 0.136
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.032 0.049
VCP VCP: Transitional endoplasmic reticulum ATPase 0.032 0.171
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.0308 0.056
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.0308 0.114
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.029 0.038
BMX N/A 0.029 0.062
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.029 0.029
BRIP1 BRIP1, BACH1, FANCJ: Fanconi anemia group J protein 0.029 0.029
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.029 0.0818
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.038
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.029 0.033
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.029 0.029
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.029 0.046
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.029 0.038
CCNH CCNH: Cyclin-H 0.029 0.041
ETS1 ETS1, EWSR2: Protein C-ets-1 0.029 0.041
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.029 0.029
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.165
C20orf18 N/A 0.028 0.049
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
LOC642558 FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1 0.028 0.109
PPEF1 N/A 0.028 0.028
MAPKAPK5 N/A 0.028 0.028
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.028 0.028
HNRPC HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2 0.028 0.109
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.028 0.028
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.028 0.049
MAPK15 N/A 0.028 0.028
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.028 0.049
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.028
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.028 0.028
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.028 0.049
PHLDB2 N/A 0.028 0.028
RAVER1 RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1 0.028 0.109
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.028 0.049
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.028
NIPA1 NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1 0.028 0.049
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.028 0.0333
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.028 0.086
SORBS3 SORBS3, SCAM1: Vinexin 0.027 0.056
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.027 0.056
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.027 0.069
USP21 USP21, USP23: Ubiquitin carboxyl-terminal hydrolase 21 0.027 0.0425
HD HD, IT15: Huntingtin 0.027 0.032
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.0263 0.062
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.026 0.029
PSD TYL: TYL protein 0.026 0.038
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.026 0.046
ERF ERF: ETS domain-containing transcription factor ERF 0.026 0.0453
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.026 0.026
GRLF1 N/A 0.026 0.032
FAM65A FAM65A, KIAA1930: Protein FAM65A 0.026 0.026
MDM4 MDM4, MDMX: Mdm4 protein 0.026 0.037
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.026 0.026
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.026 0.032
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.025 0.025
MAP2K3 N/A 0.025 0.025
FARSLA FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain 0.025 0.044
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.025 0.036
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.025 0.025
HNRPA2B1 HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1 0.025 0.098
TIA1 TIA1: Nucleolysin TIA-1 isoform p40 0.025 0.098
DDX20 DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20 0.025 0.044
SAP14 SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14 0.025 0.098
BCOR N/A 0.025 0.025
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.025 0.025
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.025 0.044
RBM10 RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10 0.025 0.098
WWTR1 WWTR1, TAZ: WW domain-containing transcription regulator protein 1 0.025 0.044
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.025 0.086
CCNT2 CCNT2: Cyclin-T2 0.025 0.036
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.025 0.025
ADK ADK: Adenosine kinase 0.025 0.025
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.025 0.025
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.025 0.025
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.025 0.044
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.025 0.025
CAMKK1 N/A 0.025 0.025
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.025
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.025 0.025
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.025 0.025
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
HNRPD HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0 0.025 0.098
DHX8 DHX8, DDX8: ATP-dependent RNA helicase DHX8 0.025 0.098
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.025
CAMK2A N/A 0.025 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.148
NIPBL N/A 0.025 0.025
CDC2 CDC2: Cell division control protein 2 homolog 0.025 0.028
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
GRK6 N/A 0.025 0.025
CDC25C CDC25C: M-phase inducer phosphatase 3 0.025 0.025
MKI67IP MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein 0.025 0.098
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.025
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.025 0.044
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.025 0.028
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.025
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.025 0.028
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.025 0.025
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.025 0.025
HNRPM HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M 0.025 0.098
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.148
GIT2 N/A 0.025 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.025 0.028
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.025 0.044
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.025
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.025 0.025
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.025 0.028
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.025 0.028
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.025 0.025
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.025 0.086
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.148
SFRS9 SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9 0.025 0.098
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.025 0.044
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.025 0.025
PRKCB1 N/A 0.025 0.025
0.572
Total Score 2.19