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Evidence of Interaction Between LIG1 and CHAF1A

The interaction score between LIG1 and CHAF1A is 5.13.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between LIG1 and CHAF1A = 0.80

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismLIG1 OrthologueCHAF1A OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm Q27474 1 Q9U380 1
fly Q960P4 1 Q9W3D1 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 4.85E-3
Post-translational Modifications

Protein: LIG1

PTMResidueReference
Phosphorylation 66 PubMed, HPRD
Phosphorylation 76 PubMed, HPRD
Phosphorylation 141 PubMed, HPRD
Phosphorylation 195 PubMed, HPRD
Phosphorylation 911 PubMed, HPRD
Phosphoserine 66 HPRD
Phosphoserine 76 HPRD
Phosphoserine 141 HPRD
Phosphoserine 911 HPRD
Phosphothreonine 195 HPRD

Protein: CHAF1A

PTMResidueReference
Phosphorylation 141 PubMed, HPRD
Phosphorylation 206 PubMed, HPRD
Phosphoserine 123 HPRD
Phosphoserine 188 HPRD
Localisation

Protein: LIG1

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD

Protein: CHAF1A

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between LIG1 and CHAF1A that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between LIG1 andCHAF1A. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , LIG1 has 892 interactors and CHAF1A has 101 interactors of which there are 73 common interactors.

Common InteractorName of Common InteractorScore for LIG1-Interactor (?)Score for CHAF1A-Interactor (?)
PCNA PCNA: Proliferating cell nuclear antigen 73.00 0.0479
FEN1 FEN1, RAD2: Flap endonuclease 1 12.60 0.0479
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.704 0.081
ESPL1 N/A 0.307 0.025
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.307 0.025
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.307 0.025
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.307 0.053
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.307 0.053
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.307 0.025
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.276 0.0479
KIF11 N/A 0.276 0.0479
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.276 0.0479
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.276 0.0479
MCM3 MCM3: DNA replication licensing factor MCM3 0.276 0.0479
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.276 0.0479
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 0.276 0.0479
CBX3 CBX3: Chromobox protein homolog 3 0.276 0.0479
SUZ12 SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12 0.276 0.0479
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.144 0.025
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.144 0.025
MKI67 MKI67: Antigen KI-67 0.144 0.025
SET SET: Protein SET 0.144 0.025
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.144 0.025
BAZ1B BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain 0.144 0.025
RBM14 RBM14, SIP: RNA-binding protein 14 0.144 0.025
PTMA N/A 0.144 0.053
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.144 0.053
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.141 0.0479
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.129 0.0479
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.129 0.0479
CSPG6 SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3 0.129 0.0479
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.129 0.0479
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.129 0.0479
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.129 0.0479
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.129 0.0479
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.129 0.0479
APEX1 APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase 0.129 0.0479
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.129 0.0479
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.129 0.0479
ZCCHC8 ZCCHC8: Zinc finger CCHC domain-containing protein 8 0.129 0.0479
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.129 0.0479
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.129 0.0479
UNG N/A 0.129 0.0479
NUP153 N/A 0.129 0.0479
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.087 0.025
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.087 0.025
DDX21 DDX21: Nucleolar RNA helicase 2 0.087 0.025
AOF2 AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1 0.087 0.025
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.078 0.0479
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.074 0.025
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.070 0.025
MYB MYB: Myb proto-oncogene protein 0.070 0.025
XPO1 XPO1, CRM1: Exportin-1 0.066 0.0479
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.066 0.0479
TPX2 TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2 0.053 0.025
EZH2 EZH2: Enhancer of zeste homolog 2 0.0479 0.0479
SLBP SLBP, HBP: Histone RNA hairpin-binding protein 0.0479 0.0479
KNTC2 KNTC2, HEC, HEC1: Kinetochore protein Hec1 0.0479 0.0479
DKC1 DKC1, NOLA4: H/ACA ribonucleoprotein complex subunit 4 0.0479 0.0479
PA2G4 PA2G4, EBP1: Proliferation-associated protein 2G4 0.0479 0.0479
TMPO N/A 0.027 0.027
C18orf56 N/A 0.027 0.027
RAD51AP1 N/A 0.027 0.027
ITGB3BP N/A 0.027 0.027
SMC4L1 N/A 0.027 0.027
KIAA0101 PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor 0.027 0.027
ZWINT N/A 0.027 0.027
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.025 0.053
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.025 0.025
TACC3 TACC3, ERIC1: Transforming acidic coiled-coil-containing protein 3 0.025 0.053
GMNN GMNN: Geminin 0.025 0.053
GTSE1 GTSE1: G2 and S phase-expressed protein 1 0.025 0.025
DBF4 DBF4, ASK: Protein DBF4 homolog 0.025 0.025
0.572
Total Score 5.13