PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between TP53 and JUN

The interaction score between TP53 and JUN is 2.23.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between TP53 and JUN = 0.09

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

1.85E-3

Orthology

Organism	TP53 Orthologue		JUN Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
human	IPI00215713	0.16	IPI00013439	0.294
human	IPI00215713	0.16	IPI00289547	0.286
fly	Q8IH92	0.16	P18289	0.286

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3

Domains

Domains present in TP53 and JUN:

Domains in TP53

Domains in JUN

IPR008967	p53-like transcription factor, DNA-binding
IPR002117	p53 tumor antigen
IPR010991	p53, tetramerisation
IPR011615	P53_DNA_bd.
IPR012346	P53_RUNT_DNA_bd.

IPR004827	Basic-leucine zipper (bZIP) transcription factor
IPR008917	Eukaryotic transcription factor, DNA-binding
IPR002112	Transcription factor Jun
IPR005643	Jun-like transcription factor
IPR011616	bZIP_1.

The Chi square scores for co-occurrence of domains that are present in TP53 and JUN are listed below.

Domain 1		Domain 2		Chi Square
IPR008967	p53-like transcription factor, DNA-binding	IPR004827	Basic-leucine zipper (bZIP) transcription factor	0.0789881

The background colour of the table refers to:

Blue Domain is only present in TP53
Yellow Domain is only present in JUN
Green Domain is present in both TP53 and JUN

0.028

Post-translational Modifications

Protein: TP53

PTM	Residue	Reference
Acetylation	305	PubMed, HPRD
Acetylation	320	PubMed, HPRD
Acetylation	370	PubMed, HPRD
Acetylation	372	PubMed, HPRD
Acetylation	373	PubMed, HPRD
Acetylation	381	PubMed, HPRD
Acetylation	382	PubMed, HPRD
Deacylation	382	PubMed, HPRD
Dephosphorylation	315	PubMed, HPRD
N6-acetyllysine	305	HPRD
N6-acetyllysine	373	HPRD
N6-acetyllysine	382	HPRD
Phosphorylation	6	PubMed, HPRD
Phosphorylation	9	PubMed, HPRD
Phosphorylation	15	PubMed, HPRD
Phosphorylation	18	PubMed, HPRD
Phosphorylation	20	PubMed, HPRD
Phosphorylation	33	PubMed, HPRD
Phosphorylation	37	PubMed, HPRD
Phosphorylation	46	PubMed, HPRD
Phosphorylation	55	PubMed, HPRD
Phosphorylation	81	PubMed, HPRD
Phosphorylation	155	PubMed, HPRD
Phosphorylation	315	PubMed, HPRD
Phosphorylation	366	PubMed, HPRD
Phosphorylation	371	PubMed, HPRD
Phosphorylation	378	PubMed, HPRD
Phosphorylation	392	PubMed, HPRD
Phosphoserine	15	PubMed, HPRD
Phosphoserine	46	PubMed, HPRD
Phosphoserine	315	PubMed, HPRD
Phosphothreonine	18	PubMed, HPRD
Phosphothreonine	55	PubMed, HPRD
Proteolytic Cleavage	18	PubMed, HPRD
Proteolytic Cleavage	20	PubMed, HPRD
Proteolytic Cleavage	23	PubMed, HPRD
Sumoylation	386	PubMed, HPRD
Ubiquitination	351	PubMed, HPRD
Ubiquitination	357	PubMed, HPRD
Ubiquitination	370	PubMed, HPRD
Ubiquitination	372	PubMed, HPRD
Ubiquitination	373	PubMed, HPRD
Ubiquitination	381	PubMed, HPRD
Ubiquitination	382	PubMed, HPRD
Ubiquitination	386	PubMed, HPRD

Protein: JUN

PTM	Residue	Reference
Acetylation	271	PubMed, HPRD
Phosphorylation	63	PubMed, HPRD
Phosphorylation	73	PubMed, HPRD
Phosphorylation	170	PubMed, HPRD
Phosphorylation	231	PubMed, HPRD
Phosphorylation	249	PubMed, HPRD
Phosphoserine	63	PubMed, HPRD
Phosphoserine	73	PubMed, HPRD

Localisation

Protein: TP53

Localisation	Reference
ER	HPRD
Nucleus	HPRD
Mitochondrion	HPRD
Nucleolus	HPRD
Cytoplasm	HPRD

Protein: JUN

Localisation	Reference
Nucleus	HPRD

Transitive Score

The common interactors between TP53 and JUN that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TP53 andJUN. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TP53 has 1099 interactors and JUN has 854 interactors of which there are 669 common interactors.

Common Interactor	Name of Common Interactor	Score for TP53-Interactor (?)	Score for JUN-Interactor (?)
H3F3A	H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3	2.54	0.063
HIST1H1E	HIST1H1E, H1F4: Histone H1.4	2.08	0.225
NR5A1	NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1	1.58	0.056
SMAD4	SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4	1.58	0.086
HIST1H1B	HIST1H1B, H1F5: Histone H1.5	1.26	0.136
PGR	PGR, NR3C3: Progesterone receptor	1.00	0.055
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.964	0.140
NR4A2	NR4A2, NOT, NURR1, TINUR: Orphan nuclear receptor NR4A2	0.902	0.188
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.822	0.069
KHDRBS1	KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate	0.704	0.038
HDAC1	HDAC1, RPD3L1: Histone deacetylase 1	0.704	0.038
NR3C1	NR3C1, GRL: Glucocorticoid receptor	0.651	0.127
SP100	N/A	0.525	0.155
SREBF2	N/A	0.475	0.026
NBN	NBN, NBS, NBS1, P95: Nibrin	0.430	0.096
TRIM28	TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta	0.430	0.123
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.430	0.077
ZNF318	ZNF318, HRIHFB2436: Zinc finger protein 318	0.430	0.077
XRCC6	XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1	0.430	0.080
BARD1	BARD1: BRCA1-associated RING domain protein 1	0.430	0.056
DDX21	DDX21: Nucleolar RNA helicase 2	0.430	0.052
HMGB2	HMGB2, HMG2: High mobility group protein B2	0.385	0.069
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	0.385	0.029
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.385	0.043
CCNB1	Cyclin B1	0.385	0.044
SP3	SP3: Transcription factor Sp3	0.347	0.086
SRF	SRF: Serum response factor	0.344	0.114
HSF2	HSF2, HSTF2: Heat shock factor protein 2	0.318	0.111
HSF1	HSF1, HSTF1: Heat shock factor protein 1	0.284	0.136
ELAVL1	ELAVL1, HUR: ELAV-like protein 1	0.276	0.029
SYNCRIP	SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q	0.276	0.038
HNRPF	HNRPF: Heterogeneous nuclear ribonucleoprotein F	0.276	0.029
SMC1L1	SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos	0.276	0.029
BAZ1B	BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain	0.260	0.123
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.260	0.0425
BRCA1	BRCA1, RNF53: Breast cancer type 1 susceptibility protein	0.260	0.097
UBTF	UBTF, UBF, UBF1: Nucleolar transcription factor 1	0.260	0.077
EP300	N/A	0.254	0.063
SUZ12	SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12	0.233	0.086
TOPBP1	TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1	0.233	0.086
ANAPC5	ANAPC5, APC5: Anaphase-promoting complex subunit 5	0.233	0.029
PTEN	PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du	0.233	0.038
YY1	YY1: Transcriptional repressor protein YY1	0.233	0.114
SAFB	SAFB, HAP, HET, SAFB1: Scaffold attachment factor B	0.233	0.054
ZNF76	ZNF76, D6S229E: Zinc finger protein 76	0.216	0.086
NFKBIA	NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha	0.216	0.276
BAZ2A	BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A	0.210	0.171
RB1	RB1: Retinoblastoma-associated protein	0.210	0.096
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.210	0.123
ELF1	ELF1: ETS-related transcription factor Elf-1	0.210	0.307
MATR3	MATR3, KIAA0723: Matrin-3	0.210	0.077
HIF1A	HIF1A, MOP1: Hypoxia-inducible factor 1 alpha	0.208	0.071
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.188	0.063
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.188	0.038
ATR	ATR, FRP1: Serine/threonine-protein kinase ATR	0.188	0.029
ACIN1	ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus	0.188	0.043
AKAP8	AKAP8, AKAP95: A-kinase anchor protein 8	0.188	0.114
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	0.188	0.086
CXorf9	N/A	0.188	0.114
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.188	0.038
ZNF217	ZNF217, ZABC1: Zinc finger protein 217	0.188	0.069
STAT1	STAT1: Signal transducer and activator of transcription 1-alpha/beta	0.187	0.075
MYB	MYB: Myb proto-oncogene protein	0.176	0.123
CEBPB	CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta	0.172	0.275
CEBPE	CEBPE: CCAAT/enhancer-binding protein epsilon	0.172	0.097
TRAF2	TRAF2, TRAP3: TNF receptor-associated factor 2	0.162	0.030
CEBPA	CEBPA: CCAAT/enhancer-binding protein alpha	0.156	0.152
ZNF148	ZNF148, ZBP89: Zinc finger protein 148	0.155	0.155
PIK3CD	PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i	0.155	0.0425
ZNF267	ZNF267: Zinc finger protein 267	0.155	0.062
ERF	ERF: ETS domain-containing transcription factor ERF	0.155	0.152
XRCC1	XRCC1: DNA-repair protein XRCC1	0.155	0.077
MITF	MITF: Microphthalmia-associated transcription factor	0.152	0.028
AR	AR, DHTR, NR3C4: Androgen receptor	0.152	0.028
ARNT	ARNT: Aryl hydrocarbon receptor nuclear translocator	0.152	0.052
HMGA1	HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y	0.152	0.052
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.146	0.225
SMAD2	SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2	0.146	0.114
CDC6	CDC6, CDC18L: Cell division control protein 6 homolog	0.146	0.088
ABCF1	N/A	0.144	0.026
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.144	0.032
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.144	0.077
HMGN1	HMGN1, HMG14: Non-histone chromosomal protein HMG-14	0.144	0.032
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	0.144	0.032
PTMA	N/A	0.144	0.0425
SAT	SAT1, SAT: Diamine acetyltransferase 1	0.140	0.052
LEF1	LEF1: Lymphoid enhancer-binding factor 1	0.140	0.049
ETV6	ETV6, TEL, TEL1: Transcription factor ETV6	0.139	0.225
WDHD1	WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1	0.139	0.049
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.139	0.078
COPE	COPE: Coatomer subunit epsilon	0.139	0.038
BRD2	BRD2, KIAA9001, RING3: Bromodomain-containing protein 2	0.139	0.275
RELA	RELA, NFKB3: Transcription factor p65	0.139	0.086
KIAA1012	KIAA1012: Protein TRS85 homolog	0.139	0.063
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.139	0.046
NCOA3	NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3	0.137	0.047
CDC25C	CDC25C: M-phase inducer phosphatase 3	0.137	0.025
LMNA	LMNA, LMN1: Lamin-A/C	0.137	0.025
EWSR1	EWSR1, EWS: RNA-binding protein EWS	0.137	0.047
HNRPH3	HNRPH3: Heterogeneous nuclear ribonucleoprotein H3	0.137	0.025
E2F1	E2F1, RBBP3: Transcription factor E2F1	0.132	0.098
IRF3	IRF3: Interferon regulatory factor 3	0.132	0.191
CDK4	CDK4: Cell division protein kinase 4	0.129	0.049
ZNF330	ZNF330, NOA36: Zinc finger protein 330	0.129	0.029
CSNK2A1	CSNK2A1: CSNK2A1 protein	0.129	0.069
APEX1	APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase	0.129	0.029
SFRS1	SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1	0.129	0.029
HDAC3	HDAC3: Histone deacetylase 3	0.129	0.029
OXSR1	OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1	0.129	0.114
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	0.129	0.029
CSPG6	SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3	0.129	0.029
PABPC4	PABPC4, APP1, PABP4: Polyadenylate-binding protein 4	0.129	0.029
CHEK1	CHEK1, CHK1: Serine/threonine-protein kinase Chk1	0.129	0.049
TP53BP1	TP53BP1: Tumor suppressor p53-binding protein 1	0.127	0.077
ZNF335	ZNF335: Zinc finger protein 335	0.127	0.069
ZFX	ZFX: Zinc finger X-chromosomal protein	0.127	0.077
HIVEP1	N/A	0.127	0.077
SALL1	SALL1, SAL1: Sal-like protein 1	0.125	0.049
ATAD2	ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2	0.124	0.064
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.118	0.225
ORC1L	ORC1L, ORC1, PARC1: Origin recognition complex subunit 1	0.118	0.097
KLF13	KLF13, BTEB3, NSLP1: Krueppel-like factor 13	0.114	0.114
UTX	UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein	0.114	0.029
SSH1	SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1	0.114	0.029
ETS1	ETS1, EWSR2: Protein C-ets-1	0.114	0.136
TMEM1	TMEM1, EHOC1: Transmembrane protein 1	0.114	0.029
CENTB2	CENTB2, KIAA0041: Centaurin-beta 2	0.114	0.063
AKAP8L	AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like	0.114	0.069
PIK3CG	PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i	0.114	0.038
CCNH	CCNH: Cyclin-H	0.114	0.056
ZNF24	ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24	0.114	0.086
MTF1	MTF1: Metal regulatory transcription factor 1	0.114	0.188
CBLB	CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B	0.114	0.043
CCNL1	CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1	0.114	0.385
AIP	AIP, XAP2: AH receptor-interacting protein	0.114	0.029
PPP1R12A	PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A	0.114	0.038
TRIM25	TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25	0.114	0.043
STAT5B	STAT5B: Signal transducer and activator of transcription 5B	0.114	0.086
MAPK12	MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12	0.114	0.099
ZBTB16	ZBTB16, PLZF, ZNF145: Zinc finger and BTB domain-containing protein 16	0.111	0.069
TYK2	TYK2: Non-receptor tyrosine-protein kinase TYK2	0.111	0.032
STAT6	STAT6: Signal transducer and activator of transcription 6	0.111	0.111
HDAC4	HDAC4, KIAA0288: Histone deacetylase 4	0.102	0.038
GTF2F2	N/A	0.0971	0.152
STAT2	STAT2: Signal transducer and activator of transcription 2	0.096	0.096
NFATC1	N/A	0.096	0.127
SMARCA3	HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor	0.096	0.034
EEA1	EEA1, ZFYVE2: Early endosome antigen 1	0.096	0.086
LCP2	LCP2: Lymphocyte cytosolic protein 2	0.096	0.096
SATB2	SATB2, KIAA1034: DNA-binding protein SATB2	0.090	0.049
TCF7L2	N/A	0.090	0.026
MAPK6	MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6	0.087	0.062
GNB2L1	Lung cancer oncogene 7	0.087	0.0425
RBM3	RBM3, RNPL: Putative RNA-binding protein 3	0.087	0.052
NCOA3	N/A	0.087	0.052
SET	SET: Protein SET	0.087	0.026
RBM14	RBM14, SIP: RNA-binding protein 14	0.087	0.0425
RNPS1	RNPS1, LDC2: RNA-binding protein with serine-rich domain 1	0.087	0.032
IFI16	N/A	0.087	0.0425
BATF	BATF: Basic leucine zipper transcriptional factor ATF-like	0.087	1.50
TGIF2	TGIF2: Homeobox protein TGIF2	0.087	0.096
HMGN2	HMGN2, HMG17: Non-histone chromosomal protein HMG-17	0.087	0.0425
EIF4G1	EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1	0.087	0.032
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.087	0.136
SMAD3	SMAD3, MADH3: Mothers against decapentaplegic homolog 3	0.087	0.086
SOX4	SOX4: Transcription factor SOX-4	0.086	0.069
RBL2	RBL2, RB2: Retinoblastoma-like protein 2	0.086	0.086
BRD3	BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3	0.086	0.275
BRPF1	BRPF1, BR140: Peregrin	0.086	0.225
MAPK1	MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1	0.086	0.225
MLL	MLL, ALL1, HRX, HTRX, TRX1: Zinc finger protein HRX	0.086	0.097
ZNF224	ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27: Zinc finger protein 224	0.086	0.069
DDX3Y	DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y	0.086	0.046
CCND1	CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1	0.086	0.056
CTDP1	CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase	0.086	0.114
CREBBP	CREBBP, CBP: CREB-binding protein	0.086	0.225
PPEF1	N/A	0.083	0.028
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.083	0.165
POGZ	POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain	0.083	0.083
MAPK15	N/A	0.083	0.165
C20orf18	N/A	0.083	0.083
ELF2	ELF2, NERF: ETS-related transcription factor Elf-2	0.083	0.165
ZNF644	ZNF644, KIAA1221, ZEP2: Zinc finger protein 644	0.083	0.083
UHRF1		0.083	0.083
ZHX1	ZHX1: Zinc fingers and homeoboxes protein 1	0.083	0.083
EEF2K	EEF2K: Elongation factor 2 kinase	0.083	0.025
ZFP91	ZFP91, FKSG11: Zinc finger protein 91 homolog	0.083	0.083
NFATC2	NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2	0.083	0.083
MLL2	MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2	0.083	0.083
ZNF579	ZNF579: Zinc finger protein 579	0.083	0.083
CCAR1	CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1	0.083	0.052
ZNF295	ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295	0.083	0.083
SMARCAD1	SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator	0.083	0.028
NFATC3	NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3	0.083	0.083
DPF2	DPF2, REQ, UBID4: Zinc finger protein ubi-d4	0.0818	0.067
HIPK2	HIPK2: Homeodomain-interacting protein kinase 2	0.081	0.049
H1FX	H1FX: Histone H1x	0.080	0.307
SF3B4	SF3B4, SAP49: Splicing factor 3B subunit 4	0.078	0.038
PSMD4	PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4	0.078	0.038
RBM15	RBM15, OTT: Putative RNA-binding protein 15	0.078	0.038
FNBP1	N/A	0.078	0.038
WBSCR1	EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H	0.078	0.029
CDK2	CDK2: Cell division protein kinase 2	0.078	0.049
PABPC1	PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1	0.078	0.038
PABPN1	PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2	0.078	0.038
SFRS2	SFRS2: Splicing factor, arginine/serine-rich 2	0.078	0.038
ANP32B	ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb	0.078	0.029
TDG	TDG: G/T mismatch-specific thymine DNA glycosylase	0.078	0.038
NAP1L1	NAP1L1, NRP: Nucleosome assembly protein 1-like 1	0.078	0.029
SKIIP	SNW1, SKIIP, SKIP: SNW domain-containing protein 1	0.078	0.029
PAPOLA	PAPOLA, PAP: Poly(A) polymerase alpha	0.078	0.046
ZCCHC8	ZCCHC8: Zinc finger CCHC domain-containing protein 8	0.078	0.029
AURKA	AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6	0.078	0.044
STK24	STK24, MST3, STK3: Serine/threonine-protein kinase 24	0.078	0.071
SFRS4	SFRS4, SRP75: Splicing factor, arginine/serine-rich 4	0.078	0.029
CDK7	CDK7, MO15: Cell division protein kinase 7	0.078	0.049
MYBL2	MYBL2, BMYB: Myb-related protein B	0.078	0.049
IRAK1	IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1	0.078	0.118
TCF3	TCF3, E2A, ITF1: Transcription factor E2-alpha	0.078	0.043
NEK9	NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9	0.078	0.086
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.078	0.029
SFRS10	SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10	0.078	0.046
TIAL1	TIAL1: Nucleolysin TIAR	0.078	0.029
ETS2	ETS2: Protein C-ets-2	0.077	0.416
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.077	0.034
ERG	ERG: Transcriptional regulator ERG	0.077	0.123
MDM4	MDM4, MDMX: Mdm4 protein	0.077	0.039
SNAI1	SNAI1, SNAH: Zinc finger protein SNAI1	0.077	0.056
REST	REST, NRSF, XBR: RE1-silencing transcription factor	0.077	0.077
CDKN2D	CDKN2D: Cyclin-dependent kinase 4 inhibitor D	0.077	0.0425
ZNF174	ZNF174, ZSCAN8: Zinc finger protein 174	0.075	0.075
RFFL	RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin	0.075	0.047
BRD4	N/A	0.075	0.148
SOX8	SOX8: Transcription factor SOX-8	0.075	0.075
SSH2	SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2	0.075	0.025
TRERF1	TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1	0.075	0.075
PRDM2	PRDM2, RIZ: PR domain zinc finger protein 2	0.075	0.075
GIT2	N/A	0.075	0.025
RBM10	RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10	0.075	0.075
DHX8	DHX8, DDX8: ATP-dependent RNA helicase DHX8	0.075	0.025
EXO1	EXO1, EXOI, HEX1: Exonuclease 1	0.075	0.025
CCNT2	CCNT2: Cyclin-T2	0.075	0.075
DUSP6	DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6	0.075	0.025
OSR1	OSR1, ODD: Protein odd-skipped-related 1	0.075	0.075
RBL1	RBL1: Retinoblastoma-like protein 1	0.075	0.075
ATRX	ATRX, RAD54L, XH2: Transcriptional regulator ATRX	0.075	0.075
C14orf4	C14orf4, KIAA1865, My039: RING finger protein C14orf4	0.075	0.047
DDX20	DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20	0.075	0.025
ZFPM1	ZFPM1, FOG1: Zinc finger protein ZFPM1	0.075	0.075
DUSP16	DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16	0.075	0.025
RNF113A	RNF113A, RNF113, ZNF183: RING finger protein 113A	0.075	0.047
CCNE1	CCNE1, CCNE: G1/S-specific cyclin-E1	0.075	0.075
C10orf9	CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y	0.075	0.075
RNF20		0.075	0.047
HIST1H1D	HIST1H1D, H1F3: Histone H1.3	0.071	0.171
TLK1	TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1	0.070	0.096
WDR1	N/A	0.070	0.0425
PLEK	PLEK, P47: Pleckstrin	0.070	0.0425
STK16	N/A	0.070	0.055
KIAA0853	N/A	0.070	0.0425
HNRPA0	HNRPA0: Heterogeneous nuclear ribonucleoprotein A0	0.070	0.032
MYBBP1A	MYBBP1A, P160: Myb-binding protein 1A	0.070	0.032
IKBKG	IKBKG, FIP3, NEMO: NF-kappa-B essential modulator	0.070	0.0425
SH2BP1	CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog	0.070	0.032
ZNF551	N/A	0.069	0.069
ZBTB7A	ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A	0.069	65.60
LIG4	LIG4: DNA ligase 4	0.069	0.049
GCN5L2	GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2	0.069	0.097
ZBTB40	ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40	0.069	0.056
PTPN12	PTPN12: Tyrosine-protein phosphatase non-receptor type 12	0.069	0.038
TCF8	ZEB1, AREB6, TCF8: Zinc finger E-box-binding homeobox 1	0.069	0.233
KLF1	KLF1, EKLF: Krueppel-like factor 1	0.069	0.049
DUSP1	DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1	0.069	0.129
FOS	FOS, G0S7: Proto-oncogene protein c-fos	0.069	2.90E3
STAT5A	STAT5A, STAT5: Signal transducer and activator of transcription 5A	0.067	0.051
ILK	ILK, ILK1, ILK2: Integrin-linked protein kinase	0.067	0.033
SUMO2	SUMO2, SMT3B, SMT3H2: Small ubiquitin-related modifier 2 precursor	0.0668	0.046
SYK	SYK: Tyrosine-protein kinase SYK	0.067	0.040
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.063	0.029
KIAA0683	DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized	0.063	0.038
CORO1C	CORO1C, CRNN4: Coronin-1C	0.063	0.046
EIF4G2	EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2	0.063	0.046
PPP1R8	N/A	0.063	0.029
MTA1	MTA1: Metastasis-associated protein MTA1	0.063	0.035
ATF1	ATF1: Cyclic AMP-dependent transcription factor ATF-1	0.063	0.225
RPS6KB1	N/A	0.063	0.114
SEC31L1	N/A	0.063	0.038
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.063	0.046
WBSCR20A	N/A	0.063	0.029
PHF10	N/A	0.063	0.114
VRK1	VRK1: Serine/threonine-protein kinase VRK1	0.063	0.035
PRKD2	PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2	0.063	0.086
NACA	NACA, HSD48: Nascent polypeptide-associated complex subunit alpha	0.063	0.046
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.063	0.029
EIF3S4	EIF3S4: Eukaryotic translation initiation factor 3 subunit 4	0.063	0.046
CPSF1	CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1	0.063	0.029
MYH9	MYH9: Myosin-9	0.063	0.038
DDX51	DDX51: ATP-dependent RNA helicase DDX51	0.063	0.029
PBK	PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase	0.063	0.044
COPA	COPA: Coatomer subunit alpha	0.063	0.038
TAF10	TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10	0.063	0.029
STAG2	STAG2, SA2: Cohesin subunit SA-2	0.063	0.038
NCOR1	NCOR1, KIAA1047: Nuclear receptor corepressor 1	0.063	0.086
WEE1	WEE1: Wee1-like protein kinase	0.063	0.028
PRPF4B	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol	0.063	0.114
TERF2IP	TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1	0.062	0.062
SH3BP3		0.062	0.096
DDIT3	DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3	0.062	0.098
ZBTB33	KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso	0.062	0.062
LYN	LYN: Tyrosine-protein kinase Lyn	0.061	0.032
FOXO1A	FOXO1A, FKHR: Forkhead box protein O1A	0.060	0.171
FOXJ2	FOXJ2, FHX: Forkhead box protein J2	0.060	0.251
DAPK1	DAPK1, DAPK: Death-associated protein kinase 1	0.057	0.051
MYCBP2	MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2	0.056	0.026
PIK3CB	PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit	0.056	0.029
PCAF	PCAF: Histone acetyltransferase PCAF	0.056	0.111
FOSL2	FOSL2, FRA2: Fos-related antigen 2	0.056	856.00
SP1	SP1, TSFP1: Transcription factor Sp1	0.056	0.086
CBL	CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL	0.056	0.035
ETV1	ETV1, ER81: ETS translocation variant 1	0.056	0.098
STAT4	STAT4: Signal transducer and activator of transcription 4	0.055	0.049
CBLC	CBLC, CBL3, RNF57: Signal transduction protein CBL-C	0.055	0.034
TAF1	TAF1, BA2R, CCG1, CCGS, TAF2A: Transcription initiation factor TFIID subunit 1	0.055	0.098
SOS1	SOS1: Son of sevenless homolog 1	0.054	0.029
ESRRA	ESRRA, ERR1, ESRL1, NR3B1: Steroid hormone receptor ERR1	0.054	0.049
FOXM1	FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1	0.052	0.165
HTATIP	HTATIP, TIP60: Histone acetyltransferase HTATIP	0.052	0.165
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.052	0.032
CHUK	N/A	0.052	0.026
AFF1	N/A	0.052	0.026
TERF2	TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2	0.052	0.062
TOP2B	N/A	0.052	0.032
FNBP4	FNBP4, FBP30, KIAA1014: Formin-binding protein 4	0.052	0.032
ARFGAP1	N/A	0.052	0.032
ROCK1	ROCK1: Rho-associated protein kinase 1	0.052	0.096
JMJD1A	JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr	0.052	0.032
PHF3	PHF3, KIAA0244: PHD finger protein 3	0.052	0.127
ZNF638	ZNF638, NP220, ZFML: Zinc finger protein 638	0.052	0.026
ITGB1BP1	ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1	0.052	0.026
USP24	USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24	0.052	0.032
KIAA0528	KIAA0528: Uncharacterized protein KIAA0528	0.052	0.052
MAPK13	MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13	0.051	0.073
JAK2	JAK2: Tyrosine-protein kinase JAK2	0.051	0.032
RNF11	RNF11, CGI-123: RING finger protein 11	0.050	0.0308
SMARCA1	SMARCA1, SNF2L, SNF2L1: Probable global transcription activator SNF2L1	0.050	0.028
ZHX3	ZHX3, KIAA0395, TIX1: Zinc fingers and homeoboxes protein 3	0.049	0.055
MAPK10	MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10	0.049	0.109
TRIM39	TRIM39, RNF23, TFP: Tripartite motif-containing protein 39	0.049	0.04
STAT3		0.049	0.044
MAPK8	MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8	0.049	0.109
BNC1	BNC1, BNC: Zinc finger protein basonuclin-1	0.049	0.044
ANKS1A	ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A	0.049	0.038
MAPK3	MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3	0.049	65.60
ELK1	ELK1: ETS domain-containing protein Elk-1	0.049	0.088
SOX11	SOX11: Transcription factor SOX-11	0.049	0.049
KLF5	KLF5, BTEB2, CKLF, IKLF: Krueppel-like factor 5	0.049	0.056
RXRA	RXRA, NR2B1: Retinoic acid receptor RXR-alpha	0.048	0.155
ZAK	MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT	0.048	0.077
PPARA	PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha	0.048	0.055
FARSLA	FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain	0.047	0.148
PHC2	PHC2, EDR2, PH2: Polyhomeotic-like protein 2	0.047	0.025
HIST2H2AC	HIST2H2AC, H2AFQ: Histone H2A type 2-C	0.047	0.025
SMAD1	SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1	0.047	0.075
HIST1H1C	HIST1H1C, H1F2: Histone H1.2	0.047	0.148
CARHSP1	CARHSP1: Calcium-regulated heat stable protein 1	0.047	0.025
SCYL3	SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin	0.046	0.114
SAPS3	N/A	0.046	0.029
MAP2K1	MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1	0.046	0.086
CUL5	CUL5, VACM1: Cullin-5	0.046	0.038
SFRS6	SFRS6, SRP55: Splicing factor, arginine/serine-rich 6	0.046	0.063
RPS6KB2	RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2	0.046	0.139
PKMYT1	PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito	0.046	0.028
SNF1LK2	SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2	0.046	0.049
CDC7	CDC7, CDC7L1: Cell division cycle 7-related protein kinase	0.046	0.0308
GNB1	GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.046	0.046
ARPC1B	ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B	0.046	0.078
ADRBK1	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1	0.046	0.139
USP34	USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34	0.046	0.038
GNB2	GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.046	0.046
STK38L	STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like	0.046	0.114
HGS	HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate	0.046	0.038
DIAPH1	Diaphanous 1	0.046	0.046
JARID1A	JARID1A, RBBP2, RBP2: Histone demethylase JARID1A	0.046	0.139
STK3	STK3, MST2: Serine/threonine-protein kinase 3	0.046	0.069
DOK1	DOK1: Docking protein 1	0.046	0.038
PIK4CB	PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic,	0.046	0.046
KLHDC4	N/A	0.046	0.029
DUSP22	DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22	0.046	0.038
RPS6KA1	RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1	0.046	0.114
AKT1	AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase	0.046	0.114
GSK3B	N/A	0.046	0.046
TAOK3	TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3	0.046	0.188
MGMT	MGMT: Methylated-DNA--protein-cysteine methyltransferase	0.046	0.081
BIRC4	BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4	0.0453	0.030
S100A9	S100A9, CAGB, CFAG, MRP14: Protein S100-A9	0.0453	0.027
EGR1	EGR1, ZNF225: Early growth response protein 1	0.044	0.188
DUSP3	DUSP3, VHR: Dual specificity protein phosphatase 3	0.044	0.026
HIST3H3	HIST3H3, H3FT: Histone H3.1t	0.043	0.038
VDR	VDR, NR1I1: Vitamin D3 receptor	0.043	0.114
FOXO3A	FOXO3A, FKHRL1: Forkhead box protein O3A	0.043	0.136
POU2F1	POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1	0.0425	0.077
PRKR	EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki	0.0425	0.060
RFXDC2	RFXDC2: Regulatory factor X domain-containing protein 2.	0.0425	0.032
DEF6	DEF6, IBP: Differentially expressed in FDCP 6	0.0425	0.032
SNAPC4	SNAPC4, SNAP190: snRNA-activating protein complex subunit 4	0.0425	0.077
CDKN1A	CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1: Cyclin-dependent kinase inhi	0.0425	0.026
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.0425	0.210
TRAFD1	TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1	0.0425	0.026
SMARCC2	N/A	0.0425	0.026
VCPIP1	VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135	0.0425	0.0425
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.0425	0.127
OSBPL11	OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11	0.0425	0.0425
PASK	PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase	0.0425	0.055
RBM6	RBM6, DEF3: RNA-binding protein 6	0.0425	0.026
RGS14	N/A	0.0425	0.032
MARK2	N/A	0.0425	0.0425
COIL	COIL, CLN80: Coilin	0.0425	0.026
FGR	FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR	0.041	0.032
EXOC2	N/A	0.041	0.051
THOP1	THOP1: Thimet oligopeptidase	0.040	0.027
TESK1	TESK1: Dual specificity testis-specific protein kinase 1	0.039	0.026
PPARG	CREB3L2-PPARgamma	0.039	0.049
STK38	STK38, NDR1: Serine/threonine-protein kinase 38	0.038	0.114
MAPKAPK3	MAPKAPK3: MAP kinase-activated protein kinase 3	0.038	0.139
NEK7	NEK7: Serine/threonine-protein kinase Nek7	0.038	0.086
IQGAP2	IQGAP2: Ras GTPase-activating-like protein IQGAP2	0.038	0.087
RBM8A	RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A	0.038	0.038
SPEN	SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein	0.038	0.038
ARID3A	ARID3A, DRIL1, DRIL3, DRX, E2FBP1: AT-rich interactive domain-containing protein	0.038	0.038
MEF2D	MEF2D: Myocyte-specific enhancer factor 2D	0.038	0.086
SNRP70	SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa	0.038	0.029
CRKRS	CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7	0.038	0.035
PKN2	PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2	0.038	0.114
STK10	STK10: Uncharacterized protein STK10	0.038	0.114
MAFG	MAFG: Transcription factor MafG	0.038	2.17
TCEB3	TCEB3, MSTP059: Transcription elongation factor B polypeptide 3	0.038	0.029
SIRT1	SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1	0.038	0.029
NRBP1	NRBP1, BCON3, NRBP: Nuclear receptor-binding protein	0.038	0.038
RREB1	RREB1, FINB: RAS-responsive element-binding protein 1	0.038	0.038
SFRS5	SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5	0.038	0.046
RHOA	RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor	0.036	0.036
LIMS1	N/A	0.036	0.027
H1F0	H1F0, H1FV: Histone H1.0	0.035	0.033
MYST4	MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4	0.035	0.088
SMAD7	SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7	0.034	0.062
FOXL2	FOXL2: Forkhead box protein L2	0.034	0.088
AXL	AXL, UFO: Tyrosine-protein kinase receptor UFO precursor	0.034	0.034
INSL3	JAK3: Tyrosine-protein kinase JAK3	0.032	0.026
BACH1	BACH1: Transcription regulator protein BACH1	0.032	0.307
MAPK7	mitogen-activated protein kinase 7 isoform 1	0.032	0.052
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.032	0.077
ID2	ID2: DNA-binding protein inhibitor ID-2	0.032	0.0971
STRN3	STRN3, GS2NA, SG2NA: Striatin-3	0.032	0.032
MAPKAPK2	MAPKAPK2: MAP kinase-activated protein kinase 2	0.032	0.127
MAP3K8	MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8	0.032	0.127
VIM	VIM: Vimentin	0.032	0.052
TERF1	TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1	0.032	0.077
SFRS15	SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15	0.032	0.032
GTF3C1	N/A	0.032	0.032
MAP3K14	MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14	0.032	0.060
ID3	ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3	0.032	0.039
APPL	APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha	0.032	0.026
AHR	AHR: Aryl hydrocarbon receptor precursor	0.032	0.146
MAP2K3	MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki	0.032	0.048
SNX17	SNX17, KIAA0064: Sorting nexin-17	0.032	0.032
MAP2K2	MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki	0.032	0.041
RAF1	RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase	0.032	0.054
HCLS1	HCLS1, HS1: Hematopoietic lineage cell-specific protein	0.032	0.032
FLII	FLII, FLIL: Protein flightless-1 homolog	0.032	0.032
DOCK2	DOCK2, KIAA0209: Dedicator of cytokinesis protein 2	0.032	0.032
CUL2	CUL2: Cullin-2	0.032	0.058
NR1D1	NR1D1, EAR1, HREV, THRAL: Orphan nuclear receptor NR1D1	0.031	0.044
NFIB	N/A	0.031	0.049
ESR1	ESR1, ESR, NR3A1: Estrogen receptor	0.031	0.049
RFX1	RFX1: MHC class II regulatory factor RFX1	0.0308	0.097
HIST1H1A	HIST1H1A, H1F1: Histone H1.1	0.0308	0.097
EPHA8	EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor	0.030	0.030
NFE2L2	NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2	0.029	0.171
JUND	JUND: Transcription factor jun-D	0.029	39.70
GMCL1L	GMCL1L, GCL: Germ cell-less protein-like 1-like	0.029	0.111
EML4	EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4	0.029	0.029
ATF6	ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha	0.029	0.171
SMCX	JARID1C, DXS1272E, SMCX, XE169: Histone demethylase JARID1C	0.029	0.050
CSNK1E	CSNK1E: Casein kinase I isoform epsilon	0.029	0.043
RPS6KA5	RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5	0.029	0.136
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.029	0.029
RUNX1	N/A	0.029	0.029
STK4	STK4, MST1: Serine/threonine-protein kinase 4	0.029	0.086
WDR44	WDR44: WD repeat-containing protein 44	0.029	0.038
JUNB	JUNB: Transcription factor jun-B	0.029	24.40
STK25	STK25, SOK1, YSK1: Serine/threonine-protein kinase 25	0.029	0.086
STK11	STK11, LKB1, PJS: Serine/threonine-protein kinase 11	0.029	0.069
GRK5	GRK5, GPRK5: G protein-coupled receptor kinase 5	0.029	0.114
COL5A2	COL5A2: Collagen alpha-2(V) chain precursor	0.029	0.029
COL1A2	COL1A2: Collagen alpha-2(I) chain precursor	0.029	0.029
BID	BID: BH3-interacting domain death agonist	0.028	0.028
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.028	0.052
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.028	0.083
TLE3	TLE3, KIAA1547: Transducin-like enhancer protein 3	0.028	0.028
DYRK1A	DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin	0.028	0.052
SGK2	SGK2: Serine/threonine-protein kinase Sgk2	0.028	0.083
KIAA1443	HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez	0.028	0.083
SYTL4	Endocrine transmitter regulatory protein	0.028	0.028
NF2	NF2, SCH: Merlin	0.028	0.028
HES6	HES6: Transcription cofactor HES-6	0.028	0.052
ZNF265	N/A	0.028	0.028
PTBP1	PTBP1: Polypyrimidine tract binding protein 1	0.028	0.028
FBXO4	FBXO4, FBX4: F-box only protein 4	0.028	0.028
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.028	0.083
DYRK1B	DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.028	0.047
DKFZp434K1815	DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815	0.028	0.028
LOC642558	FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1	0.028	0.028
ZCCHC3	ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3	0.028	0.028
MLL4	WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7	0.028	0.075
RAVER1	RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1	0.028	0.028
ATXN2L	ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein	0.028	0.028
C14orf151	C14orf151: Uncharacterized protein C14orf151 (Fragment)	0.028	0.028
ILF3	ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3	0.028	0.028
CUTL1	CUTL1: Homeobox protein cut-like 1	0.028	0.083
ZNF687	ZNF687, KIAA1441: Zinc finger protein 687	0.028	0.028
C13orf8	N/A	0.028	0.028
DUSP15	N/A	0.028	0.028
RAB4A	N/A	0.028	0.028
SF1	SF1, ZFM1, ZNF162: Splicing factor 1	0.028	0.028
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.028	0.052
PHLDB2	N/A	0.028	0.028
NSBP1	NSBP1: Nucleosome-binding protein 1	0.028	0.028
HNRPC	HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2	0.028	0.028
IRF7	N/A	0.028	0.028
WDR54	N/A	0.028	0.028
GPRASP2	GPRASP2: G-protein coupled receptor-associated sorting protein 2	0.028	0.028
TCF20	TCF20, KIAA0292, SPBP: Transcription factor 20	0.028	0.083
CBFA2T2	CBFA2T2, EHT, MTGR1: Protein CBFA2T2	0.028	0.028
TMPO	TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha	0.028	0.028
KIF1B	N/A	0.028	0.028
HDAC8	N/A	0.028	0.028
JDP2	jdp2, JDP2: Jun dimerization protein 2	0.028	0.028
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.028	0.052
NES	N/A	0.028	0.028
SNRPB	N/A	0.028	0.028
FLJ21816	PALB2, FANCN: Partner and localizer of BRCA2	0.028	0.028
PKN3	PKN3, PKNBETA: Serine/threonine-protein kinase N3	0.028	0.075
NIPA1	NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1	0.028	0.052
MAPKAPK5	N/A	0.028	0.052
TFAP4	TFAP4: Transcription factor AP-4	0.028	0.047
CDC2	CDC2: Cell division control protein 2 homolog	0.028	0.075
CORO6	N/A	0.028	0.028
NEK6	NEK6: Serine/threonine-protein kinase Nek6	0.028	0.075
FLJ23436	N/A	0.028	0.025
DSP	DSP: Desmoplakin	0.028	0.028
ZC3HAV1	ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1	0.028	0.028
CABLES1	N/A	0.028	0.028
HDAC7A	N/A	0.028	0.025
PPP1R12C	PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C	0.028	0.028
NFIA	NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A	0.028	0.028
EPHA2	EPHA2, ECK: Ephrin type-A receptor 2 precursor	0.028	0.028
RFX5	RFX5: DNA-binding protein RFX5	0.0278	0.0308
NR4A1	CDNA FLJ16818 fis, clone TRACH1000193, highly similar to Orphan nuclear receptor	0.028	0.056
C20orf116	C20orf116: Uncharacterized protein C20orf116 precursor	0.027	0.027
VAV2	VAV2, RP11-153P4.1-003: Vav 2 oncogene	0.027	0.027
TRADD	TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein	0.027	0.027
CIITA	CIITA, MHC2TA: MHC class II transactivator	0.027	0.027
NEK1	NEK1, KIAA1901: Serine/threonine-protein kinase Nek1	0.026	0.049
PRKAA1	N/A	0.026	0.062
PHF8	PHF8, KIAA1111, ZNF422: PHD finger protein 8	0.026	0.026
SRPK2	SRPK2: Serine/threonine-protein kinase SRPK2	0.026	0.077
MEF2A	N/A	0.026	0.155
NUP214	N/A	0.026	0.032
ZFP36	ZFP36, G0S24, RNF162A, TIS11A, TTP: Tristetraproline	0.026	0.276
MECP2	MECP2: Methyl-CpG-binding protein 2	0.026	0.048
FAM65A	FAM65A, KIAA1930: Protein FAM65A	0.026	0.026
AGTPBP1	AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein	0.026	0.063
PCTK1	PCTK1: Serine/threonine-protein kinase PCTAIRE-1	0.026	0.044
ATXN7	ATXN7, SCA7: Ataxin-7	0.0253	0.0253
CIC	CIC, KIAA0306: Protein capicua homolog	0.025	0.031
MKNK2	MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2	0.025	0.075
LATS2	LATS2, KPM: Serine/threonine-protein kinase LATS2	0.025	0.075
CPNE1	RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12	0.025	0.025
SON		0.025	0.025
EDF1	EDF1: Endothelial differentiation-related factor 1	0.025	0.025
PHF16	PHF16, JADE3, KIAA0215: Protein Jade-3	0.025	0.075
PSIP1	PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein	0.025	0.047
CDC25A	CDC25A: M-phase inducer phosphatase 1	0.025	0.025
HNRPUL1	HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1	0.025	0.025
MAP2K3	N/A	0.025	0.025
HNRPD	HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0	0.025	0.025
PRKACA	PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit	0.025	0.075
NHN1	NHN1: Conserved nuclear protein NHN1	0.025	0.025
NSUN2	NSUN2, SAKI, TRM4: tRNA	0.025	0.025
AKT3	AKT3: RAC-gamma serine/threonine-protein kinase	0.025	0.075
BCOR	N/A	0.025	0.025
CAMKK1	N/A	0.025	0.025
BUB3	BUB3: Mitotic checkpoint protein BUB3	0.025	0.025
GEMIN5	GEMIN5: Gem-associated protein 5	0.025	0.025
DLX3	DLX3: Homeobox protein DLX-3	0.025	0.148
SSBP4	SSBP4: Single-stranded DNA-binding protein 4	0.025	0.025
H2-ALPHA	TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain	0.025	0.025
KCTD1		0.025	0.025
MAPK8IP3	N/A	0.025	0.025
MAX	MAX: Protein max	0.025	0.047
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.025	0.075
ARID1A	ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A	0.025	0.025
MSL3L1	MSL3L1: Male-specific lethal 3-like 1	0.025	0.025
FBXL10	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio	0.025	0.075
WNK4	WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4	0.025	0.047
SMARCA2	SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2	0.025	0.025
MLXIPL	MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein	0.025	0.047
RPS6KA2	RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2	0.025	0.075
PRKCB1	N/A	0.025	0.025
CREB1	CREB1: cAMP response element-binding protein	0.025	0.148
NEK8	NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8	0.025	0.075
NFYA	NFYA: Nuclear transcription factor Y subunit alpha	0.025	0.025
MAP3K7	MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7	0.025	0.047
ARID4A	ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A	0.025	0.025
FLJ40432	FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227	0.025	0.025
ISL2	ISL2: Insulin gene enhancer protein ISL-2	0.025	0.075
LATS1	LATS1, WARTS: Serine/threonine-protein kinase LATS1	0.025	0.075
PURB	PURB: Transcriptional activator protein Pur-beta	0.025	0.025
NEDD4	NEDD4: Uncharacterized protein NEDD4	0.025	0.025
REXO1	REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog	0.025	0.025
NUP98	N/A	0.025	0.025
RBBP6	RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6	0.025	0.025
SEC13L1	N/A	0.025	0.025
NIPBL	N/A	0.025	0.025
SAP14	SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14	0.025	0.025
POLR1C	POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1	0.025	0.025
HNRPA2B1	HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1	0.025	0.025
MIER1	MIER1, KIAA1610: Mesoderm induction early response protein 1	0.025	0.047
ARL5A	ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A	0.025	0.025
ATXN2L	N/A	0.025	0.025
ELMO1	N/A	0.025	0.025
HEXIM2	HEXIM2, L3: Protein HEXIM2	0.025	0.025
HOXA10	HOXA10, HOX1H: Homeobox protein Hox-A10	0.025	0.075
SYAP1	SYAP1, PRO3113: Synapse-associated protein 1	0.025	0.025
GRK6	N/A	0.025	0.025
SMU1	SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog	0.025	0.025
C20orf77	N/A	0.025	0.025
PLK1	PLK1, PLK: Serine/threonine-protein kinase PLK1	0.025	3.89
ADK	ADK: Adenosine kinase	0.025	0.025
TAL2	TAL2: T-cell acute lymphocytic leukemia protein 2	0.025	0.047
HIST3H2A	HIST3H2A: Histone H2A type 3	0.025	0.025
CAMK1D	CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D	0.025	0.075
raptor	RAPTOR, KIAA1303: Regulatory-associated protein of mTOR	0.025	0.025
PHKG1	PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo	0.025	0.075
ZNF598	ZNF598: Zinc finger protein 598	0.025	0.025
TIA1	TIA1: Nucleolysin TIA-1 isoform p40	0.025	0.025
SETD3	SETD3, C14orf154: SET domain-containing protein 3	0.025	0.025
FAF1	FAF1, CGI-03: FAS-associated factor 1	0.025	0.025
CAMK2A	N/A	0.025	0.025
PDPK1	PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1	0.025	0.075
GATAD2B	GATAD2B, KIAA1150: Transcriptional repressor p66 beta	0.025	0.025
RAD51	RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1	0.025	0.025
HTATIP	N/A	0.025	0.025
PDE8B	PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies	0.025	0.025
CETN1	CETN1, CEN1, CETN: Centrin-1	0.025	0.025
DIDO1	N/A	0.025	0.075
PPP1R9B	PPP1R9B, PPP1R6: Neurabin-2	0.025	0.025
SFRS9	SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9	0.025	0.025
WWTR1	WWTR1, TAZ: WW domain-containing transcription regulator protein 1	0.025	0.047
SMC4L1	SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4	0.025	0.025
HNRPM	HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M	0.025	0.025
SMN2	SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein	0.025	0.025
TCEA1	N/A	0.025	0.025
RPS6KA4	RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4	0.025	0.075
CHEK2	CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2	0.025	0.075
IWS1	IWS1, IWS1L: IWS1 homolog	0.025	0.025
MKNK1	MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1	0.025	0.075
MKI67IP	MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein	0.025	0.025
CDC2L5	CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5	0.025	0.075

0.299

Total Score

2.23