PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between TP53 and HIST1H1B

The interaction score between TP53 and HIST1H1B is 1.09.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between TP53 and HIST1H1B = 0.13

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

2.30E-3

Orthology

Organism	TP53 Orthologue		HIST1H1B Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
human	IPI00215713	0.16	IPI00217466	1
human	IPI00215713	0.16	IPI00217465	0.685
human	IPI00215713	0.16	IPI00419983	0.175
human	IPI00215713	0.16	IPI00217469	0.452
fly	Q8IH92	0.16	P02255	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3

Domains

Domains present in TP53 and HIST1H1B:

Domains in TP53

Domains in HIST1H1B

IPR008967	p53-like transcription factor, DNA-binding
IPR002117	p53 tumor antigen
IPR010991	p53, tetramerisation
IPR011615	P53_DNA_bd.
IPR012346	P53_RUNT_DNA_bd.

IPR005818	Histone H1/H5
IPR005819	Histone H5
IPR011991	Wing_hlx_DNA_bd.

The Chi square scores for co-occurrence of domains that are present in TP53 and HIST1H1B are listed below.

Domain 1		Domain 2		Chi Square
IPR008967	p53-like transcription factor, DNA-binding	IPR011991	Wing_hlx_DNA_bd.	0.00778109

The background colour of the table refers to:

Blue Domain is only present in TP53
Yellow Domain is only present in HIST1H1B
Green Domain is present in both TP53 and HIST1H1B

1.53

Post-translational Modifications

Protein: TP53

PTM	Residue	Reference
Acetylation	305	PubMed, HPRD
Acetylation	320	PubMed, HPRD
Acetylation	370	PubMed, HPRD
Acetylation	372	PubMed, HPRD
Acetylation	373	PubMed, HPRD
Acetylation	381	PubMed, HPRD
Acetylation	382	PubMed, HPRD
Deacylation	382	PubMed, HPRD
Dephosphorylation	315	PubMed, HPRD
N6-acetyllysine	305	HPRD
N6-acetyllysine	373	HPRD
N6-acetyllysine	382	HPRD
Phosphorylation	6	PubMed, HPRD
Phosphorylation	9	PubMed, HPRD
Phosphorylation	15	PubMed, HPRD
Phosphorylation	18	PubMed, HPRD
Phosphorylation	20	PubMed, HPRD
Phosphorylation	33	PubMed, HPRD
Phosphorylation	37	PubMed, HPRD
Phosphorylation	46	PubMed, HPRD
Phosphorylation	55	PubMed, HPRD
Phosphorylation	81	PubMed, HPRD
Phosphorylation	155	PubMed, HPRD
Phosphorylation	315	PubMed, HPRD
Phosphorylation	366	PubMed, HPRD
Phosphorylation	371	PubMed, HPRD
Phosphorylation	378	PubMed, HPRD
Phosphorylation	392	PubMed, HPRD
Phosphoserine	15	PubMed, HPRD
Phosphoserine	46	PubMed, HPRD
Phosphoserine	315	PubMed, HPRD
Phosphothreonine	18	PubMed, HPRD
Phosphothreonine	55	PubMed, HPRD
Proteolytic Cleavage	18	PubMed, HPRD
Proteolytic Cleavage	20	PubMed, HPRD
Proteolytic Cleavage	23	PubMed, HPRD
Sumoylation	386	PubMed, HPRD
Ubiquitination	351	PubMed, HPRD
Ubiquitination	357	PubMed, HPRD
Ubiquitination	370	PubMed, HPRD
Ubiquitination	372	PubMed, HPRD
Ubiquitination	373	PubMed, HPRD
Ubiquitination	381	PubMed, HPRD
Ubiquitination	382	PubMed, HPRD
Ubiquitination	386	PubMed, HPRD

Protein: HIST1H1B

PTM	Residue	Reference
Acetylation	2	PubMed, HPRD
Acetylation	26	PubMed, HPRD
Deacetylation	26	PubMed, HPRD
N-acetylserine	1	HPRD
Phosphorylation	138	PubMed, HPRD
Phosphorylation	155	PubMed, HPRD

Localisation

Protein: TP53

Localisation	Reference
ER	HPRD
Nucleus	HPRD
Mitochondrion	HPRD
Nucleolus	HPRD
Cytoplasm	HPRD

Protein: HIST1H1B

Localisation	Reference
Nucleus	HPRD
Nucleolus	HPRD

Transitive Score

The common interactors between TP53 and HIST1H1B that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TP53 andHIST1H1B. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TP53 has 1099 interactors and HIST1H1B has 748 interactors of which there are 617 common interactors.

Common Interactor	Name of Common Interactor	Score for TP53-Interactor (?)	Score for HIST1H1B-Interactor (?)
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	4.77	0.062
H2AFX	H2AFX, H2AX: Histone H2A.x	4.27	0.102
H3F3A	H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3	2.54	0.126
HIST1H1E	HIST1H1E, H1F4: Histone H1.4	2.08	0.069
NR5A1	NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1	1.58	0.102
HIST1H3A	HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD,	1.58	0.158
SMAD4	SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4	1.58	0.216
PGR	PGR, NR3C3: Progesterone receptor	1.00	0.140
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.964	0.216
HIST1H4A	HIST1H4A, H4/A, HIST1H4B, H4/I, H4/G, HIST1H4D, H4/B, H4/J, HIST1H4F, HIST4H4, H	0.902	0.158
NR4A2	NR4A2, NOT, NURR1, TINUR: Orphan nuclear receptor NR4A2	0.902	0.126
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.822	0.069
HDAC1	HDAC1, RPD3L1: Histone deacetylase 1	0.704	0.126
PCNA	PCNA: Proliferating cell nuclear antigen	0.704	0.102
NR3C1	NR3C1, GRL: Glucocorticoid receptor	0.651	0.140
SP100	N/A	0.525	0.192
MCM3	MCM3: DNA replication licensing factor MCM3	0.515	0.136
SREBF2	N/A	0.475	0.114
BLM	BLM, RECQ2, RECQL3: Bloom syndrome protein	0.471	0.126
NBN	NBN, NBS, NBS1, P95: Nibrin	0.430	0.077
TRIM28	TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta	0.430	0.152
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.430	0.048
ZNF318	ZNF318, HRIHFB2436: Zinc finger protein 318	0.430	0.096
PRKDC	PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit	0.430	0.152
XRCC6	XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1	0.430	0.026
TOP2A	TOP2A, TOP2: DNA topoisomerase 2-alpha	0.430	0.026
BARD1	BARD1: BRCA1-associated RING domain protein 1	0.430	0.069
DDX21	DDX21: Nucleolar RNA helicase 2	0.430	0.026
HMGB2	HMGB2, HMG2: High mobility group protein B2	0.385	0.069
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.385	0.043
CCNB1	Cyclin B1	0.385	0.111
SP3	SP3: Transcription factor Sp3	0.347	0.140
SRF	SRF: Serum response factor	0.344	0.140
HSF2	HSF2, HSTF2: Heat shock factor protein 2	0.318	0.172
DAXX	DAXX, BING2, DAP6: Death domain-associated protein 6	0.290	0.102
HSF1	HSF1, HSTF1: Heat shock factor protein 1	0.284	0.123
CENPA	CENPA: Histone H3-like centromeric protein A	0.269	0.026
BAZ1B	BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain	0.260	0.152
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.260	0.026
BRCA1	BRCA1, RNF53: Breast cancer type 1 susceptibility protein	0.260	0.069
UBTF	UBTF, UBF, UBF1: Nucleolar transcription factor 1	0.260	0.077
EP300	N/A	0.254	0.158
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.241	0.069
MCM2	MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2	0.241	0.136
MCM4	MCM4, CDC21: DNA replication licensing factor MCM4	0.241	0.136
SUZ12	SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12	0.233	0.086
TOPBP1	TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1	0.233	0.086
YY1	YY1: Transcriptional repressor protein YY1	0.233	0.069
SAFB	SAFB, HAP, HET, SAFB1: Scaffold attachment factor B	0.233	0.029
ZNF76	ZNF76, D6S229E: Zinc finger protein 76	0.216	0.216
NFKBIA	NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha	0.216	0.126
BAZ2A	BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A	0.210	0.171
RB1	RB1: Retinoblastoma-associated protein	0.210	0.123
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.210	0.123
ELF1	ELF1: ETS-related transcription factor Elf-1	0.210	0.096
MATR3	MATR3, KIAA0723: Matrin-3	0.210	0.062
HIF1A	HIF1A, MOP1: Hypoxia-inducible factor 1 alpha	0.208	1.02
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.188	0.171
ATR	ATR, FRP1: Serine/threonine-protein kinase ATR	0.188	0.171
AKAP8	AKAP8, AKAP95: A-kinase anchor protein 8	0.188	0.069
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	0.188	0.111
ZNF217	ZNF217, ZABC1: Zinc finger protein 217	0.188	0.056
STAT1	STAT1: Signal transducer and activator of transcription 1-alpha/beta	0.187	0.187
MYB	MYB: Myb proto-oncogene protein	0.176	0.241
CEBPB	CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta	0.172	0.103
CEBPE	CEBPE: CCAAT/enhancer-binding protein epsilon	0.172	0.103
TRAF2	TRAF2, TRAP3: TNF receptor-associated factor 2	0.162	0.031
TP73	TP73, P73: Tumor protein p73	0.156	0.114
CEBPA	CEBPA: CCAAT/enhancer-binding protein alpha	0.156	0.130
ZNF148	ZNF148, ZBP89: Zinc finger protein 148	0.155	0.096
PIK3CD	PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i	0.155	0.077
ZNF267	ZNF267: Zinc finger protein 267	0.155	0.062
ERF	ERF: ETS domain-containing transcription factor ERF	0.155	0.062
XRCC1	XRCC1: DNA-repair protein XRCC1	0.155	0.062
MITF	MITF: Microphthalmia-associated transcription factor	0.152	0.152
AR	AR, DHTR, NR3C4: Androgen receptor	0.152	0.152
ARNT	ARNT: Aryl hydrocarbon receptor nuclear translocator	0.152	1.53
HMGA1	HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y	0.152	0.028
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.146	0.069
YBX1	YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1	0.146	0.056
SMAD2	SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2	0.146	0.056
YARS	YARS: Tyrosyl-tRNA synthetase, cytoplasmic	0.146	0.056
CDC6	CDC6, CDC18L: Cell division control protein 6 homolog	0.146	0.069
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.144	0.026
MKI67	MKI67: Antigen KI-67	0.144	0.062
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.144	0.077
HMGN1	HMGN1, HMG14: Non-histone chromosomal protein HMG-14	0.144	0.026
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	0.144	0.032
PTMA	N/A	0.144	0.032
SAT	SAT1, SAT: Diamine acetyltransferase 1	0.140	0.137
LEF1	LEF1: Lymphoid enhancer-binding factor 1	0.140	0.172
ETV6	ETV6, TEL, TEL1: Transcription factor ETV6	0.139	0.114
WDHD1	WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1	0.139	0.069
BRD2	BRD2, KIAA9001, RING3: Bromodomain-containing protein 2	0.139	0.136
RELA	RELA, NFKB3: Transcription factor p65	0.139	0.056
NCOA3	NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3	0.137	1.37
CDC25C	CDC25C: M-phase inducer phosphatase 3	0.137	0.137
LMNA	LMNA, LMN1: Lamin-A/C	0.137	0.025
EWSR1	EWSR1, EWS: RNA-binding protein EWS	0.137	0.047
HNRPH3	HNRPH3: Heterogeneous nuclear ribonucleoprotein H3	0.137	0.025
E2F1	E2F1, RBBP3: Transcription factor E2F1	0.132	0.062
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.132	0.077
IRF3	IRF3: Interferon regulatory factor 3	0.132	0.062
CDK4	CDK4: Cell division protein kinase 4	0.129	0.069
CSNK2A1	CSNK2A1: CSNK2A1 protein	0.129	0.056
APEX1	APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase	0.129	0.086
OXSR1	OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1	0.129	0.069
CHEK1	CHEK1, CHK1: Serine/threonine-protein kinase Chk1	0.129	0.086
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.129	0.029
TP53BP1	TP53BP1: Tumor suppressor p53-binding protein 1	0.127	0.062
ZNF335	ZNF335: Zinc finger protein 335	0.127	0.069
ZFX	ZFX: Zinc finger X-chromosomal protein	0.127	0.077
HIVEP1	N/A	0.127	0.062
SALL1	SALL1, SAL1: Sal-like protein 1	0.125	0.111
ATAD2	ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2	0.124	0.073
EIF2B5	EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon	0.118	0.069
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.118	0.086
ORC1L	ORC1L, ORC1, PARC1: Origin recognition complex subunit 1	0.118	0.056
KLF13	KLF13, BTEB3, NSLP1: Krueppel-like factor 13	0.114	0.056
ETS1	ETS1, EWSR2: Protein C-ets-1	0.114	0.056
AKAP8L	AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like	0.114	0.056
PIK3CG	PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i	0.114	0.069
CCNH	CCNH: Cyclin-H	0.114	0.097
ZNF24	ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24	0.114	0.086
MTF1	MTF1: Metal regulatory transcription factor 1	0.114	0.069
CCNL1	CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1	0.114	0.171
STAT5B	STAT5B: Signal transducer and activator of transcription 5B	0.114	0.069
MAPK12	MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12	0.114	0.069
FXR1	FXR1: Fragile X mental retardation syndrome-related protein 1	0.112	0.041
CSK	CSK: Tyrosine-protein kinase CSK	0.112	0.041
BTK	BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK	0.112	0.051
ZBTB16	ZBTB16, PLZF, ZNF145: Zinc finger and BTB domain-containing protein 16	0.111	0.123
KPNA2	KPNA2, RCH1, SRP1: Importin subunit alpha-2	0.111	0.073
TYK2	TYK2: Non-receptor tyrosine-protein kinase TYK2	0.111	0.041
STAT6	STAT6: Signal transducer and activator of transcription 6	0.111	0.041
HDAC4	HDAC4, KIAA0288: Histone deacetylase 4	0.102	0.102
TFAP2C	TFAP2C: Transcription factor AP-2 gamma	0.102	0.0898
GTF2F2	N/A	0.0971	0.062
STAT2	STAT2: Signal transducer and activator of transcription 2	0.096	0.077
NFATC1	N/A	0.096	0.251
SMARCA3	HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor	0.096	0.035
EEA1	EEA1, ZFYVE2: Early endosome antigen 1	0.096	0.086
SATB2	SATB2, KIAA1034: DNA-binding protein SATB2	0.090	0.123
TCF7L2	N/A	0.090	0.100
TFAP2B	TFAP2B: Transcription factor AP-2 beta	0.090	0.114
MAPK6	MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6	0.087	0.062
GNB2L1	Lung cancer oncogene 7	0.087	0.026
RBM3	RBM3, RNPL: Putative RNA-binding protein 3	0.087	0.026
NCOA3	N/A	0.087	0.026
SET	SET: Protein SET	0.087	0.026
RBM14	RBM14, SIP: RNA-binding protein 14	0.087	0.026
TCOF1	N/A	0.087	0.026
IFI16	N/A	0.087	0.026
KIF23	N/A	0.087	0.026
BATF	BATF: Basic leucine zipper transcriptional factor ATF-like	0.087	0.123
TGIF2	TGIF2: Homeobox protein TGIF2	0.087	0.127
HMGN2	HMGN2, HMG17: Non-histone chromosomal protein HMG-17	0.087	0.026
UNG	N/A	0.087	0.029
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.087	0.056
EXOSC2	EXOSC2, RRP4: Exosome complex exonuclease RRP4	0.087	0.069
SMAD3	SMAD3, MADH3: Mothers against decapentaplegic homolog 3	0.087	0.069
SOX4	SOX4: Transcription factor SOX-4	0.086	0.086
RBL2	RBL2, RB2: Retinoblastoma-like protein 2	0.086	0.111
BRD3	BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3	0.086	0.136
BRPF1	BRPF1, BR140: Peregrin	0.086	0.136
MAPK1	MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1	0.086	0.049
MLL	MLL, ALL1, HRX, HTRX, TRX1: Zinc finger protein HRX	0.086	0.136
ZNF224	ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27: Zinc finger protein 224	0.086	0.056
DDX3Y	DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y	0.086	0.029
CCND1	CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1	0.086	0.097
CTDP1	CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase	0.086	0.056
CREBBP	CREBBP, CBP: CREB-binding protein	0.086	0.111
ATM	ATM: Serine-protein kinase ATM	0.086	0.056
PPEF1	N/A	0.083	0.028
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.083	0.083
POGZ	POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain	0.083	0.083
MAPK15	N/A	0.083	0.083
C20orf18	N/A	0.083	0.052
ELF2	ELF2, NERF: ETS-related transcription factor Elf-2	0.083	0.083
ZNF644	ZNF644, KIAA1221, ZEP2: Zinc finger protein 644	0.083	0.083
UHRF1		0.083	0.028
ZHX1	ZHX1: Zinc fingers and homeoboxes protein 1	0.083	0.083
EEF2K	EEF2K: Elongation factor 2 kinase	0.083	0.075
ZFP91	ZFP91, FKSG11: Zinc finger protein 91 homolog	0.083	0.083
NFATC2	NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2	0.083	0.165
MLL2	MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2	0.083	0.028
ZNF579	ZNF579: Zinc finger protein 579	0.083	0.083
CCAR1	CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1	0.083	0.028
ZNF295	ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295	0.083	0.083
SMARCAD1	SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator	0.083	0.052
NFATC3	NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3	0.083	0.165
DPF2	DPF2, REQ, UBID4: Zinc finger protein ubi-d4	0.0818	0.041
HIPK2	HIPK2: Homeodomain-interacting protein kinase 2	0.081	0.123
HIF3A	N/A	0.081	0.102
H1FX	H1FX: Histone H1x	0.080	0.062
PSMD4	PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4	0.078	0.043
RBM15	RBM15, OTT: Putative RNA-binding protein 15	0.078	0.029
CDK2	CDK2: Cell division protein kinase 2	0.078	0.069
CSTF1	CSTF1: Cleavage stimulation factor 50 kDa subunit	0.078	0.029
PABPN1	PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2	0.078	0.029
NAP1L1	NAP1L1, NRP: Nucleosome assembly protein 1-like 1	0.078	0.126
AURKA	AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6	0.078	0.056
STK24	STK24, MST3, STK3: Serine/threonine-protein kinase 24	0.078	0.056
CDK7	CDK7, MO15: Cell division protein kinase 7	0.078	0.056
MYBL2	MYBL2, BMYB: Myb-related protein B	0.078	0.056
IRAK1	IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1	0.078	0.069
TCF3	TCF3, E2A, ITF1: Transcription factor E2-alpha	0.078	0.054
NEK9	NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9	0.078	0.086
SFRS10	SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10	0.078	0.029
ETS2	ETS2: Protein C-ets-2	0.077	0.077
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.077	0.123
ERG	ERG: Transcriptional regulator ERG	0.077	0.096
MDM4	MDM4, MDMX: Mdm4 protein	0.077	0.048
SNAI1	SNAI1, SNAH: Zinc finger protein SNAI1	0.077	0.069
REST	REST, NRSF, XBR: RE1-silencing transcription factor	0.077	0.096
ZNF174	ZNF174, ZSCAN8: Zinc finger protein 174	0.075	0.075
RFFL	RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin	0.075	0.025
BRD4	N/A	0.075	0.148
SOX8	SOX8: Transcription factor SOX-8	0.075	0.075
SSH2	SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2	0.075	0.025
TRERF1	TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1	0.075	0.075
PRDM2	PRDM2, RIZ: PR domain zinc finger protein 2	0.075	0.075
GIT2	N/A	0.075	0.025
RBM10	RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10	0.075	0.075
DHX8	DHX8, DDX8: ATP-dependent RNA helicase DHX8	0.075	0.075
EXO1	EXO1, EXOI, HEX1: Exonuclease 1	0.075	0.025
CCNT2	CCNT2: Cyclin-T2	0.075	0.148
DUSP6	DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6	0.075	0.025
OSR1	OSR1, ODD: Protein odd-skipped-related 1	0.075	0.075
RBL1	RBL1: Retinoblastoma-like protein 1	0.075	0.148
ATRX	ATRX, RAD54L, XH2: Transcriptional regulator ATRX	0.075	0.047
C14orf4	C14orf4, KIAA1865, My039: RING finger protein C14orf4	0.075	0.025
DDX20	DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20	0.075	0.025
ZFPM1	ZFPM1, FOG1: Zinc finger protein ZFPM1	0.075	0.075
DUSP16	DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16	0.075	0.025
RNF113A	RNF113A, RNF113, ZNF183: RING finger protein 113A	0.075	0.025
CCNE1	CCNE1, CCNE: G1/S-specific cyclin-E1	0.075	0.148
C10orf9	CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y	0.075	0.148
RNF20		0.075	0.075
SRC	SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src	0.074	0.037
HIST1H1D	HIST1H1D, H1F3: Histone H1.3	0.071	0.069
TLK1	TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1	0.070	0.096
PLEK	PLEK, P47: Pleckstrin	0.070	0.026
FANCA	FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein	0.070	0.026
STK16	N/A	0.070	0.062
KIAA0853	N/A	0.070	0.026
HNRPA0	HNRPA0: Heterogeneous nuclear ribonucleoprotein A0	0.070	0.026
MYBBP1A	MYBBP1A, P160: Myb-binding protein 1A	0.070	0.026
IKBKG	IKBKG, FIP3, NEMO: NF-kappa-B essential modulator	0.070	0.026
SH2BP1	CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog	0.070	0.026
ZNF551	N/A	0.069	0.139
ZBTB7A	ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A	0.069	0.056
LIG4	LIG4: DNA ligase 4	0.069	0.086
GCN5L2	GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2	0.069	0.111
ZBTB40	ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40	0.069	0.069
TCF8	ZEB1, AREB6, TCF8: Zinc finger E-box-binding homeobox 1	0.069	0.069
KLF1	KLF1, EKLF: Krueppel-like factor 1	0.069	0.049
FOS	FOS, G0S7: Proto-oncogene protein c-fos	0.069	0.111
STAT5A	STAT5A, STAT5: Signal transducer and activator of transcription 5A	0.067	0.041
ILK	ILK, ILK1, ILK2: Integrin-linked protein kinase	0.067	0.029
SYK	SYK: Tyrosine-protein kinase SYK	0.067	0.041
CSE1L	CSE1L, CAS, XPO2: Exportin-2	0.066	0.030
KPNB1	KPNB1, NTF97: Importin subunit beta-1	0.066	0.036
PPP1R8	N/A	0.063	0.069
MTA1	MTA1: Metastasis-associated protein MTA1	0.063	0.069
ATF1	ATF1: Cyclic AMP-dependent transcription factor ATF-1	0.063	0.111
RPS6KB1	N/A	0.063	0.086
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.063	0.136
PHF10	N/A	0.063	0.029
VRK1	VRK1: Serine/threonine-protein kinase VRK1	0.063	0.056
PRKD2	PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2	0.063	0.056
NACA	NACA, HSD48: Nascent polypeptide-associated complex subunit alpha	0.063	0.029
CPSF1	CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1	0.063	0.029
PSMD1	PSMD1: 26S proteasome non-ATPase regulatory subunit 1	0.063	0.111
PBK	PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase	0.063	0.069
TIMELESS	TIMELESS, TIM, TIM1, TIMELESS1: Protein timeless homolog	0.063	0.029
NCOR1	NCOR1, KIAA1047: Nuclear receptor corepressor 1	0.063	0.086
WEE1	WEE1: Wee1-like protein kinase	0.063	0.069
PRPF4B	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol	0.063	0.069
TERF2IP	TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1	0.062	0.055
SH3BP3		0.062	0.062
DDIT3	DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3	0.062	0.123
ZBTB33	KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso	0.062	0.077
LYN	LYN: Tyrosine-protein kinase Lyn	0.061	0.033
LCK	LCK: Proto-oncogene tyrosine-protein kinase LCK	0.061	0.030
ABL1	ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1	0.061	0.032
FOXO1A	FOXO1A, FKHR: Forkhead box protein O1A	0.060	0.069
FOXJ2	FOXJ2, FHX: Forkhead box protein J2	0.060	0.062
DAPK1	DAPK1, DAPK: Death-associated protein kinase 1	0.057	0.033
PIK3CB	PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit	0.056	0.049
PCAF	PCAF: Histone acetyltransferase PCAF	0.056	0.097
FOSL2	FOSL2, FRA2: Fos-related antigen 2	0.056	0.111
SP1	SP1, TSFP1: Transcription factor Sp1	0.056	0.056
PIK3C2A	PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po	0.056	0.049
ETV1	ETV1, ER81: ETS translocation variant 1	0.056	0.062
STAT4	STAT4: Signal transducer and activator of transcription 4	0.055	0.056
TAF1	TAF1, BA2R, CCG1, CCGS, TAF2A: Transcription initiation factor TFIID subunit 1	0.055	0.123
SOS1	SOS1: Son of sevenless homolog 1	0.054	0.086
FOXM1	FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1	0.052	0.083
HTATIP	HTATIP, TIP60: Histone acetyltransferase HTATIP	0.052	0.083
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.052	0.026
DRIM	UTP20, DRIM: Small subunit processome component 20 homolog	0.052	0.123
CHUK	N/A	0.052	0.032
TERF2	TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2	0.052	0.077
TOP2B	N/A	0.052	0.026
FNBP4	FNBP4, FBP30, KIAA1014: Formin-binding protein 4	0.052	0.026
ROCK1	ROCK1: Rho-associated protein kinase 1	0.052	0.096
JMJD1A	JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr	0.052	0.032
PHF3	PHF3, KIAA0244: PHD finger protein 3	0.052	0.032
ZNF638	ZNF638, NP220, ZFML: Zinc finger protein 638	0.052	0.026
USP24	USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24	0.052	0.032
KIAA0528	KIAA0528: Uncharacterized protein KIAA0528	0.052	0.032
JAK1		0.051	0.033
MAPK13	MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13	0.051	0.033
JAK2	JAK2: Tyrosine-protein kinase JAK2	0.051	0.033
RANBP2	RANBP2, NUP358: E3 SUMO-protein ligase RanBP2	0.051	0.033
SMARCA1	SMARCA1, SNF2L, SNF2L1: Probable global transcription activator SNF2L1	0.050	0.035
ZHX3	ZHX3, KIAA0395, TIX1: Zinc fingers and homeoboxes protein 3	0.049	0.055
MAPK10	MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10	0.049	0.049
STAT3		0.049	0.044
MAPK8	MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8	0.049	0.049
BNC1	BNC1, BNC: Zinc finger protein basonuclin-1	0.049	0.056
MAPK3	MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3	0.049	0.044
ELK1	ELK1: ETS domain-containing protein Elk-1	0.049	0.049
SPAG1	SPAG1: Sperm-associated antigen 1	0.049	0.029
SOX11	SOX11: Transcription factor SOX-11	0.049	0.049
KLF5	KLF5, BTEB2, CKLF, IKLF: Krueppel-like factor 5	0.049	0.056
ZAK	MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT	0.048	0.062
PPARA	PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha	0.048	0.026
FARSLA	FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain	0.047	0.075
PHC2	PHC2, EDR2, PH2: Polyhomeotic-like protein 2	0.047	0.025
HIST2H2AC	HIST2H2AC, H2AFQ: Histone H2A type 2-C	0.047	0.025
SMAD1	SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1	0.047	0.075
HIST1H1C	HIST1H1C, H1F2: Histone H1.2	0.047	0.075
CARHSP1	CARHSP1: Calcium-regulated heat stable protein 1	0.047	0.075
SCYL3	SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin	0.046	0.136
MAP2K1	MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1	0.046	0.049
SYMPK	SYMPK, SPK: Symplekin	0.046	0.069
SFRS6	SFRS6, SRP55: Splicing factor, arginine/serine-rich 6	0.046	0.029
RPS6KB2	RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2	0.046	0.069
PKMYT1	PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito	0.046	0.056
SNF1LK2	SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2	0.046	0.069
CDC7	CDC7, CDC7L1: Cell division cycle 7-related protein kinase	0.046	0.069
ADRBK1	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1	0.046	0.069
USP34	USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34	0.046	0.029
STK38L	STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like	0.046	0.069
HGS	HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate	0.046	0.035
STK3	STK3, MST2: Serine/threonine-protein kinase 3	0.046	0.056
RPS6KA1	RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1	0.046	0.056
AKT1	AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase	0.046	0.049
TAOK3	TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3	0.046	0.086
MGMT	MGMT: Methylated-DNA--protein-cysteine methyltransferase	0.046	0.037
EGR1	EGR1, ZNF225: Early growth response protein 1	0.044	0.069
FOXO3A	FOXO3A, FKHRL1: Forkhead box protein O3A	0.043	0.049
POU2F1	POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1	0.0425	0.077
PRKR	EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki	0.0425	0.077
RFXDC2	RFXDC2: Regulatory factor X domain-containing protein 2.	0.0425	0.032
XRCC4	N/A	0.0425	0.026
DEF6	DEF6, IBP: Differentially expressed in FDCP 6	0.0425	0.026
SNAPC4	SNAPC4, SNAP190: snRNA-activating protein complex subunit 4	0.0425	0.077
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.0425	0.077
TRAFD1	TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1	0.0425	0.026
VCPIP1	VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135	0.0425	0.026
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.0425	0.062
PASK	PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase	0.0425	0.077
RBM6	RBM6, DEF3: RNA-binding protein 6	0.0425	0.032
RGS14	N/A	0.0425	0.026
COIL	COIL, CLN80: Coilin	0.0425	0.032
FGR	FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR	0.041	0.033
EXOC2	N/A	0.041	0.041
MATK	MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase	0.04	0.049
ABL2	ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2	0.04	0.04
CCT2	CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta	0.040	0.033
XPO1	XPO1, CRM1: Exportin-1	0.040	0.090
TESK1	TESK1: Dual specificity testis-specific protein kinase 1	0.039	0.055
STK38	STK38, NDR1: Serine/threonine-protein kinase 38	0.038	0.069
MAPKAPK3	MAPKAPK3: MAP kinase-activated protein kinase 3	0.038	0.056
NEK7	NEK7: Serine/threonine-protein kinase Nek7	0.038	0.056
PSMD5	PSMD5, KIAA0072: 26S proteasome non-ATPase regulatory subunit 5	0.038	0.033
MEF2D	MEF2D: Myocyte-specific enhancer factor 2D	0.038	0.069
CRKRS	CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7	0.038	0.069
PKN2	PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2	0.038	0.086
FHOD1	FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1	0.038	0.111
STK10	STK10: Uncharacterized protein STK10	0.038	0.056
MAFG	MAFG: Transcription factor MafG	0.038	0.136
TCEB3	TCEB3, MSTP059: Transcription elongation factor B polypeptide 3	0.038	0.029
SIRT1	SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1	0.038	0.136
NRBP1	NRBP1, BCON3, NRBP: Nuclear receptor-binding protein	0.038	0.035
RREB1	RREB1, FINB: RAS-responsive element-binding protein 1	0.038	0.029
SFRS5	SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5	0.038	0.029
PTK6	PTK6, BRK: Tyrosine-protein kinase 6	0.037	0.037
YES1	YES1, YES: Proto-oncogene tyrosine-protein kinase Yes	0.037	0.029
HD	HD, IT15: Huntingtin	0.036	0.126
MNAR	PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1	0.036	0.100
PTK2B	PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta	0.036	0.036
FYN	FYN: Proto-oncogene tyrosine-protein kinase Fyn	0.036	0.044
ITK	ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK	0.036	0.044
H1F0	H1F0, H1FV: Histone H1.0	0.035	0.049
MYST4	MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4	0.035	0.069
SMAD7	SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7	0.034	0.055
FOXL2	FOXL2: Forkhead box protein L2	0.034	0.049
AXL	AXL, UFO: Tyrosine-protein kinase receptor UFO precursor	0.034	0.034
AXIN1		0.0333	1.53
FER	FER, TYK3: Proto-oncogene tyrosine-protein kinase FER	0.033	0.041
HCK	N/A	0.033	0.033
ZAP70	ZAP70: Uncharacterized protein ZAP70	0.033	0.029
INSL3	JAK3: Tyrosine-protein kinase JAK3	0.032	0.037
BACH1	BACH1: Transcription regulator protein BACH1	0.032	0.152
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.032	0.077
ID2	ID2: DNA-binding protein inhibitor ID-2	0.032	0.055
STRN3	STRN3, GS2NA, SG2NA: Striatin-3	0.032	0.026
MAPKAPK2	MAPKAPK2: MAP kinase-activated protein kinase 2	0.032	0.077
MAP3K8	MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8	0.032	0.077
TERF1	TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1	0.032	0.062
SFRS15	SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15	0.032	0.032
MAP3K14	MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14	0.032	0.077
ID3	ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3	0.032	0.062
AHR	AHR: Aryl hydrocarbon receptor precursor	0.032	0.056
MAP2K3	MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki	0.032	0.055
CTNNB1	CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1	0.032	0.064
MAP2K2	MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki	0.032	0.033
RAF1	RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase	0.032	0.033
DOCK2	DOCK2, KIAA0209: Dedicator of cytokinesis protein 2	0.032	0.090
FLT3	FLT3, STK1: FL cytokine receptor precursor	0.031	0.035
NFIB	N/A	0.031	0.049
RFX1	RFX1: MHC class II regulatory factor RFX1	0.0308	0.136
HIST1H1A	HIST1H1A, H1F1: Histone H1.1	0.0308	0.056
SOCS3	SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3	0.031	0.038
NFE2L2	NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2	0.029	0.111
JUND	JUND: Transcription factor jun-D	0.029	0.136
CSDA	CSDA, DBPA: DNA-binding protein A	0.029	0.056
ATF6	ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha	0.029	0.111
RCP9	CRCP: DNA-directed RNA polymerase III subunit RPC9	0.029	0.029
CSNK1E	CSNK1E: Casein kinase I isoform epsilon	0.029	0.056
RPS6KA5	RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5	0.029	0.056
RUNX1	N/A	0.029	0.038
STK4	STK4, MST1: Serine/threonine-protein kinase 4	0.029	0.069
JUNB	JUNB: Transcription factor jun-B	0.029	0.111
STK25	STK25, SOK1, YSK1: Serine/threonine-protein kinase 25	0.029	0.049
STK11	STK11, LKB1, PJS: Serine/threonine-protein kinase 11	0.029	0.049
GRK5	GRK5, GPRK5: G protein-coupled receptor kinase 5	0.029	0.049
COL5A2	COL5A2: Collagen alpha-2(V) chain precursor	0.029	0.029
NEIL2	NEIL2: Endonuclease VIII-like 2	0.029	0.029
COL1A2	COL1A2: Collagen alpha-2(I) chain precursor	0.029	0.029
BID	BID: BH3-interacting domain death agonist	0.028	0.028
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.028	0.083
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.028	0.083
TLE3	TLE3, KIAA1547: Transducin-like enhancer protein 3	0.028	0.028
DYRK1A	DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin	0.028	0.083
SGK2	SGK2: Serine/threonine-protein kinase Sgk2	0.028	0.075
KIAA1443	HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez	0.028	0.083
SYTL4	Endocrine transmitter regulatory protein	0.028	0.028
NF2	NF2, SCH: Merlin	0.028	0.028
HES6	HES6: Transcription cofactor HES-6	0.028	0.052
ZNF265	N/A	0.028	0.028
PTBP1	PTBP1: Polypyrimidine tract binding protein 1	0.028	0.028
FBXO4	FBXO4, FBX4: F-box only protein 4	0.028	0.028
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.028	0.083
DYRK1B	DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.028	0.075
DKFZp434K1815	DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815	0.028	0.028
LOC642558	FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1	0.028	0.028
PRKACB	PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit	0.028	0.083
ZCCHC3	ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3	0.028	0.028
MLL4	WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7	0.028	0.025
RAVER1	RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1	0.028	0.028
ATXN2L	ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein	0.028	0.028
C14orf151	C14orf151: Uncharacterized protein C14orf151 (Fragment)	0.028	0.028
ILF3	ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3	0.028	0.028
CUTL1	CUTL1: Homeobox protein cut-like 1	0.028	0.083
ZNF687	ZNF687, KIAA1441: Zinc finger protein 687	0.028	0.028
C13orf8	N/A	0.028	0.028
DUSP15	N/A	0.028	0.028
RAB4A	N/A	0.028	0.028
SF1	SF1, ZFM1, ZNF162: Splicing factor 1	0.028	0.028
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.028	0.083
PHLDB2	N/A	0.028	0.028
NSBP1	NSBP1: Nucleosome-binding protein 1	0.028	0.028
HNRPC	HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2	0.028	0.028
IRF7	N/A	0.028	0.028
WDR54	N/A	0.028	0.028
GPRASP2	GPRASP2: G-protein coupled receptor-associated sorting protein 2	0.028	0.028
TCF20	TCF20, KIAA0292, SPBP: Transcription factor 20	0.028	0.028
CBFA2T2	CBFA2T2, EHT, MTGR1: Protein CBFA2T2	0.028	0.028
TMPO	TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha	0.028	0.028
KIF1B	N/A	0.028	0.028
HDAC8	N/A	0.028	0.028
JDP2	jdp2, JDP2: Jun dimerization protein 2	0.028	0.028
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.028	0.083
NES	N/A	0.028	0.025
SNRPB	N/A	0.028	0.028
FLJ21816	PALB2, FANCN: Partner and localizer of BRCA2	0.028	0.028
PKN3	PKN3, PKNBETA: Serine/threonine-protein kinase N3	0.028	0.075
NIPA1	NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1	0.028	0.028
MAPKAPK5	N/A	0.028	0.083
TFAP4	TFAP4: Transcription factor AP-4	0.028	0.075
CDC2	CDC2: Cell division control protein 2 homolog	0.028	0.075
CORO6	N/A	0.028	0.028
NEK6	NEK6: Serine/threonine-protein kinase Nek6	0.028	0.075
FLJ23436	N/A	0.028	0.025
DSP	DSP: Desmoplakin	0.028	0.028
ZC3HAV1	ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1	0.028	0.028
CABLES1	N/A	0.028	0.028
HDAC7A	N/A	0.028	0.025
PPP1R12C	PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C	0.028	0.028
NFIA	NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A	0.028	0.028
FRK	FRK, PTK5, RAK: Tyrosine-protein kinase FRK	0.027	0.033
FXR2	FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2	0.027	0.029
TEC	TEC, PSCTK4: Tyrosine-protein kinase Tec	0.027	0.041
TXK	TXK, PTK4: Tyrosine-protein kinase TXK	0.027	0.029
NRIP1	NRIP1: Nuclear receptor-interacting protein 1	0.027	0.044
IPO9	IPO9, IMP9, HSPC273, KIAA1192, RANBP9: Importin-9	0.027	0.033
BMX	N/A	0.0263	0.037
FANCD2	FANCD2, FACD: Fanconi anemia group D2 protein	0.026	0.026
NEK1	NEK1, KIAA1901: Serine/threonine-protein kinase Nek1	0.026	0.077
PRKAA1	N/A	0.026	0.062
SRPK2	SRPK2: Serine/threonine-protein kinase SRPK2	0.026	0.077
MEF2A	N/A	0.026	0.062
MECP2	MECP2: Methyl-CpG-binding protein 2	0.026	0.026
AANAT	AANAT, SNAT: Serotonin N-acetyltransferase	0.026	0.062
PCTK1	PCTK1: Serine/threonine-protein kinase PCTAIRE-1	0.026	0.044
KRT18	KRT18: Uncharacterized protein KRT18	0.026	0.034
ATXN7	ATXN7, SCA7: Ataxin-7	0.0253	0.0253
CIC	CIC, KIAA0306: Protein capicua homolog	0.025	0.025
MKNK2	MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2	0.025	0.075
LATS2	LATS2, KPM: Serine/threonine-protein kinase LATS2	0.025	0.075
CPNE1	RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12	0.025	0.025
SON		0.025	0.025
EDF1	EDF1: Endothelial differentiation-related factor 1	0.025	0.025
PHF16	PHF16, JADE3, KIAA0215: Protein Jade-3	0.025	0.025
PSIP1	PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein	0.025	0.025
CDC25A	CDC25A: M-phase inducer phosphatase 1	0.025	0.025
HNRPUL1	HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1	0.025	0.025
MAP2K3	N/A	0.025	0.025
HNRPD	HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0	0.025	0.025
PRKACA	PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit	0.025	0.075
NHN1	NHN1: Conserved nuclear protein NHN1	0.025	0.025
NSUN2	NSUN2, SAKI, TRM4: tRNA	0.025	0.025
AKT3	AKT3: RAC-gamma serine/threonine-protein kinase	0.025	0.075
BCOR	N/A	0.025	0.025
CAMKK1	N/A	0.025	0.025
BUB3	BUB3: Mitotic checkpoint protein BUB3	0.025	0.025
GEMIN5	GEMIN5: Gem-associated protein 5	0.025	0.025
DLX3	DLX3: Homeobox protein DLX-3	0.025	0.075
SSBP4	SSBP4: Single-stranded DNA-binding protein 4	0.025	0.025
H2-ALPHA	TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain	0.025	0.025
KCTD1		0.025	0.025
MAPK8IP3	N/A	0.025	0.025
MAX	MAX: Protein max	0.025	0.047
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.025	0.075
ARID1A	ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A	0.025	0.148
MSL3L1	MSL3L1: Male-specific lethal 3-like 1	0.025	0.025
FBXL10	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio	0.025	0.025
WNK4	WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4	0.025	0.075
SMARCA2	SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2	0.025	0.025
MLXIPL	MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein	0.025	0.047
RPS6KA2	RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2	0.025	0.075
PRKCB1	N/A	0.025	0.025
CREB1	CREB1: cAMP response element-binding protein	0.025	0.148
NEK8	NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8	0.025	0.075
NFYA	NFYA: Nuclear transcription factor Y subunit alpha	0.025	0.025
MAP3K7	MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7	0.025	0.075
ARID4A	ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A	0.025	0.025
FLJ40432	FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227	0.025	0.025
ISL2	ISL2: Insulin gene enhancer protein ISL-2	0.025	0.075
LATS1	LATS1, WARTS: Serine/threonine-protein kinase LATS1	0.025	0.075
PURB	PURB: Transcriptional activator protein Pur-beta	0.025	0.025
NEDD4	NEDD4: Uncharacterized protein NEDD4	0.025	0.025
REXO1	REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog	0.025	0.025
NUP98	N/A	0.025	0.025
RBBP6	RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6	0.025	0.025
SEC13L1	N/A	0.025	0.025
NIPBL	N/A	0.025	0.148
SAP14	SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14	0.025	0.025
POLR1C	POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1	0.025	0.025
HNRPA2B1	HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1	0.025	0.025
MIER1	MIER1, KIAA1610: Mesoderm induction early response protein 1	0.025	0.025
ARL5A	ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A	0.025	0.025
ATXN2L	N/A	0.025	0.025
ELMO1	N/A	0.025	0.148
HEXIM2	HEXIM2, L3: Protein HEXIM2	0.025	0.025
HOXA10	HOXA10, HOX1H: Homeobox protein Hox-A10	0.025	0.075
SYAP1	SYAP1, PRO3113: Synapse-associated protein 1	0.025	0.025
GRK6	N/A	0.025	0.025
SMU1	SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog	0.025	0.025
C20orf77	N/A	0.025	0.025
PLK1	PLK1, PLK: Serine/threonine-protein kinase PLK1	0.025	0.075
ADK	ADK: Adenosine kinase	0.025	0.025
TAL2	TAL2: T-cell acute lymphocytic leukemia protein 2	0.025	0.075
HIST3H2A	HIST3H2A: Histone H2A type 3	0.025	0.025
CAMK1D	CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D	0.025	0.075
raptor	RAPTOR, KIAA1303: Regulatory-associated protein of mTOR	0.025	0.148
PHKG1	PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo	0.025	0.075
ZNF598	ZNF598: Zinc finger protein 598	0.025	0.025
TIA1	TIA1: Nucleolysin TIA-1 isoform p40	0.025	0.025
SETD3	SETD3, C14orf154: SET domain-containing protein 3	0.025	0.025
FAF1	FAF1, CGI-03: FAS-associated factor 1	0.025	0.025
CAMK2A	N/A	0.025	0.025
PDPK1	PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1	0.025	0.075
GATAD2B	GATAD2B, KIAA1150: Transcriptional repressor p66 beta	0.025	0.075
RAD51	RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1	0.025	0.025
HTATIP	N/A	0.025	0.025
PDE8B	PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies	0.025	0.025
CETN1	CETN1, CEN1, CETN: Centrin-1	0.025	0.025
DIDO1	N/A	0.025	0.025
PPP1R9B	PPP1R9B, PPP1R6: Neurabin-2	0.025	0.025
SFRS9	SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9	0.025	0.025
WWTR1	WWTR1, TAZ: WW domain-containing transcription regulator protein 1	0.025	0.025
SMC4L1	SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4	0.025	0.025
HNRPM	HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M	0.025	0.025
SMN2	SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein	0.025	0.025
TCEA1	N/A	0.025	0.025
RPS6KA4	RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4	0.025	0.075
CHEK2	CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2	0.025	3.97
IWS1	IWS1, IWS1L: IWS1 homolog	0.025	0.025
MKNK1	MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1	0.025	0.075
MKI67IP	MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein	0.025	0.025
CDC2L5	CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5	0.025	0.075

2.15E-3

Total Score

1.09