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Evidence of Interaction Between TP53 and MAPK3

The interaction score between TP53 and MAPK3 is 5.86.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between TP53 and MAPK3 = -0.01

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology
OrganismTP53 OrthologueMAPK3 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00215713 0.16 IPI00003479 0.749
fly Q8IH92 0.16 P40417 0.342

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in TP53 and MAPK3:
Domains in TP53Domains in MAPK3
IPR008967 p53-like transcription factor, DNA-binding
IPR002117 p53 tumor antigen
IPR010991 p53, tetramerisation
IPR011615 P53_DNA_bd.
IPR012346 P53_RUNT_DNA_bd.
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008351 JNK MAP kinase
IPR008349 ERK1/2 MAP kinase

The Chi square scores for co-occurrence of domains that are present in TP53 and MAPK3 are listed below.

Domain 1Domain 2Chi Square
IPR008967 p53-like transcription factor, DNA-binding IPR003527 MAP kinase 13.3166
IPR008967 p53-like transcription factor, DNA-binding IPR008351 JNK MAP kinase 9.65734
IPR012346 P53_RUNT_DNA_bd. IPR008351 JNK MAP kinase 8.54168
IPR011615 P53_DNA_bd. IPR008351 JNK MAP kinase 8.54168
IPR010991 p53, tetramerisation IPR008351 JNK MAP kinase 8.54168
IPR002117 p53 tumor antigen IPR008351 JNK MAP kinase 8.54168
IPR002117 p53 tumor antigen IPR008271 Serine/threonine protein kinase, active site 4.60701
IPR010991 p53, tetramerisation IPR008271 Serine/threonine protein kinase, active site 4.60701
IPR011615 P53_DNA_bd. IPR008271 Serine/threonine protein kinase, active site 4.60701
IPR012346 P53_RUNT_DNA_bd. IPR008271 Serine/threonine protein kinase, active site 4.60701
IPR011615 P53_DNA_bd. IPR003527 MAP kinase 4.12115
IPR010991 p53, tetramerisation IPR003527 MAP kinase 4.12115
IPR002117 p53 tumor antigen IPR003527 MAP kinase 4.12115
IPR012346 P53_RUNT_DNA_bd. IPR003527 MAP kinase 4.12115
IPR002117 p53 tumor antigen IPR002290 Serine/threonine protein kinase 3.23646
IPR010991 p53, tetramerisation IPR002290 Serine/threonine protein kinase 3.23646
IPR011615 P53_DNA_bd. IPR002290 Serine/threonine protein kinase 3.23646
IPR012346 P53_RUNT_DNA_bd. IPR002290 Serine/threonine protein kinase 3.23646
IPR008967 p53-like transcription factor, DNA-binding IPR008349 ERK1/2 MAP kinase 2.09064
IPR008967 p53-like transcription factor, DNA-binding IPR002290 Serine/threonine protein kinase 1.43889
IPR008967 p53-like transcription factor, DNA-binding IPR008271 Serine/threonine protein kinase, active site 0.974716
IPR008967 p53-like transcription factor, DNA-binding IPR000719 Protein kinase 0.163761
IPR011615 P53_DNA_bd. IPR011009 Protein kinase-like 0.00633063
IPR010991 p53, tetramerisation IPR011009 Protein kinase-like 0.00633063
IPR002117 p53 tumor antigen IPR011009 Protein kinase-like 0.00633063
IPR012346 P53_RUNT_DNA_bd. IPR011009 Protein kinase-like 0.00633063
IPR008967 p53-like transcription factor, DNA-binding IPR011009 Protein kinase-like 0.00476462
IPR012346 P53_RUNT_DNA_bd. IPR000719 Protein kinase 0.000322699
IPR011615 P53_DNA_bd. IPR000719 Protein kinase 0.000322699
IPR010991 p53, tetramerisation IPR000719 Protein kinase 0.000322699
IPR002117 p53 tumor antigen IPR000719 Protein kinase 0.000322699

The background colour of the table refers to:

  • Blue Domain is only present in TP53
  • Yellow Domain is only present in MAPK3
  • Green Domain is present in both TP53 and MAPK3

 0.083
Post-translational Modifications

Protein: TP53

PTMResidueReference
Acetylation 305 PubMed, HPRD
Acetylation 320 PubMed, HPRD
Acetylation 370 PubMed, HPRD
Acetylation 372 PubMed, HPRD
Acetylation 373 PubMed, HPRD
Acetylation 381 PubMed, HPRD
Acetylation 382 PubMed, HPRD
Deacylation 382 PubMed, HPRD
Dephosphorylation 315 PubMed, HPRD
N6-acetyllysine 305 HPRD
N6-acetyllysine 373 HPRD
N6-acetyllysine 382 HPRD
Phosphorylation 6 PubMed, HPRD
Phosphorylation 9 PubMed, HPRD
Phosphorylation 15 PubMed, HPRD
Phosphorylation 18 PubMed, HPRD
Phosphorylation 20 PubMed, HPRD
Phosphorylation 33 PubMed, HPRD
Phosphorylation 37 PubMed, HPRD
Phosphorylation 46 PubMed, HPRD
Phosphorylation 55 PubMed, HPRD
Phosphorylation 81 PubMed, HPRD
Phosphorylation 155 PubMed, HPRD
Phosphorylation 315 PubMed, HPRD
Phosphorylation 366 PubMed, HPRD
Phosphorylation 371 PubMed, HPRD
Phosphorylation 378 PubMed, HPRD
Phosphorylation 392 PubMed, HPRD
Phosphoserine 15 PubMed, HPRD
Phosphoserine 46 PubMed, HPRD
Phosphoserine 315 PubMed, HPRD
Phosphothreonine 18 PubMed, HPRD
Phosphothreonine 55 PubMed, HPRD
Proteolytic Cleavage 18 PubMed, HPRD
Proteolytic Cleavage 20 PubMed, HPRD
Proteolytic Cleavage 23 PubMed, HPRD
Sumoylation 386 PubMed, HPRD
Ubiquitination 351 PubMed, HPRD
Ubiquitination 357 PubMed, HPRD
Ubiquitination 370 PubMed, HPRD
Ubiquitination 372 PubMed, HPRD
Ubiquitination 373 PubMed, HPRD
Ubiquitination 381 PubMed, HPRD
Ubiquitination 382 PubMed, HPRD
Ubiquitination 386 PubMed, HPRD

Protein: MAPK3

PTMResidueReference
Phosphorylation 202 PubMed, HPRD
Phosphorylation 204 PubMed, HPRD
Phosphothreonine 202 PubMed, HPRD
Phosphotyrosine 204 PubMed, HPRD
Localisation

Protein: TP53

LocalisationReference
ER HPRD
Nucleus HPRD
Mitochondrion HPRD
Nucleolus HPRD
Cytoplasm HPRD

Protein: MAPK3

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD
Transitive Score

The common interactors between TP53 and MAPK3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TP53 andMAPK3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TP53 has 1099 interactors and MAPK3 has 1361 interactors of which there are 649 common interactors.

Common InteractorName of Common InteractorScore for TP53-Interactor (?)Score for MAPK3-Interactor (?)
HIST1H1E HIST1H1E, H1F4: Histone H1.4 2.08 0.056
NR5A1 NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1 1.58 0.049
SMAD4 SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4 1.58 0.056
HIST1H1B HIST1H1B, H1F5: Histone H1.5 1.26 0.044
PGR PGR, NR3C3: Progesterone receptor 1.00 0.049
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.964 0.0898
NR4A2 NR4A2, NOT, NURR1, TINUR: Orphan nuclear receptor NR4A2 0.902 23.60
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.822 0.0308
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.704 0.102
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.651 0.077
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.541 0.077
SP100 N/A 0.525 0.039
MCM3 MCM3: DNA replication licensing factor MCM3 0.515 0.028
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 0.503 0.069
NBN NBN, NBS, NBS1, P95: Nibrin 0.430 0.039
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.430 0.055
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.430 0.026
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.430 0.049
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.425 0.054
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.385 0.0308
CCNB1 Cyclin B1 0.385 0.088
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.318 0.097
DAXX DAXX, BING2, DAP6: Death domain-associated protein 6 0.290 0.056
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.284 65.60
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.276 0.028
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.260 0.048
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.253 0.062
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.245 0.056
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.241 0.0308
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.233 0.069
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.233 0.874
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.227 0.049
RB1 RB1: Retinoblastoma-associated protein 0.210 0.062
ELF1 ELF1: ETS-related transcription factor Elf-1 0.210 0.123
MATR3 MATR3, KIAA0723: Matrin-3 0.210 0.032
HIF1A HIF1A, MOP1: Hypoxia-inducible factor 1 alpha 0.208 0.069
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.188 0.056
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.188 0.029
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.188 0.056
CXorf9 N/A 0.188 0.049
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.187 71.20
MYB MYB: Myb proto-oncogene protein 0.176 0.055
CEBPB CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta 0.172 0.136
CEBPE CEBPE: CCAAT/enhancer-binding protein epsilon 0.172 0.136
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.162 0.055
TP73 TP73, P73: Tumor protein p73 0.156 0.056
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.156 0.123
ZNF148 ZNF148, ZBP89: Zinc finger protein 148 0.155 0.026
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.155 0.062
ERF ERF: ETS domain-containing transcription factor ERF 0.155 0.123
XRCC1 XRCC1: DNA-repair protein XRCC1 0.155 0.026
MITF MITF: Microphthalmia-associated transcription factor 0.152 0.028
AR AR, DHTR, NR3C4: Androgen receptor 0.152 0.028
ARNT ARNT: Aryl hydrocarbon receptor nuclear translocator 0.152 0.083
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.152 0.174
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.146 0.086
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.146 33.10
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.146 0.044
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.144 0.026
MKI67 MKI67: Antigen KI-67 0.144 0.031
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.144 0.055
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.144 0.109
PTMA N/A 0.144 0.039
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.141 0.097
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.141 0.097
LEF1 LEF1: Lymphoid enhancer-binding factor 1 0.140 0.028
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.139 0.111
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.139 0.031
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.139 0.049
CLTC CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1 0.139 0.086
COPE COPE: Coatomer subunit epsilon 0.139 0.114
RELA RELA, NFKB3: Transcription factor p65 0.139 0.069
KIAA1012 KIAA1012: Protein TRS85 homolog 0.139 0.069
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.139 0.029
CDC23 CDC23: Cell division cycle protein 23 homolog 0.137 0.049
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.137 0.069
NCOA3 NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3 0.137 0.075
CDC25C CDC25C: M-phase inducer phosphatase 3 0.137 0.148
LMNA LMNA, LMN1: Lamin-A/C 0.137 0.047
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.137 0.137
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.137 0.137
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.132 0.055
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.132 0.098
IRF3 IRF3: Interferon regulatory factor 3 0.132 0.077
CDK4 CDK4: Cell division protein kinase 4 0.129 0.049
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.129 0.056
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.129 0.056
NPM1 NPM1, NPM: Nucleophosmin 0.129 0.044
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.129 0.050
CDC20 CDC20: Cell division cycle protein 20 homolog 0.129 0.044
TP53BP1 TP53BP1: Tumor suppressor p53-binding protein 1 0.127 0.026
SALL1 SALL1, SAL1: Sal-like protein 1 0.125 0.029
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.118 0.056
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.118 0.069
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.118 0.044
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.114 0.044
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.114 30.70
ETS1 ETS1, EWSR2: Protein C-ets-1 0.114 0.136
C20orf4 C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4 0.114 0.056
FKBP4 FKBP4: FK506-binding protein 4 0.114 0.069
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.114 0.069
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.114 0.136
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.114 0.069
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.114 0.056
CCNH CCNH: Cyclin-H 0.114 0.136
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.114 0.111
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.114 0.111
AIP AIP, XAP2: AH receptor-interacting protein 0.114 0.069
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.114 0.029
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.114 53.10
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.114 0.044
CSK CSK: Tyrosine-protein kinase CSK 0.112 0.111
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.112 0.111
HSP90AA1 Hsp89-alpha-delta-N 0.111 0.069
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.111 0.136
STAT6 STAT6: Signal transducer and activator of transcription 6 0.111 65.60
HDAC4 HDAC4, KIAA0288: Histone deacetylase 4 0.102 0.038
GTF2F2 N/A 0.0971 0.062
STAT2 STAT2: Signal transducer and activator of transcription 2 0.096 0.109
NFATC1 N/A 0.096 0.055
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.096 0.152
TCF7L2 N/A 0.090 0.032
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.087 0.062
RBM14 RBM14, SIP: RNA-binding protein 14 0.087 0.026
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.087 0.032
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.087 0.109
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.087 0.123
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.087 0.077
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.087 0.069
SMAD3 SMAD3, MADH3: Mothers against decapentaplegic homolog 3 0.087 26.80
SOX4 SOX4: Transcription factor SOX-4 0.086 0.0308
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.086 0.069
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 0.086 0.029
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.086 153.00
CCND1 CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1 0.086 0.111
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.086 0.038
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.086 0.086
CREBBP CREBBP, CBP: CREB-binding protein 0.086 0.029
DNAJC7 DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7 0.086 0.086
ATM ATM: Serine-protein kinase ATM 0.086 0.056
GHR GHR: Growth hormone receptor precursor 0.085 0.032
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.084 0.026
PPEF1 N/A 0.083 0.028
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.083
POGZ POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain 0.083 0.028
MAPK15 N/A 0.083 0.083
C20orf18 N/A 0.083 0.028
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.083 0.165
ZNF644 ZNF644, KIAA1221, ZEP2: Zinc finger protein 644 0.083 0.028
UHRF1 0.083 0.028
ZHX1 ZHX1: Zinc fingers and homeoboxes protein 1 0.083 0.028
EEF2K EEF2K: Elongation factor 2 kinase 0.083 0.148
ZFP91 ZFP91, FKSG11: Zinc finger protein 91 homolog 0.083 0.028
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.083 0.083
MLL2 MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2 0.083 0.028
ZNF579 ZNF579: Zinc finger protein 579 0.083 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.083 0.028
ZNF295 ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295 0.083 0.028
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.083 0.028
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.083 0.083
NAPG NAPG, SNAPG: Gamma-soluble NSF attachment protein 0.0818 0.056
KIAA0664 KIAA0664: Putative eukaryotic translation initiation factor 3 subunit 0.0818 0.056
TRAP1 TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor 0.0818 0.049
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.0818 0.029
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.081 0.114
H1FX H1FX: Histone H1x 0.080 0.077
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.078 0.029
FNBP1 N/A 0.078 0.069
WBSCR1 EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H 0.078 0.029
CDK2 CDK2: Cell division protein kinase 2 0.078 2.30
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.078 0.0308
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.078 0.049
SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 0.078 1.59
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.078 0.044
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.078 0.056
CDK7 CDK7, MO15: Cell division protein kinase 7 0.078 0.049
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.078 0.069
TCF3 TCF3, E2A, ITF1: Transcription factor E2-alpha 0.078 0.049
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.078 0.056
YEATS2 KIAA1197, YEATS2: YEATS domain-containing protein 2 0.078 0.029
ETS2 ETS2: Protein C-ets-2 0.077 0.191
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.077 0.062
ERG ERG: Transcriptional regulator ERG 0.077 0.109
MDM4 MDM4, MDMX: Mdm4 protein 0.077 0.049
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.077 0.032
ZNF174 ZNF174, ZSCAN8: Zinc finger protein 174 0.075 0.025
RFFL RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin 0.075 0.025
BRD4 N/A 0.075 0.025
SOX8 SOX8: Transcription factor SOX-8 0.075 0.047
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.075 33.30
TRERF1 TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1 0.075 0.025
PRDM2 PRDM2, RIZ: PR domain zinc finger protein 2 0.075 0.025
GIT2 N/A 0.075 0.075
RBM10 RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10 0.075 0.025
DHX8 DHX8, DDX8: ATP-dependent RNA helicase DHX8 0.075 0.025
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.075 0.025
CCNT2 CCNT2: Cyclin-T2 0.075 0.148
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.075 33.30
OSR1 OSR1, ODD: Protein odd-skipped-related 1 0.075 0.025
RBL1 RBL1: Retinoblastoma-like protein 1 0.075 0.075
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.075 0.025
C14orf4 C14orf4, KIAA1865, My039: RING finger protein C14orf4 0.075 0.025
DDX20 DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20 0.075 0.025
ZFPM1 ZFPM1, FOG1: Zinc finger protein ZFPM1 0.075 0.025
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.075 0.050
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.075 33.30
RNF113A RNF113A, RNF113, ZNF183: RING finger protein 113A 0.075 0.025
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.075 0.148
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.075 0.148
RNF20 0.075 0.025
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.074 0.123
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.071 0.056
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.071 0.064
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.070 0.077
WDR1 N/A 0.070 0.026
PLEK PLEK, P47: Pleckstrin 0.070 0.123
STK16 N/A 0.070 0.055
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.070 0.032
MYBBP1A MYBBP1A, P160: Myb-binding protein 1A 0.070 0.032
ZBTB7A ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A 0.069 8.99
GCN5L2 GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2 0.069 0.029
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.069 0.033
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.069 0.086
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.069 0.136
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.069 38.50
FOS FOS, G0S7: Proto-oncogene protein c-fos 0.069 0.136
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.067 112.00
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.067 0.086
SYK SYK: Tyrosine-protein kinase SYK 0.067 0.111
HSPD1 0.066 0.790
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.066 0.049
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.066 0.069
VCP VCP: Transitional endoplasmic reticulum ATPase 0.066 0.029
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.066 0.0308
CTPS CTPS: CTP synthase 1 0.066 0.044
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.066 0.044
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.066 0.097
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.063 0.069
PPP1R8 N/A 0.063 0.035
MTA1 MTA1: Metastasis-associated protein MTA1 0.063 0.056
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.063 0.111
RPS6KB1 N/A 0.063 0.056
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.063 0.049
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.063 0.111
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.063 0.056
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.063 0.029
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.063 0.050
COPA COPA: Coatomer subunit alpha 0.063 0.029
WEE1 WEE1: Wee1-like protein kinase 0.063 0.050
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.063 0.069
TERF2IP TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1 0.062 0.0425
SH3BP3 0.062 0.032
DDIT3 DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3 0.062 0.109
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.062 46.90
LYN LYN: Tyrosine-protein kinase Lyn 0.061 0.136
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.061 0.109
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.061 0.191
FOXO1A FOXO1A, FKHR: Forkhead box protein O1A 0.060 0.049
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.060 0.062
S100B S100B: Protein S100-B 0.058 0.026
FAM82B FAM82B, CGI-90: Protein FAM82B 0.057 0.412
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.057 0.026
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.057 0.086
MYCBP2 MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2 0.056 0.051
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.056 0.114
FOSL2 FOSL2, FRA2: Fos-related antigen 2 0.056 0.111
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.056 0.114
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.056 0.097
ETV1 ETV1, ER81: ETS translocation variant 1 0.056 0.109
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.0554 0.043
STAT4 STAT4: Signal transducer and activator of transcription 4 0.055 0.097
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.055 0.098
UBE2E3 UBE2E3, UBCE4, UBCH9: Ubiquitin-conjugating enzyme E2 E3 0.054 0.029
SOS1 SOS1: Son of sevenless homolog 1 0.054 0.111
ESRRA ESRRA, ERR1, ESRL1, NR3B1: Steroid hormone receptor ERR1 0.054 0.049
SUPT5H SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5 0.054 0.044
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.052 0.083
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.052 0.083
TERF2 TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2 0.052 0.032
TOP2B N/A 0.052 0.026
EMD EMD, EDMD, STA: Emerin 0.052 0.026
ARFGAP1 N/A 0.052 0.096
ROCK1 ROCK1: Rho-associated protein kinase 1 0.052 0.109
ZNF638 ZNF638, NP220, ZFML: Zinc finger protein 638 0.052 0.026
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.052 0.0425
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.052 0.026
JAK1 0.051 0.136
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.051 0.049
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.051 0.136
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.051 0.097
RNF11 RNF11, CGI-123: RING finger protein 11 0.050 0.063
ZHX3 ZHX3, KIAA0395, TIX1: Zinc fingers and homeoboxes protein 3 0.049 0.0425
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.083
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.049 0.165
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.049 0.028
STAT3 0.049 0.148
NASP NASP: Nuclear autoantigenic sperm protein 0.049 0.083
S100A16 S100A16, AAG13: Protein S100-A16 0.049 0.028
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.083
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.049 0.225
ELK1 ELK1: ETS domain-containing protein Elk-1 0.049 0.136
SPAG1 SPAG1: Sperm-associated antigen 1 0.049 0.049
SOX11 SOX11: Transcription factor SOX-11 0.049 0.035
RXRA RXRA, NR2B1: Retinoic acid receptor RXR-alpha 0.048 0.077
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.048 0.055
PPARA PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha 0.048 0.055
FARSLA FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain 0.047 0.075
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.047 0.025
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.047 0.025
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.047 0.075
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.047 0.075
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.047 0.025
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.046 0.056
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.046 0.114
CUL5 CUL5, VACM1: Cullin-5 0.046 0.029
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.046 0.069
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.046 0.049
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.046 0.049
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.046 0.049
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.046 0.046
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.046 0.097
CSTF2T CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant 0.046 0.029
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.046 0.038
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.046 0.069
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.046 0.038
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.046 0.054
DIAPH1 Diaphanous 1 0.046 0.995
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.046 0.056
DOK1 DOK1: Docking protein 1 0.046 0.136
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.046 0.038
MBD3 MBD3: Methyl-CpG-binding domain protein 3 0.046 0.029
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.046 0.056
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.046 0.171
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.046 0.086
PPP2CB PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.0462 30.30
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.046 0.062
BIRC4 BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4 0.0453 0.034
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0453 0.026
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.0446 0.109
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.0446 0.031
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.069
KLC2 KLC2: Kinesin light chain 2 0.044 0.139
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.044 1.98
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.044 0.148
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.044 0.025
VDR VDR, NR1I1: Vitamin D3 receptor 0.043 0.056
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.043 0.056
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.0425 0.055
SNAPC4 SNAPC4, SNAP190: snRNA-activating protein complex subunit 4 0.0425 0.026
CDKN1A CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1: Cyclin-dependent kinase inhi 0.0425 0.062
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.0425 0.055
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.0425 0.062
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.0425 0.062
SMARCC2 N/A 0.0425 0.0425
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0425 0.096
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.0425 0.152
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.0425 0.062
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.0425 0.054
RGS14 N/A 0.0425 0.026
MARK2 N/A 0.0425 0.026
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.041 0.136
STUB1 STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1 0.041 0.139
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.04 0.165
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.04 0.165
CD2AP CD2AP: CD2-associated protein 0.040 0.049
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.040 0.136
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.039 0.032
PPARG CREB3L2-PPARgamma 0.039 0.049
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.039 0.037
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.038 0.056
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.038 0.069
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.038 0.114
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.038 0.056
RBM8A RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A 0.038 0.029
SNRP70 SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa 0.038 0.029
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.038 0.056
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.038 0.056
STK10 STK10: Uncharacterized protein STK10 0.038 0.069
MAFG MAFG: Transcription factor MafG 0.038 0.136
FKBP1A FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A 0.038 0.038
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.038 0.029
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.037 0.098
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.037 0.111
HD HD, IT15: Huntingtin 0.036 0.077
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.036 0.060
LIMS1 N/A 0.036 0.026
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.036 0.123
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.036 0.049
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.036 0.025
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.036 0.075
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.036 0.148
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.036 0.148
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.035 0.049
SMAD7 SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7 0.034 0.096
FOXL2 FOXL2: Forkhead box protein L2 0.034 0.044
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.034 0.109
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.034 0.109
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.034 0.049
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.034 0.049
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.034 0.049
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.034 0.049
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.034 0.049
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.034 0.049
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.034 0.034
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.034 0.098
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.034 0.098
AXIN1 0.0333 0.028
YWHAG YWHAG: 14-3-3 protein gamma 0.0333 0.028
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.033 0.097
HCK N/A 0.033 0.136
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.033 0.111
MAGED2 N/A 0.033 0.046
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.032 0.098
BACH1 BACH1: Transcription regulator protein BACH1 0.032 0.152
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.032 0.032
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.032 0.055
ID2 ID2: DNA-binding protein inhibitor ID-2 0.032 0.077
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.062
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.032 0.062
VIM VIM: Vimentin 0.032 0.048
TERF1 TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1 0.032 0.026
GTF3C1 N/A 0.032 0.0425
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.032 0.062
ID3 ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3 0.032 0.077
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.032 0.152
AHR AHR: Aryl hydrocarbon receptor precursor 0.032 0.069
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.032 0.062
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.032 0.086
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.032 41.40
RPS10 RPS10: 40S ribosomal protein S10 0.032 0.056
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.032 82.20
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.032 0.069
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.032 0.043
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.056
ACTG1 ACTB: Actin, cytoplasmic 1 0.032 0.029
NRAS NRAS, HRAS1: GTPase NRas precursor 0.032 0.035
FLII FLII, FLIL: Protein flightless-1 homolog 0.032 0.029
PLD1 PLD1: Phospholipase D1 0.032 0.088
PREP PREP, PEP: Prolyl endopeptidase 0.032 0.029
HSPH1 HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa 0.032 0.029
CRKL CRKL: Crk-like protein 0.032 0.111
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.032 0.111
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.032 0.056
NR1D1 NR1D1, EAR1, HREV, THRAL: Orphan nuclear receptor NR1D1 0.031 41.40
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.031 0.029
EPOR EPOR: Erythropoietin receptor precursor 0.031 0.037
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.031 0.029
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.031 0.037
NFIB N/A 0.031 0.096
ESR1 ESR1, ESR, NR3A1: Estrogen receptor 0.031 0.056
RFX1 RFX1: MHC class II regulatory factor RFX1 0.0308 0.049
HIST1H1A HIST1H1A, H1F1: Histone H1.1 0.0308 0.049
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.031 0.098
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.030 0.098
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.030 0.044
SEL1L SEL1L, TSA305, UNQ128/PRO1063: Protein sel-1 homolog 1 precursor 0.030 0.030
FKBP8 DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment) 0.029 0.114
NFE2L2 NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2 0.029 0.136
JUND JUND: Transcription factor jun-D 0.029 0.171
ATF6 ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha 0.029 0.111
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.086
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.029 41.40
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.049
WDR44 WDR44: WD repeat-containing protein 44 0.029 0.029
JUNB JUNB: Transcription factor jun-B 0.029 82.20
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.029 0.114
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.029 0.069
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.069
BID BID: BH3-interacting domain death agonist 0.028 0.165
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.083
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.028 0.083
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.028 0.028
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.028 0.083
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.028 0.075
KIAA1443 HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez 0.028 0.028
SYTL4 Endocrine transmitter regulatory protein 0.028 0.028
NF2 NF2, SCH: Merlin 0.028 0.165
HES6 HES6: Transcription cofactor HES-6 0.028 0.083
ZNF265 N/A 0.028 0.028
PTBP1 PTBP1: Polypyrimidine tract binding protein 1 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.028 0.083
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.028 0.075
DKFZp434K1815 DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815 0.028 0.028
LOC642558 FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1 0.028 0.028
ZCCHC3 ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3 0.028 0.028
MLL4 WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7 0.028 0.025
RAVER1 RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1 0.028 0.028
ATXN2L ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
ILF3 ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3 0.028 0.028
CUTL1 CUTL1: Homeobox protein cut-like 1 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
C13orf8 N/A 0.028 0.028
DUSP15 N/A 0.028 0.028
RAB4A N/A 0.028 0.052
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.083
PHLDB2 N/A 0.028 0.028
NSBP1 NSBP1: Nucleosome-binding protein 1 0.028 0.165
HNRPC HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2 0.028 0.028
IRF7 N/A 0.028 0.028
WDR54 N/A 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
TCF20 TCF20, KIAA0292, SPBP: Transcription factor 20 0.028 0.028
CBFA2T2 CBFA2T2, EHT, MTGR1: Protein CBFA2T2 0.028 0.028
TMPO TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha 0.028 0.028
KIF1B N/A 0.028 0.028
HDAC8 N/A 0.028 0.028
JDP2 jdp2, JDP2: Jun dimerization protein 2 0.028 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.028 0.083
NES N/A 0.028 0.025
SNRPB N/A 0.028 0.028
FLJ21816 PALB2, FANCN: Partner and localizer of BRCA2 0.028 0.028
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.028 0.075
NIPA1 NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1 0.028 0.028
MAPKAPK5 N/A 0.028 0.083
TFAP4 TFAP4: Transcription factor AP-4 0.028 0.075
CDC2 CDC2: Cell division control protein 2 homolog 0.028 0.075
CORO6 N/A 0.028 0.028
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.028 0.075
FLJ23436 N/A 0.028 0.025
DSP DSP: Desmoplakin 0.028 0.028
ZC3HAV1 ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1 0.028 0.028
CABLES1 N/A 0.028 0.028
HDAC7A N/A 0.028 0.025
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
NFIA NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A 0.028 0.028
NR4A1 CDNA FLJ16818 fis, clone TRACH1000193, highly similar to Orphan nuclear receptor 0.028 0.044
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.027 0.097
FXR2 FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2 0.027 0.046
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.027 0.097
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.027 0.097
MPG N/A 0.027 0.026
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.027 0.077
YWHAQ YWHAQ: 14-3-3 protein theta 0.027 0.0425
CIITA CIITA, MHC2TA: MHC class II transactivator 0.027 0.055
BMX N/A 0.0263 0.098
TH TH, TYH: Tyrosine 3-monooxygenase 0.026 0.046
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.026 0.049
PRKAA1 N/A 0.026 0.055
GRLF1 N/A 0.026 0.077
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.026 0.096
MEF2A N/A 0.026 0.052
NUP214 N/A 0.026 0.026
MECP2 MECP2: Methyl-CpG-binding protein 2 0.026 0.052
FAM65A FAM65A, KIAA1930: Protein FAM65A 0.026 0.026
TERT TERT, EST2, TCS1, TRT: Telomerase reverse transcriptase 0.026 0.050
AGTPBP1 AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein 0.026 0.029
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.026 0.114
KRT18 KRT18: Uncharacterized protein KRT18 0.026 0.034
ITGB4 N/A 0.025 0.032
IL9R IL9R: Interleukin-9 receptor precursor 0.025 0.029
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.025 0.032
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.025 0.037
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.025 0.075
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.025 0.075
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
SON 0.025 0.025
EDF1 EDF1: Endothelial differentiation-related factor 1 0.025 0.025
PHF16 PHF16, JADE3, KIAA0215: Protein Jade-3 0.025 0.025
PSIP1 PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein 0.025 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.148
HNRPUL1 HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1 0.025 0.025
MAP2K3 N/A 0.025 0.025
HNRPD HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0 0.025 0.025
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.025 0.075
NHN1 NHN1: Conserved nuclear protein NHN1 0.025 0.025
NSUN2 NSUN2, SAKI, TRM4: tRNA 0.025 0.025
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.025 0.148
BCOR N/A 0.025 0.025
CAMKK1 N/A 0.025 0.025
BUB3 BUB3: Mitotic checkpoint protein BUB3 0.025 0.025
GEMIN5 GEMIN5: Gem-associated protein 5 0.025 0.025
DLX3 DLX3: Homeobox protein DLX-3 0.025 0.025
SSBP4 SSBP4: Single-stranded DNA-binding protein 4 0.025 0.025
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.025 0.047
KCTD1 0.025 0.025
MAPK8IP3 N/A 0.025 0.025
MAX MAX: Protein max 0.025 0.075
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.025 0.075
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.025
MSL3L1 MSL3L1: Male-specific lethal 3-like 1 0.025 0.025
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.025
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.025 0.075
SMARCA2 SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2 0.025 0.025
MLXIPL MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein 0.025 0.075
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.025 35.90
PRKCB1 N/A 0.025 0.025
CREB1 CREB1: cAMP response element-binding protein 0.025 0.148
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.025 0.075
NFYA NFYA: Nuclear transcription factor Y subunit alpha 0.025 0.025
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.025 0.075
ARID4A ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A 0.025 0.025
FLJ40432 FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227 0.025 0.025
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.025 0.025
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.025 0.075
PURB PURB: Transcriptional activator protein Pur-beta 0.025 0.025
NEDD4 NEDD4: Uncharacterized protein NEDD4 0.025 0.025
REXO1 REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog 0.025 0.025
NUP98 N/A 0.025 0.025
RBBP6 RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6 0.025 0.025
SEC13L1 N/A 0.025 0.025
NIPBL N/A 0.025 0.025
SAP14 SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14 0.025 0.025
POLR1C POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1 0.025 0.025
HNRPA2B1 HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1 0.025 0.025
MIER1 MIER1, KIAA1610: Mesoderm induction early response protein 1 0.025 0.025
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.025
ATXN2L N/A 0.025 0.025
ELMO1 N/A 0.025 0.148
HEXIM2 HEXIM2, L3: Protein HEXIM2 0.025 0.025
HOXA10 HOXA10, HOX1H: Homeobox protein Hox-A10 0.025 0.025
SYAP1 SYAP1, PRO3113: Synapse-associated protein 1 0.025 0.025
GRK6 N/A 0.025 0.025
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.025
C20orf77 N/A 0.025 0.025
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.025 35.90
ADK ADK: Adenosine kinase 0.025 0.025
TAL2 TAL2: T-cell acute lymphocytic leukemia protein 2 0.025 0.075
HIST3H2A HIST3H2A: Histone H2A type 3 0.025 0.025
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.025 0.075
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.025 0.025
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.025 0.075
ZNF598 ZNF598: Zinc finger protein 598 0.025 0.025
TIA1 TIA1: Nucleolysin TIA-1 isoform p40 0.025 0.025
SETD3 SETD3, C14orf154: SET domain-containing protein 3 0.025 0.025
FAF1 FAF1, CGI-03: FAS-associated factor 1 0.025 0.025
CAMK2A N/A 0.025 0.025
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.025 0.148
GATAD2B GATAD2B, KIAA1150: Transcriptional repressor p66 beta 0.025 0.075
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
HTATIP N/A 0.025 0.025
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.025
DIDO1 N/A 0.025 0.025
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
SFRS9 SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9 0.025 0.025
WWTR1 WWTR1, TAZ: WW domain-containing transcription regulator protein 1 0.025 0.025
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
HNRPM HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M 0.025 0.025
SMN2 SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein 0.025 0.025
TCEA1 N/A 0.025 0.025
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.025 0.075
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.025 0.075
IWS1 IWS1, IWS1L: IWS1 homolog 0.025 0.025
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.025 35.90
MKI67IP MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein 0.025 0.025
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.025 0.075
0.299
Total Score 5.86