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Evidence of Interaction Between TP53 and RPA1

The interaction score between TP53 and RPA1 is 4.84.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between TP53 and RPA1 = 0.80

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismTP53 OrthologueRPA1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
fly Q8IH92 0.16 Q24492 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in TP53 and RPA1:
Domains in TP53Domains in RPA1
IPR008967 p53-like transcription factor, DNA-binding
IPR002117 p53 tumor antigen
IPR010991 p53, tetramerisation
IPR011615 P53_DNA_bd.
IPR012346 P53_RUNT_DNA_bd.
IPR008994 Nucleic acid-binding OB-fold
IPR004365 OB-fold nucleic acid binding
IPR004591 Replication factor-a protein 1 Rpa1
IPR007199 Replication factor-A protein 1, N-terminal
IPR012340 OB_NA_bd_sub.

The Chi square scores for co-occurrence of domains that are present in TP53 and RPA1 are listed below.

Domain 1Domain 2Chi Square
IPR008967 p53-like transcription factor, DNA-binding IPR008994 Nucleic acid-binding OB-fold 4.96744
IPR002117 p53 tumor antigen IPR008994 Nucleic acid-binding OB-fold 3.49438
IPR010991 p53, tetramerisation IPR008994 Nucleic acid-binding OB-fold 3.49438
IPR011615 P53_DNA_bd. IPR008994 Nucleic acid-binding OB-fold 3.49438
IPR012346 P53_RUNT_DNA_bd. IPR008994 Nucleic acid-binding OB-fold 3.49438

The background colour of the table refers to:

  • Blue Domain is only present in TP53
  • Yellow Domain is only present in RPA1
  • Green Domain is present in both TP53 and RPA1

 5.38E-3
Post-translational Modifications

Protein: TP53

PTMResidueReference
Acetylation 305 PubMed, HPRD
Acetylation 320 PubMed, HPRD
Acetylation 370 PubMed, HPRD
Acetylation 372 PubMed, HPRD
Acetylation 373 PubMed, HPRD
Acetylation 381 PubMed, HPRD
Acetylation 382 PubMed, HPRD
Deacylation 382 PubMed, HPRD
Dephosphorylation 315 PubMed, HPRD
N6-acetyllysine 305 HPRD
N6-acetyllysine 373 HPRD
N6-acetyllysine 382 HPRD
Phosphorylation 6 PubMed, HPRD
Phosphorylation 9 PubMed, HPRD
Phosphorylation 15 PubMed, HPRD
Phosphorylation 18 PubMed, HPRD
Phosphorylation 20 PubMed, HPRD
Phosphorylation 33 PubMed, HPRD
Phosphorylation 37 PubMed, HPRD
Phosphorylation 46 PubMed, HPRD
Phosphorylation 55 PubMed, HPRD
Phosphorylation 81 PubMed, HPRD
Phosphorylation 155 PubMed, HPRD
Phosphorylation 315 PubMed, HPRD
Phosphorylation 366 PubMed, HPRD
Phosphorylation 371 PubMed, HPRD
Phosphorylation 378 PubMed, HPRD
Phosphorylation 392 PubMed, HPRD
Phosphoserine 15 PubMed, HPRD
Phosphoserine 46 PubMed, HPRD
Phosphoserine 315 PubMed, HPRD
Phosphothreonine 18 PubMed, HPRD
Phosphothreonine 55 PubMed, HPRD
Proteolytic Cleavage 18 PubMed, HPRD
Proteolytic Cleavage 20 PubMed, HPRD
Proteolytic Cleavage 23 PubMed, HPRD
Sumoylation 386 PubMed, HPRD
Ubiquitination 351 PubMed, HPRD
Ubiquitination 357 PubMed, HPRD
Ubiquitination 370 PubMed, HPRD
Ubiquitination 372 PubMed, HPRD
Ubiquitination 373 PubMed, HPRD
Ubiquitination 381 PubMed, HPRD
Ubiquitination 382 PubMed, HPRD
Ubiquitination 386 PubMed, HPRD

Protein: RPA1

PTMResidueReference
Localisation

Protein: TP53

LocalisationReference
ER HPRD
Nucleus HPRD
Mitochondrion HPRD
Nucleolus HPRD
Cytoplasm HPRD

Protein: RPA1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD
Transitive Score

The common interactors between TP53 and RPA1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TP53 andRPA1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TP53 has 1099 interactors and RPA1 has 291 interactors of which there are 115 common interactors.

Common InteractorName of Common InteractorScore for TP53-Interactor (?)Score for RPA1-Interactor (?)
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 4.77 0.067
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 2.54 1.10
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 1.58 0.108
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.704 0.123
MCM3 MCM3: DNA replication licensing factor MCM3 0.515 0.263
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.471 0.060
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.430 0.137
DDX21 DDX21: Nucleolar RNA helicase 2 0.430 0.137
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.385 0.782
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.385 0.263
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.385 0.123
CCNB1 Cyclin B1 0.385 0.038
SNRPA SNRPA: U1 small nuclear ribonucleoprotein A 0.307 0.081
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.304 0.0968
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.276 0.038
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.276 0.081
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.276 0.081
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.260 0.137
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.241 0.263
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.241 69.60
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.241 0.123
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 0.241 0.123
SAFB SAFB, HAP, HET, SAFB1: Scaffold attachment factor B 0.233 0.038
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.210 0.067
ELF1 ELF1: ETS-related transcription factor Elf-1 0.210 0.0255
MATR3 MATR3, KIAA0723: Matrin-3 0.210 0.042
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.188 0.123
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.188 0.123
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.188 3.99
MRE11A MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A 0.188 0.890
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.188 0.074
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.188 0.053
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.188 0.074
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.146 0.038
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.146 0.123
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.146 0.074
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.146 0.074
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.144 0.090
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 0.141 0.0968
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.141 0.051
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.139 0.060
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.139 0.074
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.139 0.060
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.139 0.060
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.132 0.0255
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.132 0.050
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.129 0.242
SNRPB2 SNRPB2: U2 small nuclear ribonucleoprotein B'' 0.129 0.038
MSH6 MSH6, GTBP: DNA mismatch repair protein MSH6 0.129 1.82
EIF2S2 EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2 0.129 0.123
PABPC4 PABPC4, APP1, PABP4: Polyadenylate-binding protein 4 0.129 0.038
SSB SSB: Lupus La protein 0.129 0.038
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 0.129 0.038
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.124 0.059
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.118 0.074
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.118 0.060
ERCC3 ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit 0.114 0.044
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.112 0.059
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.096 0.044
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.087 0.042
RBM14 RBM14, SIP: RNA-binding protein 14 0.087 0.042
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.087 0.0255
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.087 80.90
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.087 0.044
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.086 0.044
DDX24 DDX24: ATP-dependent RNA helicase DDX24 0.086 0.044
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.083 0.027
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.078 0.038
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.078 0.038
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.078 0.081
SFRS4 SFRS4, SRP75: Splicing factor, arginine/serine-rich 4 0.078 0.081
U2AF1 U2AF1, U2AF35, U2AFBP: Splicing factor U2AF 35 kDa subunit 0.078 0.038
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.078 0.081
TIAL1 TIAL1: Nucleolysin TIAR 0.078 0.081
EEF2 EEF2, EF2: Elongation factor 2 0.075 0.047
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.070 0.0255
VCP VCP: Transitional endoplasmic reticulum ATPase 0.066 0.059
KPNB1 KPNB1, NTF97: Importin subunit beta-1 0.066 11.10
CORO1C CORO1C, CRNN4: Coronin-1C 0.063 0.890
ZNF638 ZNF638, NP220, ZFML: Zinc finger protein 638 0.052 0.0255
MDN1 MDN1, KIAA0301: Midasin 0.046 0.060
FUBP1 N/A 0.0446 0.108
HIST3H3 HIST3H3, H3FT: Histone H3.1t 0.043 0.082
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.042 0.293
HELLS HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase 0.042 0.074
LCP1 LCP1, PLS2: Plastin-2 0.040 0.123
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.040 25.60
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.040 0.0968
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.040 0.059
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.040 0.047
HRB2 KRR1, HRB2: KRR1 small subunit processome component homolog 0.040 0.0968
POLR2A POLR2A: Uncharacterized protein POLR2A 0.038 2.95
DDX47 E4-DBP: DEAD box protein 0.038 0.123
BAT1 N/A 0.038 0.123
DDX19A DDX19A, DDX19L: ATP-dependent RNA helicase DDX19A 0.038 0.123
CCNA2 CCNA2, CCN1, CCNA: Cyclin-A2 0.038 0.038
DDX18 DDX18: ATP-dependent RNA helicase DDX18 0.038 0.263
EIF4A1 EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I 0.038 0.123
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.038 0.123
SRPR SRPR: Uncharacterized protein SRPR 0.036 0.065
RPL3 RPL3, OK/SW-cl.32: 60S ribosomal protein L3 0.032 0.059
EEF1A1 EEF1A1: Elongation factor 1-alpha 0.032 0.047
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.032 0.059
CSDA CSDA, DBPA: DNA-binding protein A 0.029 0.036
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.027
RFX5 RFX5: DNA-binding protein RFX5 0.0278 0.042
HIST2H2BE HIST2H2BE, H2BFQ: Histone H2B type 2-E 0.028 0.210
BUB3 N/A 0.027 0.027
SERBP1 N/A 0.027 0.027
IFIH1 IFIH1, MDA5, RH116: Interferon-induced helicase C domain-containing protein 1 0.0255 3.96
DDX50 DDX50: ATP-dependent RNA helicase DDX50 0.0255 0.137
RECQL RECQL, RECQL1: ATP-dependent DNA helicase Q1 0.0255 0.123
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 6.33
C11orf58 SMAP, C11orf58: Small acidic protein 0.025 0.027
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.025 0.027
0.228
Total Score 4.84