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Evidence of Interaction Between TP53 and DUSP1

The interaction score between TP53 and DUSP1 is 9.55.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between TP53 and DUSP1 = 0.14

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.30E-3
Orthology
OrganismTP53 OrthologueDUSP1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00215713 0.16 IPI00419454 0.122

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in TP53 and DUSP1:
Domains in TP53Domains in DUSP1
IPR008967 p53-like transcription factor, DNA-binding
IPR002117 p53 tumor antigen
IPR010991 p53, tetramerisation
IPR011615 P53_DNA_bd.
IPR012346 P53_RUNT_DNA_bd.
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase
IPR001763 Rhodanese-like
IPR000340 Dual specificity protein phosphatase
IPR008343 MAP kinase phosphatase

The Chi square scores for co-occurrence of domains that are present in TP53 and DUSP1 are listed below.

Domain 1Domain 2Chi Square
IPR008967 p53-like transcription factor, DNA-binding IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 0.0365131

The background colour of the table refers to:

  • Blue Domain is only present in TP53
  • Yellow Domain is only present in DUSP1
  • Green Domain is present in both TP53 and DUSP1

 0.083
Post-translational Modifications

Protein: TP53

PTMResidueReference
Acetylation 305 PubMed, HPRD
Acetylation 320 PubMed, HPRD
Acetylation 370 PubMed, HPRD
Acetylation 372 PubMed, HPRD
Acetylation 373 PubMed, HPRD
Acetylation 381 PubMed, HPRD
Acetylation 382 PubMed, HPRD
Deacylation 382 PubMed, HPRD
Dephosphorylation 315 PubMed, HPRD
N6-acetyllysine 305 HPRD
N6-acetyllysine 373 HPRD
N6-acetyllysine 382 HPRD
Phosphorylation 6 PubMed, HPRD
Phosphorylation 9 PubMed, HPRD
Phosphorylation 15 PubMed, HPRD
Phosphorylation 18 PubMed, HPRD
Phosphorylation 20 PubMed, HPRD
Phosphorylation 33 PubMed, HPRD
Phosphorylation 37 PubMed, HPRD
Phosphorylation 46 PubMed, HPRD
Phosphorylation 55 PubMed, HPRD
Phosphorylation 81 PubMed, HPRD
Phosphorylation 155 PubMed, HPRD
Phosphorylation 315 PubMed, HPRD
Phosphorylation 366 PubMed, HPRD
Phosphorylation 371 PubMed, HPRD
Phosphorylation 378 PubMed, HPRD
Phosphorylation 392 PubMed, HPRD
Phosphoserine 15 PubMed, HPRD
Phosphoserine 46 PubMed, HPRD
Phosphoserine 315 PubMed, HPRD
Phosphothreonine 18 PubMed, HPRD
Phosphothreonine 55 PubMed, HPRD
Proteolytic Cleavage 18 PubMed, HPRD
Proteolytic Cleavage 20 PubMed, HPRD
Proteolytic Cleavage 23 PubMed, HPRD
Sumoylation 386 PubMed, HPRD
Ubiquitination 351 PubMed, HPRD
Ubiquitination 357 PubMed, HPRD
Ubiquitination 370 PubMed, HPRD
Ubiquitination 372 PubMed, HPRD
Ubiquitination 373 PubMed, HPRD
Ubiquitination 381 PubMed, HPRD
Ubiquitination 382 PubMed, HPRD
Ubiquitination 386 PubMed, HPRD

Protein: DUSP1

PTMResidueReference
Phosphorylation 359 PubMed, HPRD
Phosphorylation 364 PubMed, HPRD
Localisation

Protein: TP53

LocalisationReference
ER HPRD
Nucleus HPRD
Mitochondrion HPRD
Nucleolus HPRD
Cytoplasm HPRD

Protein: DUSP1

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between TP53 and DUSP1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TP53 andDUSP1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TP53 has 1099 interactors and DUSP1 has 1224 interactors of which there are 690 common interactors.

Common InteractorName of Common InteractorScore for TP53-Interactor (?)Score for DUSP1-Interactor (?)
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 2.54 0.129
HIST1H1E HIST1H1E, H1F4: Histone H1.4 2.08 0.038
SMAD4 SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4 1.58 0.0425
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.964 0.100
NR4A2 NR4A2, NOT, NURR1, TINUR: Orphan nuclear receptor NR4A2 0.902 0.046
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.704 0.029
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.704 0.038
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.651 0.052
SP100 N/A 0.525 0.052
NBN NBN, NBS, NBS1, P95: Nibrin 0.430 0.032
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.430 0.032
ZNF318 ZNF318, HRIHFB2436: Zinc finger protein 318 0.430 0.026
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.430 0.055
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.430 0.0425
DDX21 DDX21: Nucleolar RNA helicase 2 0.430 0.0425
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.385 0.029
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.385 0.038
CCNB1 Cyclin B1 0.385 0.088
SP3 SP3: Transcription factor Sp3 0.347 0.038
SRF SRF: Serum response factor 0.344 0.029
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.304 0.041
EIF3S6 EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6 0.304 0.027
DAXX DAXX, BING2, DAP6: Death domain-associated protein 6 0.290 0.032
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.276 0.032
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.276 0.029
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.276 0.032
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.276 0.029
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.260 0.0425
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.260 0.026
EP300 N/A 0.254 0.070
GGCX GGCX, GC: Vitamin K-dependent gamma-carboxylase 0.254 0.032
SUZ12 SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12 0.233 0.032
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.233 0.032
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.233 0.032
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.233 0.139
YY1 YY1: Transcriptional repressor protein YY1 0.233 0.063
SAFB SAFB, HAP, HET, SAFB1: Scaffold attachment factor B 0.233 0.0425
ZNF76 ZNF76, D6S229E: Zinc finger protein 76 0.216 0.029
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.216 0.307
BAZ2A BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A 0.210 0.032
RB1 RB1: Retinoblastoma-associated protein 0.210 0.096
ELF1 ELF1: ETS-related transcription factor Elf-1 0.210 0.070
MATR3 MATR3, KIAA0723: Matrin-3 0.210 0.026
HIF1A HIF1A, MOP1: Hypoxia-inducible factor 1 alpha 0.208 0.038
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.188 0.063
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.188 0.114
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.188 0.086
MRE11A MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A 0.188 0.029
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.188 0.032
ACIN1 ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus 0.188 0.032
AKAP8 AKAP8, AKAP95: A-kinase anchor protein 8 0.188 0.038
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.188 0.114
CXorf9 N/A 0.188 0.372
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.188 0.052
ZNF217 ZNF217, ZABC1: Zinc finger protein 217 0.188 0.029
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.187 0.148
CEBPB CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta 0.172 0.276
TP73 TP73, P73: Tumor protein p73 0.156 0.098
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.156 0.0425
ZNF148 ZNF148, ZBP89: Zinc finger protein 148 0.155 0.052
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.155 0.307
ZNF267 ZNF267: Zinc finger protein 267 0.155 0.026
ERF ERF: ETS domain-containing transcription factor ERF 0.155 0.026
XRCC1 XRCC1: DNA-repair protein XRCC1 0.155 0.032
MITF MITF: Microphthalmia-associated transcription factor 0.152 0.028
AR AR, DHTR, NR3C4: Androgen receptor 0.152 0.028
ARNT ARNT: Aryl hydrocarbon receptor nuclear translocator 0.152 0.028
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.152 0.028
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.146 0.0425
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.146 0.046
ABCF1 N/A 0.144 0.026
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.144 0.032
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.144 0.152
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.144 0.026
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.144 0.032
PTMA N/A 0.144 0.0425
SAT SAT1, SAT: Diamine acetyltransferase 1 0.140 0.087
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.139 0.114
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.139 0.026
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.139 0.029
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.139 0.078
COPE COPE: Coatomer subunit epsilon 0.139 0.052
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 0.139 0.046
RELA RELA, NFKB3: Transcription factor p65 0.139 0.038
KIAA1012 KIAA1012: Protein TRS85 homolog 0.139 0.070
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.139 0.070
NCOA3 NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3 0.137 0.028
CDC25C CDC25C: M-phase inducer phosphatase 3 0.137 0.025
LMNA LMNA, LMN1: Lamin-A/C 0.137 0.025
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.137 0.025
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.137 0.025
IRF3 IRF3: Interferon regulatory factor 3 0.132 0.0425
CDK4 CDK4: Cell division protein kinase 4 0.129 0.097
ZNF330 ZNF330, NOA36: Zinc finger protein 330 0.129 0.032
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.129 0.136
APEX1 APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase 0.129 0.032
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.129 0.032
SNRPB2 SNRPB2: U2 small nuclear ribonucleoprotein B'' 0.129 0.029
HDAC3 HDAC3: Histone deacetylase 3 0.129 0.0425
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.129 0.225
CBX3 CBX3: Chromobox protein homolog 3 0.129 0.032
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.129 0.029
CSPG6 SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3 0.129 0.029
PABPC4 PABPC4, APP1, PABP4: Polyadenylate-binding protein 4 0.129 0.029
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 0.129 0.029
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.129 0.088
ZNF335 ZNF335: Zinc finger protein 335 0.127 0.032
ZFX ZFX: Zinc finger X-chromosomal protein 0.127 0.026
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.118 0.071
KLF13 KLF13, BTEB3, NSLP1: Krueppel-like factor 13 0.114 0.046
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.114 0.029
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.114 0.054
ETS1 ETS1, EWSR2: Protein C-ets-1 0.114 0.029
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.114 0.0425
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.114 0.146
AKAP8L AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like 0.114 0.026
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.114 0.275
CCNH CCNH: Cyclin-H 0.114 0.111
ZNF24 ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24 0.114 0.038
MTF1 MTF1: Metal regulatory transcription factor 1 0.114 0.078
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.114 0.191
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.114 0.461
AIP AIP, XAP2: AH receptor-interacting protein 0.114 0.029
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.114 0.046
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.114 0.225
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.114 0.781
CSK CSK: Tyrosine-protein kinase CSK 0.112 0.181
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.112 0.274
KPNA2 KPNA2, RCH1, SRP1: Importin subunit alpha-2 0.111 0.029
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.111 0.340
STAT6 STAT6: Signal transducer and activator of transcription 6 0.111 0.503
HDAC4 HDAC4, KIAA0288: Histone deacetylase 4 0.102 0.038
GTF2F2 N/A 0.0971 0.026
STAT2 STAT2: Signal transducer and activator of transcription 2 0.096 0.191
NFATC1 N/A 0.096 0.0425
EEA1 EEA1, ZFYVE2: Early endosome antigen 1 0.096 0.0425
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.096 0.416
TCF7L2 N/A 0.090 0.032
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.087 0.109
GNB2L1 Lung cancer oncogene 7 0.087 0.052
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.087 0.070
NCOA3 N/A 0.087 0.052
SET SET: Protein SET 0.087 0.026
RBM14 RBM14, SIP: RNA-binding protein 14 0.087 0.0425
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.087 0.026
IFI16 N/A 0.087 0.052
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.087 0.0425
TGIF2 TGIF2: Homeobox protein TGIF2 0.087 0.032
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.087 0.0425
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.087 0.032
SMAD3 SMAD3, MADH3: Mothers against decapentaplegic homolog 3 0.087 0.038
SOX4 SOX4: Transcription factor SOX-4 0.086 0.026
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.086 0.127
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 0.086 0.063
BRPF1 BRPF1, BR140: Peregrin 0.086 0.046
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.086 115.00
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.086 0.046
CCND1 CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1 0.086 0.097
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.086 0.070
CREBBP CREBBP, CBP: CREB-binding protein 0.086 0.038
DNAJC7 DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7 0.086 0.026
ATM ATM: Serine-protein kinase ATM 0.086 0.191
GHR GHR: Growth hormone receptor precursor 0.085 0.045
PPEF1 N/A 0.083 0.028
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 1.30
POGZ POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain 0.083 0.028
MAPK15 N/A 0.083 1.30
C20orf18 N/A 0.083 0.028
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.083 0.028
ZNF644 ZNF644, KIAA1221, ZEP2: Zinc finger protein 644 0.083 0.028
UHRF1 0.083 0.028
ZHX1 ZHX1: Zinc fingers and homeoboxes protein 1 0.083 0.028
EEF2K EEF2K: Elongation factor 2 kinase 0.083 0.165
ZFP91 ZFP91, FKSG11: Zinc finger protein 91 homolog 0.083 0.028
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.083 0.028
MLL2 MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2 0.083 0.028
ZNF579 ZNF579: Zinc finger protein 579 0.083 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.083 0.028
ZNF295 ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295 0.083 0.028
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.083 0.028
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.083 0.028
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.0818 0.027
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.081 0.088
H1FX H1FX: Histone H1x 0.080 0.070
SF3B4 SF3B4, SAP49: Splicing factor 3B subunit 4 0.078 0.038
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.078 0.063
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.078 0.038
FNBP1 N/A 0.078 0.114
WBSCR1 EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H 0.078 0.032
CDK2 CDK2: Cell division protein kinase 2 0.078 0.097
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.078 0.026
PABPC1 PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1 0.078 0.046
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.078 0.0425
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.078 0.038
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.078 0.029
TDG TDG: G/T mismatch-specific thymine DNA glycosylase 0.078 0.0425
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.078 0.029
SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 0.078 0.038
PAPOLA PAPOLA, PAP: Poly(A) polymerase alpha 0.078 0.046
ZCCHC8 ZCCHC8: Zinc finger CCHC domain-containing protein 8 0.078 0.0425
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.078 0.088
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.078 0.225
SFRS4 SFRS4, SRP75: Splicing factor, arginine/serine-rich 4 0.078 0.038
CDK7 CDK7, MO15: Cell division protein kinase 7 0.078 0.111
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.078 0.372
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.078 0.191
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.078 0.029
YEATS2 KIAA1197, YEATS2: YEATS domain-containing protein 2 0.078 0.026
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.078 0.046
TIAL1 TIAL1: Nucleolysin TIAR 0.078 0.029
ETS2 ETS2: Protein C-ets-2 0.077 0.155
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.077 0.109
REST REST, NRSF, XBR: RE1-silencing transcription factor 0.077 0.032
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.077 0.052
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.076 0.041
ZNF174 ZNF174, ZSCAN8: Zinc finger protein 174 0.075 0.025
RFFL RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin 0.075 0.025
BRD4 N/A 0.075 0.025
SOX8 SOX8: Transcription factor SOX-8 0.075 0.028
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.075 0.047
TRERF1 TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1 0.075 0.025
PRDM2 PRDM2, RIZ: PR domain zinc finger protein 2 0.075 0.025
GIT2 N/A 0.075 0.025
RBM10 RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10 0.075 0.028
DHX8 DHX8, DDX8: ATP-dependent RNA helicase DHX8 0.075 0.025
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.075 0.025
CCNT2 CCNT2: Cyclin-T2 0.075 0.148
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.075 0.047
OSR1 OSR1, ODD: Protein odd-skipped-related 1 0.075 0.028
RBL1 RBL1: Retinoblastoma-like protein 1 0.075 0.075
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.075 0.025
C14orf4 C14orf4, KIAA1865, My039: RING finger protein C14orf4 0.075 0.025
DDX20 DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20 0.075 0.028
ZFPM1 ZFPM1, FOG1: Zinc finger protein ZFPM1 0.075 0.028
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.075 0.047
RNF113A RNF113A, RNF113, ZNF183: RING finger protein 113A 0.075 0.025
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.075 0.165
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.075 0.148
RNF20 0.075 0.028
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.074 0.126
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.071 0.031
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.070 0.191
WDR1 N/A 0.070 0.052
PLEK PLEK, P47: Pleckstrin 0.070 0.132
STK16 N/A 0.070 0.123
KIAA0853 N/A 0.070 0.0425
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.070 0.032
API5 N/A 0.070 0.026
MYBBP1A MYBBP1A, P160: Myb-binding protein 1A 0.070 0.026
IKBKG IKBKG, FIP3, NEMO: NF-kappa-B essential modulator 0.070 0.070
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.070 0.032
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.069 0.114
TCF8 ZEB1, AREB6, TCF8: Zinc finger E-box-binding homeobox 1 0.069 0.070
FOS FOS, G0S7: Proto-oncogene protein c-fos 0.069 0.827
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.067 0.148
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.067 0.166
SYK SYK: Tyrosine-protein kinase SYK 0.067 0.340
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.066 0.033
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.063 0.029
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.063 0.0425
CORO1C CORO1C, CRNN4: Coronin-1C 0.063 0.046
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.063 0.046
PPP1R8 N/A 0.063 0.0425
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.063 0.038
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.063 0.038
RPS6KB1 N/A 0.063 0.225
SEC31L1 N/A 0.063 0.038
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.063 0.139
WBSCR20A N/A 0.063 0.029
PHF10 N/A 0.063 0.0425
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.063 0.123
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.063 0.191
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.063 0.063
SND1 SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1 0.063 0.032
EIF3S4 EIF3S4: Eukaryotic translation initiation factor 3 subunit 4 0.063 0.063
CPSF1 CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1 0.063 0.038
MYH9 MYH9: Myosin-9 0.063 0.087
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.063 0.0308
DDX51 DDX51: ATP-dependent RNA helicase DDX51 0.063 0.038
COPB2 COPB2: Coatomer subunit beta' 0.063 0.029
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.063 0.098
COPA COPA: Coatomer subunit alpha 0.063 0.046
TAF10 TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10 0.063 0.052
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.063 0.046
NCOR1 NCOR1, KIAA1047: Nuclear receptor corepressor 1 0.063 0.029
WEE1 WEE1: Wee1-like protein kinase 0.063 0.098
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.063 0.307
CRLF3 N/A 0.063 0.173
SH3BP3 0.062 0.0425
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.062 0.030
LYN LYN: Tyrosine-protein kinase Lyn 0.061 0.561
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.061 0.100
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.061 0.081
FOXO1A FOXO1A, FKHR: Forkhead box protein O1A 0.060 0.029
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.060 0.0425
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.057 0.202
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.057 0.041
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.056 0.225
FOSL2 FOSL2, FRA2: Fos-related antigen 2 0.056 0.046
SP1 SP1, TSFP1: Transcription factor Sp1 0.056 0.029
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.056 0.097
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.056 0.111
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.0554 0.032
STAT4 STAT4: Signal transducer and activator of transcription 4 0.055 0.123
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.055 0.109
SOS1 SOS1: Son of sevenless homolog 1 0.054 0.171
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.052 0.028
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.052 0.028
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.052 0.032
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.052 0.055
CHUK N/A 0.052 0.032
AFF1 N/A 0.052 0.026
TOP2B N/A 0.052 0.026
FNBP4 FNBP4, FBP30, KIAA1014: Formin-binding protein 4 0.052 0.032
EMD EMD, EDMD, STA: Emerin 0.052 0.026
ARFGAP1 N/A 0.052 0.0425
ROCK1 ROCK1: Rho-associated protein kinase 1 0.052 0.251
JMJD1A JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr 0.052 0.026
PHF3 PHF3, KIAA0244: PHD finger protein 3 0.052 0.0425
ZNF638 ZNF638, NP220, ZFML: Zinc finger protein 638 0.052 0.026
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.052 0.026
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.052 0.032
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.052 0.052
JAK1 0.051 0.202
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.051 0.655
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.051 0.503
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.980
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.049 0.109
STAT3 0.049 0.109
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.980
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.049 0.171
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.049 38.50
RXRA RXRA, NR2B1: Retinoic acid receptor RXR-alpha 0.048 0.144
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.048 0.152
FARSLA FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain 0.047 0.025
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.047 0.148
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.047 0.025
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.047 0.025
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.047 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.047 0.025
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.046 0.251
SAPS3 N/A 0.046 0.038
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.046 0.225
SYMPK SYMPK, SPK: Symplekin 0.046 0.077
CUL5 CUL5, VACM1: Cullin-5 0.046 0.0425
SFRS6 SFRS6, SRP55: Splicing factor, arginine/serine-rich 6 0.046 0.052
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.046 0.416
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.046 0.098
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.046 0.098
FZR1 N/A 0.046 0.029
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.046 0.097
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.046 0.046
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.046 0.276
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.046 0.275
USP34 USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34 0.046 0.0425
CSTF2T CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant 0.046 0.029
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.046 0.078
TOPORS TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors 0.046 0.032
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.046 0.225
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.046 0.046
DIAPH1 Diaphanous 1 0.046 0.063
JARID1A JARID1A, RBBP2, RBP2: Histone demethylase JARID1A 0.046 0.063
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.046 0.191
DOK1 DOK1: Docking protein 1 0.046 0.461
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.046 0.063
KLHDC4 N/A 0.046 0.038
DUSP22 DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22 0.046 0.0425
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.046 0.372
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.046 0.225
CUL4B N/A 0.046 0.029
GSK3B N/A 0.046 0.063
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.046 0.416
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0453 0.074
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.0446 0.100
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.111
EGR1 EGR1, ZNF225: Early growth response protein 1 0.044 0.038
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.044 0.048
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.044 0.098
HIST3H3 HIST3H3, H3FT: Histone H3.1t 0.043 0.063
VDR VDR, NR1I1: Vitamin D3 receptor 0.043 0.046
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.043 0.029
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.0425 0.191
RFXDC2 RFXDC2: Regulatory factor X domain-containing protein 2. 0.0425 0.032
XRCC4 N/A 0.0425 0.026
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.0425 0.0425
CDKN1A CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1: Cyclin-dependent kinase inhi 0.0425 0.026
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.0425 0.515
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.0425 0.0425
SMARCC2 N/A 0.0425 0.026
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.0425 0.052
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0425 0.307
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.0425 0.132
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.0425 0.123
RBM6 RBM6, DEF3: RNA-binding protein 6 0.0425 0.026
RGS14 N/A 0.0425 0.052
MARK2 N/A 0.0425 0.087
COIL COIL, CLN80: Coilin 0.0425 0.026
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.041 1.07
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.04 0.109
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.04 0.109
LCP1 LCP1, PLS2: Plastin-2 0.040 0.111
ACTR3 ACTR3, ARP3: Actin-related protein 3 0.040 0.111
CD2AP CD2AP: CD2-associated protein 0.040 0.041
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.040 0.064
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.040 0.032
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.040 0.032
XPO1 XPO1, CRM1: Exportin-1 0.040 0.051
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.039 0.152
SORL1 SORL1: Sortilin-related receptor precursor 0.039 0.114
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.039 0.105
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.038 0.372
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.038 0.515
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.038 0.225
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.038 0.078
RBM8A RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A 0.038 0.052
SPEN SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein 0.038 0.032
ARID3A ARID3A, DRIL1, DRIL3, DRX, E2FBP1: AT-rich interactive domain-containing protein 0.038 0.038
MEF2D MEF2D: Myocyte-specific enhancer factor 2D 0.038 0.038
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.038 0.136
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.038 0.225
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.038 0.060
STK10 STK10: Uncharacterized protein STK10 0.038 0.416
MAFG MAFG: Transcription factor MafG 0.038 0.038
FKBP1A FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A 0.038 0.029
SIRT1 SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1 0.038 0.029
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.038 0.275
RREB1 RREB1, FINB: RAS-responsive element-binding protein 1 0.038 0.052
SFRS5 SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5 0.038 0.063
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.037 0.072
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.037 0.058
SRPR SRPR: Uncharacterized protein SRPR 0.036 0.027
HD HD, IT15: Huntingtin 0.036 0.057
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.036 0.074
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.036 0.037
LIMS1 N/A 0.036 0.036
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.036 0.091
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.036 0.032
IFI35 N/A 0.036 0.036
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.036 0.109
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.036 0.098
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.036 0.109
SCML2 SCML2: Sex comb on midleg-like protein 2 0.034 0.110
FN1 N/A 0.034 0.0688
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.034 0.034
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.034 0.0688
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.034 0.0688
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.034 0.0688
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.034 0.0688
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.034 0.0688
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.034 0.0688
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.034 0.0688
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.034 0.062
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.034 0.030
YWHAG YWHAG: 14-3-3 protein gamma 0.0333 0.109
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.033 0.064
HCK N/A 0.033 1.07
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.033 0.090
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.032 0.0727
BACH1 BACH1: Transcription regulator protein BACH1 0.032 0.070
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.032 0.087
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.032 0.251
ID2 ID2: DNA-binding protein inhibitor ID-2 0.032 0.070
STRN3 STRN3, GS2NA, SG2NA: Striatin-3 0.032 0.032
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.251
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.032 0.191
VIM VIM: Vimentin 0.032 0.070
TERF1 TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1 0.032 0.026
SFRS15 SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15 0.032 0.032
GTF3C1 N/A 0.032 0.032
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.032 0.251
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.032 0.048
AHR AHR: Aryl hydrocarbon receptor precursor 0.032 0.087
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.032 0.251
ARHGDIB ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2 0.032 0.040
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.032 0.0453
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.032 0.066
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.032 0.113
EEF1G EEF1G, EF1G, PRO1608: Elongation factor 1-gamma 0.032 0.054
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.032 0.245
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.032 0.227
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.032 0.046
ACTG1 ACTB: Actin, cytoplasmic 1 0.032 0.137
FLII FLII, FLIL: Protein flightless-1 homolog 0.032 0.0446
CRKL CRKL: Crk-like protein 0.032 0.090
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.032 0.253
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.031 0.063
EPOR EPOR: Erythropoietin receptor precursor 0.031 0.051
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.031 0.051
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.031 0.041
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.031 0.063
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.031 0.100
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.030 0.062
CNTN4 CNTN4: Contactin-4 precursor 0.030 0.062
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.030 0.062
CNTN1 CNTN1: Contactin-1 precursor 0.030 0.062
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.030 0.062
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.030 0.062
NFE2L2 NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2 0.029 0.029
JUND JUND: Transcription factor jun-D 0.029 0.144
EML4 EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4 0.029 0.029
ATF6 ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha 0.029 0.038
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.111
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.029 0.171
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.029 0.029
RUNX1 N/A 0.029 0.038
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.225
WDR44 WDR44: WD repeat-containing protein 44 0.029 0.052
JUNB JUNB: Transcription factor jun-B 0.029 0.827
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.029 0.171
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.029 0.191
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.171
BID BID: BH3-interacting domain death agonist 0.028 0.028
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.165
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.028 0.165
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.028 0.028
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.028 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.028 0.148
KIAA1443 HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez 0.028 0.028
SYTL4 Endocrine transmitter regulatory protein 0.028 0.028
NF2 NF2, SCH: Merlin 0.028 0.165
HES6 HES6: Transcription cofactor HES-6 0.028 0.028
ZNF265 N/A 0.028 0.028
PTBP1 PTBP1: Polypyrimidine tract binding protein 1 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.028 0.165
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.028 0.165
DKFZp434K1815 DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815 0.028 0.028
LOC642558 FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1 0.028 0.028
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.028 0.056
ZCCHC3 ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3 0.028 0.028
MLL4 WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7 0.028 0.028
RAVER1 RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1 0.028 0.028
ATXN2L ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
ILF3 ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3 0.028 0.028
CUTL1 CUTL1: Homeobox protein cut-like 1 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
C13orf8 N/A 0.028 0.028
DUSP15 N/A 0.028 0.028
RAB4A N/A 0.028 0.028
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.165
PHLDB2 N/A 0.028 0.028
NSBP1 NSBP1: Nucleosome-binding protein 1 0.028 0.028
HNRPC HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2 0.028 0.028
IRF7 N/A 0.028 0.028
WDR54 N/A 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
TCF20 TCF20, KIAA0292, SPBP: Transcription factor 20 0.028 0.028
CBFA2T2 CBFA2T2, EHT, MTGR1: Protein CBFA2T2 0.028 0.028
TMPO TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha 0.028 0.028
KIF1B N/A 0.028 0.028
HDAC8 N/A 0.028 0.028
JDP2 jdp2, JDP2: Jun dimerization protein 2 0.028 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.028 0.165
NES N/A 0.028 0.025
SNRPB N/A 0.028 0.028
FLJ21816 PALB2, FANCN: Partner and localizer of BRCA2 0.028 0.028
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.028 0.165
NIPA1 NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1 0.028 0.028
MAPKAPK5 N/A 0.028 0.165
TFAP4 TFAP4: Transcription factor AP-4 0.028 0.028
CDC2 CDC2: Cell division control protein 2 homolog 0.028 0.165
CORO6 N/A 0.028 0.028
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.028 0.165
FLJ23436 N/A 0.028 0.025
DSP DSP: Desmoplakin 0.028 0.052
ZC3HAV1 ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1 0.028 0.028
CABLES1 N/A 0.028 0.028
HDAC7A N/A 0.028 0.028
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
NFIA NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A 0.028 0.028
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.028 0.046
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.027 0.090
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.027 0.064
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.027 0.100
GSTP1 GSTP1, FAEES3, GST3: Glutathione S-transferase P 0.027 0.037
VAV2 VAV2, RP11-153P4.1-003: Vav 2 oncogene 0.027 0.027
MPG N/A 0.027 0.027
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.027 0.036
YWHAQ YWHAQ: 14-3-3 protein theta 0.027 0.081
BMX N/A 0.0263 0.065
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.026 0.098
PRKAA1 N/A 0.026 0.123
PHF8 PHF8, KIAA1111, ZNF422: PHD finger protein 8 0.026 0.026
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.026 0.152
MEF2A N/A 0.026 0.0425
NUP214 N/A 0.026 0.087
ZFP36 ZFP36, G0S24, RNF162A, TIS11A, TTP: Tristetraproline 0.026 0.923
FAM65A FAM65A, KIAA1930: Protein FAM65A 0.026 0.026
AGTPBP1 AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein 0.026 0.070
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.026 0.098
ITGB4 N/A 0.025 0.045
IL9R IL9R: Interleukin-9 receptor precursor 0.025 0.041
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.025 0.063
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.025 0.063
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.025 0.165
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.025 0.165
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
SON 0.025 0.028
EDF1 EDF1: Endothelial differentiation-related factor 1 0.025 0.025
PHF16 PHF16, JADE3, KIAA0215: Protein Jade-3 0.025 0.025
PSIP1 PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein 0.025 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.025
HNRPUL1 HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1 0.025 0.025
MAP2K3 N/A 0.025 0.025
HNRPD HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0 0.025 0.025
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.025 0.148
NHN1 NHN1: Conserved nuclear protein NHN1 0.025 0.028
NSUN2 NSUN2, SAKI, TRM4: tRNA 0.025 0.025
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.025 0.165
BCOR N/A 0.025 0.025
CAMKK1 N/A 0.025 0.025
BUB3 BUB3: Mitotic checkpoint protein BUB3 0.025 0.028
GEMIN5 GEMIN5: Gem-associated protein 5 0.025 0.028
DLX3 DLX3: Homeobox protein DLX-3 0.025 0.025
SSBP4 SSBP4: Single-stranded DNA-binding protein 4 0.025 0.025
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.025 0.025
KCTD1 0.025 0.025
MAPK8IP3 N/A 0.025 0.028
MAX MAX: Protein max 0.025 0.028
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.025 0.165
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.047
MSL3L1 MSL3L1: Male-specific lethal 3-like 1 0.025 0.028
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.025
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.025 0.148
SMARCA2 SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2 0.025 0.025
MLXIPL MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein 0.025 0.025
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.025 0.148
PRKCB1 N/A 0.025 0.025
CREB1 CREB1: cAMP response element-binding protein 0.025 0.025
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.025 0.148
NFYA NFYA: Nuclear transcription factor Y subunit alpha 0.025 0.028
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.025 0.165
ARID4A ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A 0.025 0.025
FLJ40432 FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227 0.025 0.028
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.025 0.028
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.025 0.148
PURB PURB: Transcriptional activator protein Pur-beta 0.025 0.025
NEDD4 NEDD4: Uncharacterized protein NEDD4 0.025 0.025
REXO1 REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog 0.025 0.025
NUP98 N/A 0.025 0.025
RBBP6 RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6 0.025 0.025
SEC13L1 N/A 0.025 0.025
NIPBL N/A 0.025 0.075
SAP14 SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14 0.025 0.028
POLR1C POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1 0.025 0.025
HNRPA2B1 HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1 0.025 0.025
MIER1 MIER1, KIAA1610: Mesoderm induction early response protein 1 0.025 0.025
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.028
ATXN2L N/A 0.025 0.028
ELMO1 N/A 0.025 0.047
HEXIM2 HEXIM2, L3: Protein HEXIM2 0.025 0.025
HOXA10 HOXA10, HOX1H: Homeobox protein Hox-A10 0.025 0.025
SYAP1 SYAP1, PRO3113: Synapse-associated protein 1 0.025 0.028
GRK6 N/A 0.025 0.028
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.028
C20orf77 N/A 0.025 0.025
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.025 0.148
ADK ADK: Adenosine kinase 0.025 0.025
TAL2 TAL2: T-cell acute lymphocytic leukemia protein 2 0.025 0.025
HIST3H2A HIST3H2A: Histone H2A type 3 0.025 0.025
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.025 0.148
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.025 0.075
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.025 0.165
ZNF598 ZNF598: Zinc finger protein 598 0.025 0.028
TIA1 TIA1: Nucleolysin TIA-1 isoform p40 0.025 0.025
SETD3 SETD3, C14orf154: SET domain-containing protein 3 0.025 0.028
FAF1 FAF1, CGI-03: FAS-associated factor 1 0.025 0.025
CAMK2A N/A 0.025 0.025
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.025 0.148
GATAD2B GATAD2B, KIAA1150: Transcriptional repressor p66 beta 0.025 0.028
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
HTATIP N/A 0.025 0.025
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.028
DIDO1 N/A 0.025 0.025
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
SFRS9 SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9 0.025 0.025
WWTR1 WWTR1, TAZ: WW domain-containing transcription regulator protein 1 0.025 0.025
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
HNRPM HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M 0.025 0.028
SMN2 SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein 0.025 0.025
TCEA1 N/A 0.025 0.025
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.025 0.165
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.025 0.148
IWS1 IWS1, IWS1L: IWS1 homolog 0.025 0.025
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.025 0.148
MKI67IP MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein 0.025 0.025
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.025 0.148
0.347
Total Score 9.55