PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between TP53 and MAP2K2

The interaction score between TP53 and MAP2K2 is 3.85.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between TP53 and MAP2K2 = 0.52

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

6.27E-3

Orthology

Organism	TP53 Orthologue		MAP2K2 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
human	IPI00215713	0.16	IPI00219604	0.702
fly	Q8IH92	0.16	Q24324	0.5

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3

Domains

Domains present in TP53 and MAP2K2:

Domains in TP53

Domains in MAP2K2

IPR008967	p53-like transcription factor, DNA-binding
IPR002117	p53 tumor antigen
IPR010991	p53, tetramerisation
IPR011615	P53_DNA_bd.
IPR012346	P53_RUNT_DNA_bd.

IPR000719	Protein kinase
IPR002290	Serine/threonine protein kinase
IPR011009	Protein kinase-like
IPR008271	Serine/threonine protein kinase, active site

The Chi square scores for co-occurrence of domains that are present in TP53 and MAP2K2 are listed below.

Domain 1		Domain 2		Chi Square
IPR012346	P53_RUNT_DNA_bd.	IPR008271	Serine/threonine protein kinase, active site	4.60701
IPR011615	P53_DNA_bd.	IPR008271	Serine/threonine protein kinase, active site	4.60701
IPR010991	p53, tetramerisation	IPR008271	Serine/threonine protein kinase, active site	4.60701
IPR002117	p53 tumor antigen	IPR008271	Serine/threonine protein kinase, active site	4.60701
IPR011615	P53_DNA_bd.	IPR002290	Serine/threonine protein kinase	3.23646
IPR010991	p53, tetramerisation	IPR002290	Serine/threonine protein kinase	3.23646
IPR002117	p53 tumor antigen	IPR002290	Serine/threonine protein kinase	3.23646
IPR012346	P53_RUNT_DNA_bd.	IPR002290	Serine/threonine protein kinase	3.23646
IPR008967	p53-like transcription factor, DNA-binding	IPR002290	Serine/threonine protein kinase	1.43889
IPR008967	p53-like transcription factor, DNA-binding	IPR008271	Serine/threonine protein kinase, active site	0.974716
IPR008967	p53-like transcription factor, DNA-binding	IPR000719	Protein kinase	0.163761
IPR002117	p53 tumor antigen	IPR011009	Protein kinase-like	0.00633063
IPR010991	p53, tetramerisation	IPR011009	Protein kinase-like	0.00633063
IPR011615	P53_DNA_bd.	IPR011009	Protein kinase-like	0.00633063
IPR012346	P53_RUNT_DNA_bd.	IPR011009	Protein kinase-like	0.00633063
IPR008967	p53-like transcription factor, DNA-binding	IPR011009	Protein kinase-like	0.00476462
IPR012346	P53_RUNT_DNA_bd.	IPR000719	Protein kinase	0.000322699
IPR011615	P53_DNA_bd.	IPR000719	Protein kinase	0.000322699
IPR010991	p53, tetramerisation	IPR000719	Protein kinase	0.000322699
IPR002117	p53 tumor antigen	IPR000719	Protein kinase	0.000322699

The background colour of the table refers to:

Blue Domain is only present in TP53
Yellow Domain is only present in MAP2K2
Green Domain is present in both TP53 and MAP2K2

0.014

Post-translational Modifications

Protein: TP53

PTM	Residue	Reference
Acetylation	305	PubMed, HPRD
Acetylation	320	PubMed, HPRD
Acetylation	370	PubMed, HPRD
Acetylation	372	PubMed, HPRD
Acetylation	373	PubMed, HPRD
Acetylation	381	PubMed, HPRD
Acetylation	382	PubMed, HPRD
Deacylation	382	PubMed, HPRD
Dephosphorylation	315	PubMed, HPRD
N6-acetyllysine	305	HPRD
N6-acetyllysine	373	HPRD
N6-acetyllysine	382	HPRD
Phosphorylation	6	PubMed, HPRD
Phosphorylation	9	PubMed, HPRD
Phosphorylation	15	PubMed, HPRD
Phosphorylation	18	PubMed, HPRD
Phosphorylation	20	PubMed, HPRD
Phosphorylation	33	PubMed, HPRD
Phosphorylation	37	PubMed, HPRD
Phosphorylation	46	PubMed, HPRD
Phosphorylation	55	PubMed, HPRD
Phosphorylation	81	PubMed, HPRD
Phosphorylation	155	PubMed, HPRD
Phosphorylation	315	PubMed, HPRD
Phosphorylation	366	PubMed, HPRD
Phosphorylation	371	PubMed, HPRD
Phosphorylation	378	PubMed, HPRD
Phosphorylation	392	PubMed, HPRD
Phosphoserine	15	PubMed, HPRD
Phosphoserine	46	PubMed, HPRD
Phosphoserine	315	PubMed, HPRD
Phosphothreonine	18	PubMed, HPRD
Phosphothreonine	55	PubMed, HPRD
Proteolytic Cleavage	18	PubMed, HPRD
Proteolytic Cleavage	20	PubMed, HPRD
Proteolytic Cleavage	23	PubMed, HPRD
Sumoylation	386	PubMed, HPRD
Ubiquitination	351	PubMed, HPRD
Ubiquitination	357	PubMed, HPRD
Ubiquitination	370	PubMed, HPRD
Ubiquitination	372	PubMed, HPRD
Ubiquitination	373	PubMed, HPRD
Ubiquitination	381	PubMed, HPRD
Ubiquitination	382	PubMed, HPRD
Ubiquitination	386	PubMed, HPRD

Protein: MAP2K2

PTM	Residue	Reference
Dephosphorylation	244	PubMed, HPRD
Phosphorylation	394	PubMed, HPRD
Phosphothreonine	394	HPRD

Localisation

Protein: TP53

Localisation	Reference
ER	HPRD
Nucleus	HPRD
Mitochondrion	HPRD
Nucleolus	HPRD
Cytoplasm	HPRD

Protein: MAP2K2

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between TP53 and MAP2K2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TP53 andMAP2K2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TP53 has 1099 interactors and MAP2K2 has 1492 interactors of which there are 692 common interactors.

Common Interactor	Name of Common Interactor	Score for TP53-Interactor (?)	Score for MAP2K2-Interactor (?)
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	4.77	0.070
H2AFX	H2AFX, H2AX: Histone H2A.x	4.27	0.032
H3F3A	H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3	2.54	0.032
HIST1H1E	HIST1H1E, H1F4: Histone H1.4	2.08	0.067
HIST1H1B	HIST1H1B, H1F5: Histone H1.5	1.26	0.033
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.964	0.0554
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.822	0.040
KHDRBS1	KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate	0.704	0.425
HDAC1	HDAC1, RPD3L1: Histone deacetylase 1	0.704	0.040
PCNA	PCNA: Proliferating cell nuclear antigen	0.704	0.032
NR3C1	NR3C1, GRL: Glucocorticoid receptor	0.651	0.027
STIP1	STIP1: Stress-induced-phosphoprotein 1	0.541	0.052
SP100	N/A	0.525	0.027
MCM3	MCM3: DNA replication licensing factor MCM3	0.515	0.090
PSMD11	PSMD11: 26S proteasome non-ATPase regulatory subunit 11	0.503	0.063
EIF3S8	EIF3S8: Eukaryotic translation initiation factor 3 subunit 8	0.503	0.129
SREBF2	N/A	0.475	0.036
NBN	NBN, NBS, NBS1, P95: Nibrin	0.430	0.125
TRIM28	TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta	0.430	0.0446
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.430	0.0446
ZNF318	ZNF318, HRIHFB2436: Zinc finger protein 318	0.430	0.027
PRKDC	PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit	0.430	0.210
XRCC6	XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1	0.430	0.074
TOP2A	TOP2A, TOP2: DNA topoisomerase 2-alpha	0.430	0.124
DDX21	DDX21: Nucleolar RNA helicase 2	0.430	0.036
TUBA1	TUBA4A, TUBA1: Tubulin alpha-4A chain	0.425	0.090
HMGB2	HMGB2, HMG2: High mobility group protein B2	0.385	0.040
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	0.385	0.040
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.385	0.032
CCNB1	Cyclin B1	0.385	0.181
SP3	SP3: Transcription factor Sp3	0.347	0.032
HSF2	HSF2, HSTF2: Heat shock factor protein 2	0.318	0.051
PSMC2	PSMC2, MSS1: 26S protease regulatory subunit 7	0.304	0.078
EIF3S6	EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6	0.304	0.063
DAXX	DAXX, BING2, DAP6: Death domain-associated protein 6	0.290	0.111
HSF1	HSF1, HSTF1: Heat shock factor protein 1	0.284	0.111
ELAVL1	ELAVL1, HUR: ELAV-like protein 1	0.276	0.066
SYNCRIP	SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q	0.276	0.040
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	0.276	0.040
HNRPF	HNRPF: Heterogeneous nuclear ribonucleoprotein F	0.276	0.040
LMNB1	LMNB1, LMN2, LMNB: Lamin-B1	0.276	0.032
SMC1L1	SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos	0.276	0.032
CENPA	CENPA: Histone H3-like centromeric protein A	0.269	0.027
BAZ1B	BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain	0.260	0.036
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.260	0.0446
UBTF	UBTF, UBF, UBF1: Nucleolar transcription factor 1	0.260	0.036
HSP90AB1	HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta	0.253	0.155
COPS3	COPS3, CSN3: COP9 signalosome complex subunit 3	0.245	0.078
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.241	0.040
MCM2	MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2	0.241	0.090
MCM4	MCM4, CDC21: DNA replication licensing factor MCM4	0.241	0.032
SUZ12	SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12	0.233	0.040
TOPBP1	TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1	0.233	0.032
ANAPC5	ANAPC5, APC5: Anaphase-promoting complex subunit 5	0.233	0.078
PTEN	PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du	0.233	0.372
YY1	YY1: Transcriptional repressor protein YY1	0.233	0.066
SAFB	SAFB, HAP, HET, SAFB1: Scaffold attachment factor B	0.233	0.040
MLH1	MLH1, COCA2: DNA mismatch repair protein Mlh1	0.227	0.233
NFKBIA	NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha	0.216	0.029
BAZ2A	BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A	0.210	0.032
RB1	RB1: Retinoblastoma-associated protein	0.210	0.124
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.210	0.0446
ELF1	ELF1: ETS-related transcription factor Elf-1	0.210	0.124
MATR3	MATR3, KIAA0723: Matrin-3	0.210	0.036
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.188	0.032
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.188	0.032
ATR	ATR, FRP1: Serine/threonine-protein kinase ATR	0.188	0.188
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.188	0.040
AKAP8	AKAP8, AKAP95: A-kinase anchor protein 8	0.188	0.040
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	0.188	0.111
CXorf9	N/A	0.188	0.139
STAT1	STAT1: Signal transducer and activator of transcription 1-alpha/beta	0.187	0.098
MYB	MYB: Myb proto-oncogene protein	0.176	0.075
CEBPB	CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta	0.172	0.041
CEBPE	CEBPE: CCAAT/enhancer-binding protein epsilon	0.172	0.033
TRAF2	TRAF2, TRAP3: TNF receptor-associated factor 2	0.162	0.210
CEBPA	CEBPA: CCAAT/enhancer-binding protein alpha	0.156	0.037
ZNF148	ZNF148, ZBP89: Zinc finger protein 148	0.155	0.027
PIK3CD	PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i	0.155	0.155
ZNF267	ZNF267: Zinc finger protein 267	0.155	0.027
ERF	ERF: ETS domain-containing transcription factor ERF	0.155	0.057
XRCC1	XRCC1: DNA-repair protein XRCC1	0.155	0.027
HMGA1	HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y	0.152	0.096
PSMD12	PSMD12: 26S proteasome non-ATPase regulatory subunit 12	0.148	0.027
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.146	0.066
YBX1	YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1	0.146	0.078
SMAD2	SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2	0.146	0.032
YARS	YARS: Tyrosyl-tRNA synthetase, cytoplasmic	0.146	0.032
PPP2CA	PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	0.145	0.038
ABCF1	N/A	0.144	0.087
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.144	0.087
MKI67	MKI67: Antigen KI-67	0.144	0.074
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.144	0.0971
HMGN1	HMGN1, HMG14: Non-histone chromosomal protein HMG-14	0.144	0.340
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	0.144	0.0446
ESPL1	N/A	0.144	0.052
PTMA	N/A	0.144	0.125
RRM2	RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2	0.141	0.046
EIF2S3	EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3	0.141	0.063
PSMA5	PSMA5: Proteasome subunit alpha type-5	0.141	0.461
G3BP	G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1	0.141	0.063
PSMA3	PSMA3, PSC8: Proteasome subunit alpha type-3	0.141	0.372
SAT	SAT1, SAT: Diamine acetyltransferase 1	0.140	0.032
ETV6	ETV6, TEL, TEL1: Transcription factor ETV6	0.139	0.067
FKBP5	FKBP5, AIG6, FKBP51: FK506-binding protein 5	0.139	0.038
SKIV2L	SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti	0.139	0.040
COPE	COPE: Coatomer subunit epsilon	0.139	0.078
BRD2	BRD2, KIAA9001, RING3: Bromodomain-containing protein 2	0.139	0.032
WRN	WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase	0.139	0.032
RELA	RELA, NFKB3: Transcription factor p65	0.139	0.0818
KIAA1012	KIAA1012: Protein TRS85 homolog	0.139	0.063
CDC23	CDC23: Cell division cycle protein 23 homolog	0.137	0.078
PPID	PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase	0.137	0.078
CDC25C	CDC25C: M-phase inducer phosphatase 3	0.137	0.148
EWSR1	EWSR1, EWS: RNA-binding protein EWS	0.137	0.030
HNRPH3	HNRPH3: Heterogeneous nuclear ribonucleoprotein H3	0.137	0.030
E2F1	E2F1, RBBP3: Transcription factor E2F1	0.132	0.036
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.132	0.096
IRF3	IRF3: Interferon regulatory factor 3	0.132	0.036
CDK4	CDK4: Cell division protein kinase 4	0.129	0.063
ZNF330	ZNF330, NOA36: Zinc finger protein 330	0.129	0.032
CSNK2A1	CSNK2A1: CSNK2A1 protein	0.129	0.078
APEX1	APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase	0.129	0.040
SFRS1	SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1	0.129	0.040
SNRPB2	SNRPB2: U2 small nuclear ribonucleoprotein B''	0.129	0.040
SNRPC	SNRPC: U1 small nuclear ribonucleoprotein C	0.129	0.040
MSH6	MSH6, GTBP: DNA mismatch repair protein MSH6	0.129	0.032
LSM2	LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2	0.129	0.040
HDAC3	HDAC3: Histone deacetylase 3	0.129	0.032
OXSR1	OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1	0.129	0.078
EIF3S2	EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2	0.129	0.032
EIF2S2	EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2	0.129	0.040
CBX3	CBX3: Chromobox protein homolog 3	0.129	0.066
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	0.129	0.040
CSPG6	SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3	0.129	0.040
NPM1	NPM1, NPM: Nucleophosmin	0.129	0.111
PABPC4	PABPC4, APP1, PABP4: Polyadenylate-binding protein 4	0.129	0.040
NUP153	N/A	0.129	0.040
SSB	SSB: Lupus La protein	0.129	0.066
KIF11	N/A	0.129	0.032
EIF3S9	EIF3S9: Eukaryotic translation initiation factor 3 subunit 9	0.129	0.066
CHEK1	CHEK1, CHK1: Serine/threonine-protein kinase Chk1	0.129	0.046
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.129	0.078
CDC20	CDC20: Cell division cycle protein 20 homolog	0.129	0.111
HIVEP1	N/A	0.127	0.027
ATAD2	ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2	0.124	0.046
EIF2B5	EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon	0.118	0.111
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.118	0.188
UTX	UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein	0.114	0.038
SSH1	SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1	0.114	0.148
ETS1	ETS1, EWSR2: Protein C-ets-1	0.114	0.051
C20orf4	C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4	0.114	0.046
FKBP4	FKBP4: FK506-binding protein 4	0.114	0.063
TMEM1	TMEM1, EHOC1: Transmembrane protein 1	0.114	0.046
CENTB2	CENTB2, KIAA0041: Centaurin-beta 2	0.114	0.275
SGTA	SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A	0.114	0.063
AKAP8L	AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like	0.114	0.032
PIK3CG	PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i	0.114	0.114
CCNH	CCNH: Cyclin-H	0.114	0.113
CBLB	CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B	0.114	0.148
CCNL1	CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1	0.114	0.148
AIP	AIP, XAP2: AH receptor-interacting protein	0.114	0.063
PPP1R12A	PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A	0.114	0.046
TRIM25	TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25	0.114	0.029
STAT5B	STAT5B: Signal transducer and activator of transcription 5B	0.114	0.181
MAPK12	MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12	0.114	3.66
FXR1	FXR1: Fragile X mental retardation syndrome-related protein 1	0.112	0.063
CSK	CSK: Tyrosine-protein kinase CSK	0.112	0.461
BTK	BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK	0.112	0.275
KPNA2	KPNA2, RCH1, SRP1: Importin subunit alpha-2	0.111	0.063
HSP90AA1	Hsp89-alpha-delta-N	0.111	0.188
TYK2	TYK2: Non-receptor tyrosine-protein kinase TYK2	0.111	0.372
STAT6	STAT6: Signal transducer and activator of transcription 6	0.111	0.275
STAT2	STAT2: Signal transducer and activator of transcription 2	0.096	0.100
NFATC1	N/A	0.096	0.075
LCP2	LCP2: Lymphocyte cytosolic protein 2	0.096	0.166
PDK1	PDK1: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial precu	0.094	0.046
PPIA	PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A	0.093	0.078
MAPK6	MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6	0.087	0.052
GNB2L1	Lung cancer oncogene 7	0.087	0.0446
RBM3	RBM3, RNPL: Putative RNA-binding protein 3	0.087	0.036
NCOA3	N/A	0.087	0.027
SET	SET: Protein SET	0.087	0.036
RBM14	RBM14, SIP: RNA-binding protein 14	0.087	0.0446
TCOF1	N/A	0.087	0.036
RNPS1	RNPS1, LDC2: RNA-binding protein with serine-rich domain 1	0.087	0.074
IFI16	N/A	0.087	0.027
DNMT1	DNMT1, AIM, DNMT: DNA	0.087	0.0446
BATF	BATF: Basic leucine zipper transcriptional factor ATF-like	0.087	0.091
TGIF2	TGIF2: Homeobox protein TGIF2	0.087	0.027
HMGN2	HMGN2, HMG17: Non-histone chromosomal protein HMG-17	0.087	0.340
UNG	N/A	0.087	0.032
EIF4G1	EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1	0.087	0.153
TAF6	TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6	0.087	0.040
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.087	0.078
EXOSC2	EXOSC2, RRP4: Exosome complex exonuclease RRP4	0.087	0.038
RBL2	RBL2, RB2: Retinoblastoma-like protein 2	0.086	0.067
BRPF1	BRPF1, BR140: Peregrin	0.086	0.046
MAPK1	MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1	0.086	0.139
CCND1	CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1	0.086	0.073
CTDP1	CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase	0.086	0.0818
CREBBP	CREBBP, CBP: CREB-binding protein	0.086	11.40
DNAJC7	DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7	0.086	0.029
ATM	ATM: Serine-protein kinase ATM	0.086	0.086
GHR	GHR: Growth hormone receptor precursor	0.085	0.096
RANGAP1	RANGAP1, SD: Ran GTPase-activating protein 1	0.084	0.087
PPEF1	N/A	0.083	0.028
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.083	0.083
MAPK15	N/A	0.083	0.083
ELF2	ELF2, NERF: ETS-related transcription factor Elf-2	0.083	0.049
EEF2K	EEF2K: Elongation factor 2 kinase	0.083	0.148
NFATC2	NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2	0.083	0.049
CCAR1	CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1	0.083	0.028
NFATC3	NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3	0.083	0.049
NAPG	NAPG, SNAPG: Gamma-soluble NSF attachment protein	0.0818	0.038
KIAA0664	KIAA0664: Putative eukaryotic translation initiation factor 3 subunit	0.0818	0.046
TRAP1	TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor	0.0818	0.139
DPF2	DPF2, REQ, UBID4: Zinc finger protein ubi-d4	0.0818	0.063
H1FX	H1FX: Histone H1x	0.080	0.124
SF3B4	SF3B4, SAP49: Splicing factor 3B subunit 4	0.078	0.040
PSMD4	PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4	0.078	0.066
RBM15	RBM15, OTT: Putative RNA-binding protein 15	0.078	0.032
FNBP1	N/A	0.078	0.188
WBSCR1	EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H	0.078	0.040
CDK2	CDK2: Cell division protein kinase 2	0.078	0.063
CSTF1	CSTF1: Cleavage stimulation factor 50 kDa subunit	0.078	0.040
PABPC1	PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1	0.078	0.040
UBA2	SAE2, UBA2, HRIHFB2115, UBLE1B: SUMO-activating enzyme subunit 2	0.078	0.040
PABPN1	PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2	0.078	0.040
LIG1	LIG1: DNA ligase 1	0.078	0.040
SFRS2	SFRS2: Splicing factor, arginine/serine-rich 2	0.078	0.040
ANP32B	ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb	0.078	0.040
TDG	TDG: G/T mismatch-specific thymine DNA glycosylase	0.078	0.040
TUBB	TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain	0.078	0.067
NAP1L1	NAP1L1, NRP: Nucleosome assembly protein 1-like 1	0.078	36.30
NOL1	N/A	0.078	0.032
SKIIP	SNW1, SKIIP, SKIP: SNW domain-containing protein 1	0.078	0.066
PAPOLA	PAPOLA, PAP: Poly(A) polymerase alpha	0.078	0.040
ZCCHC8	ZCCHC8: Zinc finger CCHC domain-containing protein 8	0.078	0.040
AURKA	AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6	0.078	0.046
STK24	STK24, MST3, STK3: Serine/threonine-protein kinase 24	0.078	0.078
SFRS4	SFRS4, SRP75: Splicing factor, arginine/serine-rich 4	0.078	0.040
CDK7	CDK7, MO15: Cell division protein kinase 7	0.078	0.046
IRAK1	IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1	0.078	0.233
TCF3	TCF3, E2A, ITF1: Transcription factor E2-alpha	0.078	0.040
NEK9	NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9	0.078	0.111
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.078	0.078
YEATS2	KIAA1197, YEATS2: YEATS domain-containing protein 2	0.078	0.032
SFRS10	SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10	0.078	0.040
TIAL1	TIAL1: Nucleolysin TIAR	0.078	0.040
ETS2	ETS2: Protein C-ets-2	0.077	0.0453
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.077	0.096
ERG	ERG: Transcriptional regulator ERG	0.077	0.037
MDM4	MDM4, MDMX: Mdm4 protein	0.077	0.032
CDKN2D	CDKN2D: Cyclin-dependent kinase 4 inhibitor D	0.077	0.0425
EEF2	EEF2, EF2: Elongation factor 2	0.075	0.078
SSH2	SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2	0.075	0.098
GIT2	N/A	0.075	0.075
EXO1	EXO1, EXOI, HEX1: Exonuclease 1	0.075	0.025
CCNT2	CCNT2: Cyclin-T2	0.075	0.098
DUSP6	DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6	0.075	0.148
RBL1	RBL1: Retinoblastoma-like protein 1	0.075	0.044
PTP4A3	PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3	0.075	0.050
DUSP16	DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16	0.075	0.148
CCNE1	CCNE1, CCNE: G1/S-specific cyclin-E1	0.075	0.098
C10orf9	CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y	0.075	0.098
SRC	SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src	0.074	0.191
GSR	GSR, GLUR, GRD1: Glutathione reductase, mitochondrial precursor	0.074	0.063
PHB2	PHB2, BAP, REA: Prohibitin-2	0.074	0.087
STOML2	STOML2, SLP2, HSPC108: Stomatin-like protein 2	0.074	0.087
HIST1H1D	HIST1H1D, H1F3: Histone H1.3	0.071	0.0818
PTPN1	PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1	0.071	0.136
TLK1	TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1	0.070	0.052
AOF2	AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1	0.070	0.036
WDR1	N/A	0.070	0.036
PLEK	PLEK, P47: Pleckstrin	0.070	0.202
KIF22	KIF22, KID, KNSL4: Kinesin-like protein KIF22	0.070	0.027
FANCA	FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein	0.070	0.070
STK16	N/A	0.070	0.0425
KIAA0853	N/A	0.070	0.036
HNRPA0	HNRPA0: Heterogeneous nuclear ribonucleoprotein A0	0.070	0.036
API5	N/A	0.070	0.052
UBAP2	N/A	0.070	0.087
MYBBP1A	MYBBP1A, P160: Myb-binding protein 1A	0.070	0.036
IKBKG	IKBKG, FIP3, NEMO: NF-kappa-B essential modulator	0.070	0.036
SH2BP1	CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog	0.070	0.070
PTP4A1	PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1	0.069	0.037
GIT1	GIT1: ARF GTPase-activating protein GIT1	0.069	0.114
PTPN12	PTPN12: Tyrosine-protein phosphatase non-receptor type 12	0.069	0.225
DUSP1	DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1	0.069	0.113
FOS	FOS, G0S7: Proto-oncogene protein c-fos	0.069	0.033
PPP1CB	PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit	0.067	0.038
STAT5A	STAT5A, STAT5: Signal transducer and activator of transcription 5A	0.067	0.275
ILK	ILK, ILK1, ILK2: Integrin-linked protein kinase	0.067	0.046
SYK	SYK: Tyrosine-protein kinase SYK	0.067	0.225
MAPRE1	MAPRE1: Microtubule-associated protein RP/EB family member 1	0.066	0.078
HSPD1		0.066	0.046
CSE1L	CSE1L, CAS, XPO2: Exportin-2	0.066	0.063
CAD	CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase	0.066	0.233
NMT1	NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1	0.066	0.233
VCP	VCP: Transitional endoplasmic reticulum ATPase	0.066	0.078
RAN	RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran	0.066	0.146
QARS	QARS: Glutaminyl-tRNA synthetase	0.066	0.078
EPRS	EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes:	0.066	0.078
RARS	RARS: Arginyl-tRNA synthetase, cytoplasmic	0.066	0.063
CTPS	CTPS: CTP synthase 1	0.066	0.139
CCT8	CCT8: Uncharacterized protein CCT8	0.066	0.063
IMPDH2	IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2	0.066	0.139
USP10	USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10	0.066	0.063
TCP1	CCT1, CCTA, TCP1: T-complex protein 1 subunit alpha	0.066	0.078
CCT6A	CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta	0.066	0.078
HNRPK	N/A	0.066	0.078
PSMA2	PSMA2, PSC3: Proteasome subunit alpha type-2	0.066	0.461
GPI	GPI: Glucose-6-phosphate isomerase	0.066	0.046
CCT4	CCT4, CCTD, SRB: T-complex protein 1 subunit delta	0.066	0.078
KPNB1	KPNB1, NTF97: Importin subunit beta-1	0.066	0.078
MTHFD1	MTHFD1, MTHFC, MTHFD: C-1-tetrahydrofolate synthase, cytoplasmic	0.066	0.063
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.063	0.032
KIAA0683	DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized	0.063	0.063
EIF4G2	EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2	0.063	0.111
PPP1R8	N/A	0.063	0.112
MTA1	MTA1: Metastasis-associated protein MTA1	0.063	0.040
SEC24C	SEC24C, KIAA0079: Protein transport protein Sec24C	0.063	0.063
ATF1	ATF1: Cyclic AMP-dependent transcription factor ATF-1	0.063	0.245
NOC2L	NOC2L: Nucleolar complex protein 2 homolog	0.063	0.078
RPS6KB1	N/A	0.063	0.063
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.063	0.046
WBSCR20A	N/A	0.063	0.032
PHF10	N/A	0.063	0.032
VRK1	VRK1: Serine/threonine-protein kinase VRK1	0.063	0.078
PRKD2	PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2	0.063	0.372
NACA	NACA, HSD48: Nascent polypeptide-associated complex subunit alpha	0.063	0.111
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.063	0.032
EIF3S4	EIF3S4: Eukaryotic translation initiation factor 3 subunit 4	0.063	0.040
CPSF1	CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1	0.063	0.040
PSMD1	PSMD1: 26S proteasome non-ATPase regulatory subunit 1	0.063	0.046
COPB2	COPB2: Coatomer subunit beta'	0.063	0.032
HDAC2	HDAC2: Histone deacetylase 2	0.063	0.040
PBK	PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase	0.063	0.046
COPA	COPA: Coatomer subunit alpha	0.063	0.046
TAF10	TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10	0.063	0.066
STAG2	STAG2, SA2: Cohesin subunit SA-2	0.063	0.078
WEE1	WEE1: Wee1-like protein kinase	0.063	0.046
PRPF4B	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol	0.063	0.063
CRLF3	N/A	0.063	0.070
DDIT3	DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3	0.062	0.037
PTPN2	PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2	0.062	0.148
LYN	LYN: Tyrosine-protein kinase Lyn	0.061	0.275
LCK	LCK: Proto-oncogene tyrosine-protein kinase LCK	0.061	0.191
ABL1	ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1	0.061	0.307
S100A11	MLN70, S100A11, S100C: Protein S100-A11	0.057	0.032
DAPK1	DAPK1, DAPK: Death-associated protein kinase 1	0.057	0.056
MYCBP2	MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2	0.056	0.0818
PIK3CB	PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit	0.056	0.086
PIK3C2A	PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po	0.056	0.086
CBL	CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL	0.056	0.073
ETV1	ETV1, ER81: ETS translocation variant 1	0.056	0.033
RAP1B	RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor	0.0554	0.118
STAT4	STAT4: Signal transducer and activator of transcription 4	0.055	0.073
CBLC	CBLC, CBL3, RNF57: Signal transduction protein CBL-C	0.055	0.072
UBE2E3	UBE2E3, UBCE4, UBCH9: Ubiquitin-conjugating enzyme E2 E3	0.054	0.063
SOS1	SOS1: Son of sevenless homolog 1	0.054	0.148
SUPT5H	SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5	0.054	0.0727
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.052	0.036
DRIM	UTP20, DRIM: Small subunit processome component 20 homolog	0.052	0.0425
CHUK	N/A	0.052	0.052
TERF2	TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2	0.052	0.027
TOP2B	N/A	0.052	0.036
EMD	EMD, EDMD, STA: Emerin	0.052	0.036
TRRAP	N/A	0.052	0.070
ARFGAP1	N/A	0.052	0.153
ROCK1	ROCK1: Rho-associated protein kinase 1	0.052	0.251
JMJD1A	JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr	0.052	0.027
PHF3	PHF3, KIAA0244: PHD finger protein 3	0.052	0.027
ZNF638	ZNF638, NP220, ZFML: Zinc finger protein 638	0.052	0.027
ITGB1BP1	ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1	0.052	0.070
USP24	USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24	0.052	0.070
KIAA0528	KIAA0528: Uncharacterized protein KIAA0528	0.052	0.070
JAK1		0.051	0.225
MAPK13	MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13	0.051	3.66
JAK2	JAK2: Tyrosine-protein kinase JAK2	0.051	0.225
RANBP2	RANBP2, NUP358: E3 SUMO-protein ligase RanBP2	0.051	0.171
MAPK10	MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10	0.049	0.083
PTPN6	PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6	0.049	0.165
TRIM39	TRIM39, RNF23, TFP: Tripartite motif-containing protein 39	0.049	0.028
STAT3		0.049	0.148
NASP	NASP: Nuclear autoantigenic sperm protein	0.049	0.028
S100A16	S100A16, AAG13: Protein S100-A16	0.049	0.028
MAPK8	MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8	0.049	0.083
ANKS1A	ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A	0.049	0.111
MAPK3	MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3	0.049	41.40
ELK1	ELK1: ETS domain-containing protein Elk-1	0.049	0.033
ZAK	MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT	0.048	0.032
HIST1H1C	HIST1H1C, H1F2: Histone H1.2	0.047	0.044
CARHSP1	CARHSP1: Calcium-regulated heat stable protein 1	0.047	0.025
SCYL3	SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin	0.046	0.046
SAPS3	N/A	0.046	0.063
MAP2K1	MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1	0.046	0.046
SYMPK	SYMPK, SPK: Symplekin	0.046	0.046
SFRS6	SFRS6, SRP55: Splicing factor, arginine/serine-rich 6	0.046	0.032
MDN1	MDN1, KIAA0301: Midasin	0.046	0.046
RPS6KB2	RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2	0.046	0.063
PKMYT1	PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito	0.046	0.046
SNF1LK2	SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2	0.046	0.139
HDGF	HDGF, HMG1L2: Hepatoma-derived growth factor	0.046	0.032
CDC7	CDC7, CDC7L1: Cell division cycle 7-related protein kinase	0.046	0.046
GNB1	GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.046	0.032
ADRBK1	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1	0.046	0.225
USP34	USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34	0.046	0.038
CSTF2T	CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant	0.046	0.040
GNB2	GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.046	0.040
TOPORS	TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors	0.046	0.040
STK38L	STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like	0.046	0.038
HGS	HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate	0.046	0.040
K-ALPHA-1	TUBA1B: Tubulin alpha-1B chain	0.046	0.090
DIAPH1	Diaphanous 1	0.046	0.063
JARID1A	JARID1A, RBBP2, RBP2: Histone demethylase JARID1A	0.046	0.032
STK3	STK3, MST2: Serine/threonine-protein kinase 3	0.046	0.086
DOK1	DOK1: Docking protein 1	0.046	0.275
PIK4CB	PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic,	0.046	0.078
KLHDC4	N/A	0.046	0.063
MBD3	MBD3: Methyl-CpG-binding domain protein 3	0.046	0.040
DUSP22	DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22	0.046	0.032
RPS6KA1	RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1	0.046	0.063
AKT1	AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase	0.046	0.461
GSK3B	N/A	0.046	0.063
TAOK3	TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3	0.046	0.046
MGMT	MGMT: Methylated-DNA--protein-cysteine methyltransferase	0.046	0.127
HSP90B1	HSP90B1, TRA1: Endoplasmin precursor	0.046	0.067
BIRC4	BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4	0.0453	0.048
S100A9	S100A9, CAGB, CFAG, MRP14: Protein S100-A9	0.0453	0.026
APEH	APEH, D3F15S2, D3S48E, DNF15S2: Acylamino-acid-releasing enzyme	0.0446	0.078
BLNK	BLNK, BASH, SLP65: B-cell linker protein	0.0446	0.191
BIRC5	BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5	0.0446	0.0971
NME1	NME1, NDPKA, NM23: Nucleoside diphosphate kinase A	0.0446	0.052
TK1	TK1: Thymidine kinase, cytosolic	0.0446	0.046
FUBP1	N/A	0.0446	0.070
CASKIN2	CASKIN2, KIAA1139: Caskin-2	0.044	0.049
DUSP3	DUSP3, VHR: Dual specificity protein phosphatase 3	0.044	0.065
DGKD	DGKD, KIAA0145: Diacylglycerol kinase delta	0.044	0.148
NDNL2	NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1	0.044	0.025
RFXDC2	RFXDC2: Regulatory factor X domain-containing protein 2.	0.0425	0.027
DEF6	DEF6, IBP: Differentially expressed in FDCP 6	0.0425	0.032
SNAPC4	SNAPC4, SNAP190: snRNA-activating protein complex subunit 4	0.0425	0.027
CDKN1A	CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1: Cyclin-dependent kinase inhi	0.0425	0.0453
HUWE1	HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1	0.0425	0.077
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.0425	0.0425
TRAFD1	TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1	0.0425	0.127
SMARCC2	N/A	0.0425	0.027
VCPIP1	VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135	0.0425	0.032
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.0425	0.052
OSBPL11	OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11	0.0425	0.251
PASK	PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase	0.0425	0.032
TUBA6	TUBA1C, TUBA6: Tubulin alpha-1C chain	0.0425	0.067
MARK2	N/A	0.0425	0.0425
FGR	FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR	0.041	0.275
EXOC2	N/A	0.041	0.029
CDC34	CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1	0.041	0.063
STUB1	STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1	0.041	0.046
MATK	MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase	0.04	0.165
ABL2	ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2	0.04	0.165
LCP1	LCP1, PLS2: Plastin-2	0.040	0.046
ACTR3	ACTR3, ARP3: Actin-related protein 3	0.040	0.078
CD2AP	CD2AP: CD2-associated protein	0.040	0.139
ME2	ME2: NAD-dependent malic enzyme, mitochondrial precursor	0.040	0.063
RACGAP1	RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1	0.040	0.063
CARS	CARS: Cysteinyl-tRNA synthetase, cytoplasmic	0.040	0.078
PSMC1	PSMC1: 26S protease regulatory subunit 4	0.040	0.078
LDHB	LDHB: L-lactate dehydrogenase B chain	0.040	0.063
CCT2	CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta	0.040	0.078
PSMB7	PSMB7: Proteasome subunit beta type-7 precursor	0.040	0.461
THOP1	THOP1: Thimet oligopeptidase	0.040	0.063
NME2	NME2, NM23B: Nucleoside diphosphate kinase B	0.040	0.063
PCBP1	PCBP1: Poly(rC)-binding protein 1	0.040	0.078
RPL8	RPL8: 60S ribosomal protein L8	0.040	0.129
RPS3	RPS3, OK/SW-cl.26: 40S ribosomal protein S3	0.040	0.078
PCBP2	PCBP2: Poly(rC)-binding protein 2	0.040	0.078
TRIP13	TRIP13: Thyroid receptor-interacting protein 13	0.040	0.046
ENO1	ENO1, ENO1L1, MBPB1, MPB1: Alpha-enolase	0.040	0.046
LAMR1	RPSA, LAMBR, LAMR1: 40S ribosomal protein SA	0.040	0.078
EEF1B2	EEF1B2, EEF1B, EF1B: Elongation factor 1-beta	0.040	0.063
LPXN	LPXN, LDLP: Leupaxin	0.040	0.046
XPO1	XPO1, CRM1: Exportin-1	0.040	0.078
TESK1	TESK1: Dual specificity testis-specific protein kinase 1	0.039	0.0425
SORL1	SORL1: Sortilin-related receptor precursor	0.039	0.038
CSF2RB	CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor	0.039	0.096
STK38	STK38, NDR1: Serine/threonine-protein kinase 38	0.038	0.046
MAPKAPK3	MAPKAPK3: MAP kinase-activated protein kinase 3	0.038	0.038
POLR2A	POLR2A: Uncharacterized protein POLR2A	0.038	0.032
NEK7	NEK7: Serine/threonine-protein kinase Nek7	0.038	0.038
IQGAP2	IQGAP2: Ras GTPase-activating-like protein IQGAP2	0.038	0.0818
SPEN	SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein	0.038	0.032
SNRP70	SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa	0.038	0.032
CRKRS	CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7	0.038	0.038
PKN2	PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2	0.038	0.046
FHOD1	FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1	0.038	0.063
STK10	STK10: Uncharacterized protein STK10	0.038	0.046
MAFG	MAFG: Transcription factor MafG	0.038	0.067
FKBP1A	FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A	0.038	0.046
NRBP1	NRBP1, BCON3, NRBP: Nuclear receptor-binding protein	0.038	0.046
CCNG1	CCNG1, CCNG, CYCG1: Cyclin-G1	0.038	0.047
CCNA2	CCNA2, CCN1, CCNA: Cyclin-A2	0.038	0.047
PTK6	PTK6, BRK: Tyrosine-protein kinase 6	0.037	0.109
YES1	YES1, YES: Proto-oncogene tyrosine-protein kinase Yes	0.037	0.111
SRPR	SRPR: Uncharacterized protein SRPR	0.036	0.052
HD	HD, IT15: Huntingtin	0.036	0.070
RHOA	RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor	0.036	0.132
MNAR	PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1	0.036	0.052
LIMS1	N/A	0.036	0.070
NCF4	NCF4, SH3PXD4: Neutrophil cytosol factor 4	0.036	0.251
MPP6	MPP6, VAM1: MAGUK p55 subfamily member 6	0.036	0.096
IFI35	N/A	0.036	0.052
UBE2A	UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A	0.036	0.025
PTK2B	PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta	0.036	0.075
FYN	FYN: Proto-oncogene tyrosine-protein kinase Fyn	0.036	0.148
ITK	ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK	0.036	0.148
MYST4	MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4	0.035	0.026
FN1	N/A	0.034	0.028
PTPRR	PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor	0.034	0.165
PTPRS	PTPRS: Receptor-type tyrosine-protein phosphatase S precursor	0.034	0.165
MDGA1	MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein	0.034	0.028
AXL	AXL, UFO: Tyrosine-protein kinase receptor UFO precursor	0.034	0.028
TRPV1	TRPV1: Vanilloid receptor variant TRPV1b	0.034	0.083
IL6ST	IL6ST: Interleukin-6 receptor subunit beta precursor	0.034	0.083
IL4R	IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor	0.034	0.083
LEPR	LEPR, DB, OBR: Leptin receptor precursor	0.034	0.083
TRPV4	TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb	0.034	0.083
IL6R	IL6R: Interleukin-6 receptor alpha chain precursor	0.034	0.049
PTPRC	PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ	0.034	0.148
PTPRE	PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor	0.034	0.148
AXIN1		0.0333	0.028
YWHAG	YWHAG: 14-3-3 protein gamma	0.0333	0.028
FER	FER, TYK3: Proto-oncogene tyrosine-protein kinase FER	0.033	0.136
HCK	N/A	0.033	0.171
ZAP70	ZAP70: Uncharacterized protein ZAP70	0.033	0.171
INSL3	JAK3: Tyrosine-protein kinase JAK3	0.032	0.098
BACH1	BACH1: Transcription regulator protein BACH1	0.032	0.075
MAPK7	mitogen-activated protein kinase 7 isoform 1	0.032	0.052
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.032	0.096
MAPKAPK2	MAPKAPK2: MAP kinase-activated protein kinase 2	0.032	0.0425
MAP3K8	MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8	0.032	0.0425
TERF1	TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1	0.032	0.027
GTF3C1	N/A	0.032	0.036
MAP3K14	MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14	0.032	0.026
APPL	APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha	0.032	0.191
MAP2K3	MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki	0.032	0.0425
ARHGDIB	ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2	0.032	0.046
CTNNB1	CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1	0.032	0.029
FRG1	FRG1: Protein FRG1	0.032	0.063
SNX17	SNX17, KIAA0064: Sorting nexin-17	0.032	0.139
RPS10	RPS10: 40S ribosomal protein S10	0.032	0.233
EEF1G	EEF1G, EF1G, PRO1608: Elongation factor 1-gamma	0.032	0.063
RAF1	RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase	0.032	501.00
RPL3	RPL3, OK/SW-cl.32: 60S ribosomal protein L3	0.032	0.063
HCLS1	HCLS1, HS1: Hematopoietic lineage cell-specific protein	0.032	0.139
CASP3	CASP3, CPP32: Caspase-3 precursor	0.032	0.063
TXNL1	TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1	0.032	0.241
EEF1A1	EEF1A1: Elongation factor 1-alpha	0.032	0.046
TAGLN2	TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein	0.032	0.139
ACTG1	ACTB: Actin, cytoplasmic 1	0.032	0.063
NRAS	NRAS, HRAS1: GTPase NRas precursor	0.032	41.80
FLII	FLII, FLIL: Protein flightless-1 homolog	0.032	0.063
PLD1	PLD1: Phospholipase D1	0.032	0.136
PREP	PREP, PEP: Prolyl endopeptidase	0.032	0.046
PPARBP	N/A	0.032	0.063
RAB11A	RAB11A, RAB11: Ras-related protein Rab-11A	0.032	0.032
HSPH1	HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa	0.032	0.046
CRKL	CRKL: Crk-like protein	0.032	0.372
ACP1	ACP1: Low molecular weight phosphotyrosine protein phosphatase	0.032	0.372
EIF5B	EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B	0.032	0.063
DOCK2	DOCK2, KIAA0209: Dedicator of cytokinesis protein 2	0.032	0.139
PRDX1	PRDX1, PAGA, PAGB, TDPX2: Peroxiredoxin-1	0.032	0.038
USP7	USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7	0.032	0.063
FLT3	FLT3, STK1: FL cytokine receptor precursor	0.031	0.056
EPOR	EPOR: Erythropoietin receptor precursor	0.031	0.127
IL12B	IL12B, NKSF2: Interleukin-12 subunit beta precursor	0.031	0.037
MPL	MPL, TPOR: Thrombopoietin receptor precursor	0.031	0.062
IL2RB	IL2RB: Interleukin-2 receptor subunit beta precursor	0.031	0.096
HIST1H1A	HIST1H1A, H1F1: Histone H1.1	0.0308	0.029
SOCS3	SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3	0.031	0.123
PTPRF	PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor	0.030	0.148
CNTN4	CNTN4: Contactin-4 precursor	0.030	0.025
EPHA8	EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor	0.030	0.025
CNTN1	CNTN1: Contactin-1 precursor	0.030	0.025
L1CAM	L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor	0.030	0.025
TRPV6	TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6	0.030	0.075
SEL1L	SEL1L, TSA305, UNQ128/PRO1063: Protein sel-1 homolog 1 precursor	0.030	0.053
FKBP8	DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment)	0.029	0.029
NFE2L2	NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2	0.029	0.067
JUND	JUND: Transcription factor jun-D	0.029	0.0818
CSDA	CSDA, DBPA: DNA-binding protein A	0.029	0.046
ATF6	ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha	0.029	0.051
CSNK1E	CSNK1E: Casein kinase I isoform epsilon	0.029	0.038
RPS6KA5	RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5	0.029	13.90
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.029	0.078
STK4	STK4, MST1: Serine/threonine-protein kinase 4	0.029	0.086
REXO2	REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor	0.029	0.032
JUNB	JUNB: Transcription factor jun-B	0.029	0.067
STK25	STK25, SOK1, YSK1: Serine/threonine-protein kinase 25	0.029	0.078
STK11	STK11, LKB1, PJS: Serine/threonine-protein kinase 11	0.029	0.078
GRK5	GRK5, GPRK5: G protein-coupled receptor kinase 5	0.029	0.029
BID	BID: BH3-interacting domain death agonist	0.028	0.049
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.028	0.028
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.028	0.052
DYRK1A	DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin	0.028	0.028
SGK2	SGK2: Serine/threonine-protein kinase Sgk2	0.028	0.025
NF2	NF2, SCH: Merlin	0.028	0.165
FBXO4	FBXO4, FBX4: F-box only protein 4	0.028	0.028
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.028	0.028
DYRK1B	DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.028	0.025
C14orf151	C14orf151: Uncharacterized protein C14orf151 (Fragment)	0.028	0.028
ZNF687	ZNF687, KIAA1441: Zinc finger protein 687	0.028	0.028
RAB4A	N/A	0.028	0.04
SF1	SF1, ZFM1, ZNF162: Splicing factor 1	0.028	0.028
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.028	0.028
PHLDB2	N/A	0.028	0.028
NSBP1	NSBP1: Nucleosome-binding protein 1	0.028	0.109
GPRASP2	GPRASP2: G-protein coupled receptor-associated sorting protein 2	0.028	0.028
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.028	0.028
PKN3	PKN3, PKNBETA: Serine/threonine-protein kinase N3	0.028	0.025
MAPKAPK5	N/A	0.028	0.028
CDC2	CDC2: Cell division control protein 2 homolog	0.028	0.025
NEK6	NEK6: Serine/threonine-protein kinase Nek6	0.028	0.025
PPP1R12C	PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C	0.028	0.028
NOTCH2	NOTCH2: Neurogenic locus notch homolog protein 2 precursor	0.028	0.038
FRK	FRK, PTK5, RAK: Tyrosine-protein kinase FRK	0.027	0.097
FXR2	FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2	0.027	0.029
TEC	TEC, PSCTK4: Tyrosine-protein kinase Tec	0.027	0.111
TXK	TXK, PTK4: Tyrosine-protein kinase TXK	0.027	0.136
CAPNS1	CAPNS1, CAPN4, CAPNS: Calpain small subunit 1	0.027	0.070
GSTP1	GSTP1, FAEES3, GST3: Glutathione S-transferase P	0.027	0.029
VAV2	VAV2, RP11-153P4.1-003: Vav 2 oncogene	0.027	0.0425
MPG	N/A	0.027	0.070
NAT1	NAT1, AAC1: Arylamine N-acetyltransferase 1	0.027	0.0425
TRADD	TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein	0.027	0.127
LASP1	LASP1, MLN50: LIM and SH3 domain protein 1	0.027	0.210
YWHAQ	YWHAQ: 14-3-3 protein theta	0.027	0.087
CIITA	CIITA, MHC2TA: MHC class II transactivator	0.027	0.127
BMX	N/A	0.0263	0.110
TH	TH, TYH: Tyrosine 3-monooxygenase	0.026	0.046
PRKAA1	N/A	0.026	0.032
GRLF1	N/A	0.026	0.096
SRPK2	SRPK2: Serine/threonine-protein kinase SRPK2	0.026	0.032
FAM65A	FAM65A, KIAA1930: Protein FAM65A	0.026	0.0425
TERT	TERT, EST2, TCS1, TRT: Telomerase reverse transcriptase	0.026	0.029
AGTPBP1	AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein	0.026	0.038
AANAT	AANAT, SNAT: Serotonin N-acetyltransferase	0.026	0.026
PCTK1	PCTK1: Serine/threonine-protein kinase PCTAIRE-1	0.026	0.029
ITGB4	N/A	0.025	0.062
IL9R	IL9R: Interleukin-9 receptor precursor	0.025	0.062
IL12RB2	IL12RB2: Interleukin-12 receptor beta-2 chain precursor	0.025	0.062
IFNAR1	IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor	0.025	0.062
MKNK2	MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2	0.025	0.025
LATS2	LATS2, KPM: Serine/threonine-protein kinase LATS2	0.025	0.075
CPNE1	RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12	0.025	0.025
CDC25A	CDC25A: M-phase inducer phosphatase 1	0.025	0.148
THOC4	THOC4, ALY, BEF: THO complex subunit 4	0.025	0.795
MAP2K3	N/A	0.025	0.025
PRKACA	PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit	0.025	0.025
AKT3	AKT3: RAC-gamma serine/threonine-protein kinase	0.025	0.148
BCOR	N/A	0.025	0.025
CAMKK1	N/A	0.025	0.025
H2-ALPHA	TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain	0.025	0.036
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.025	0.075
ARID1A	ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A	0.025	0.025
FBXL10	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio	0.025	0.025
WNK4	WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4	0.025	0.025
RPS6KA2	RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2	0.025	0.025
PRKCB1	N/A	0.025	0.025
CREB1	CREB1: cAMP response element-binding protein	0.025	0.098
NEK8	NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8	0.025	0.044
MAP3K7	MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7	0.025	0.025
LATS1	LATS1, WARTS: Serine/threonine-protein kinase LATS1	0.025	0.075
NIPBL	N/A	0.025	0.025
ARL5A	ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A	0.025	0.025
ELMO1	N/A	0.025	0.148
GRK6	N/A	0.025	0.025
PLK1	PLK1, PLK: Serine/threonine-protein kinase PLK1	0.025	21.10
ADK	ADK: Adenosine kinase	0.025	0.025
CAMK1D	CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D	0.025	0.025
PHKG1	PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo	0.025	0.025
CAMK2A	N/A	0.025	0.025
PDPK1	PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1	0.025	0.148
RAD51	RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1	0.025	0.025
PDE8B	PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies	0.025	0.025
PPP1R9B	PPP1R9B, PPP1R6: Neurabin-2	0.025	0.025
SMC4L1	SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4	0.025	0.025
RPS6KA4	RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4	0.025	0.025
CHEK2	CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2	0.025	0.036
MKNK1	MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1	0.025	0.025
CDC2L5	CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5	0.025	0.025
PTGES3	PTGES3, P23, TEBP: Prostaglandin E synthase 3	0.025	0.050

0.299

Total Score

3.85