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Evidence of Interaction Between TP53 and CKS1B

The interaction score between TP53 and CKS1B is 1.37.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between TP53 and CKS1B = 0.71

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismTP53 OrthologueCKS1B OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00215713 0.16 IPI00015104 1
human IPI00215713 0.16 IPI00477748 0.393
human IPI00215713 0.16 IPI00413006 0.929
fly Q8IH92 0.16 Q24152 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction N/A
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between TP53 and CKS1B that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TP53 andCKS1B. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TP53 has 1099 interactors and CKS1B has 77 interactors of which there are 17 common interactors.

Common InteractorName of Common InteractorScore for TP53-Interactor (?)Score for CKS1B-Interactor (?)
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.430 0.027
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.430 0.027
CCNB1 Cyclin B1 0.385 33.10
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.304 0.371
CENPA CENPA: Histone H3-like centromeric protein A 0.269 0.027
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.146 1.31
MKI67 MKI67: Antigen KI-67 0.144 0.027
ESPL1 N/A 0.144 0.027
CDC23 CDC23: Cell division cycle protein 23 homolog 0.137 0.371
PSMD3 PSMD3: 26S proteasome non-ATPase regulatory subunit 3 0.0968 0.371
CDK2 CDK2: Cell division protein kinase 2 0.078 33.10
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.066 0.0739
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.0446 0.027
NME1 NME1, NDPKA, NM23: Nucleoside diphosphate kinase A 0.0446 0.027
EIF4A1 EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I 0.038 0.300
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.032 0.291
EEF1A1 EEF1A1: Elongation factor 1-alpha 0.032 0.355
0.299
Total Score 1.37