Home
Advanced Search
Help
Update History
Statistics
Downloads
The Barton Group
<<< Back to TP53

Evidence of Interaction Between TP53 and CSNK2B

The interaction score between TP53 and CSNK2B is 3.11.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between TP53 and CSNK2B = 0.71

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismTP53 OrthologueCSNK2B OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
fly Q8IH92 0.16 P08182 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 4.85E-3
Post-translational Modifications

Protein: TP53

PTMResidueReference
Acetylation 305 PubMed, HPRD
Acetylation 320 PubMed, HPRD
Acetylation 370 PubMed, HPRD
Acetylation 372 PubMed, HPRD
Acetylation 373 PubMed, HPRD
Acetylation 381 PubMed, HPRD
Acetylation 382 PubMed, HPRD
Deacylation 382 PubMed, HPRD
Dephosphorylation 315 PubMed, HPRD
N6-acetyllysine 305 HPRD
N6-acetyllysine 373 HPRD
N6-acetyllysine 382 HPRD
Phosphorylation 6 PubMed, HPRD
Phosphorylation 9 PubMed, HPRD
Phosphorylation 15 PubMed, HPRD
Phosphorylation 18 PubMed, HPRD
Phosphorylation 20 PubMed, HPRD
Phosphorylation 33 PubMed, HPRD
Phosphorylation 37 PubMed, HPRD
Phosphorylation 46 PubMed, HPRD
Phosphorylation 55 PubMed, HPRD
Phosphorylation 81 PubMed, HPRD
Phosphorylation 155 PubMed, HPRD
Phosphorylation 315 PubMed, HPRD
Phosphorylation 366 PubMed, HPRD
Phosphorylation 371 PubMed, HPRD
Phosphorylation 378 PubMed, HPRD
Phosphorylation 392 PubMed, HPRD
Phosphoserine 15 PubMed, HPRD
Phosphoserine 46 PubMed, HPRD
Phosphoserine 315 PubMed, HPRD
Phosphothreonine 18 PubMed, HPRD
Phosphothreonine 55 PubMed, HPRD
Proteolytic Cleavage 18 PubMed, HPRD
Proteolytic Cleavage 20 PubMed, HPRD
Proteolytic Cleavage 23 PubMed, HPRD
Sumoylation 386 PubMed, HPRD
Ubiquitination 351 PubMed, HPRD
Ubiquitination 357 PubMed, HPRD
Ubiquitination 370 PubMed, HPRD
Ubiquitination 372 PubMed, HPRD
Ubiquitination 373 PubMed, HPRD
Ubiquitination 381 PubMed, HPRD
Ubiquitination 382 PubMed, HPRD
Ubiquitination 386 PubMed, HPRD

Protein: CSNK2B

PTMResidueReference
Phosphorylation 2 PubMed, HPRD
Phosphorylation 3 PubMed, HPRD
Phosphorylation 209 PubMed, HPRD
Phosphoserine 2 PubMed, HPRD
Localisation

Protein: TP53

LocalisationReference
ER HPRD
Nucleus HPRD
Mitochondrion HPRD
Nucleolus HPRD
Cytoplasm HPRD

Protein: CSNK2B

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between TP53 and CSNK2B that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TP53 andCSNK2B. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TP53 has 1099 interactors and CSNK2B has 148 interactors of which there are 91 common interactors.

Common InteractorName of Common InteractorScore for TP53-Interactor (?)Score for CSNK2B-Interactor (?)
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.964 0.081
HIST1H4A HIST1H4A, H4/A, HIST1H4B, H4/I, H4/G, HIST1H4D, H4/B, H4/J, HIST1H4F, HIST4H4, H 0.902 0.759
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.822 5.94
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.704 0.722
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 0.503 5.94
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.430 0.025
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.430 0.025
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.430 0.025
ABCF1 N/A 0.144 0.025
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.144 0.025
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.144 0.055
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.144 0.025
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.141 0.0479
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 0.139 0.722
CDK4 CDK4: Cell division protein kinase 4 0.129 0.061
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.129 136.00
SNRPC SNRPC: U1 small nuclear ribonucleoprotein C 0.129 0.0479
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.129 0.061
PABPC4 PABPC4, APP1, PABP4: Polyadenylate-binding protein 4 0.129 0.0479
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 0.129 5.94
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.129 0.049
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.129 5.94
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.124 2.14
KLF13 KLF13, BTEB3, NSLP1: Krueppel-like factor 13 0.114 0.566
MTF1 MTF1: Metal regulatory transcription factor 1 0.114 2.14
CSK CSK: Tyrosine-protein kinase CSK 0.112 0.027
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.112 0.027
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.087 0.068
SET SET: Protein SET 0.087 0.025
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.087 0.025
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 0.086 1.33
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.086 0.036
CDK2 CDK2: Cell division protein kinase 2 0.078 0.061
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.078 0.036
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.078 0.061
CDK7 CDK7, MO15: Cell division protein kinase 7 0.078 0.061
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.078 0.049
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.078 0.061
BRD4 N/A 0.075 0.232
PHB2 PHB2, BAP, REA: Prohibitin-2 0.074 0.025
STOML2 STOML2, SLP2, HSPC108: Stomatin-like protein 2 0.074 0.025
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.070 0.0407
STK16 N/A 0.070 0.0407
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.067 0.036
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.066 2.51
RPS6KB1 N/A 0.063 0.036
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.063 0.049
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.063 0.036
EIF3S4 EIF3S4: Eukaryotic translation initiation factor 3 subunit 4 0.063 3.59
HDAC2 HDAC2: Histone deacetylase 2 0.063 2.90
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.063 0.049
WEE1 WEE1: Wee1-like protein kinase 0.063 0.049
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.063 0.049
EIF3S10 EIF3S10, KIAA0139: Eukaryotic translation initiation factor 3 subunit 10 0.059 1.84
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.052 0.025
ROCK1 ROCK1: Rho-associated protein kinase 1 0.052 0.0407
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.051 0.030
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.046 0.030
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.046 0.049
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.046 0.036
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.046 0.049
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.046 0.049
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.046 0.036
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.046 0.036
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.046 0.030
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.046 0.030
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.046 0.049
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.046 0.036
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.046 0.036
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.0425 0.0253
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.0425 0.0253
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0425 0.033
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.0425 0.0253
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.038 0.030
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.038 0.036
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.038 0.030
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.038 0.030
STK10 STK10: Uncharacterized protein STK10 0.038 0.030
PES1 PES1: Pescadillo homolog 1 0.038 3.05
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.033
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.032 0.0253
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.032 0.0253
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.032 0.0253
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.032 0.061
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.032 0.049
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.029 0.030
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.029 0.036
PRKAA1 N/A 0.026 0.033
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.026 0.033
PSME3 PSME3: Proteasome activator complex subunit 3 0.025 0.053
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.025 0.025
0.347
Total Score 3.11