PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between TP53 and HIST1H3A

The interaction score between TP53 and HIST1H3A is 1.37.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between TP53 and HIST1H3A = 0.30

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

2.88E-3

Orthology

Organism	TP53 Orthologue		HIST1H3A Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
human	IPI00215713	0.16	IPI00465070	1
human	IPI00215713	0.16	IPI00219038	0.625
human	IPI00215713	0.16	IPI00216402	0.375
human	IPI00215713	0.16	IPI00171611	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3

Domains

No domains were used in calculating likelihood of interaction

1.53

Post-translational Modifications

Protein: TP53

PTM	Residue	Reference
Acetylation	305	PubMed, HPRD
Acetylation	320	PubMed, HPRD
Acetylation	370	PubMed, HPRD
Acetylation	372	PubMed, HPRD
Acetylation	373	PubMed, HPRD
Acetylation	381	PubMed, HPRD
Acetylation	382	PubMed, HPRD
Deacylation	382	PubMed, HPRD
Dephosphorylation	315	PubMed, HPRD
N6-acetyllysine	305	HPRD
N6-acetyllysine	373	HPRD
N6-acetyllysine	382	HPRD
Phosphorylation	6	PubMed, HPRD
Phosphorylation	9	PubMed, HPRD
Phosphorylation	15	PubMed, HPRD
Phosphorylation	18	PubMed, HPRD
Phosphorylation	20	PubMed, HPRD
Phosphorylation	33	PubMed, HPRD
Phosphorylation	37	PubMed, HPRD
Phosphorylation	46	PubMed, HPRD
Phosphorylation	55	PubMed, HPRD
Phosphorylation	81	PubMed, HPRD
Phosphorylation	155	PubMed, HPRD
Phosphorylation	315	PubMed, HPRD
Phosphorylation	366	PubMed, HPRD
Phosphorylation	371	PubMed, HPRD
Phosphorylation	378	PubMed, HPRD
Phosphorylation	392	PubMed, HPRD
Phosphoserine	15	PubMed, HPRD
Phosphoserine	46	PubMed, HPRD
Phosphoserine	315	PubMed, HPRD
Phosphothreonine	18	PubMed, HPRD
Phosphothreonine	55	PubMed, HPRD
Proteolytic Cleavage	18	PubMed, HPRD
Proteolytic Cleavage	20	PubMed, HPRD
Proteolytic Cleavage	23	PubMed, HPRD
Sumoylation	386	PubMed, HPRD
Ubiquitination	351	PubMed, HPRD
Ubiquitination	357	PubMed, HPRD
Ubiquitination	370	PubMed, HPRD
Ubiquitination	372	PubMed, HPRD
Ubiquitination	373	PubMed, HPRD
Ubiquitination	381	PubMed, HPRD
Ubiquitination	382	PubMed, HPRD
Ubiquitination	386	PubMed, HPRD

Protein: HIST1H3A

PTM	Residue	Reference
Methylation	5	PubMed, HPRD
Methylation	10	PubMed, HPRD
N6-acetyllysine	14	HPRD
N6-acetyllysine	23	HPRD
N6-methyllysine	9	HPRD
N6-methyllysine	27	HPRD
N6-methyllysine	36	HPRD

Localisation

Protein: TP53

Localisation	Reference
ER	HPRD
Nucleus	HPRD
Mitochondrion	HPRD
Nucleolus	HPRD
Cytoplasm	HPRD

Protein: HIST1H3A

Localisation	Reference
Nucleus	HPRD

Transitive Score

The common interactors between TP53 and HIST1H3A that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TP53 andHIST1H3A. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TP53 has 1099 interactors and HIST1H3A has 1056 interactors of which there are 712 common interactors.

Common Interactor	Name of Common Interactor	Score for TP53-Interactor (?)	Score for HIST1H3A-Interactor (?)
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	4.77	0.032
H2AFX	H2AFX, H2AX: Histone H2A.x	4.27	9.59
H3F3A	H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3	2.54	390.00
HIST1H1E	HIST1H1E, H1F4: Histone H1.4	2.08	0.208
SMAD4	SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4	1.58	0.029
HIST1H1B	HIST1H1B, H1F5: Histone H1.5	1.26	0.158
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.964	0.284
HIST1H4A	HIST1H4A, H4/A, HIST1H4B, H4/I, H4/G, HIST1H4D, H4/B, H4/J, HIST1H4F, HIST4H4, H	0.902	156.00
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.822	2.02
KHDRBS1	KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate	0.704	0.254
HDAC1	HDAC1, RPD3L1: Histone deacetylase 1	0.704	0.063
PCNA	PCNA: Proliferating cell nuclear antigen	0.704	0.126
NR3C1	NR3C1, GRL: Glucocorticoid receptor	0.651	0.232
SP100	N/A	0.525	0.052
MCM3	MCM3: DNA replication licensing factor MCM3	0.515	0.038
SREBF2	N/A	0.475	0.026
BLM	BLM, RECQ2, RECQL3: Bloom syndrome protein	0.471	0.029
NBN	NBN, NBS, NBS1, P95: Nibrin	0.430	0.127
TRIM28	TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta	0.430	0.251
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.430	0.307
ZNF318	ZNF318, HRIHFB2436: Zinc finger protein 318	0.430	0.032
PRKDC	PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit	0.430	0.032
XRCC6	XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1	0.430	0.032
TOP2A	TOP2A, TOP2: DNA topoisomerase 2-alpha	0.430	0.026
BARD1	BARD1: BRCA1-associated RING domain protein 1	0.430	0.086
DDX21	DDX21: Nucleolar RNA helicase 2	0.430	0.0425
TUBA1	TUBA4A, TUBA1: Tubulin alpha-4A chain	0.425	0.158
HMGB2	HMGB2, HMG2: High mobility group protein B2	0.385	0.824
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	0.385	0.063
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.385	0.824
SP3	SP3: Transcription factor Sp3	0.347	0.038
SRF	SRF: Serum response factor	0.344	0.038
HSF2	HSF2, HSTF2: Heat shock factor protein 2	0.318	0.216
SNRPA	SNRPA: U1 small nuclear ribonucleoprotein A	0.307	0.038
DAXX	DAXX, BING2, DAP6: Death domain-associated protein 6	0.290	0.070
HSF1	HSF1, HSTF1: Heat shock factor protein 1	0.284	0.069
ELAVL1	ELAVL1, HUR: ELAV-like protein 1	0.276	0.038
SYNCRIP	SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q	0.276	0.038
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	0.276	0.038
POLA2	POLA2: DNA polymerase subunit alpha B	0.276	0.038
HNRPF	HNRPF: Heterogeneous nuclear ribonucleoprotein F	0.276	0.046
LMNB1	LMNB1, LMN2, LMNB: Lamin-B1	0.276	0.038
SMC1L1	SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos	0.276	0.038
CENPA	CENPA: Histone H3-like centromeric protein A	0.269	0.152
BAZ1B	BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain	0.260	0.251
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.260	0.0425
BRCA1	BRCA1, RNF53: Breast cancer type 1 susceptibility protein	0.260	0.086
UBTF	UBTF, UBF, UBF1: Nucleolar transcription factor 1	0.260	0.0425
EP300	N/A	0.254	0.208
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.241	0.038
MCM2	MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2	0.241	0.029
MCM4	MCM4, CDC21: DNA replication licensing factor MCM4	0.241	0.029
POLR2H	POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3	0.241	0.029
SUZ12	SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12	0.233	0.052
TOPBP1	TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1	0.233	0.114
ANAPC5	ANAPC5, APC5: Anaphase-promoting complex subunit 5	0.233	0.046
PTEN	PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du	0.233	0.038
YY1	YY1: Transcriptional repressor protein YY1	0.233	0.046
SAFB	SAFB, HAP, HET, SAFB1: Scaffold attachment factor B	0.233	0.052
ZNF76	ZNF76, D6S229E: Zinc finger protein 76	0.216	0.046
NFKBIA	NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha	0.216	0.140
BAZ2A	BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A	0.210	0.275
RB1	RB1: Retinoblastoma-associated protein	0.210	0.026
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.210	0.096
ELF1	ELF1: ETS-related transcription factor Elf-1	0.210	0.210
MATR3	MATR3, KIAA0723: Matrin-3	0.210	0.032
HIF1A	HIF1A, MOP1: Hypoxia-inducible factor 1 alpha	0.208	0.126
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.188	0.038
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.188	0.046
ATR	ATR, FRP1: Serine/threonine-protein kinase ATR	0.188	0.046
MRE11A	MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A	0.188	0.038
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.188	0.038
ACIN1	ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus	0.188	0.038
AKAP8	AKAP8, AKAP95: A-kinase anchor protein 8	0.188	0.046
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	0.188	0.038
CXorf9	N/A	0.188	0.275
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.188	0.046
ZNF217	ZNF217, ZABC1: Zinc finger protein 217	0.188	0.046
STAT1	STAT1: Signal transducer and activator of transcription 1-alpha/beta	0.187	0.025
MYB	MYB: Myb proto-oncogene protein	0.176	0.032
CEBPE	CEBPE: CCAAT/enhancer-binding protein epsilon	0.172	0.029
TRAF2	TRAF2, TRAP3: TNF receptor-associated factor 2	0.162	0.051
TP73	TP73, P73: Tumor protein p73	0.156	0.039
ZNF148	ZNF148, ZBP89: Zinc finger protein 148	0.155	0.0425
PIK3CD	PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i	0.155	0.070
ZNF267	ZNF267: Zinc finger protein 267	0.155	0.032
ERF	ERF: ETS domain-containing transcription factor ERF	0.155	0.077
XRCC1	XRCC1: DNA-repair protein XRCC1	0.155	0.096
MITF	MITF: Microphthalmia-associated transcription factor	0.152	0.152
AR	AR, DHTR, NR3C4: Androgen receptor	0.152	0.028
ARNT	ARNT: Aryl hydrocarbon receptor nuclear translocator	0.152	0.028
HMGA1	HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y	0.152	0.152
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.146	0.038
YBX1	YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1	0.146	0.029
SMAD2	SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2	0.146	0.038
YARS	YARS: Tyrosyl-tRNA synthetase, cytoplasmic	0.146	0.029
CDC6	CDC6, CDC18L: Cell division control protein 6 homolog	0.146	0.029
ABCF1	N/A	0.144	0.0425
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.144	0.0425
MKI67	MKI67: Antigen KI-67	0.144	0.026
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.144	0.0425
HMGN1	HMGN1, HMG14: Non-histone chromosomal protein HMG-14	0.144	0.052
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	0.144	0.052
ESPL1	N/A	0.144	0.026
PTMA	N/A	0.144	0.307
SAT	SAT1, SAT: Diamine acetyltransferase 1	0.140	0.114
ETV6	ETV6, TEL, TEL1: Transcription factor ETV6	0.139	0.114
WDHD1	WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1	0.139	0.136
FKBP5	FKBP5, AIG6, FKBP51: FK506-binding protein 5	0.139	0.038
SKIV2L	SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti	0.139	0.038
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.139	0.038
COPE	COPE: Coatomer subunit epsilon	0.139	0.038
BRD2	BRD2, KIAA9001, RING3: Bromodomain-containing protein 2	0.139	3.23
WRN	WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase	0.139	0.029
RELA	RELA, NFKB3: Transcription factor p65	0.139	0.114
KIAA1012	KIAA1012: Protein TRS85 homolog	0.139	0.038
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.139	0.038
NCOA3	NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3	0.137	0.152
CDC25C	CDC25C: M-phase inducer phosphatase 3	0.137	0.137
LMNA	LMNA, LMN1: Lamin-A/C	0.137	0.025
EWSR1	EWSR1, EWS: RNA-binding protein EWS	0.137	0.137
HNRPH3	HNRPH3: Heterogeneous nuclear ribonucleoprotein H3	0.137	0.137
E2F1	E2F1, RBBP3: Transcription factor E2F1	0.132	0.026
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.132	0.026
IRF3	IRF3: Interferon regulatory factor 3	0.132	0.052
CDK4	CDK4: Cell division protein kinase 4	0.129	0.038
ZNF330	ZNF330, NOA36: Zinc finger protein 330	0.129	0.0425
CSNK2A1	CSNK2A1: CSNK2A1 protein	0.129	1.53
APEX1	APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase	0.129	0.046
SFRS1	SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1	0.129	0.046
SNRPB2	SNRPB2: U2 small nuclear ribonucleoprotein B''	0.129	0.029
SNRPC	SNRPC: U1 small nuclear ribonucleoprotein C	0.129	0.038
MSH6	MSH6, GTBP: DNA mismatch repair protein MSH6	0.129	0.029
LSM2	LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2	0.129	0.029
HDAC3	HDAC3: Histone deacetylase 3	0.129	0.0425
OXSR1	OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1	0.129	0.038
RBBP4	RBBP4, RBAP48: Histone-binding protein RBBP4	0.129	11.90
EIF3S2	EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2	0.129	0.225
EIF2S2	EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2	0.129	0.029
CBX3	CBX3: Chromobox protein homolog 3	0.129	0.114
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	0.129	0.038
CSPG6	SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3	0.129	0.038
LSM5	LSM5: U6 snRNA-associated Sm-like protein LSm5	0.129	0.038
NPM1	NPM1, NPM: Nucleophosmin	0.129	0.032
PABPC4	PABPC4, APP1, PABP4: Polyadenylate-binding protein 4	0.129	0.038
NUP153	N/A	0.129	0.046
SSB	SSB: Lupus La protein	0.129	0.038
KIF11	N/A	0.129	0.029
EIF3S9	EIF3S9: Eukaryotic translation initiation factor 3 subunit 9	0.129	0.038
CHEK1	CHEK1, CHK1: Serine/threonine-protein kinase Chk1	0.129	0.029
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.129	0.225
CDC20	CDC20: Cell division cycle protein 20 homolog	0.129	0.136
CHAF1B	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B	0.129	0.171
TP53BP1	TP53BP1: Tumor suppressor p53-binding protein 1	0.127	0.096
ZNF335	ZNF335: Zinc finger protein 335	0.127	0.046
ZFX	ZFX: Zinc finger X-chromosomal protein	0.127	0.0425
HIVEP1	N/A	0.127	0.032
ATAD2	ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2	0.124	0.041
EIF2B5	EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon	0.118	0.038
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.118	0.046
ORC1L	ORC1L, ORC1, PARC1: Origin recognition complex subunit 1	0.118	0.029
KLF13	KLF13, BTEB3, NSLP1: Krueppel-like factor 13	0.114	0.029
UTX	UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein	0.114	0.038
ETS1	ETS1, EWSR2: Protein C-ets-1	0.114	0.139
C20orf4	C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4	0.114	0.029
TMEM1	TMEM1, EHOC1: Transmembrane protein 1	0.114	0.052
CENTB2	CENTB2, KIAA0041: Centaurin-beta 2	0.114	0.038
AKAP8L	AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like	0.114	0.032
PIK3CG	PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i	0.114	0.029
ZNF24	ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24	0.114	0.046
MTF1	MTF1: Metal regulatory transcription factor 1	0.114	0.029
CBLB	CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B	0.114	0.046
CCNL1	CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1	0.114	0.038
AIP	AIP, XAP2: AH receptor-interacting protein	0.114	0.038
PPP1R12A	PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A	0.114	0.038
STAT5B	STAT5B: Signal transducer and activator of transcription 5B	0.114	0.063
ERCC3	ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit	0.114	0.029
CSK	CSK: Tyrosine-protein kinase CSK	0.112	0.181
BTK	BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK	0.112	0.166
GNB3	GNB3: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3	0.102	0.097
GTF2F2	N/A	0.0971	0.026
STAT2	STAT2: Signal transducer and activator of transcription 2	0.096	0.032
NFATC1	N/A	0.096	0.210
LCP2	LCP2: Lymphocyte cytosolic protein 2	0.096	0.070
PPIA	PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A	0.093	0.045
MAPK6	MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6	0.087	0.026
GNB2L1	Lung cancer oncogene 7	0.087	0.307
RBM3	RBM3, RNPL: Putative RNA-binding protein 3	0.087	0.052
NCOA3	N/A	0.087	0.0425
SET	SET: Protein SET	0.087	0.0425
RBM14	RBM14, SIP: RNA-binding protein 14	0.087	0.0425
TCOF1	N/A	0.087	0.251
RNPS1	RNPS1, LDC2: RNA-binding protein with serine-rich domain 1	0.087	0.0425
IFI16	N/A	0.087	0.0425
KIF23	N/A	0.087	0.026
DNMT1	DNMT1, AIM, DNMT: DNA	0.087	0.0425
BATF	BATF: Basic leucine zipper transcriptional factor ATF-like	0.087	0.0425
TGIF2	TGIF2: Homeobox protein TGIF2	0.087	0.070
HMGN2	HMGN2, HMG17: Non-histone chromosomal protein HMG-17	0.087	0.052
UNG	N/A	0.087	0.029
EIF4G1	EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1	0.087	0.032
TAF6	TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6	0.087	9.09
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.087	0.038
EXOSC2	EXOSC2, RRP4: Exosome complex exonuclease RRP4	0.087	0.029
SMAD3	SMAD3, MADH3: Mothers against decapentaplegic homolog 3	0.087	0.038
SOX4	SOX4: Transcription factor SOX-4	0.086	0.032
RBL2	RBL2, RB2: Retinoblastoma-like protein 2	0.086	0.063
BRD3	BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3	0.086	4.59
BRPF1	BRPF1, BR140: Peregrin	0.086	0.225
MAPK1	MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1	0.086	0.029
MLL	MLL, ALL1, HRX, HTRX, TRX1: Zinc finger protein HRX	0.086	0.225
ZNF224	ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27: Zinc finger protein 224	0.086	0.046
DDX3Y	DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y	0.086	0.038
DDX24	DDX24: ATP-dependent RNA helicase DDX24	0.086	0.029
CTDP1	CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase	0.086	0.096
CREBBP	CREBBP, CBP: CREB-binding protein	0.086	0.114
ATM	ATM: Serine-protein kinase ATM	0.086	0.063
PPEF1	N/A	0.083	0.028
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.083	0.028
POGZ	POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain	0.083	0.028
MAPK15	N/A	0.083	0.028
C20orf18	N/A	0.083	0.083
ELF2	ELF2, NERF: ETS-related transcription factor Elf-2	0.083	0.083
ZNF644	ZNF644, KIAA1221, ZEP2: Zinc finger protein 644	0.083	0.028
UHRF1		0.083	0.165
ZHX1	ZHX1: Zinc fingers and homeoboxes protein 1	0.083	0.028
EEF2K	EEF2K: Elongation factor 2 kinase	0.083	0.025
ZFP91	ZFP91, FKSG11: Zinc finger protein 91 homolog	0.083	0.028
NFATC2	NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2	0.083	0.083
MLL2	MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2	0.083	0.165
ZNF579	ZNF579: Zinc finger protein 579	0.083	0.028
CCAR1	CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1	0.083	0.028
ZNF295	ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295	0.083	0.028
SMARCAD1	SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator	0.083	0.028
NFATC3	NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3	0.083	0.083
DPF2	DPF2, REQ, UBID4: Zinc finger protein ubi-d4	0.0818	0.181
HIF3A	N/A	0.081	0.081
RPL29	RPL29: 60S ribosomal protein L29	0.081	0.048
H1FX	H1FX: Histone H1x	0.080	0.0425
SF3B4	SF3B4, SAP49: Splicing factor 3B subunit 4	0.078	0.038
PSMD4	PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4	0.078	0.038
RBM15	RBM15, OTT: Putative RNA-binding protein 15	0.078	0.046
FNBP1	N/A	0.078	0.275
WBSCR1	EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H	0.078	0.029
CDK2	CDK2: Cell division protein kinase 2	0.078	0.038
CSTF1	CSTF1: Cleavage stimulation factor 50 kDa subunit	0.078	0.225
PABPC1	PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1	0.078	0.046
UBA2	SAE2, UBA2, HRIHFB2115, UBLE1B: SUMO-activating enzyme subunit 2	0.078	0.029
LSM3	LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3	0.078	0.038
PABPN1	PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2	0.078	0.038
LIG1	LIG1: DNA ligase 1	0.078	0.046
SFRS2	SFRS2: Splicing factor, arginine/serine-rich 2	0.078	0.046
ANP32B	ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb	0.078	0.046
TDG	TDG: G/T mismatch-specific thymine DNA glycosylase	0.078	0.0425
NAP1L1	NAP1L1, NRP: Nucleosome assembly protein 1-like 1	0.078	11.90
NOL1	N/A	0.078	0.046
SKIIP	SNW1, SKIIP, SKIP: SNW domain-containing protein 1	0.078	0.038
PAPOLA	PAPOLA, PAP: Poly(A) polymerase alpha	0.078	0.046
ZCCHC8	ZCCHC8: Zinc finger CCHC domain-containing protein 8	0.078	0.0425
AURKA	AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6	0.078	31.00
STK24	STK24, MST3, STK3: Serine/threonine-protein kinase 24	0.078	0.038
SFRS4	SFRS4, SRP75: Splicing factor, arginine/serine-rich 4	0.078	0.046
MYBL2	MYBL2, BMYB: Myb-related protein B	0.078	0.026
IRAK1	IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1	0.078	0.029
TCF3	TCF3, E2A, ITF1: Transcription factor E2-alpha	0.078	0.038
U2AF1	U2AF1, U2AF35, U2AFBP: Splicing factor U2AF 35 kDa subunit	0.078	0.046
NEK9	NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9	0.078	0.046
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.078	0.275
RBM28	RBM28: RNA-binding protein 28	0.078	0.029
YEATS2	KIAA1197, YEATS2: YEATS domain-containing protein 2	0.078	0.032
SFRS10	SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10	0.078	0.038
TIAL1	TIAL1: Nucleolysin TIAR	0.078	0.038
ETS2	ETS2: Protein C-ets-2	0.077	0.077
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.077	0.077
ERG	ERG: Transcriptional regulator ERG	0.077	0.077
MDM4	MDM4, MDMX: Mdm4 protein	0.077	0.026
REST	REST, NRSF, XBR: RE1-silencing transcription factor	0.077	0.026
CDKN2D	CDKN2D: Cyclin-dependent kinase 4 inhibitor D	0.077	0.032
EEF2	EEF2, EF2: Elongation factor 2	0.075	0.045
ZNF174	ZNF174, ZSCAN8: Zinc finger protein 174	0.075	0.025
RFFL	RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin	0.075	0.025
BRD4	N/A	0.075	2.13
SOX8	SOX8: Transcription factor SOX-8	0.075	0.028
SSH2	SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2	0.075	0.025
TRERF1	TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1	0.075	0.025
PRDM2	PRDM2, RIZ: PR domain zinc finger protein 2	0.075	0.148
GIT2	N/A	0.075	0.025
RBM10	RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10	0.075	0.025
DHX8	DHX8, DDX8: ATP-dependent RNA helicase DHX8	0.075	0.025
EXO1	EXO1, EXOI, HEX1: Exonuclease 1	0.075	0.025
CCNT2	CCNT2: Cyclin-T2	0.075	0.025
DUSP6	DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6	0.075	0.025
OSR1	OSR1, ODD: Protein odd-skipped-related 1	0.075	0.025
RBL1	RBL1: Retinoblastoma-like protein 1	0.075	0.025
ATRX	ATRX, RAD54L, XH2: Transcriptional regulator ATRX	0.075	0.148
C14orf4	C14orf4, KIAA1865, My039: RING finger protein C14orf4	0.075	0.025
DDX20	DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20	0.075	0.028
ZFPM1	ZFPM1, FOG1: Zinc finger protein ZFPM1	0.075	0.028
PTP4A3	PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3	0.075	0.025
DUSP16	DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16	0.075	0.025
RNF113A	RNF113A, RNF113, ZNF183: RING finger protein 113A	0.075	0.025
CCNE1	CCNE1, CCNE: G1/S-specific cyclin-E1	0.075	0.025
C10orf9	CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y	0.075	0.025
RNF20		0.075	0.025
SRC	SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src	0.074	0.100
PTTG1	PTTG1, EAP1, PTTG, TUTR1: Securin	0.0727	0.027
HIST1H1D	HIST1H1D, H1F3: Histone H1.3	0.071	0.038
TLK1	TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1	0.070	0.0425
AOF2	AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1	0.070	0.032
WDR1	N/A	0.070	0.251
PLEK	PLEK, P47: Pleckstrin	0.070	0.0425
KIF22	KIF22, KID, KNSL4: Kinesin-like protein KIF22	0.070	0.032
FANCA	FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein	0.070	0.026
STK16	N/A	0.070	0.032
KIAA0853	N/A	0.070	0.0425
HNRPA0	HNRPA0: Heterogeneous nuclear ribonucleoprotein A0	0.070	0.0425
API5	N/A	0.070	0.032
UBAP2	N/A	0.070	0.032
MYBBP1A	MYBBP1A, P160: Myb-binding protein 1A	0.070	0.032
IKBKG	IKBKG, FIP3, NEMO: NF-kappa-B essential modulator	0.070	0.052
SH2BP1	CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog	0.070	0.0425
ZNF551	N/A	0.069	0.038
ZBTB7A	ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A	0.069	0.029
LIG4	LIG4: DNA ligase 4	0.069	0.056
GCN5L2	GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2	0.069	75.10
ZBTB40	ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40	0.069	0.046
SUMO2	SUMO2, SMT3B, SMT3H2: Small ubiquitin-related modifier 2 precursor	0.0668	0.046
VCP	VCP: Transitional endoplasmic reticulum ATPase	0.066	0.788
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.063	0.225
KIAA0683	DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized	0.063	0.038
CORO1C	CORO1C, CRNN4: Coronin-1C	0.063	7.26
EIF4G2	EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2	0.063	0.029
PPP1R8	N/A	0.063	0.038
MTA1	MTA1: Metastasis-associated protein MTA1	0.063	0.029
SEC24C	SEC24C, KIAA0079: Protein transport protein Sec24C	0.063	0.046
ATF1	ATF1: Cyclic AMP-dependent transcription factor ATF-1	0.063	0.029
RPS6KB1	N/A	0.063	0.046
SEC31L1	N/A	0.063	0.171
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.063	2.47
RBM7		0.063	0.029
WBSCR20A	N/A	0.063	0.063
PHF10	N/A	0.063	0.372
VRK1	VRK1: Serine/threonine-protein kinase VRK1	0.063	0.029
PRKD2	PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2	0.063	0.063
NACA	NACA, HSD48: Nascent polypeptide-associated complex subunit alpha	0.063	0.046
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.063	0.029
EIF3S4	EIF3S4: Eukaryotic translation initiation factor 3 subunit 4	0.063	0.063
CPSF1	CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1	0.063	0.275
MYH9	MYH9: Myosin-9	0.063	0.046
DDX51	DDX51: ATP-dependent RNA helicase DDX51	0.063	0.038
COPB2	COPB2: Coatomer subunit beta'	0.063	0.171
HDAC2	HDAC2: Histone deacetylase 2	0.063	0.029
PBK	PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase	0.063	0.026
Nle	NLE1, HUSSY-07: Notchless protein homolog 1	0.063	0.171
COPA	COPA: Coatomer subunit alpha	0.063	0.171
TAF10	TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10	0.063	0.225
RAB8A	RAB8A: RAB8A protein	0.063	0.071
TIMELESS	TIMELESS, TIM, TIM1, TIMELESS1: Protein timeless homolog	0.063	0.029
STAG2	STAG2, SA2: Cohesin subunit SA-2	0.063	0.038
NCOR1	NCOR1, KIAA1047: Nuclear receptor corepressor 1	0.063	0.046
WEE1	WEE1: Wee1-like protein kinase	0.063	0.032
PRPF4B	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol	0.063	0.046
TERF2IP	TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1	0.062	0.062
SH3BP3		0.062	0.109
ZBTB33	KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso	0.062	0.032
LYN	LYN: Tyrosine-protein kinase Lyn	0.061	0.113
LCK	LCK: Proto-oncogene tyrosine-protein kinase LCK	0.061	0.202
ABL1	ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1	0.061	0.100
FOXO1A	FOXO1A, FKHR: Forkhead box protein O1A	0.060	0.038
FOXJ2	FOXJ2, FHX: Forkhead box protein J2	0.060	0.0425
PCAF	PCAF: Histone acetyltransferase PCAF	0.056	2.96
PIK3C2A	PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po	0.056	0.044
ETV1	ETV1, ER81: ETS translocation variant 1	0.056	0.049
RAP1B	RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor	0.0554	0.090
STAT4	STAT4: Signal transducer and activator of transcription 4	0.055	0.046
TAF1	TAF1, BA2R, CCG1, CCGS, TAF2A: Transcription initiation factor TFIID subunit 1	0.055	0.062
HCC-1	HCC1, HSPC316: Nuclear protein Hcc-1	0.055	0.032
UBE2E3	UBE2E3, UBCE4, UBCH9: Ubiquitin-conjugating enzyme E2 E3	0.054	0.041
SOS1	SOS1: Son of sevenless homolog 1	0.054	0.275
SUPT5H	SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5	0.054	0.027
RPA1	RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit	0.053	0.108
FOXM1	FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1	0.052	0.028
HTATIP	HTATIP, TIP60: Histone acetyltransferase HTATIP	0.052	0.028
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.052	0.032
DRIM	UTP20, DRIM: Small subunit processome component 20 homolog	0.052	0.026
CHUK	N/A	0.052	0.0425
AFF1	N/A	0.052	0.032
TERF2	TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2	0.052	0.032
CENPF	N/A	0.052	0.026
TOP2B	N/A	0.052	0.0425
FNBP4	FNBP4, FBP30, KIAA1014: Formin-binding protein 4	0.052	0.052
EMD	EMD, EDMD, STA: Emerin	0.052	0.026
TRRAP	N/A	0.052	0.0425
ARFGAP1	N/A	0.052	0.0425
ROCK1	ROCK1: Rho-associated protein kinase 1	0.052	0.032
JMJD1A	JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr	0.052	0.052
PHF3	PHF3, KIAA0244: PHD finger protein 3	0.052	0.307
ZNF638	ZNF638, NP220, ZFML: Zinc finger protein 638	0.052	0.0425
ITGB1BP1	ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1	0.052	0.026
USP24	USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24	0.052	0.0425
KIAA0528	KIAA0528: Uncharacterized protein KIAA0528	0.052	0.0425
ELK1	ELK1: ETS domain-containing protein Elk-1	0.049	0.049
SPAG1	SPAG1: Sperm-associated antigen 1	0.049	0.026
ZAK	MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT	0.048	0.026
PPARA	PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha	0.048	0.026
FARSLA	FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain	0.047	0.025
PHC2	PHC2, EDR2, PH2: Polyhomeotic-like protein 2	0.047	0.025
HIST2H2AC	HIST2H2AC, H2AFQ: Histone H2A type 2-C	0.047	4.22
SMAD1	SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1	0.047	0.025
HIST1H1C	HIST1H1C, H1F2: Histone H1.2	0.047	0.025
CARHSP1	CARHSP1: Calcium-regulated heat stable protein 1	0.047	0.025
SCYL3	SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin	0.046	0.052
SAPS3	N/A	0.046	0.038
SYMPK	SYMPK, SPK: Symplekin	0.046	0.029
CUL5	CUL5, VACM1: Cullin-5	0.046	0.038
SFRS6	SFRS6, SRP55: Splicing factor, arginine/serine-rich 6	0.046	0.038
MDN1	MDN1, KIAA0301: Midasin	0.046	0.046
RPS6KB2	RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2	0.046	0.038
SNF1LK2	SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2	0.046	0.026
CDC7	CDC7, CDC7L1: Cell division cycle 7-related protein kinase	0.046	0.029
GNB1	GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.046	0.136
ARPC1B	ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B	0.046	0.171
ADRBK1	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1	0.046	0.046
USP34	USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34	0.046	0.052
CSTF2T	CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant	0.046	0.038
GNB2	GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.046	0.171
RBMX2	RBMX2, CGI-79: RNA-binding motif protein, X-linked 2	0.046	0.038
TOPORS	TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors	0.046	0.052
HGS	HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate	0.046	0.038
DIAPH1	Diaphanous 1	0.046	0.046
JARID1A	JARID1A, RBBP2, RBP2: Histone demethylase JARID1A	0.046	0.275
DOK1	DOK1: Docking protein 1	0.046	0.038
PIK4CB	PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic,	0.046	0.038
KLHDC4	N/A	0.046	0.046
DUSP22	DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22	0.046	0.026
RPS6KA1	RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1	0.046	0.038
CRSP2	MED14, ARC150, CRSP2, CXorf4, DRIP150, EXLM1, RGR1, TRAP170: Mediator of RNA pol	0.046	0.029
AKT1	AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase	0.046	0.029
CUL4B	N/A	0.046	0.038
ARMET	ARMET, ARP: Protein ARMET precursor	0.046	0.029
TAOK3	TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3	0.046	0.038
FUBP1	N/A	0.0446	0.036
CASKIN2	CASKIN2, KIAA1139: Caskin-2	0.044	0.088
HIST3H3	HIST3H3, H3FT: Histone H3.1t	0.043	3.88
POU2F1	POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1	0.0425	0.032
PRKR	EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki	0.0425	0.026
RFXDC2	RFXDC2: Regulatory factor X domain-containing protein 2.	0.0425	0.0425
XRCC4	N/A	0.0425	0.032
DEF6	DEF6, IBP: Differentially expressed in FDCP 6	0.0425	0.070
SNAPC4	SNAPC4, SNAP190: snRNA-activating protein complex subunit 4	0.0425	0.0425
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.0425	0.155
TRAFD1	TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1	0.0425	0.0425
SMARCC2	N/A	0.0425	0.032
VCPIP1	VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135	0.0425	0.032
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.0425	0.026
OSBPL11	OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11	0.0425	0.026
PASK	PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase	0.0425	0.070
RBM6	RBM6, DEF3: RNA-binding protein 6	0.0425	0.0425
RGS14	N/A	0.0425	0.0425
MARK2	N/A	0.0425	0.052
COIL	COIL, CLN80: Coilin	0.0425	0.032
FGR	FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR	0.041	0.113
EXOC2	N/A	0.041	0.067
CDC34	CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1	0.041	0.041
MATK	MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase	0.04	0.109
ABL2	ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2	0.04	0.109
CD2AP	CD2AP: CD2-associated protein	0.040	0.148
THOP1	THOP1: Thimet oligopeptidase	0.040	0.051
RPS3	RPS3, OK/SW-cl.26: 40S ribosomal protein S3	0.040	0.032
ETF1	ETF1, ERF1, RF1, SUP45L1: Eukaryotic peptide chain release factor subunit 1	0.040	0.090
STK38	STK38, NDR1: Serine/threonine-protein kinase 38	0.038	0.046
MAPKAPK3	MAPKAPK3: MAP kinase-activated protein kinase 3	0.038	0.029
NEK7	NEK7: Serine/threonine-protein kinase Nek7	0.038	0.038
IQGAP2	IQGAP2: Ras GTPase-activating-like protein IQGAP2	0.038	0.038
PSMD5	PSMD5, KIAA0072: 26S proteasome non-ATPase regulatory subunit 5	0.038	0.032
RBM8A	RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A	0.038	0.038
SPEN	SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein	0.038	0.038
ARID3A	ARID3A, DRIL1, DRIL3, DRX, E2FBP1: AT-rich interactive domain-containing protein	0.038	0.029
MEF2D	MEF2D: Myocyte-specific enhancer factor 2D	0.038	0.029
SNRP70	SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa	0.038	0.038
CRKRS	CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7	0.038	0.038
PKN2	PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2	0.038	0.029
FHOD1	FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1	0.038	0.038
STK10	STK10: Uncharacterized protein STK10	0.038	0.046
SIRT1	SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1	0.038	0.824
NRBP1	NRBP1, BCON3, NRBP: Nuclear receptor-binding protein	0.038	0.029
RREB1	RREB1, FINB: RAS-responsive element-binding protein 1	0.038	0.052
SFRS5	SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5	0.038	0.046
PTK6	PTK6, BRK: Tyrosine-protein kinase 6	0.037	0.072
YES1	YES1, YES: Proto-oncogene tyrosine-protein kinase Yes	0.037	0.064
RHOA	RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor	0.036	0.061
NCF4	NCF4, SH3PXD4: Neutrophil cytosol factor 4	0.036	0.166
MPP6	MPP6, VAM1: MAGUK p55 subfamily member 6	0.036	0.100
UBE2A	UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A	0.036	2.34
FYN	FYN: Proto-oncogene tyrosine-protein kinase Fyn	0.036	0.098
ITK	ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK	0.036	0.109
MYST4	MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4	0.035	0.171
YWHAG	YWHAG: 14-3-3 protein gamma	0.0333	0.0333
FER	FER, TYK3: Proto-oncogene tyrosine-protein kinase FER	0.033	0.073
HCK	N/A	0.033	0.090
BACH1	BACH1: Transcription regulator protein BACH1	0.032	0.032
MAPK7	mitogen-activated protein kinase 7 isoform 1	0.032	0.026
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.032	0.032
ID2	ID2: DNA-binding protein inhibitor ID-2	0.032	0.032
MAPKAPK2	MAPKAPK2: MAP kinase-activated protein kinase 2	0.032	0.032
MAP3K8	MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8	0.032	0.032
VIM	VIM: Vimentin	0.032	0.026
TERF1	TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1	0.032	0.032
SFRS15	SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15	0.032	0.052
GTF3C1	N/A	0.032	0.0425
MAP3K14	MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14	0.032	0.052
MAP2K3	MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki	0.032	0.026
ARHGDIB	ARHGDIB, GDIA2, GDID4, RAP1GN1: Rho GDP-dissociation inhibitor 2	0.032	0.032
SNX17	SNX17, KIAA0064: Sorting nexin-17	0.032	0.067
RPS10	RPS10: 40S ribosomal protein S10	0.032	0.032
EEF1G	EEF1G, EF1G, PRO1608: Elongation factor 1-gamma	0.032	0.032
HCLS1	HCLS1, HS1: Hematopoietic lineage cell-specific protein	0.032	0.181
NRAS	NRAS, HRAS1: GTPase NRas precursor	0.032	0.041
PLD1	PLD1: Phospholipase D1	0.032	0.033
PPARBP	N/A	0.032	0.027
RAB11A	RAB11A, RAB11: Ras-related protein Rab-11A	0.032	0.041
CRKL	CRKL: Crk-like protein	0.032	0.181
DOCK2	DOCK2, KIAA0209: Dedicator of cytokinesis protein 2	0.032	0.148
JUND	JUND: Transcription factor jun-D	0.029	0.029
GMCL1L	GMCL1L, GCL: Germ cell-less protein-like 1-like	0.029	0.038
EML4	EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4	0.029	0.225
ATF6	ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha	0.029	0.029
RCP9	CRCP: DNA-directed RNA polymerase III subunit RPC9	0.029	0.029
SMCX	JARID1C, DXS1272E, SMCX, XE169: Histone demethylase JARID1C	0.029	0.097
RPS6KA5	RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5	0.029	0.171
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.029	9.09
RUNX1	N/A	0.029	0.038
STK4	STK4, MST1: Serine/threonine-protein kinase 4	0.029	0.046
WDR44	WDR44: WD repeat-containing protein 44	0.029	0.029
JUNB	JUNB: Transcription factor jun-B	0.029	0.029
STK11	STK11, LKB1, PJS: Serine/threonine-protein kinase 11	0.029	0.029
NEIL2	NEIL2: Endonuclease VIII-like 2	0.029	0.029
BID	BID: BH3-interacting domain death agonist	0.028	0.028
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.028	0.028
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.028	0.028
TLE3	TLE3, KIAA1547: Transducin-like enhancer protein 3	0.028	0.165
DYRK1A	DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin	0.028	0.028
SGK2	SGK2: Serine/threonine-protein kinase Sgk2	0.028	0.025
KIAA1443	HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez	0.028	0.028
SYTL4	Endocrine transmitter regulatory protein	0.028	0.028
NF2	NF2, SCH: Merlin	0.028	0.028
HES6	HES6: Transcription cofactor HES-6	0.028	0.028
ZNF265	N/A	0.028	0.028
PTBP1	PTBP1: Polypyrimidine tract binding protein 1	0.028	0.028
FBXO4	FBXO4, FBX4: F-box only protein 4	0.028	0.028
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.028	0.028
DYRK1B	DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.028	0.025
DKFZp434K1815	DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815	0.028	0.028
LOC642558	FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1	0.028	0.028
PRKACB	PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit	0.028	0.028
ZCCHC3	ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3	0.028	0.028
MLL4	WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7	0.028	0.148
RAVER1	RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1	0.028	0.028
ATXN2L	ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein	0.028	0.028
C14orf151	C14orf151: Uncharacterized protein C14orf151 (Fragment)	0.028	0.028
ILF3	ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3	0.028	0.028
CUTL1	CUTL1: Homeobox protein cut-like 1	0.028	0.028
ZNF687	ZNF687, KIAA1441: Zinc finger protein 687	0.028	0.028
C13orf8	N/A	0.028	0.028
DUSP15	N/A	0.028	0.028
RAB4A	N/A	0.028	0.028
SF1	SF1, ZFM1, ZNF162: Splicing factor 1	0.028	0.028
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.028	0.028
PHLDB2	N/A	0.028	0.028
NSBP1	NSBP1: Nucleosome-binding protein 1	0.028	0.028
HNRPC	HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2	0.028	0.028
IRF7	N/A	0.028	0.028
WDR54	N/A	0.028	0.165
GPRASP2	GPRASP2: G-protein coupled receptor-associated sorting protein 2	0.028	0.028
TCF20	TCF20, KIAA0292, SPBP: Transcription factor 20	0.028	0.165
CBFA2T2	CBFA2T2, EHT, MTGR1: Protein CBFA2T2	0.028	0.165
TMPO	TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha	0.028	0.028
KIF1B	N/A	0.028	0.028
HDAC8	N/A	0.028	0.028
JDP2	jdp2, JDP2: Jun dimerization protein 2	0.028	0.028
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.028	0.028
NES	N/A	0.028	0.025
SNRPB	N/A	0.028	0.028
FLJ21816	PALB2, FANCN: Partner and localizer of BRCA2	0.028	0.028
PKN3	PKN3, PKNBETA: Serine/threonine-protein kinase N3	0.028	0.025
NIPA1	NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1	0.028	0.028
MAPKAPK5	N/A	0.028	0.028
TFAP4	TFAP4: Transcription factor AP-4	0.028	0.025
CDC2	CDC2: Cell division control protein 2 homolog	0.028	0.025
CORO6	N/A	0.028	0.028
NEK6	NEK6: Serine/threonine-protein kinase Nek6	0.028	0.025
FLJ23436	N/A	0.028	0.025
DSP	DSP: Desmoplakin	0.028	0.028
ZC3HAV1	ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1	0.028	0.028
CABLES1	N/A	0.028	0.028
HDAC7A	N/A	0.028	0.025
PPP1R12C	PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C	0.028	0.028
NFIA	NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A	0.028	0.028
HIST2H2BE	HIST2H2BE, H2BFQ: Histone H2B type 2-E	0.028	11.90
FRK	FRK, PTK5, RAK: Tyrosine-protein kinase FRK	0.027	0.064
TEC	TEC, PSCTK4: Tyrosine-protein kinase Tec	0.027	0.090
TXK	TXK, PTK4: Tyrosine-protein kinase TXK	0.027	0.166
NRIP1	NRIP1: Nuclear receptor-interacting protein 1	0.027	0.044
TRADD	TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein	0.027	0.036
LASP1	LASP1, MLN50: LIM and SH3 domain protein 1	0.027	0.126
FANCD2	FANCD2, FACD: Fanconi anemia group D2 protein	0.026	0.029
PRKAA1	N/A	0.026	0.032
PHF8	PHF8, KIAA1111, ZNF422: PHD finger protein 8	0.026	0.0425
SRPK2	SRPK2: Serine/threonine-protein kinase SRPK2	0.026	0.026
NUP214	N/A	0.026	0.191
MECP2	MECP2: Methyl-CpG-binding protein 2	0.026	0.026
AANAT	AANAT, SNAT: Serotonin N-acetyltransferase	0.026	0.026
MKNK2	MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2	0.025	0.025
LATS2	LATS2, KPM: Serine/threonine-protein kinase LATS2	0.025	0.025
CPNE1	RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12	0.025	0.025
SON		0.025	0.025
EDF1	EDF1: Endothelial differentiation-related factor 1	0.025	0.025
PHF16	PHF16, JADE3, KIAA0215: Protein Jade-3	0.025	0.148
PSIP1	PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein	0.025	0.025
CDC25A	CDC25A: M-phase inducer phosphatase 1	0.025	0.025
THOC4	THOC4, ALY, BEF: THO complex subunit 4	0.025	0.025
HNRPUL1	HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1	0.025	0.025
MAP2K3	N/A	0.025	0.025
HNRPD	HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0	0.025	0.025
PRKACA	PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit	0.025	0.025
NHN1	NHN1: Conserved nuclear protein NHN1	0.025	0.028
NSUN2	NSUN2, SAKI, TRM4: tRNA	0.025	0.025
AKT3	AKT3: RAC-gamma serine/threonine-protein kinase	0.025	0.025
BCOR	N/A	0.025	0.025
CAMKK1	N/A	0.025	0.025
BUB3	BUB3: Mitotic checkpoint protein BUB3	0.025	0.148
GEMIN5	GEMIN5: Gem-associated protein 5	0.025	0.165
DLX3	DLX3: Homeobox protein DLX-3	0.025	0.025
SSBP4	SSBP4: Single-stranded DNA-binding protein 4	0.025	0.148
H2-ALPHA	TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain	0.025	0.025
KCTD1		0.025	0.025
MAPK8IP3	N/A	0.025	0.025
MAX	MAX: Protein max	0.025	0.025
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.025	0.165
ARID1A	ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A	0.025	0.025
MSL3L1	MSL3L1: Male-specific lethal 3-like 1	0.025	0.083
FBXL10	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio	0.025	0.148
WNK4	WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4	0.025	0.025
SMARCA2	SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2	0.025	1.33
MLXIPL	MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein	0.025	0.025
RPS6KA2	RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2	0.025	0.025
PRKCB1	N/A	0.025	0.025
CREB1	CREB1: cAMP response element-binding protein	0.025	0.025
NEK8	NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8	0.025	0.025
NFYA	NFYA: Nuclear transcription factor Y subunit alpha	0.025	0.028
MAP3K7	MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7	0.025	0.025
ARID4A	ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A	0.025	0.075
FLJ40432	FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227	0.025	0.025
ISL2	ISL2: Insulin gene enhancer protein ISL-2	0.025	0.025
LATS1	LATS1, WARTS: Serine/threonine-protein kinase LATS1	0.025	0.025
PURB	PURB: Transcriptional activator protein Pur-beta	0.025	0.025
NEDD4	NEDD4: Uncharacterized protein NEDD4	0.025	0.025
REXO1	REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog	0.025	0.025
NUP98	N/A	0.025	0.025
RBBP6	RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6	0.025	0.025
SEC13L1	N/A	0.025	0.025
NIPBL	N/A	0.025	0.025
SAP14	SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14	0.025	0.025
POLR1C	POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1	0.025	0.025
HNRPA2B1	HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1	0.025	0.025
MIER1	MIER1, KIAA1610: Mesoderm induction early response protein 1	0.025	0.025
ARL5A	ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A	0.025	0.025
ATXN2L	N/A	0.025	0.025
ELMO1	N/A	0.025	0.025
HEXIM2	HEXIM2, L3: Protein HEXIM2	0.025	0.025
HOXA10	HOXA10, HOX1H: Homeobox protein Hox-A10	0.025	0.025
SYAP1	SYAP1, PRO3113: Synapse-associated protein 1	0.025	0.025
GRK6	N/A	0.025	0.025
RAB1B	RAB1B: Ras-related protein Rab-1B	0.025	0.025
SMU1	SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog	0.025	0.148
C20orf77	N/A	0.025	0.025
PLK1	PLK1, PLK: Serine/threonine-protein kinase PLK1	0.025	0.025
ADK	ADK: Adenosine kinase	0.025	0.025
TAL2	TAL2: T-cell acute lymphocytic leukemia protein 2	0.025	0.025
HIST3H2A	HIST3H2A: Histone H2A type 3	0.025	0.714
CAMK1D	CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D	0.025	0.025
raptor	RAPTOR, KIAA1303: Regulatory-associated protein of mTOR	0.025	0.148
PHKG1	PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo	0.025	0.025
ZNF598	ZNF598: Zinc finger protein 598	0.025	0.028
NPM3	NPM3: Nucleoplasmin-3	0.025	12.00
TIA1	TIA1: Nucleolysin TIA-1 isoform p40	0.025	0.025
EXOSC3	EXOSC3, RRP40, CGI-102: Exosome complex exonuclease RRP40	0.025	0.025
SETD3	SETD3, C14orf154: SET domain-containing protein 3	0.025	0.025
FAF1	FAF1, CGI-03: FAS-associated factor 1	0.025	0.025
CAMK2A	N/A	0.025	0.025
PDPK1	PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1	0.025	0.025
GATAD2B	GATAD2B, KIAA1150: Transcriptional repressor p66 beta	0.025	0.025
RAD51	RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1	0.025	0.025
HTATIP	N/A	0.025	1.33
PDE8B	PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies	0.025	0.025
CETN1	CETN1, CEN1, CETN: Centrin-1	0.025	0.028
DIDO1	N/A	0.025	0.148
PPP1R9B	PPP1R9B, PPP1R6: Neurabin-2	0.025	0.025
SFRS9	SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9	0.025	0.025
WWTR1	WWTR1, TAZ: WW domain-containing transcription regulator protein 1	0.025	0.025
GNB4	GNB4: Guanine nucleotide-binding protein subunit beta-4	0.025	0.148
SMC4L1	SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4	0.025	0.025
HNRPM	HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M	0.025	0.025
SMN2	SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein	0.025	0.025
TCEA1	N/A	0.025	0.025
RPS6KA4	RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4	0.025	0.025
CHEK2	CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2	0.025	1.33
IWS1	IWS1, IWS1L: IWS1 homolog	0.025	0.025
MKNK1	MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1	0.025	0.025
MKI67IP	MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein	0.025	0.025
CDC2L5	CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5	0.025	0.025
NOLC1	NOLC1, KIAA0035: Nucleolar phosphoprotein p130	0.025	0.0782

2.15E-3

Total Score

1.37