PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between TP53 and HSF1

The interaction score between TP53 and HSF1 is 33.90.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between TP53 and HSF1 = 0.37

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

3.80E-3

Orthology

Organism	TP53 Orthologue		HSF1 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
human	IPI00215713	0.16	IPI00012878	0.135
human	IPI00215713	0.16	IPI00220197	0.097
human	IPI00215713	0.16	IPI00412469	0.794
fly	Q8IH92	0.16	P22813	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3

Domains

Domains present in TP53 and HSF1:

Domains in TP53

Domains in HSF1

IPR008967	p53-like transcription factor, DNA-binding
IPR002117	p53 tumor antigen
IPR010991	p53, tetramerisation
IPR011615	P53_DNA_bd.
IPR012346	P53_RUNT_DNA_bd.

IPR000232	Heat shock factor (HSF)-type DNA-binding domain
IPR010542	Vertebrate heat shock transcription factor
IPR002341	HSF/ETS, DNA-binding
IPR011991	Wing_hlx_DNA_bd.

The Chi square scores for co-occurrence of domains that are present in TP53 and HSF1 are listed below.

Domain 1		Domain 2		Chi Square
IPR008967	p53-like transcription factor, DNA-binding	IPR011991	Wing_hlx_DNA_bd.	0.00778109

The background colour of the table refers to:

Blue Domain is only present in TP53
Yellow Domain is only present in HSF1
Green Domain is present in both TP53 and HSF1

0.209

Post-translational Modifications

Protein: TP53

PTM	Residue	Reference
Acetylation	305	PubMed, HPRD
Acetylation	320	PubMed, HPRD
Acetylation	370	PubMed, HPRD
Acetylation	372	PubMed, HPRD
Acetylation	373	PubMed, HPRD
Acetylation	381	PubMed, HPRD
Acetylation	382	PubMed, HPRD
Deacylation	382	PubMed, HPRD
Dephosphorylation	315	PubMed, HPRD
N6-acetyllysine	305	HPRD
N6-acetyllysine	373	HPRD
N6-acetyllysine	382	HPRD
Phosphorylation	6	PubMed, HPRD
Phosphorylation	9	PubMed, HPRD
Phosphorylation	15	PubMed, HPRD
Phosphorylation	18	PubMed, HPRD
Phosphorylation	20	PubMed, HPRD
Phosphorylation	33	PubMed, HPRD
Phosphorylation	37	PubMed, HPRD
Phosphorylation	46	PubMed, HPRD
Phosphorylation	55	PubMed, HPRD
Phosphorylation	81	PubMed, HPRD
Phosphorylation	155	PubMed, HPRD
Phosphorylation	315	PubMed, HPRD
Phosphorylation	366	PubMed, HPRD
Phosphorylation	371	PubMed, HPRD
Phosphorylation	378	PubMed, HPRD
Phosphorylation	392	PubMed, HPRD
Phosphoserine	15	PubMed, HPRD
Phosphoserine	46	PubMed, HPRD
Phosphoserine	315	PubMed, HPRD
Phosphothreonine	18	PubMed, HPRD
Phosphothreonine	55	PubMed, HPRD
Proteolytic Cleavage	18	PubMed, HPRD
Proteolytic Cleavage	20	PubMed, HPRD
Proteolytic Cleavage	23	PubMed, HPRD
Sumoylation	386	PubMed, HPRD
Ubiquitination	351	PubMed, HPRD
Ubiquitination	357	PubMed, HPRD
Ubiquitination	370	PubMed, HPRD
Ubiquitination	372	PubMed, HPRD
Ubiquitination	373	PubMed, HPRD
Ubiquitination	381	PubMed, HPRD
Ubiquitination	382	PubMed, HPRD
Ubiquitination	386	PubMed, HPRD

Protein: HSF1

PTM	Residue	Reference
Phosphorylation	142	PubMed, HPRD
Phosphorylation	230	PubMed, HPRD
Phosphorylation	303	PubMed, HPRD
Phosphorylation	307	PubMed, HPRD
Phosphorylation	363	PubMed, HPRD
Phosphoserine	303	HPRD
Phosphoserine	307	HPRD
Sumoylation	298	PubMed, HPRD

Localisation

Protein: TP53

Localisation	Reference
ER	HPRD
Nucleus	HPRD
Mitochondrion	HPRD
Nucleolus	HPRD
Cytoplasm	HPRD

Protein: HSF1

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between TP53 and HSF1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TP53 andHSF1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TP53 has 1099 interactors and HSF1 has 862 interactors of which there are 707 common interactors.

Common Interactor	Name of Common Interactor	Score for TP53-Interactor (?)	Score for HSF1-Interactor (?)
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	4.77	0.155
H2AFX	H2AFX, H2AX: Histone H2A.x	4.27	0.114
H3F3A	H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3	2.54	0.114
HIST1H1E	HIST1H1E, H1F4: Histone H1.4	2.08	0.069
HIST1H3A	HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD,	1.58	0.069
SMAD4	SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4	1.58	0.056
HIST1H1B	HIST1H1B, H1F5: Histone H1.5	1.26	0.123
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.964	0.216
HIST1H4A	HIST1H4A, H4/A, HIST1H4B, H4/I, H4/G, HIST1H4D, H4/B, H4/J, HIST1H4F, HIST4H4, H	0.902	0.056
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.822	0.114
KHDRBS1	KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate	0.704	0.208
HDAC1	HDAC1, RPD3L1: Histone deacetylase 1	0.704	0.038
PCNA	PCNA: Proliferating cell nuclear antigen	0.704	0.038
NR3C1	NR3C1, GRL: Glucocorticoid receptor	0.651	0.032
SP100	N/A	0.525	0.096
MCM3	MCM3: DNA replication licensing factor MCM3	0.515	0.225
SREBF2	N/A	0.475	0.0425
BLM	BLM, RECQ2, RECQL3: Bloom syndrome protein	0.471	0.029
NBN	NBN, NBS, NBS1, P95: Nibrin	0.430	0.127
TRIM28	TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta	0.430	0.416
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.430	0.080
ZNF318	ZNF318, HRIHFB2436: Zinc finger protein 318	0.430	0.127
PRKDC	PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit	0.430	0.096
XRCC6	XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1	0.430	0.052
TOP2A	TOP2A, TOP2: DNA topoisomerase 2-alpha	0.430	0.0425
BARD1	BARD1: BRCA1-associated RING domain protein 1	0.430	0.086
DDX21	DDX21: Nucleolar RNA helicase 2	0.430	0.0425
TUBA1	TUBA4A, TUBA1: Tubulin alpha-4A chain	0.425	0.208
HMGB2	HMGB2, HMG2: High mobility group protein B2	0.385	0.114
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	0.385	0.038
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.385	0.054
CCNB1	Cyclin B1	0.385	0.225
SP3	SP3: Transcription factor Sp3	0.347	0.086
SRF	SRF: Serum response factor	0.344	0.275
HSF2	HSF2, HSTF2: Heat shock factor protein 2	0.318	0.069
DAXX	DAXX, BING2, DAP6: Death domain-associated protein 6	0.290	0.038
ELAVL1	ELAVL1, HUR: ELAV-like protein 1	0.276	0.046
SYNCRIP	SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q	0.276	0.038
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	0.276	0.038
POLA2	POLA2: DNA polymerase subunit alpha B	0.276	0.038
HNRPF	HNRPF: Heterogeneous nuclear ribonucleoprotein F	0.276	0.038
LMNB1	LMNB1, LMN2, LMNB: Lamin-B1	0.276	0.038
SMC1L1	SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos	0.276	0.038
CENPA	CENPA: Histone H3-like centromeric protein A	0.269	0.155
BAZ1B	BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain	0.260	0.191
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.260	0.032
BRCA1	BRCA1, RNF53: Breast cancer type 1 susceptibility protein	0.260	0.114
UBTF	UBTF, UBF, UBF1: Nucleolar transcription factor 1	0.260	0.127
EP300	N/A	0.254	0.208
GGCX	GGCX, GC: Vitamin K-dependent gamma-carboxylase	0.254	0.029
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.241	0.114
MCM2	MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2	0.241	0.225
MCM4	MCM4, CDC21: DNA replication licensing factor MCM4	0.241	0.225
SUZ12	SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12	0.233	0.114
TOPBP1	TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1	0.233	0.086
ANAPC5	ANAPC5, APC5: Anaphase-promoting complex subunit 5	0.233	0.029
PTEN	PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du	0.233	0.038
YY1	YY1: Transcriptional repressor protein YY1	0.233	0.139
SAFB	SAFB, HAP, HET, SAFB1: Scaffold attachment factor B	0.233	0.038
ZNF76	ZNF76, D6S229E: Zinc finger protein 76	0.216	0.069
BAZ2A	BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A	0.210	0.225
RB1	RB1: Retinoblastoma-associated protein	0.210	0.251
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.210	0.251
ELF1	ELF1: ETS-related transcription factor Elf-1	0.210	0.096
MATR3	MATR3, KIAA0723: Matrin-3	0.210	0.077
HIF1A	HIF1A, MOP1: Hypoxia-inducible factor 1 alpha	0.208	0.069
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.188	0.029
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.188	0.086
ATR	ATR, FRP1: Serine/threonine-protein kinase ATR	0.188	0.086
MRE11A	MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A	0.188	0.029
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.188	0.046
ACIN1	ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus	0.188	0.038
AKAP8	AKAP8, AKAP95: A-kinase anchor protein 8	0.188	0.139
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	0.188	0.225
CXorf9	N/A	0.188	0.029
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.188	0.046
ZNF217	ZNF217, ZABC1: Zinc finger protein 217	0.188	0.086
STAT1	STAT1: Signal transducer and activator of transcription 1-alpha/beta	0.187	0.075
MYB	MYB: Myb proto-oncogene protein	0.176	0.062
CEBPB	CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta	0.172	0.136
CEBPE	CEBPE: CCAAT/enhancer-binding protein epsilon	0.172	0.171
CEBPA	CEBPA: CCAAT/enhancer-binding protein alpha	0.156	0.123
ZNF148	ZNF148, ZBP89: Zinc finger protein 148	0.155	0.096
PIK3CD	PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i	0.155	0.060
ZNF267	ZNF267: Zinc finger protein 267	0.155	0.096
ERF	ERF: ETS domain-containing transcription factor ERF	0.155	0.077
XRCC1	XRCC1: DNA-repair protein XRCC1	0.155	0.127
MITF	MITF: Microphthalmia-associated transcription factor	0.152	0.028
AR	AR, DHTR, NR3C4: Androgen receptor	0.152	0.028
ARNT	ARNT: Aryl hydrocarbon receptor nuclear translocator	0.152	0.083
HMGA1	HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y	0.152	0.152
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.146	0.139
YBX1	YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1	0.146	0.188
SMAD2	SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2	0.146	0.086
YARS	YARS: Tyrosyl-tRNA synthetase, cytoplasmic	0.146	0.086
CDC6	CDC6, CDC18L: Cell division control protein 6 homolog	0.146	0.086
ABCF1	N/A	0.144	0.052
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.144	0.052
MKI67	MKI67: Antigen KI-67	0.144	0.127
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.144	0.127
HMGN1	HMGN1, HMG14: Non-histone chromosomal protein HMG-14	0.144	0.0425
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	0.144	0.0425
ESPL1	N/A	0.144	0.0425
PTMA	N/A	0.144	0.0425
SAT	SAT1, SAT: Diamine acetyltransferase 1	0.140	0.077
LEF1	LEF1: Lymphoid enhancer-binding factor 1	0.140	0.056
ETV6	ETV6, TEL, TEL1: Transcription factor ETV6	0.139	0.069
WDHD1	WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1	0.139	0.056
SKIV2L	SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti	0.139	0.063
COPE	COPE: Coatomer subunit epsilon	0.139	0.063
BRD2	BRD2, KIAA9001, RING3: Bromodomain-containing protein 2	0.139	0.225
WRN	WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase	0.139	0.029
RELA	RELA, NFKB3: Transcription factor p65	0.139	0.114
KIAA1012	KIAA1012: Protein TRS85 homolog	0.139	0.029
NCOA3	NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3	0.137	0.075
CDC25C	CDC25C: M-phase inducer phosphatase 3	0.137	0.025
LMNA	LMNA, LMN1: Lamin-A/C	0.137	0.025
EWSR1	EWSR1, EWS: RNA-binding protein EWS	0.137	1.37
HNRPH3	HNRPH3: Heterogeneous nuclear ribonucleoprotein H3	0.137	0.137
E2F1	E2F1, RBBP3: Transcription factor E2F1	0.132	0.127
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.132	0.077
IRF3	IRF3: Interferon regulatory factor 3	0.132	0.155
CDK4	CDK4: Cell division protein kinase 4	0.129	0.114
ZNF330	ZNF330, NOA36: Zinc finger protein 330	0.129	0.046
CSNK2A1	CSNK2A1: CSNK2A1 protein	0.129	0.114
APEX1	APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase	0.129	0.086
SFRS1	SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1	0.129	0.038
MAD2L1	MAD2L1, MAD2: Mitotic spindle assembly checkpoint protein MAD2A	0.129	0.029
SNRPB2	SNRPB2: U2 small nuclear ribonucleoprotein B''	0.129	0.038
SNRPC	SNRPC: U1 small nuclear ribonucleoprotein C	0.129	0.046
MSH6	MSH6, GTBP: DNA mismatch repair protein MSH6	0.129	0.038
LSM2	LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2	0.129	0.046
HDAC3	HDAC3: Histone deacetylase 3	0.129	0.038
OXSR1	OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1	0.129	0.114
EIF3S2	EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2	0.129	0.038
EIF2S2	EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2	0.129	0.046
CBX3	CBX3: Chromobox protein homolog 3	0.129	0.038
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	0.129	0.038
CSPG6	SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3	0.129	0.038
NPM1	NPM1, NPM: Nucleophosmin	0.129	0.038
PABPC4	PABPC4, APP1, PABP4: Polyadenylate-binding protein 4	0.129	0.046
NUP153	N/A	0.129	0.038
SSB	SSB: Lupus La protein	0.129	0.038
KIF11	N/A	0.129	0.029
EIF3S9	EIF3S9: Eukaryotic translation initiation factor 3 subunit 9	0.129	0.046
CHEK1	CHEK1, CHK1: Serine/threonine-protein kinase Chk1	0.129	0.086
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.129	0.038
CDC20	CDC20: Cell division cycle protein 20 homolog	0.129	0.046
CHAF1B	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B	0.129	0.029
TP53BP1	TP53BP1: Tumor suppressor p53-binding protein 1	0.127	0.096
ZNF335	ZNF335: Zinc finger protein 335	0.127	0.086
ZFX	ZFX: Zinc finger X-chromosomal protein	0.127	0.062
HIVEP1	N/A	0.127	0.077
SALL1	SALL1, SAL1: Sal-like protein 1	0.125	0.044
ATAD2	ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2	0.124	0.148
EIF2B5	EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon	0.118	0.086
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.118	0.086
ORC1L	ORC1L, ORC1, PARC1: Origin recognition complex subunit 1	0.118	0.086
KLF13	KLF13, BTEB3, NSLP1: Krueppel-like factor 13	0.114	0.086
ETS1	ETS1, EWSR2: Protein C-ets-1	0.114	0.069
C20orf4	C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4	0.114	0.038
FKBP4	FKBP4: FK506-binding protein 4	0.114	0.029
SGTA	SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A	0.114	0.046
AKAP8L	AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like	0.114	0.139
PIK3CG	PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i	0.114	0.035
CCNH	CCNH: Cyclin-H	0.114	0.136
ZNF24	ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24	0.114	0.069
MTF1	MTF1: Metal regulatory transcription factor 1	0.114	0.086
CCNL1	CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1	0.114	0.136
AIP	AIP, XAP2: AH receptor-interacting protein	0.114	0.046
STAT5B	STAT5B: Signal transducer and activator of transcription 5B	0.114	0.086
MAPK12	MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12	0.114	0.136
FXR1	FXR1: Fragile X mental retardation syndrome-related protein 1	0.112	0.0818
ZBTB16	ZBTB16, PLZF, ZNF145: Zinc finger and BTB domain-containing protein 16	0.111	0.056
KPNA2	KPNA2, RCH1, SRP1: Importin subunit alpha-2	0.111	0.067
STAT6	STAT6: Signal transducer and activator of transcription 6	0.111	0.051
GTF2F2	N/A	0.0971	0.096
STAT2	STAT2: Signal transducer and activator of transcription 2	0.096	0.062
NFATC1	N/A	0.096	0.191
SMARCA3	HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor	0.096	0.060
EEA1	EEA1, ZFYVE2: Early endosome antigen 1	0.096	0.049
LCP2	LCP2: Lymphocyte cytosolic protein 2	0.096	0.026
SATB2	SATB2, KIAA1034: DNA-binding protein SATB2	0.090	0.044
MAPK6	MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6	0.087	0.096
GNB2L1	Lung cancer oncogene 7	0.087	0.0425
RBM3	RBM3, RNPL: Putative RNA-binding protein 3	0.087	0.032
NCOA3	N/A	0.087	0.032
SET	SET: Protein SET	0.087	0.032
RBM14	RBM14, SIP: RNA-binding protein 14	0.087	0.052
TCOF1	N/A	0.087	0.0425
RNPS1	RNPS1, LDC2: RNA-binding protein with serine-rich domain 1	0.087	0.070
IFI16	N/A	0.087	0.032
KIF23	N/A	0.087	0.0425
DNMT1	DNMT1, AIM, DNMT: DNA	0.087	0.052
BATF	BATF: Basic leucine zipper transcriptional factor ATF-like	0.087	0.251
TGIF2	TGIF2: Homeobox protein TGIF2	0.087	0.127
HMGN2	HMGN2, HMG17: Non-histone chromosomal protein HMG-17	0.087	0.0425
UNG	N/A	0.087	0.029
EIF4G1	EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1	0.087	0.070
TAF6	TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6	0.087	0.139
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.087	0.114
EXOSC2	EXOSC2, RRP4: Exosome complex exonuclease RRP4	0.087	0.069
SMAD3	SMAD3, MADH3: Mothers against decapentaplegic homolog 3	0.087	0.086
SOX4	SOX4: Transcription factor SOX-4	0.086	0.056
RBL2	RBL2, RB2: Retinoblastoma-like protein 2	0.086	0.136
BRD3	BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3	0.086	0.136
BRPF1	BRPF1, BR140: Peregrin	0.086	0.275
MAPK1	MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1	0.086	0.136
MLL	MLL, ALL1, HRX, HTRX, TRX1: Zinc finger protein HRX	0.086	0.111
ZNF224	ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27: Zinc finger protein 224	0.086	0.086
DDX3Y	DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y	0.086	0.029
CCND1	CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1	0.086	0.111
CTDP1	CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase	0.086	0.114
CREBBP	CREBBP, CBP: CREB-binding protein	0.086	0.136
ATM	ATM: Serine-protein kinase ATM	0.086	0.069
RANGAP1	RANGAP1, SD: Ran GTPase-activating protein 1	0.084	0.027
PPEF1	N/A	0.083	0.028
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.083	0.165
POGZ	POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain	0.083	0.083
MAPK15	N/A	0.083	0.165
C20orf18	N/A	0.083	0.083
ELF2	ELF2, NERF: ETS-related transcription factor Elf-2	0.083	0.083
ZNF644	ZNF644, KIAA1221, ZEP2: Zinc finger protein 644	0.083	0.083
UHRF1		0.083	0.083
ZHX1	ZHX1: Zinc fingers and homeoboxes protein 1	0.083	0.083
EEF2K	EEF2K: Elongation factor 2 kinase	0.083	0.025
ZFP91	ZFP91, FKSG11: Zinc finger protein 91 homolog	0.083	0.083
NFATC2	NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2	0.083	0.165
MLL2	MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2	0.083	0.028
ZNF579	ZNF579: Zinc finger protein 579	0.083	0.083
CCAR1	CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1	0.083	0.028
ZNF295	ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295	0.083	0.083
SMARCAD1	SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator	0.083	0.052
NFATC3	NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3	0.083	0.165
DPF2	DPF2, REQ, UBID4: Zinc finger protein ubi-d4	0.0818	0.067
HIPK2	HIPK2: Homeodomain-interacting protein kinase 2	0.081	0.050
H1FX	H1FX: Histone H1x	0.080	0.096
SF3B4	SF3B4, SAP49: Splicing factor 3B subunit 4	0.078	0.046
PSMD4	PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4	0.078	0.087
RBM15	RBM15, OTT: Putative RNA-binding protein 15	0.078	0.038
FNBP1	N/A	0.078	0.029
WBSCR1	EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H	0.078	0.029
CDK2	CDK2: Cell division protein kinase 2	0.078	0.114
CSTF1	CSTF1: Cleavage stimulation factor 50 kDa subunit	0.078	0.038
PABPC1	PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1	0.078	0.046
UBA2	SAE2, UBA2, HRIHFB2115, UBLE1B: SUMO-activating enzyme subunit 2	0.078	0.038
PABPN1	PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2	0.078	0.038
LIG1	LIG1: DNA ligase 1	0.078	0.038
SFRS2	SFRS2: Splicing factor, arginine/serine-rich 2	0.078	0.038
ANP32B	ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb	0.078	0.038
TDG	TDG: G/T mismatch-specific thymine DNA glycosylase	0.078	0.038
TUBB	TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain	0.078	0.038
NAP1L1	NAP1L1, NRP: Nucleosome assembly protein 1-like 1	0.078	0.038
NOL1	N/A	0.078	0.029
SKIIP	SNW1, SKIIP, SKIP: SNW domain-containing protein 1	0.078	0.046
PAPOLA	PAPOLA, PAP: Poly(A) polymerase alpha	0.078	0.038
ZCCHC8	ZCCHC8: Zinc finger CCHC domain-containing protein 8	0.078	0.038
AURKA	AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6	0.078	0.114
STK24	STK24, MST3, STK3: Serine/threonine-protein kinase 24	0.078	0.087
SFRS4	SFRS4, SRP75: Splicing factor, arginine/serine-rich 4	0.078	0.038
CDK7	CDK7, MO15: Cell division protein kinase 7	0.078	0.114
MYBL2	MYBL2, BMYB: Myb-related protein B	0.078	0.114
IRAK1	IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1	0.078	0.071
TCF3	TCF3, E2A, ITF1: Transcription factor E2-alpha	0.078	0.114
NEK9	NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9	0.078	0.114
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.078	0.038
YEATS2	KIAA1197, YEATS2: YEATS domain-containing protein 2	0.078	0.029
SFRS10	SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10	0.078	0.038
TIAL1	TIAL1: Nucleolysin TIAR	0.078	0.046
ETS2	ETS2: Protein C-ets-2	0.077	0.062
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.077	0.096
ERG	ERG: Transcriptional regulator ERG	0.077	0.055
MDM4	MDM4, MDMX: Mdm4 protein	0.077	0.034
SNAI1	SNAI1, SNAH: Zinc finger protein SNAI1	0.077	0.049
REST	REST, NRSF, XBR: RE1-silencing transcription factor	0.077	0.062
CDKN2D	CDKN2D: Cyclin-dependent kinase 4 inhibitor D	0.077	0.026
ZNF174	ZNF174, ZSCAN8: Zinc finger protein 174	0.075	0.075
RFFL	RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin	0.075	0.025
BRD4	N/A	0.075	0.148
SOX8	SOX8: Transcription factor SOX-8	0.075	0.075
SSH2	SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2	0.075	0.025
TRERF1	TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1	0.075	0.075
PRDM2	PRDM2, RIZ: PR domain zinc finger protein 2	0.075	0.075
GIT2	N/A	0.075	0.025
RBM10	RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10	0.075	0.075
DHX8	DHX8, DDX8: ATP-dependent RNA helicase DHX8	0.075	0.075
EXO1	EXO1, EXOI, HEX1: Exonuclease 1	0.075	0.025
CCNT2	CCNT2: Cyclin-T2	0.075	0.148
DUSP6	DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6	0.075	0.025
OSR1	OSR1, ODD: Protein odd-skipped-related 1	0.075	0.075
RBL1	RBL1: Retinoblastoma-like protein 1	0.075	0.148
ATRX	ATRX, RAD54L, XH2: Transcriptional regulator ATRX	0.075	0.047
C14orf4	C14orf4, KIAA1865, My039: RING finger protein C14orf4	0.075	0.025
DDX20	DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20	0.075	0.025
ZFPM1	ZFPM1, FOG1: Zinc finger protein ZFPM1	0.075	0.075
DUSP16	DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16	0.075	0.025
RNF113A	RNF113A, RNF113, ZNF183: RING finger protein 113A	0.075	0.025
CCNE1	CCNE1, CCNE: G1/S-specific cyclin-E1	0.075	0.148
C10orf9	CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y	0.075	0.148
RNF20		0.075	0.075
PHB2	PHB2, BAP, REA: Prohibitin-2	0.074	0.036
STOML2	STOML2, SLP2, HSPC108: Stomatin-like protein 2	0.074	0.036
HIST1H1D	HIST1H1D, H1F3: Histone H1.3	0.071	0.069
TLK1	TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1	0.070	0.077
AOF2	AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1	0.070	0.052
WDR1	N/A	0.070	0.0425
PLEK	PLEK, P47: Pleckstrin	0.070	0.032
KIF22	KIF22, KID, KNSL4: Kinesin-like protein KIF22	0.070	0.070
FANCA	FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein	0.070	0.0425
STK16	N/A	0.070	0.155
KIAA0853	N/A	0.070	0.032
HNRPA0	HNRPA0: Heterogeneous nuclear ribonucleoprotein A0	0.070	0.026
UBAP2	N/A	0.070	0.070
MYBBP1A	MYBBP1A, P160: Myb-binding protein 1A	0.070	0.032
IKBKG	IKBKG, FIP3, NEMO: NF-kappa-B essential modulator	0.070	0.0425
SH2BP1	CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog	0.070	0.032
ZNF551	N/A	0.069	0.056
ZBTB7A	ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A	0.069	0.086
LIG4	LIG4: DNA ligase 4	0.069	0.049
GCN5L2	GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2	0.069	0.136
GIT1	GIT1: ARF GTPase-activating protein GIT1	0.069	0.038
ZBTB40	ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40	0.069	0.069
TCF8	ZEB1, AREB6, TCF8: Zinc finger E-box-binding homeobox 1	0.069	0.056
KLF1	KLF1, EKLF: Krueppel-like factor 1	0.069	0.086
FOS	FOS, G0S7: Proto-oncogene protein c-fos	0.069	0.136
STAT5A	STAT5A, STAT5: Signal transducer and activator of transcription 5A	0.067	0.041
ILK	ILK, ILK1, ILK2: Integrin-linked protein kinase	0.067	0.067
SUMO2	SUMO2, SMT3B, SMT3H2: Small ubiquitin-related modifier 2 precursor	0.0668	0.046
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.063	0.029
KIAA0683	DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized	0.063	0.046
PPP1R8	N/A	0.063	0.086
MTA1	MTA1: Metastasis-associated protein MTA1	0.063	0.372
SEC24C	SEC24C, KIAA0079: Protein transport protein Sec24C	0.063	0.038
ATF1	ATF1: Cyclic AMP-dependent transcription factor ATF-1	0.063	0.225
NOC2L	NOC2L: Nucleolar complex protein 2 homolog	0.063	0.046
RPS6KB1	N/A	0.063	0.086
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.063	0.086
RBM7		0.063	0.029
WBSCR20A	N/A	0.063	0.046
PHF10	N/A	0.063	0.038
VRK1	VRK1: Serine/threonine-protein kinase VRK1	0.063	0.054
PRKD2	PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2	0.063	0.114
NACA	NACA, HSD48: Nascent polypeptide-associated complex subunit alpha	0.063	0.029
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.063	0.038
EIF3S4	EIF3S4: Eukaryotic translation initiation factor 3 subunit 4	0.063	0.046
CPSF1	CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1	0.063	0.046
MYH9	MYH9: Myosin-9	0.063	0.029
PSMD1	PSMD1: 26S proteasome non-ATPase regulatory subunit 1	0.063	0.086
COPB2	COPB2: Coatomer subunit beta'	0.063	0.038
HDAC2	HDAC2: Histone deacetylase 2	0.063	0.038
PBK	PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase	0.063	0.139
TAF10	TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10	0.063	0.233
TIMELESS	TIMELESS, TIM, TIM1, TIMELESS1: Protein timeless homolog	0.063	0.029
STAG2	STAG2, SA2: Cohesin subunit SA-2	0.063	0.038
NCOR1	NCOR1, KIAA1047: Nuclear receptor corepressor 1	0.063	0.069
WEE1	WEE1: Wee1-like protein kinase	0.063	0.071
PRPF4B	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol	0.063	0.086
TERF2IP	TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1	0.062	0.077
SH3BP3		0.062	0.062
DDIT3	DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3	0.062	0.152
ZBTB33	KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso	0.062	0.055
FOXO1A	FOXO1A, FKHR: Forkhead box protein O1A	0.060	0.056
FOXJ2	FOXJ2, FHX: Forkhead box protein J2	0.060	0.077
DAPK1	DAPK1, DAPK: Death-associated protein kinase 1	0.057	0.033
PIK3CB	PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit	0.056	0.0308
PCAF	PCAF: Histone acetyltransferase PCAF	0.056	0.136
FOSL2	FOSL2, FRA2: Fos-related antigen 2	0.056	0.097
SP1	SP1, TSFP1: Transcription factor Sp1	0.056	0.086
PIK3C2A	PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po	0.056	0.035
ETV1	ETV1, ER81: ETS translocation variant 1	0.056	0.049
STAT4	STAT4: Signal transducer and activator of transcription 4	0.055	0.056
TAF1	TAF1, BA2R, CCG1, CCGS, TAF2A: Transcription initiation factor TFIID subunit 1	0.055	0.123
UBE2E3	UBE2E3, UBCE4, UBCH9: Ubiquitin-conjugating enzyme E2 E3	0.054	0.051
SOS1	SOS1: Son of sevenless homolog 1	0.054	0.069
ESRRA	ESRRA, ERR1, ESRL1, NR3B1: Steroid hormone receptor ERR1	0.054	0.046
SUPT5H	SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5	0.054	0.054
FOXM1	FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1	0.052	0.083
HTATIP	HTATIP, TIP60: Histone acetyltransferase HTATIP	0.052	0.083
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.052	0.070
DRIM	UTP20, DRIM: Small subunit processome component 20 homolog	0.052	0.096
CHUK	N/A	0.052	0.032
AFF1	N/A	0.052	0.032
TERF2	TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2	0.052	0.062
TOP2B	N/A	0.052	0.026
FNBP4	FNBP4, FBP30, KIAA1014: Formin-binding protein 4	0.052	0.026
EMD	EMD, EDMD, STA: Emerin	0.052	0.052
TRRAP	N/A	0.052	0.052
ARFGAP1	N/A	0.052	0.052
ROCK1	ROCK1: Rho-associated protein kinase 1	0.052	0.096
JMJD1A	JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr	0.052	0.0425
PHF3	PHF3, KIAA0244: PHD finger protein 3	0.052	0.032
ZNF638	ZNF638, NP220, ZFML: Zinc finger protein 638	0.052	0.026
ITGB1BP1	ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1	0.052	0.026
USP24	USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24	0.052	0.026
KIAA0528	KIAA0528: Uncharacterized protein KIAA0528	0.052	0.032
MAPK13	MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13	0.051	0.090
RANBP2	RANBP2, NUP358: E3 SUMO-protein ligase RanBP2	0.051	0.041
SMARCA1	SMARCA1, SNF2L, SNF2L1: Probable global transcription activator SNF2L1	0.050	0.028
ZHX3	ZHX3, KIAA0395, TIX1: Zinc fingers and homeoboxes protein 3	0.049	0.055
MAPK10	MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10	0.049	0.109
STAT3		0.049	0.044
MAPK8	MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8	0.049	0.109
BNC1	BNC1, BNC: Zinc finger protein basonuclin-1	0.049	0.069
MAPK3	MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3	0.049	65.60
ELK1	ELK1: ETS domain-containing protein Elk-1	0.049	0.056
SOX11	SOX11: Transcription factor SOX-11	0.049	0.049
KLF5	KLF5, BTEB2, CKLF, IKLF: Krueppel-like factor 5	0.049	0.049
RXRA	RXRA, NR2B1: Retinoic acid receptor RXR-alpha	0.048	0.032
ZAK	MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT	0.048	0.096
FARSLA	FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain	0.047	0.075
PHC2	PHC2, EDR2, PH2: Polyhomeotic-like protein 2	0.047	0.025
HIST2H2AC	HIST2H2AC, H2AFQ: Histone H2A type 2-C	0.047	0.075
SMAD1	SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1	0.047	0.075
HIST1H1C	HIST1H1C, H1F2: Histone H1.2	0.047	0.075
CARHSP1	CARHSP1: Calcium-regulated heat stable protein 1	0.047	0.075
SCYL3	SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin	0.046	0.069
SAPS3	N/A	0.046	0.038
MAP2K1	MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1	0.046	0.069
SYMPK	SYMPK, SPK: Symplekin	0.046	0.139
MDN1	MDN1, KIAA0301: Midasin	0.046	0.029
RPS6KB2	RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2	0.046	0.139
PKMYT1	PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito	0.046	0.071
SNF1LK2	SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2	0.046	0.139
HDGF	HDGF, HMG1L2: Hepatoma-derived growth factor	0.046	0.038
FZR1	N/A	0.046	0.046
CDC7	CDC7, CDC7L1: Cell division cycle 7-related protein kinase	0.046	0.054
ARPC1B	ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B	0.046	0.038
ADRBK1	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1	0.046	0.086
GNB2	GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.046	0.046
TOPORS	TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors	0.046	0.063
STK38L	STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like	0.046	0.056
HGS	HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate	0.046	0.087
DIAPH1	Diaphanous 1	0.046	0.038
JARID1A	JARID1A, RBBP2, RBP2: Histone demethylase JARID1A	0.046	0.029
STK3	STK3, MST2: Serine/threonine-protein kinase 3	0.046	0.069
DOK1	DOK1: Docking protein 1	0.046	0.038
PIK4CB	PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic,	0.046	0.046
KLHDC4	N/A	0.046	0.038
WDR79	N/A	0.046	0.046
MBD3	MBD3: Methyl-CpG-binding domain protein 3	0.046	0.038
DUSP22	DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22	0.046	0.046
RPS6KA1	RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1	0.046	0.114
CRSP2	MED14, ARC150, CRSP2, CXorf4, DRIP150, EXLM1, RGR1, TRAP170: Mediator of RNA pol	0.046	0.029
AKT1	AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase	0.046	0.139
GSK3B	N/A	0.046	0.038
ARMET	ARMET, ARP: Protein ARMET precursor	0.046	0.029
TAOK3	TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3	0.046	0.069
MGMT	MGMT: Methylated-DNA--protein-cysteine methyltransferase	0.046	0.075
EGR1	EGR1, ZNF225: Early growth response protein 1	0.044	0.044
HIST3H3	HIST3H3, H3FT: Histone H3.1t	0.043	0.056
FOXO3A	FOXO3A, FKHRL1: Forkhead box protein O3A	0.043	0.086
POU2F1	POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1	0.0425	0.077
PRKR	EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki	0.0425	0.039
RFXDC2	RFXDC2: Regulatory factor X domain-containing protein 2.	0.0425	0.026
XRCC4	N/A	0.0425	0.026
DEF6	DEF6, IBP: Differentially expressed in FDCP 6	0.0425	0.026
SNAPC4	SNAPC4, SNAP190: snRNA-activating protein complex subunit 4	0.0425	0.127
CDKN1A	CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1: Cyclin-dependent kinase inhi	0.0425	0.032
HUWE1	HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1	0.0425	0.032
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.0425	0.077
TRAFD1	TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1	0.0425	0.0425
SMARCC2	N/A	0.0425	0.032
VCPIP1	VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135	0.0425	0.032
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.0425	0.062
OSBPL11	OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11	0.0425	0.026
PASK	PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase	0.0425	0.096
RBM6	RBM6, DEF3: RNA-binding protein 6	0.0425	0.032
RGS14	N/A	0.0425	0.026
MARK2	N/A	0.0425	0.026
COIL	COIL, CLN80: Coilin	0.0425	0.052
EXOC2	N/A	0.041	0.033
CDC34	CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1	0.041	0.137
XPO1	XPO1, CRM1: Exportin-1	0.040	0.051
TESK1	TESK1: Dual specificity testis-specific protein kinase 1	0.039	0.0425
STK38	STK38, NDR1: Serine/threonine-protein kinase 38	0.038	0.069
MAPKAPK3	MAPKAPK3: MAP kinase-activated protein kinase 3	0.038	0.139
POLR2A	POLR2A: Uncharacterized protein POLR2A	0.038	0.046
NEK7	NEK7: Serine/threonine-protein kinase Nek7	0.038	0.069
MEF2D	MEF2D: Myocyte-specific enhancer factor 2D	0.038	0.086
SNRP70	SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa	0.038	0.029
CRKRS	CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7	0.038	0.054
PKN2	PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2	0.038	0.086
FHOD1	FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1	0.038	0.188
STK10	STK10: Uncharacterized protein STK10	0.038	0.086
MAFG	MAFG: Transcription factor MafG	0.038	0.225
FKBP1A	FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A	0.038	0.029
SIRT1	SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1	0.038	0.136
NRBP1	NRBP1, BCON3, NRBP: Nuclear receptor-binding protein	0.038	0.038
CCNG1	CCNG1, CCNG, CYCG1: Cyclin-G1	0.038	0.036
CCNA2	CCNA2, CCN1, CCNA: Cyclin-A2	0.038	0.036
HD	HD, IT15: Huntingtin	0.036	0.057
MNAR	PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1	0.036	0.075
UBE2A	UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A	0.036	0.044
MYST4	MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4	0.035	0.056
SMAD7	SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7	0.034	0.055
FOXL2	FOXL2: Forkhead box protein L2	0.034	0.044
AXL	AXL, UFO: Tyrosine-protein kinase receptor UFO precursor	0.034	0.034
AXIN1		0.0333	0.04
INSL3	JAK3: Tyrosine-protein kinase JAK3	0.032	0.032
BACH1	BACH1: Transcription regulator protein BACH1	0.032	0.152
MAPK7	mitogen-activated protein kinase 7 isoform 1	0.032	0.052
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.032	0.062
ID2	ID2: DNA-binding protein inhibitor ID-2	0.032	0.077
STRN3	STRN3, GS2NA, SG2NA: Striatin-3	0.032	0.026
MAPKAPK2	MAPKAPK2: MAP kinase-activated protein kinase 2	0.032	0.096
MAP3K8	MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8	0.032	0.096
VIM	VIM: Vimentin	0.032	0.026
TERF1	TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1	0.032	0.062
SFRS15	SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15	0.032	0.026
GTF3C1	N/A	0.032	0.0425
MAP3K14	MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14	0.032	0.060
ID3	ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3	0.032	0.127
AHR	AHR: Aryl hydrocarbon receptor precursor	0.032	0.069
MAP2K3	MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki	0.032	0.080
CTNNB1	CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1	0.032	0.041
MAP2K2	MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki	0.032	0.111
RAF1	RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase	0.032	0.054
FLII	FLII, FLIL: Protein flightless-1 homolog	0.032	0.032
DOCK2	DOCK2, KIAA0209: Dedicator of cytokinesis protein 2	0.032	0.051
NFIB	N/A	0.031	0.049
RFX1	RFX1: MHC class II regulatory factor RFX1	0.0308	0.097
HIST1H1A	HIST1H1A, H1F1: Histone H1.1	0.0308	0.056
NFE2L2	NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2	0.029	0.136
JUND	JUND: Transcription factor jun-D	0.029	0.171
CSDA	CSDA, DBPA: DNA-binding protein A	0.029	0.188
ATF6	ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha	0.029	0.111
CSNK1E	CSNK1E: Casein kinase I isoform epsilon	0.029	0.043
RPS6KA5	RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5	0.029	0.049
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.029	0.046
STK4	STK4, MST1: Serine/threonine-protein kinase 4	0.029	0.056
REXO2	REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor	0.029	0.029
JUNB	JUNB: Transcription factor jun-B	0.029	0.171
STK25	STK25, SOK1, YSK1: Serine/threonine-protein kinase 25	0.029	0.114
STK11	STK11, LKB1, PJS: Serine/threonine-protein kinase 11	0.029	0.233
GRK5	GRK5, GPRK5: G protein-coupled receptor kinase 5	0.029	0.069
POLB	POLB: DNA polymerase beta	0.029	0.029
BID	BID: BH3-interacting domain death agonist	0.028	0.028
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.028	0.052
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.028	0.083
TLE3	TLE3, KIAA1547: Transducin-like enhancer protein 3	0.028	0.028
DYRK1A	DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin	0.028	0.052
SGK2	SGK2: Serine/threonine-protein kinase Sgk2	0.028	0.083
KIAA1443	HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez	0.028	0.083
SYTL4	Endocrine transmitter regulatory protein	0.028	0.028
NF2	NF2, SCH: Merlin	0.028	0.028
HES6	HES6: Transcription cofactor HES-6	0.028	0.083
ZNF265	N/A	0.028	0.028
PTBP1	PTBP1: Polypyrimidine tract binding protein 1	0.028	0.028
FBXO4	FBXO4, FBX4: F-box only protein 4	0.028	0.028
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.028	0.083
DYRK1B	DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.028	0.047
DKFZp434K1815	DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815	0.028	0.028
LOC642558	FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1	0.028	0.028
ZCCHC3	ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3	0.028	0.028
MLL4	WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7	0.028	0.025
RAVER1	RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1	0.028	0.028
ATXN2L	ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein	0.028	0.028
C14orf151	C14orf151: Uncharacterized protein C14orf151 (Fragment)	0.028	0.028
ILF3	ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3	0.028	0.028
CUTL1	CUTL1: Homeobox protein cut-like 1	0.028	0.083
ZNF687	ZNF687, KIAA1441: Zinc finger protein 687	0.028	0.028
C13orf8	N/A	0.028	0.028
DUSP15	N/A	0.028	0.028
RAB4A	N/A	0.028	0.028
SF1	SF1, ZFM1, ZNF162: Splicing factor 1	0.028	0.028
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.028	0.052
PHLDB2	N/A	0.028	0.028
NSBP1	NSBP1: Nucleosome-binding protein 1	0.028	0.028
HNRPC	HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2	0.028	0.028
IRF7	N/A	0.028	0.028
WDR54	N/A	0.028	0.028
GPRASP2	GPRASP2: G-protein coupled receptor-associated sorting protein 2	0.028	0.028
TCF20	TCF20, KIAA0292, SPBP: Transcription factor 20	0.028	0.028
CBFA2T2	CBFA2T2, EHT, MTGR1: Protein CBFA2T2	0.028	0.028
TMPO	TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha	0.028	0.028
KIF1B	N/A	0.028	0.028
HDAC8	N/A	0.028	0.028
JDP2	jdp2, JDP2: Jun dimerization protein 2	0.028	0.028
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.028	0.052
NES	N/A	0.028	0.028
SNRPB	N/A	0.028	0.028
FLJ21816	PALB2, FANCN: Partner and localizer of BRCA2	0.028	0.028
PKN3	PKN3, PKNBETA: Serine/threonine-protein kinase N3	0.028	0.075
NIPA1	NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1	0.028	0.028
MAPKAPK5	N/A	0.028	0.052
TFAP4	TFAP4: Transcription factor AP-4	0.028	0.075
CDC2	CDC2: Cell division control protein 2 homolog	0.028	0.075
CORO6	N/A	0.028	0.028
NEK6	NEK6: Serine/threonine-protein kinase Nek6	0.028	0.075
FLJ23436	N/A	0.028	0.025
DSP	DSP: Desmoplakin	0.028	0.028
ZC3HAV1	ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1	0.028	0.028
CABLES1	N/A	0.028	0.028
HDAC7A	N/A	0.028	0.025
PPP1R12C	PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C	0.028	0.028
NFIA	NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A	0.028	0.028
RFX5	RFX5: DNA-binding protein RFX5	0.0278	0.041
HIST2H2BE	HIST2H2BE, H2BFQ: Histone H2B type 2-E	0.028	0.056
FXR2	FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2	0.027	0.041
MPG	N/A	0.027	0.027
NEK1	NEK1, KIAA1901: Serine/threonine-protein kinase Nek1	0.026	0.062
PRKAA1	N/A	0.026	0.127
GRLF1	N/A	0.026	0.052
PHF8	PHF8, KIAA1111, ZNF422: PHD finger protein 8	0.026	0.032
SRPK2	SRPK2: Serine/threonine-protein kinase SRPK2	0.026	0.077
MEF2A	N/A	0.026	0.055
NUP214	N/A	0.026	0.0425
FAM65A	FAM65A, KIAA1930: Protein FAM65A	0.026	0.026
AANAT	AANAT, SNAT: Serotonin N-acetyltransferase	0.026	0.077
TRIM16	TRIM16, EBBP: Tripartite motif-containing protein 16	0.026	0.026
PCTK1	PCTK1: Serine/threonine-protein kinase PCTAIRE-1	0.026	0.114
KRT18	KRT18: Uncharacterized protein KRT18	0.026	0.039
CIC	CIC, KIAA0306: Protein capicua homolog	0.025	0.039
MKNK2	MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2	0.025	0.075
LATS2	LATS2, KPM: Serine/threonine-protein kinase LATS2	0.025	0.075
CPNE1	RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12	0.025	0.025
SON		0.025	0.025
EDF1	EDF1: Endothelial differentiation-related factor 1	0.025	0.025
PHF16	PHF16, JADE3, KIAA0215: Protein Jade-3	0.025	0.025
PSIP1	PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein	0.025	0.025
CDC25A	CDC25A: M-phase inducer phosphatase 1	0.025	0.025
HNRPUL1	HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1	0.025	0.025
MAP2K3	N/A	0.025	0.025
HNRPD	HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0	0.025	0.025
PRKACA	PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit	0.025	0.075
NHN1	NHN1: Conserved nuclear protein NHN1	0.025	0.025
NSUN2	NSUN2, SAKI, TRM4: tRNA	0.025	0.025
AKT3	AKT3: RAC-gamma serine/threonine-protein kinase	0.025	0.075
BCOR	N/A	0.025	0.025
CAMKK1	N/A	0.025	0.025
BUB3	BUB3: Mitotic checkpoint protein BUB3	0.025	0.025
GEMIN5	GEMIN5: Gem-associated protein 5	0.025	0.025
DLX3	DLX3: Homeobox protein DLX-3	0.025	0.075
SSBP4	SSBP4: Single-stranded DNA-binding protein 4	0.025	0.025
H2-ALPHA	TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain	0.025	0.025
KCTD1		0.025	0.025
MAPK8IP3	N/A	0.025	0.025
MAX	MAX: Protein max	0.025	0.075
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.025	0.075
ARID1A	ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A	0.025	0.075
MSL3L1	MSL3L1: Male-specific lethal 3-like 1	0.025	0.025
FBXL10	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio	0.025	0.025
WNK4	WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4	0.025	0.047
SMARCA2	SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2	0.025	0.025
MLXIPL	MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein	0.025	0.075
RPS6KA2	RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2	0.025	0.075
PRKCB1	N/A	0.025	0.025
CREB1	CREB1: cAMP response element-binding protein	0.025	0.148
NEK8	NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8	0.025	0.075
NFYA	NFYA: Nuclear transcription factor Y subunit alpha	0.025	0.025
MAP3K7	MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7	0.025	0.047
ARID4A	ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A	0.025	0.025
FLJ40432	FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227	0.025	0.025
ISL2	ISL2: Insulin gene enhancer protein ISL-2	0.025	0.075
LATS1	LATS1, WARTS: Serine/threonine-protein kinase LATS1	0.025	0.075
PURB	PURB: Transcriptional activator protein Pur-beta	0.025	0.025
NEDD4	NEDD4: Uncharacterized protein NEDD4	0.025	0.025
REXO1	REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog	0.025	0.025
NUP98	N/A	0.025	0.025
RBBP6	RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6	0.025	0.025
SEC13L1	N/A	0.025	0.025
NIPBL	N/A	0.025	0.075
SAP14	SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14	0.025	0.025
POLR1C	POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1	0.025	0.025
HNRPA2B1	HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1	0.025	0.025
MIER1	MIER1, KIAA1610: Mesoderm induction early response protein 1	0.025	0.025
ARL5A	ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A	0.025	0.025
ATXN2L	N/A	0.025	0.025
ELMO1	N/A	0.025	0.075
HEXIM2	HEXIM2, L3: Protein HEXIM2	0.025	0.025
HOXA10	HOXA10, HOX1H: Homeobox protein Hox-A10	0.025	0.075
SYAP1	SYAP1, PRO3113: Synapse-associated protein 1	0.025	0.025
GRK6	N/A	0.025	0.025
SMU1	SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog	0.025	0.025
C20orf77	N/A	0.025	0.025
PLK1	PLK1, PLK: Serine/threonine-protein kinase PLK1	0.025	0.075
ADK	ADK: Adenosine kinase	0.025	0.025
TAL2	TAL2: T-cell acute lymphocytic leukemia protein 2	0.025	0.075
HIST3H2A	HIST3H2A: Histone H2A type 3	0.025	0.025
CAMK1D	CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D	0.025	0.075
raptor	RAPTOR, KIAA1303: Regulatory-associated protein of mTOR	0.025	0.075
PHKG1	PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo	0.025	0.075
ZNF598	ZNF598: Zinc finger protein 598	0.025	0.025
TIA1	TIA1: Nucleolysin TIA-1 isoform p40	0.025	0.025
SETD3	SETD3, C14orf154: SET domain-containing protein 3	0.025	0.025
FAF1	FAF1, CGI-03: FAS-associated factor 1	0.025	0.025
CAMK2A	N/A	0.025	0.025
PDPK1	PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1	0.025	0.075
GATAD2B	GATAD2B, KIAA1150: Transcriptional repressor p66 beta	0.025	0.148
RAD51	RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1	0.025	0.025
HTATIP	N/A	0.025	0.025
PDE8B	PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies	0.025	0.025
CETN1	CETN1, CEN1, CETN: Centrin-1	0.025	0.025
DIDO1	N/A	0.025	0.025
PPP1R9B	PPP1R9B, PPP1R6: Neurabin-2	0.025	0.025
SFRS9	SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9	0.025	0.025
WWTR1	WWTR1, TAZ: WW domain-containing transcription regulator protein 1	0.025	0.025
SMC4L1	SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4	0.025	0.025
HNRPM	HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M	0.025	0.025
SMN2	SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein	0.025	0.025
TCEA1	N/A	0.025	0.025
RPS6KA4	RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4	0.025	0.047
CHEK2	CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2	0.025	0.075
IWS1	IWS1, IWS1L: IWS1 homolog	0.025	0.025
MKNK1	MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1	0.025	0.075
MKI67IP	MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein	0.025	0.025
CDC2L5	CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5	0.025	0.075

0.299

Total Score

33.90