The interaction score between TP53 and RELB is 1.24.
This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins
The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.
| Feature | Evidence | Score (?) |
|---|
| Gene Expression |
Pearson's Correlation between TP53 and RELB = 0.49
The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596. |
4.62E-3 |
| Orthology |
The Inparalog Score is calculated by InParanoid
The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.
|
2.23E-3 |
| Domains |
No domains were used in calculating likelihood of interaction
|
8.18E-3 |
| Post-translational Modifications |
Protein: TP53
| PTM | Residue | Reference |
|---|
| Acetylation |
305 |
PubMed, HPRD |
| Acetylation |
320 |
PubMed, HPRD |
| Acetylation |
370 |
PubMed, HPRD |
| Acetylation |
372 |
PubMed, HPRD |
| Acetylation |
373 |
PubMed, HPRD |
| Acetylation |
381 |
PubMed, HPRD |
| Acetylation |
382 |
PubMed, HPRD |
| Deacylation |
382 |
PubMed, HPRD |
| Dephosphorylation |
315 |
PubMed, HPRD |
| N6-acetyllysine |
305 |
HPRD |
| N6-acetyllysine |
373 |
HPRD |
| N6-acetyllysine |
382 |
HPRD |
| Phosphorylation |
6 |
PubMed, HPRD |
| Phosphorylation |
9 |
PubMed, HPRD |
| Phosphorylation |
15 |
PubMed, HPRD |
| Phosphorylation |
18 |
PubMed, HPRD |
| Phosphorylation |
20 |
PubMed, HPRD |
| Phosphorylation |
33 |
PubMed, HPRD |
| Phosphorylation |
37 |
PubMed, HPRD |
| Phosphorylation |
46 |
PubMed, HPRD |
| Phosphorylation |
55 |
PubMed, HPRD |
| Phosphorylation |
81 |
PubMed, HPRD |
| Phosphorylation |
155 |
PubMed, HPRD |
| Phosphorylation |
315 |
PubMed, HPRD |
| Phosphorylation |
366 |
PubMed, HPRD |
| Phosphorylation |
371 |
PubMed, HPRD |
| Phosphorylation |
378 |
PubMed, HPRD |
| Phosphorylation |
392 |
PubMed, HPRD |
| Phosphoserine |
15 |
PubMed, HPRD |
| Phosphoserine |
46 |
PubMed, HPRD |
| Phosphoserine |
315 |
PubMed, HPRD |
| Phosphothreonine |
18 |
PubMed, HPRD |
| Phosphothreonine |
55 |
PubMed, HPRD |
| Proteolytic Cleavage |
18 |
PubMed, HPRD |
| Proteolytic Cleavage |
20 |
PubMed, HPRD |
| Proteolytic Cleavage |
23 |
PubMed, HPRD |
| Sumoylation |
386 |
PubMed, HPRD |
| Ubiquitination |
351 |
PubMed, HPRD |
| Ubiquitination |
357 |
PubMed, HPRD |
| Ubiquitination |
370 |
PubMed, HPRD |
| Ubiquitination |
372 |
PubMed, HPRD |
| Ubiquitination |
373 |
PubMed, HPRD |
| Ubiquitination |
381 |
PubMed, HPRD |
| Ubiquitination |
382 |
PubMed, HPRD |
| Ubiquitination |
386 |
PubMed, HPRD |
Protein: RELB
|
| Localisation |
Protein: TP53
Protein: RELB
| Localisation | Reference |
|---|
| Nucleus |
HPRD |
| Cytoplasm |
HPRD |
|
| Transitive Score |
The common interactors between TP53 and RELB that are considered by the Transitive module are listed below. The Scores listed are the values used by the transitive module to calculate the final interaction Score between TP53 andRELB. The values listed are therefore not the final Score value for the listed interactions. With a Score value ≥0.025 , TP53 has 1099 interactors and RELB has 133 interactors of which there are 37 common interactors.
| Common Interactor | Name of Common Interactor | Score for TP53-Interactor (?) | Score for RELB-Interactor (?) |
|---|
| HDAC1 |
HDAC1, RPD3L1: Histone deacetylase 1 |
0.704 |
5.36 |
| PSMD11 |
PSMD11: 26S proteasome non-ATPase regulatory subunit 11 |
0.503 |
0.029 |
| EIF3S8 |
EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 |
0.503 |
0.029 |
| BLM |
BLM, RECQ2, RECQL3: Bloom syndrome protein |
0.471 |
0.441 |
| BARD1 |
BARD1: BRCA1-associated RING domain protein 1 |
0.430 |
0.041 |
| EIF3S6 |
EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6 |
0.304 |
0.035 |
| NFKBIA |
NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha |
0.216 |
1.14 |
| MAP4K1 |
MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 |
0.144 |
0.0255 |
| RELA |
RELA, NFKB3: Transcription factor p65 |
0.139 |
6.55 |
| APRT |
APRT: Adenine phosphoribosyltransferase |
0.137 |
0.047 |
| IRF3 |
IRF3: Interferon regulatory factor 3 |
0.132 |
0.067 |
| CENTB2 |
CENTB2, KIAA0041: Centaurin-beta 2 |
0.114 |
0.028 |
| STAT5B |
STAT5B: Signal transducer and activator of transcription 5B |
0.114 |
4.07 |
| KPNA2 |
KPNA2, RCH1, SRP1: Importin subunit alpha-2 |
0.111 |
25.00 |
| VARS |
VARS, G7A, VARS2: Valyl-tRNA synthetase |
0.0968 |
0.035 |
| PSMD3 |
PSMD3: 26S proteasome non-ATPase regulatory subunit 3 |
0.0968 |
0.029 |
| PSMD13 |
PSMD13: 26S proteasome non-ATPase regulatory subunit 13 |
0.0968 |
0.029 |
| hfl-B5 |
PCID1, EIF3M, GA17, hfl-B5, hCG_27316: PCI domain containing 1 |
0.0968 |
0.047 |
| CREBBP |
CREBBP, CBP: CREB-binding protein |
0.086 |
5.36 |
| CYCS |
CYCS, CYC: Cytochrome c |
0.078 |
0.0795 |
| GCN5L2 |
GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2 |
0.069 |
6.55 |
| GIT1 |
GIT1: ARF GTPase-activating protein GIT1 |
0.069 |
0.028 |
| STAT5A |
STAT5A, STAT5: Signal transducer and activator of transcription 5A |
0.067 |
1.66 |
| NMI |
NMI: N-myc-interactor |
0.065 |
0.032 |
| EIF3S10 |
EIF3S10, KIAA0139: Eukaryotic translation initiation factor 3 subunit 10 |
0.059 |
0.029 |
| COPS2 |
N/A |
0.059 |
0.029 |
| COPS7B |
COPS7B, CSN7B: COP9 signalosome complex subunit 7b |
0.059 |
0.029 |
| PPP2CB |
PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform |
0.0462 |
1.32 |
| CTBP1 |
CTBP1, CTBP: C-terminal-binding protein 1 |
0.039 |
0.083 |
| CEP110 |
CEP1: 110 kDa centrosomal protein |
0.039 |
0.032 |
| E2F5 |
E2F5: Transcription factor E2F5 |
0.036 |
0.074 |
| SARS |
SARS, SERS: Seryl-tRNA synthetase, cytoplasmic |
0.029 |
0.029 |
| RFX5 |
RFX5: DNA-binding protein RFX5 |
0.0278 |
0.0255 |
| TEC |
TEC, PSCTK4: Tyrosine-protein kinase Tec |
0.027 |
2.80 |
| C20orf116 |
C20orf116: Uncharacterized protein C20orf116 precursor |
0.027 |
0.027 |
| GABPB2 |
GABPB2, E4TF1B, GABPB, GABPB1: GA-binding protein beta chain |
0.0255 |
0.0308 |
| MAP2K3 |
N/A |
0.025 |
0.642 |
|
0.228 |
| Total Score |
|
1.24 |
