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Evidence of Interaction Between TP53 and DUSP2

The interaction score between TP53 and DUSP2 is 1.62.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between TP53 and DUSP2 = 0.40

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 4.62E-3
Orthology
OrganismTP53 OrthologueDUSP2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00215713 0.16 IPI00419454 0.101

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in TP53 and DUSP2:
Domains in TP53Domains in DUSP2
IPR008967 p53-like transcription factor, DNA-binding
IPR002117 p53 tumor antigen
IPR010991 p53, tetramerisation
IPR011615 P53_DNA_bd.
IPR012346 P53_RUNT_DNA_bd.
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase
IPR001763 Rhodanese-like
IPR000340 Dual specificity protein phosphatase
IPR008343 MAP kinase phosphatase

The Chi square scores for co-occurrence of domains that are present in TP53 and DUSP2 are listed below.

Domain 1Domain 2Chi Square
IPR008967 p53-like transcription factor, DNA-binding IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 0.0365131

The background colour of the table refers to:

  • Blue Domain is only present in TP53
  • Yellow Domain is only present in DUSP2
  • Green Domain is present in both TP53 and DUSP2

 8.18E-3
Post-translational Modifications

Protein: TP53

PTMResidueReference
Acetylation 305 PubMed, HPRD
Acetylation 320 PubMed, HPRD
Acetylation 370 PubMed, HPRD
Acetylation 372 PubMed, HPRD
Acetylation 373 PubMed, HPRD
Acetylation 381 PubMed, HPRD
Acetylation 382 PubMed, HPRD
Deacylation 382 PubMed, HPRD
Dephosphorylation 315 PubMed, HPRD
N6-acetyllysine 305 HPRD
N6-acetyllysine 373 HPRD
N6-acetyllysine 382 HPRD
Phosphorylation 6 PubMed, HPRD
Phosphorylation 9 PubMed, HPRD
Phosphorylation 15 PubMed, HPRD
Phosphorylation 18 PubMed, HPRD
Phosphorylation 20 PubMed, HPRD
Phosphorylation 33 PubMed, HPRD
Phosphorylation 37 PubMed, HPRD
Phosphorylation 46 PubMed, HPRD
Phosphorylation 55 PubMed, HPRD
Phosphorylation 81 PubMed, HPRD
Phosphorylation 155 PubMed, HPRD
Phosphorylation 315 PubMed, HPRD
Phosphorylation 366 PubMed, HPRD
Phosphorylation 371 PubMed, HPRD
Phosphorylation 378 PubMed, HPRD
Phosphorylation 392 PubMed, HPRD
Phosphoserine 15 PubMed, HPRD
Phosphoserine 46 PubMed, HPRD
Phosphoserine 315 PubMed, HPRD
Phosphothreonine 18 PubMed, HPRD
Phosphothreonine 55 PubMed, HPRD
Proteolytic Cleavage 18 PubMed, HPRD
Proteolytic Cleavage 20 PubMed, HPRD
Proteolytic Cleavage 23 PubMed, HPRD
Sumoylation 386 PubMed, HPRD
Ubiquitination 351 PubMed, HPRD
Ubiquitination 357 PubMed, HPRD
Ubiquitination 370 PubMed, HPRD
Ubiquitination 372 PubMed, HPRD
Ubiquitination 373 PubMed, HPRD
Ubiquitination 381 PubMed, HPRD
Ubiquitination 382 PubMed, HPRD
Ubiquitination 386 PubMed, HPRD

Protein: DUSP2

PTMResidueReference
Localisation

Protein: TP53

LocalisationReference
ER HPRD
Nucleus HPRD
Mitochondrion HPRD
Nucleolus HPRD
Cytoplasm HPRD

Protein: DUSP2

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between TP53 and DUSP2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TP53 andDUSP2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TP53 has 1099 interactors and DUSP2 has 282 interactors of which there are 115 common interactors.

Common InteractorName of Common InteractorScore for TP53-Interactor (?)Score for DUSP2-Interactor (?)
CXorf9 N/A 0.188 0.074
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.155 0.137
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.144 0.067
CDK4 CDK4: Cell division protein kinase 4 0.129 0.028
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.129 0.044
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.129 0.060
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.129 0.028
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.114 0.044
CCNH CCNH: Cyclin-H 0.114 0.028
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.114 0.881
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.114 0.060
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.114 0.060
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.114 0.177
CSK CSK: Tyrosine-protein kinase CSK 0.112 0.059
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.111 0.053
STAT6 STAT6: Signal transducer and activator of transcription 6 0.111 0.047
STAT2 STAT2: Signal transducer and activator of transcription 2 0.096 0.041
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.096 0.137
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.087 0.0308
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.086 0.090
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.086 31.70
ATM ATM: Serine-protein kinase ATM 0.086 0.293
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.265
MAPK15 N/A 0.083 0.265
EEF2K EEF2K: Elongation factor 2 kinase 0.083 0.027
FNBP1 N/A 0.078 0.038
CDK2 CDK2: Cell division protein kinase 2 0.078 0.028
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.078 0.044
CDK7 CDK7, MO15: Cell division protein kinase 7 0.078 0.028
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.078 0.036
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.078 0.083
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.075 0.027
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.070 0.050
STK16 N/A 0.070 0.0308
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.067 0.029
RPS6KB1 N/A 0.063 0.074
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.063 0.038
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.063 0.0308
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.063 0.083
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.063 0.083
CRLF3 N/A 0.063 0.037
LYN LYN: Tyrosine-protein kinase Lyn 0.061 0.032
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.061 0.108
STAT4 STAT4: Signal transducer and activator of transcription 4 0.055 0.293
SOS1 SOS1: Son of sevenless homolog 1 0.054 0.074
ROCK1 ROCK1: Rho-associated protein kinase 1 0.052 0.050
JAK1 0.051 0.108
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.051 0.225
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.051 0.029
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.217
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.217
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.049 5.04
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.046 0.067
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.046 0.044
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.046 0.050
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.046 0.028
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.046 0.044
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.046 0.028
DOK1 DOK1: Docking protein 1 0.046 0.036
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.046 0.060
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.046 0.036
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.046 0.083
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.0425 0.0308
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.0425 0.137
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0425 0.0308
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.0425 0.083
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.041 0.029
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.039 0.0308
SORL1 SORL1: Sortilin-related receptor precursor 0.039 0.027
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.038 0.263
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.038 0.0308
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.038 0.044
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.038 0.036
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.038 0.044
STK10 STK10: Uncharacterized protein STK10 0.038 0.293
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.038 0.044
CCNG1 CCNG1, CCNG, CYCG1: Cyclin-G1 0.038 0.036
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.033 0.207
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.032 0.067
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.041
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.032 0.050
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.032 0.041
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.032 0.029
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.032 0.035
CRKL CRKL: Crk-like protein 0.032 0.029
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.031 0.037
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.029 0.028
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.029 0.036
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.123
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.029 0.036
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.029 0.0308
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.036
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.028 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.028 0.027
NF2 NF2, SCH: Merlin 0.028 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.028 0.027
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.028 0.027
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.028 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.027
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.028 0.027
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.028 0.027
MAPKAPK5 N/A 0.028 0.027
CDC2 CDC2: Cell division control protein 2 homolog 0.028 0.027
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.028 0.027
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.027 0.231
PRKAA1 N/A 0.026 0.050
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.026 0.041
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.025 0.027
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.025 0.027
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.025 0.027
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.025 0.027
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.025 0.027
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.025 0.027
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.025 0.027
0.299
Total Score 1.62