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Evidence of Interaction Between TP53 and SMAD4

The interaction score between TP53 and SMAD4 is 1.37.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between TP53 and SMAD4 = 0.22

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.88E-3
Orthology
OrganismTP53 OrthologueSMAD4 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
fly Q8IH92 0.16 O61458 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 1.53
Post-translational Modifications

Protein: TP53

PTMResidueReference
Acetylation 305 PubMed, HPRD
Acetylation 320 PubMed, HPRD
Acetylation 370 PubMed, HPRD
Acetylation 372 PubMed, HPRD
Acetylation 373 PubMed, HPRD
Acetylation 381 PubMed, HPRD
Acetylation 382 PubMed, HPRD
Deacylation 382 PubMed, HPRD
Dephosphorylation 315 PubMed, HPRD
N6-acetyllysine 305 HPRD
N6-acetyllysine 373 HPRD
N6-acetyllysine 382 HPRD
Phosphorylation 6 PubMed, HPRD
Phosphorylation 9 PubMed, HPRD
Phosphorylation 15 PubMed, HPRD
Phosphorylation 18 PubMed, HPRD
Phosphorylation 20 PubMed, HPRD
Phosphorylation 33 PubMed, HPRD
Phosphorylation 37 PubMed, HPRD
Phosphorylation 46 PubMed, HPRD
Phosphorylation 55 PubMed, HPRD
Phosphorylation 81 PubMed, HPRD
Phosphorylation 155 PubMed, HPRD
Phosphorylation 315 PubMed, HPRD
Phosphorylation 366 PubMed, HPRD
Phosphorylation 371 PubMed, HPRD
Phosphorylation 378 PubMed, HPRD
Phosphorylation 392 PubMed, HPRD
Phosphoserine 15 PubMed, HPRD
Phosphoserine 46 PubMed, HPRD
Phosphoserine 315 PubMed, HPRD
Phosphothreonine 18 PubMed, HPRD
Phosphothreonine 55 PubMed, HPRD
Proteolytic Cleavage 18 PubMed, HPRD
Proteolytic Cleavage 20 PubMed, HPRD
Proteolytic Cleavage 23 PubMed, HPRD
Sumoylation 386 PubMed, HPRD
Ubiquitination 351 PubMed, HPRD
Ubiquitination 357 PubMed, HPRD
Ubiquitination 370 PubMed, HPRD
Ubiquitination 372 PubMed, HPRD
Ubiquitination 373 PubMed, HPRD
Ubiquitination 381 PubMed, HPRD
Ubiquitination 382 PubMed, HPRD
Ubiquitination 386 PubMed, HPRD

Protein: SMAD4

PTMResidueReference
Phosphorylation 277 PubMed, HPRD
Sumoylation 113 PubMed, HPRD
Sumoylation 159 PubMed, HPRD
Localisation

Protein: TP53

LocalisationReference
ER HPRD
Nucleus HPRD
Mitochondrion HPRD
Nucleolus HPRD
Cytoplasm HPRD

Protein: SMAD4

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between TP53 and SMAD4 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TP53 andSMAD4. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TP53 has 1099 interactors and SMAD4 has 867 interactors of which there are 678 common interactors.

Common InteractorName of Common InteractorScore for TP53-Interactor (?)Score for SMAD4-Interactor (?)
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 2.54 0.038
HIST1H1E HIST1H1E, H1F4: Histone H1.4 2.08 0.086
NR5A1 NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1 1.58 0.069
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 1.58 0.029
HIST1H1B HIST1H1B, H1F5: Histone H1.5 1.26 0.216
PGR PGR, NR3C3: Progesterone receptor 1.00 0.026
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.964 0.158
HIST1H4A HIST1H4A, H4/A, HIST1H4B, H4/I, H4/G, HIST1H4D, H4/B, H4/J, HIST1H4F, HIST4H4, H 0.902 0.029
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.822 0.086
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.704 0.254
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.704 0.046
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.651 0.052
SP100 N/A 0.525 0.155
NBN NBN, NBS, NBS1, P95: Nibrin 0.430 0.155
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.430 0.048
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.430 0.032
ZNF318 ZNF318, HRIHFB2436: Zinc finger protein 318 0.430 0.127
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.430 0.077
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.430 0.127
DDX21 DDX21: Nucleolar RNA helicase 2 0.430 0.0425
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.425 0.126
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.385 0.086
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.385 0.038
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.385 0.038
SP3 SP3: Transcription factor Sp3 0.347 0.114
SRF SRF: Serum response factor 0.344 0.139
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.318 0.086
DAXX DAXX, BING2, DAP6: Death domain-associated protein 6 0.290 0.029
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.284 0.056
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.276 0.029
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.276 0.038
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 0.276 0.029
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.276 0.038
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.276 0.029
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.276 0.038
CENPA CENPA: Histone H3-like centromeric protein A 0.269 0.026
BAZ1B BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain 0.260 0.048
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.260 0.0425
BRCA1 BRCA1, RNF53: Breast cancer type 1 susceptibility protein 0.260 0.056
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.260 0.096
EP300 N/A 0.254 0.254
GGCX GGCX, GC: Vitamin K-dependent gamma-carboxylase 0.254 0.038
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.241 0.029
SUZ12 SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12 0.233 0.114
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.233 0.038
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.233 0.029
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.233 0.038
YY1 YY1: Transcriptional repressor protein YY1 0.233 0.139
SAFB SAFB, HAP, HET, SAFB1: Scaffold attachment factor B 0.233 0.114
ZNF76 ZNF76, D6S229E: Zinc finger protein 76 0.216 0.127
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.216 0.038
BAZ2A BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A 0.210 0.071
RB1 RB1: Retinoblastoma-associated protein 0.210 0.080
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.210 0.039
ELF1 ELF1: ETS-related transcription factor Elf-1 0.210 0.155
MATR3 MATR3, KIAA0723: Matrin-3 0.210 0.096
HIF1A HIF1A, MOP1: Hypoxia-inducible factor 1 alpha 0.208 0.038
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.188 0.046
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.188 0.087
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.188 0.114
MRE11A MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A 0.188 0.038
ACIN1 ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus 0.188 0.069
AKAP8 AKAP8, AKAP95: A-kinase anchor protein 8 0.188 0.114
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.188 0.038
CXorf9 N/A 0.188 0.114
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.188 7.05
ZNF217 ZNF217, ZABC1: Zinc finger protein 217 0.188 0.114
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.187 0.025
MYB MYB: Myb proto-oncogene protein 0.176 0.077
CEBPB CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta 0.172 0.069
CEBPE CEBPE: CCAAT/enhancer-binding protein epsilon 0.172 0.056
TP73 TP73, P73: Tumor protein p73 0.156 0.055
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.156 0.062
ZNF148 ZNF148, ZBP89: Zinc finger protein 148 0.155 0.155
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.155 0.127
ZNF267 ZNF267: Zinc finger protein 267 0.155 0.096
ERF ERF: ETS domain-containing transcription factor ERF 0.155 0.096
XRCC1 XRCC1: DNA-repair protein XRCC1 0.155 0.026
MITF MITF: Microphthalmia-associated transcription factor 0.152 0.028
AR AR, DHTR, NR3C4: Androgen receptor 0.152 0.028
ARNT ARNT: Aryl hydrocarbon receptor nuclear translocator 0.152 0.028
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.152 0.152
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.146 0.114
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.146 0.139
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.146 0.056
ABCF1 N/A 0.144 0.032
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.144 0.0425
MKI67 MKI67: Antigen KI-67 0.144 0.077
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.144 0.0425
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.144 0.0425
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.144 0.0425
PTMA N/A 0.144 0.052
SAT SAT1, SAT: Diamine acetyltransferase 1 0.140 0.096
LEF1 LEF1: Lymphoid enhancer-binding factor 1 0.140 0.056
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.139 0.114
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.139 0.086
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.139 0.038
DDX5 DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5 0.139 0.046
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 0.139 0.071
RELA RELA, NFKB3: Transcription factor p65 0.139 0.038
KIAA1012 KIAA1012: Protein TRS85 homolog 0.139 0.046
DICER1 DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer 0.139 0.046
NCOA3 NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3 0.137 0.025
CDC25C CDC25C: M-phase inducer phosphatase 3 0.137 0.025
LMNA LMNA, LMN1: Lamin-A/C 0.137 0.025
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.137 0.137
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.137 0.137
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.132 0.062
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.132 0.032
IRF3 IRF3: Interferon regulatory factor 3 0.132 0.096
ZNF330 ZNF330, NOA36: Zinc finger protein 330 0.129 0.038
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.129 0.029
APEX1 APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase 0.129 0.038
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.129 0.038
SNRPB2 SNRPB2: U2 small nuclear ribonucleoprotein B'' 0.129 0.029
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 0.129 0.029
HDAC3 HDAC3: Histone deacetylase 3 0.129 0.038
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.129 0.038
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.129 0.069
CBX3 CBX3: Chromobox protein homolog 3 0.129 0.038
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.129 0.038
CSPG6 SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3 0.129 0.038
PABPC4 PABPC4, APP1, PABP4: Polyadenylate-binding protein 4 0.129 0.029
NUP153 N/A 0.129 0.038
SSB SSB: Lupus La protein 0.129 0.029
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 0.129 0.029
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.129 0.029
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.129 0.114
CDC20 CDC20: Cell division cycle protein 20 homolog 0.129 0.056
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.129 0.056
TP53BP1 TP53BP1: Tumor suppressor p53-binding protein 1 0.127 0.032
ZNF335 ZNF335: Zinc finger protein 335 0.127 0.086
ZFX ZFX: Zinc finger X-chromosomal protein 0.127 0.155
HIVEP1 N/A 0.127 0.127
SALL1 SALL1, SAL1: Sal-like protein 1 0.125 0.049
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.124 0.027
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.118 0.029
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.118 0.114
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.118 0.056
KLF13 KLF13, BTEB3, NSLP1: Krueppel-like factor 13 0.114 0.086
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.114 0.046
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.114 0.038
ETS1 ETS1, EWSR2: Protein C-ets-1 0.114 0.114
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.114 0.038
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.114 0.046
AKAP8L AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like 0.114 0.086
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.114 0.114
CCNH CCNH: Cyclin-H 0.114 0.029
ZNF24 ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24 0.114 0.139
MTF1 MTF1: Metal regulatory transcription factor 1 0.114 0.127
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.114 0.087
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.114 0.038
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.114 0.046
TRIM25 TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25 0.114 0.029
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.114 0.038
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.114 0.062
ZBTB16 ZBTB16, PLZF, ZNF145: Zinc finger and BTB domain-containing protein 16 0.111 0.055
HSP90AA1 Hsp89-alpha-delta-N 0.111 2.18
GTF2F2 N/A 0.0971 0.077
STAT2 STAT2: Signal transducer and activator of transcription 2 0.096 0.0425
NFATC1 N/A 0.096 0.052
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.096 0.026
EEA1 EEA1, ZFYVE2: Early endosome antigen 1 0.096 0.139
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.096 0.127
SATB2 SATB2, KIAA1034: DNA-binding protein SATB2 0.090 0.049
GNB2L1 Lung cancer oncogene 7 0.087 0.127
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.087 0.052
NCOA3 N/A 0.087 0.052
SET SET: Protein SET 0.087 0.032
RBM14 RBM14, SIP: RNA-binding protein 14 0.087 0.0425
TCOF1 N/A 0.087 0.026
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.087 0.032
IFI16 N/A 0.087 0.052
DNMT1 DNMT1, AIM, DNMT: DNA 0.087 0.026
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.087 0.096
TGIF2 TGIF2: Homeobox protein TGIF2 0.087 0.155
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.087 0.0425
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.087 0.026
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.087 0.114
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.087 0.029
SMAD3 SMAD3, MADH3: Mothers against decapentaplegic homolog 3 0.087 0.114
SOX4 SOX4: Transcription factor SOX-4 0.086 0.069
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.086 0.071
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 0.086 0.071
BRPF1 BRPF1, BR140: Peregrin 0.086 0.069
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.086 0.086
MLL MLL, ALL1, HRX, HTRX, TRX1: Zinc finger protein HRX 0.086 0.054
ZNF224 ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27: Zinc finger protein 224 0.086 0.086
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.086 0.038
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.086 0.029
CREBBP CREBBP, CBP: CREB-binding protein 0.086 0.114
ATM ATM: Serine-protein kinase ATM 0.086 0.114
PPEF1 N/A 0.083 0.028
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.083
POGZ POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain 0.083 0.083
MAPK15 N/A 0.083 0.083
C20orf18 N/A 0.083 0.052
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.083 0.083
ZNF644 ZNF644, KIAA1221, ZEP2: Zinc finger protein 644 0.083 0.083
UHRF1 0.083 0.052
ZHX1 ZHX1: Zinc fingers and homeoboxes protein 1 0.083 0.083
EEF2K EEF2K: Elongation factor 2 kinase 0.083 0.025
ZFP91 ZFP91, FKSG11: Zinc finger protein 91 homolog 0.083 0.083
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.083 0.028
MLL2 MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2 0.083 0.028
ZNF579 ZNF579: Zinc finger protein 579 0.083 0.083
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.083 0.083
ZNF295 ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295 0.083 0.083
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.083 0.028
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.083 0.028
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.0818 0.051
H1FX H1FX: Histone H1x 0.080 0.096
SF3B4 SF3B4, SAP49: Splicing factor 3B subunit 4 0.078 0.038
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.078 0.029
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.078 0.038
FNBP1 N/A 0.078 0.046
CDK2 CDK2: Cell division protein kinase 2 0.078 0.029
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.078 0.086
PABPC1 PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1 0.078 0.038
UBA2 SAE2, UBA2, HRIHFB2115, UBLE1B: SUMO-activating enzyme subunit 2 0.078 0.029
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.078 0.038
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.078 0.038
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.078 0.029
TDG TDG: G/T mismatch-specific thymine DNA glycosylase 0.078 0.046
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.078 0.038
SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 0.078 0.038
PAPOLA PAPOLA, PAP: Poly(A) polymerase alpha 0.078 0.046
ZCCHC8 ZCCHC8: Zinc finger CCHC domain-containing protein 8 0.078 0.046
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.078 0.029
SFRS4 SFRS4, SRP75: Splicing factor, arginine/serine-rich 4 0.078 0.038
MYBL2 MYBL2, BMYB: Myb-related protein B 0.078 0.056
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.078 0.029
TCF3 TCF3, E2A, ITF1: Transcription factor E2-alpha 0.078 0.029
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.078 0.038
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.078 0.114
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.078 0.046
TIAL1 TIAL1: Nucleolysin TIAR 0.078 0.038
ETS2 ETS2: Protein C-ets-2 0.077 0.077
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.077 0.055
ERG ERG: Transcriptional regulator ERG 0.077 0.096
MDM4 MDM4, MDMX: Mdm4 protein 0.077 0.032
SNAI1 SNAI1, SNAH: Zinc finger protein SNAI1 0.077 0.086
REST REST, NRSF, XBR: RE1-silencing transcription factor 0.077 0.077
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.077 0.032
EEF2 EEF2, EF2: Elongation factor 2 0.075 0.113
ZNF174 ZNF174, ZSCAN8: Zinc finger protein 174 0.075 0.075
RFFL RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin 0.075 0.075
BRD4 N/A 0.075 0.047
SOX8 SOX8: Transcription factor SOX-8 0.075 0.075
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.075 0.025
TRERF1 TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1 0.075 0.075
PRDM2 PRDM2, RIZ: PR domain zinc finger protein 2 0.075 0.083
GIT2 N/A 0.075 0.025
RBM10 RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10 0.075 0.075
DHX8 DHX8, DDX8: ATP-dependent RNA helicase DHX8 0.075 0.025
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.075 0.025
CCNT2 CCNT2: Cyclin-T2 0.075 0.025
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.075 0.025
OSR1 OSR1, ODD: Protein odd-skipped-related 1 0.075 0.075
RBL1 RBL1: Retinoblastoma-like protein 1 0.075 0.047
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.075 0.025
C14orf4 C14orf4, KIAA1865, My039: RING finger protein C14orf4 0.075 0.025
DDX20 DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20 0.075 0.025
ZFPM1 ZFPM1, FOG1: Zinc finger protein ZFPM1 0.075 0.075
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.075 0.025
RNF113A RNF113A, RNF113, ZNF183: RING finger protein 113A 0.075 0.025
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.075 0.025
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.075 0.025
RNF20 0.075 0.025
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.071 0.114
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.070 0.0425
AOF2 AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1 0.070 0.026
WDR1 N/A 0.070 0.127
PLEK PLEK, P47: Pleckstrin 0.070 0.0425
KIF22 KIF22, KID, KNSL4: Kinesin-like protein KIF22 0.070 0.026
STK16 N/A 0.070 0.026
KIAA0853 N/A 0.070 0.052
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.070 0.0425
API5 N/A 0.070 0.032
UBAP2 N/A 0.070 0.026
MYBBP1A MYBBP1A, P160: Myb-binding protein 1A 0.070 0.032
IKBKG IKBKG, FIP3, NEMO: NF-kappa-B essential modulator 0.070 0.0425
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.070 0.0425
ZNF551 N/A 0.069 0.086
ZBTB7A ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A 0.069 0.114
GCN5L2 GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2 0.069 0.056
ZBTB40 ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40 0.069 0.096
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.069 0.029
TCF8 ZEB1, AREB6, TCF8: Zinc finger E-box-binding homeobox 1 0.069 0.114
KLF1 KLF1, EKLF: Krueppel-like factor 1 0.069 0.056
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.069 0.0425
FOS FOS, G0S7: Proto-oncogene protein c-fos 0.069 0.086
PPP1CB PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0.067 0.032
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.066 0.054
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.066 0.090
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.063 0.086
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.063 0.038
CORO1C CORO1C, CRNN4: Coronin-1C 0.063 0.086
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.063 0.038
PPP1R8 N/A 0.063 0.114
MTA1 MTA1: Metastasis-associated protein MTA1 0.063 0.029
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.063 0.029
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.063 0.114
RPS6KB1 N/A 0.063 0.046
SEC31L1 N/A 0.063 0.114
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.063 0.087
RBM7 0.063 0.029
WBSCR20A N/A 0.063 0.029
PHF10 N/A 0.063 0.038
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.063 0.038
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.063 0.087
EIF3S4 EIF3S4: Eukaryotic translation initiation factor 3 subunit 4 0.063 0.038
CPSF1 CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1 0.063 0.029
MYH9 MYH9: Myosin-9 0.063 0.029
DDX51 DDX51: ATP-dependent RNA helicase DDX51 0.063 0.038
COPB2 COPB2: Coatomer subunit beta' 0.063 0.086
HDAC2 HDAC2: Histone deacetylase 2 0.063 0.029
COPA COPA: Coatomer subunit alpha 0.063 0.114
TAF10 TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10 0.063 0.029
RAB8A RAB8A: RAB8A protein 0.063 0.076
TIMELESS TIMELESS, TIM, TIM1, TIMELESS1: Protein timeless homolog 0.063 0.029
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.063 0.046
NCOR1 NCOR1, KIAA1047: Nuclear receptor corepressor 1 0.063 0.139
WEE1 WEE1: Wee1-like protein kinase 0.063 0.029
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.063 0.046
TERF2IP TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1 0.062 0.062
SH3BP3 0.062 0.077
DDIT3 DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3 0.062 0.062
ZBTB33 KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso 0.062 0.077
FOXO1A FOXO1A, FKHR: Forkhead box protein O1A 0.060 0.225
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.060 0.307
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.056 0.056
PCAF PCAF: Histone acetyltransferase PCAF 0.056 0.069
FOSL2 FOSL2, FRA2: Fos-related antigen 2 0.056 0.086
SP1 SP1, TSFP1: Transcription factor Sp1 0.056 0.069
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.056 0.069
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.056 0.0308
ETV1 ETV1, ER81: ETS translocation variant 1 0.056 0.062
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.0554 0.148
STAT4 STAT4: Signal transducer and activator of transcription 4 0.055 0.029
TAF1 TAF1, BA2R, CCG1, CCGS, TAF2A: Transcription initiation factor TFIID subunit 1 0.055 0.048
UBE2E3 UBE2E3, UBCE4, UBCH9: Ubiquitin-conjugating enzyme E2 E3 0.054 0.051
SOS1 SOS1: Son of sevenless homolog 1 0.054 0.071
SUPT5H SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5 0.054 0.027
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.052 0.165
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.052 0.083
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.052 0.026
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.052 0.048
CHUK N/A 0.052 0.052
AFF1 N/A 0.052 0.052
TERF2 TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2 0.052 0.077
TOP2B N/A 0.052 0.0425
FNBP4 FNBP4, FBP30, KIAA1014: Formin-binding protein 4 0.052 0.0425
EMD EMD, EDMD, STA: Emerin 0.052 0.032
TRRAP N/A 0.052 0.026
ARFGAP1 N/A 0.052 0.032
ROCK1 ROCK1: Rho-associated protein kinase 1 0.052 0.052
JMJD1A JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr 0.052 0.0425
PHF3 PHF3, KIAA0244: PHD finger protein 3 0.052 0.052
ZNF638 ZNF638, NP220, ZFML: Zinc finger protein 638 0.052 0.032
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.052 0.026
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.052 0.052
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.052 0.0425
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.051 0.0453
ZHX3 ZHX3, KIAA0395, TIX1: Zinc fingers and homeoboxes protein 3 0.049 0.055
SF3A3 SF3A3, SAP61: Splicing factor 3A subunit 3 0.049 0.030
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.049
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.049
BNC1 BNC1, BNC: Zinc finger protein basonuclin-1 0.049 0.056
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.049 0.056
ELK1 ELK1: ETS domain-containing protein Elk-1 0.049 0.049
SOX11 SOX11: Transcription factor SOX-11 0.049 0.056
KLF5 KLF5, BTEB2, CKLF, IKLF: Krueppel-like factor 5 0.049 0.056
RXRA RXRA, NR2B1: Retinoic acid receptor RXR-alpha 0.048 0.026
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.048 0.032
PPARA PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha 0.048 0.032
FARSLA FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain 0.047 0.075
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.047 0.025
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.047 0.025
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.047 0.075
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.047 0.075
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.047 0.025
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.046 0.087
SAPS3 N/A 0.046 0.029
SYMPK SYMPK, SPK: Symplekin 0.046 0.054
CUL5 CUL5, VACM1: Cullin-5 0.046 0.038
SFRS6 SFRS6, SRP55: Splicing factor, arginine/serine-rich 6 0.046 0.038
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.046 0.038
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.046 0.043
FZR1 N/A 0.046 0.029
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.046 0.086
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.046 0.114
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.046 0.046
USP34 USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34 0.046 0.046
CSTF2T CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant 0.046 0.038
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.046 0.086
RBMX2 RBMX2, CGI-79: RNA-binding motif protein, X-linked 2 0.046 0.029
TOPORS TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors 0.046 0.029
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.046 0.046
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.046 0.086
DIAPH1 Diaphanous 1 0.046 0.038
JARID1A JARID1A, RBBP2, RBP2: Histone demethylase JARID1A 0.046 0.046
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.046 0.038
DOK1 DOK1: Docking protein 1 0.046 0.038
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.046 0.046
KLHDC4 N/A 0.046 0.038
DUSP22 DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22 0.046 0.029
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.046 0.038
CRSP2 MED14, ARC150, CRSP2, CXorf4, DRIP150, EXLM1, RGR1, TRAP170: Mediator of RNA pol 0.046 0.029
CUL4B N/A 0.046 0.038
GSK3B N/A 0.046 0.029
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.046 0.038
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.046 0.037
GTPBP4 GTPBP4, CRFG, NOG1: Nucleolar GTP-binding protein 1 0.0446 0.067
EGR1 EGR1, ZNF225: Early growth response protein 1 0.044 0.056
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.044 0.044
HIST3H3 HIST3H3, H3FT: Histone H3.1t 0.043 0.038
VDR VDR, NR1I1: Vitamin D3 receptor 0.043 0.056
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.043 0.111
POU2F1 POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1 0.0425 0.096
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.0425 0.0425
RFXDC2 RFXDC2: Regulatory factor X domain-containing protein 2. 0.0425 0.052
XRCC4 N/A 0.0425 0.032
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.0425 0.0425
SNAPC4 SNAPC4, SNAP190: snRNA-activating protein complex subunit 4 0.0425 0.077
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.0425 0.152
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.0425 0.0971
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.0425 0.026
SMARCC2 N/A 0.0425 0.032
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.0425 0.0425
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.0425 0.0425
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.0425 0.032
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.0425 0.032
RBM6 RBM6, DEF3: RNA-binding protein 6 0.0425 0.032
RGS14 N/A 0.0425 0.0425
MARK2 N/A 0.0425 0.0425
COIL COIL, CLN80: Coilin 0.0425 0.026
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.041 0.033
LCP1 LCP1, PLS2: Plastin-2 0.040 0.054
XPO1 XPO1, CRM1: Exportin-1 0.040 0.054
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.038 0.038
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.038 0.029
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.038 0.046
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.038 0.114
RBM8A RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A 0.038 0.046
SPEN SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein 0.038 0.038
ARID3A ARID3A, DRIL1, DRIL3, DRX, E2FBP1: AT-rich interactive domain-containing protein 0.038 0.046
MEF2D MEF2D: Myocyte-specific enhancer factor 2D 0.038 0.086
SNRP70 SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa 0.038 0.029
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.038 0.029
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.038 0.063
STK10 STK10: Uncharacterized protein STK10 0.038 0.038
MAFG MAFG: Transcription factor MafG 0.038 0.056
TCEB3 TCEB3, MSTP059: Transcription elongation factor B polypeptide 3 0.038 0.136
SIRT1 SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1 0.038 0.063
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.038 0.029
RREB1 RREB1, FINB: RAS-responsive element-binding protein 1 0.038 0.046
SFRS5 SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5 0.038 0.046
SAFB2 SAFB2, KIAA0138: Scaffold attachment factor B2 0.036 0.036
HD HD, IT15: Huntingtin 0.036 0.046
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.036 0.166
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.036 0.057
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.036 0.044
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.035 0.056
SMAD7 SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7 0.034 0.077
FOXL2 FOXL2: Forkhead box protein L2 0.034 0.111
RAD18 RAD18, RNF73: E3 ubiquitin-protein ligase RAD18 0.034 0.034
AXIN1 0.0333 0.049
BACH1 BACH1: Transcription regulator protein BACH1 0.032 0.127
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.032 0.032
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.032 0.052
ID2 ID2: DNA-binding protein inhibitor ID-2 0.032 0.032
STRN3 STRN3, GS2NA, SG2NA: Striatin-3 0.032 0.052
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.032 0.032
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.032 0.0425
VIM VIM: Vimentin 0.032 0.032
TERF1 TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1 0.032 0.096
SFRS15 SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15 0.032 0.052
GTF3C1 N/A 0.032 0.026
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.032 0.032
ID3 ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3 0.032 0.026
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.032 0.032
AHR AHR: Aryl hydrocarbon receptor precursor 0.032 0.029
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.032 0.026
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.032 0.041
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.032 0.067
NRAS NRAS, HRAS1: GTPase NRas precursor 0.032 0.181
RAB11A RAB11A, RAB11: Ras-related protein Rab-11A 0.032 0.046
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.032 0.113
NR1D1 NR1D1, EAR1, HREV, THRAL: Orphan nuclear receptor NR1D1 0.031 0.044
NFIB N/A 0.031 0.055
ESR1 ESR1, ESR, NR3A1: Estrogen receptor 0.031 0.096
RFX1 RFX1: MHC class II regulatory factor RFX1 0.0308 0.049
HIST1H1A HIST1H1A, H1F1: Histone H1.1 0.0308 0.069
HTATSF1 HTATSF1: HIV Tat-specific factor 1 0.029 0.029
NFE2L2 NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2 0.029 0.114
JUND JUND: Transcription factor jun-D 0.029 0.114
GMCL1L GMCL1L, GCL: Germ cell-less protein-like 1-like 0.029 0.046
EML4 EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4 0.029 0.114
ATF6 ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha 0.029 0.086
RCP9 CRCP: DNA-directed RNA polymerase III subunit RPC9 0.029 0.038
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.029 0.046
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.029 0.114
RUNX1 N/A 0.029 0.029
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.029 0.046
WDR44 WDR44: WD repeat-containing protein 44 0.029 0.038
JUNB JUNB: Transcription factor jun-B 0.029 0.114
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.029 0.029
BID BID: BH3-interacting domain death agonist 0.028 0.028
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.028
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.028 0.028
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.028 0.083
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.028 0.028
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.028 0.028
KIAA1443 HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez 0.028 0.083
SYTL4 Endocrine transmitter regulatory protein 0.028 0.083
NF2 NF2, SCH: Merlin 0.028 0.028
HES6 HES6: Transcription cofactor HES-6 0.028 0.028
ZNF265 N/A 0.028 0.028
PTBP1 PTBP1: Polypyrimidine tract binding protein 1 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.165
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.028 0.028
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.028 0.025
DKFZp434K1815 DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815 0.028 0.028
LOC642558 FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1 0.028 0.028
ZCCHC3 ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3 0.028 0.028
MLL4 WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7 0.028 0.025
RAVER1 RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1 0.028 0.028
ATXN2L ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
ILF3 ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3 0.028 0.028
CUTL1 CUTL1: Homeobox protein cut-like 1 0.028 0.083
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
C13orf8 N/A 0.028 0.028
DUSP15 N/A 0.028 0.028
RAB4A N/A 0.028 0.165
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.028
PHLDB2 N/A 0.028 0.028
NSBP1 NSBP1: Nucleosome-binding protein 1 0.028 0.028
HNRPC HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2 0.028 0.028
IRF7 N/A 0.028 0.028
WDR54 N/A 0.028 0.083
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
TCF20 TCF20, KIAA0292, SPBP: Transcription factor 20 0.028 0.028
CBFA2T2 CBFA2T2, EHT, MTGR1: Protein CBFA2T2 0.028 0.028
TMPO TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha 0.028 0.028
KIF1B N/A 0.028 0.028
HDAC8 N/A 0.028 0.028
JDP2 jdp2, JDP2: Jun dimerization protein 2 0.028 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.028 0.028
NES N/A 0.028 0.028
SNRPB N/A 0.028 0.028
FLJ21816 PALB2, FANCN: Partner and localizer of BRCA2 0.028 0.028
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.028 0.025
NIPA1 NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1 0.028 0.083
MAPKAPK5 N/A 0.028 0.028
TFAP4 TFAP4: Transcription factor AP-4 0.028 0.025
CDC2 CDC2: Cell division control protein 2 homolog 0.028 0.025
CORO6 N/A 0.028 0.028
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.028 0.025
FLJ23436 N/A 0.028 0.025
DSP DSP: Desmoplakin 0.028 0.028
ZC3HAV1 ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1 0.028 0.028
CABLES1 N/A 0.028 0.028
HDAC7A N/A 0.028 0.025
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
NFIA NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A 0.028 0.028
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.028 0.046
HIST2H2BE HIST2H2BE, H2BFQ: Histone H2B type 2-E 0.028 0.029
GAS2 GAS2: Growth arrest-specific protein 2 0.027 0.037
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.026 0.032
PRKAA1 N/A 0.026 0.026
GRLF1 N/A 0.026 0.109
PHF8 PHF8, KIAA1111, ZNF422: PHD finger protein 8 0.026 0.052
MEF2A N/A 0.026 0.077
NUP214 N/A 0.026 0.077
ZFP36 ZFP36, G0S24, RNF162A, TIS11A, TTP: Tristetraproline 0.026 0.038
MECP2 MECP2: Methyl-CpG-binding protein 2 0.026 0.026
AGTPBP1 AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein 0.026 0.038
AANAT AANAT, SNAT: Serotonin N-acetyltransferase 0.026 0.062
ATXN7 ATXN7, SCA7: Ataxin-7 0.0253 0.033
CIC CIC, KIAA0306: Protein capicua homolog 0.025 0.025
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.025 0.025
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.025 0.047
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
SON 0.025 0.025
EDF1 EDF1: Endothelial differentiation-related factor 1 0.025 0.025
PHF16 PHF16, JADE3, KIAA0215: Protein Jade-3 0.025 0.025
PSIP1 PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein 0.025 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.025
HNRPUL1 HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1 0.025 0.025
MAP2K3 N/A 0.025 0.025
HNRPD HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0 0.025 0.025
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.025 0.025
NHN1 NHN1: Conserved nuclear protein NHN1 0.025 0.025
NSUN2 NSUN2, SAKI, TRM4: tRNA 0.025 0.025
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.025 0.025
BCOR N/A 0.025 0.025
CAMKK1 N/A 0.025 0.025
BUB3 BUB3: Mitotic checkpoint protein BUB3 0.025 0.075
GEMIN5 GEMIN5: Gem-associated protein 5 0.025 0.075
DLX3 DLX3: Homeobox protein DLX-3 0.025 0.075
SSBP4 SSBP4: Single-stranded DNA-binding protein 4 0.025 0.025
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.025 0.025
KCTD1 0.025 0.025
MAPK8IP3 N/A 0.025 0.025
MAX MAX: Protein max 0.025 0.025
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.025 0.025
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.025
MSL3L1 MSL3L1: Male-specific lethal 3-like 1 0.025 0.025
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.148
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.025 0.025
SMARCA2 SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2 0.025 0.025
MLXIPL MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein 0.025 0.025
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.025 0.025
PRKCB1 N/A 0.025 0.025
CREB1 CREB1: cAMP response element-binding protein 0.025 0.075
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.025 0.025
NFYA NFYA: Nuclear transcription factor Y subunit alpha 0.025 0.025
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.025 0.025
ARID4A ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A 0.025 0.025
FLJ40432 FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227 0.025 0.025
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.025 0.075
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.025 0.047
PURB PURB: Transcriptional activator protein Pur-beta 0.025 0.025
NEDD4 NEDD4: Uncharacterized protein NEDD4 0.025 0.025
REXO1 REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog 0.025 0.025
NUP98 N/A 0.025 0.025
RBBP6 RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6 0.025 0.025
SEC13L1 N/A 0.025 0.025
NIPBL N/A 0.025 0.047
SAP14 SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14 0.025 0.025
POLR1C POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1 0.025 0.025
HNRPA2B1 HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1 0.025 0.025
MIER1 MIER1, KIAA1610: Mesoderm induction early response protein 1 0.025 0.025
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.148
ATXN2L N/A 0.025 0.025
ELMO1 N/A 0.025 0.025
HEXIM2 HEXIM2, L3: Protein HEXIM2 0.025 0.025
HOXA10 HOXA10, HOX1H: Homeobox protein Hox-A10 0.025 0.075
SYAP1 SYAP1, PRO3113: Synapse-associated protein 1 0.025 0.025
GRK6 N/A 0.025 0.025
RAB1B RAB1B: Ras-related protein Rab-1B 0.025 0.050
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.075
C20orf77 N/A 0.025 0.025
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.025 0.025
ADK ADK: Adenosine kinase 0.025 0.025
TAL2 TAL2: T-cell acute lymphocytic leukemia protein 2 0.025 0.025
HIST3H2A HIST3H2A: Histone H2A type 3 0.025 0.025
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.025 0.025
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.025 0.075
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.025 0.025
ZNF598 ZNF598: Zinc finger protein 598 0.025 0.025
TIA1 TIA1: Nucleolysin TIA-1 isoform p40 0.025 0.025
SETD3 SETD3, C14orf154: SET domain-containing protein 3 0.025 0.025
FAF1 FAF1, CGI-03: FAS-associated factor 1 0.025 0.025
CAMK2A N/A 0.025 0.025
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.025 0.025
GATAD2B GATAD2B, KIAA1150: Transcriptional repressor p66 beta 0.025 0.025
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
HTATIP N/A 0.025 0.025
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.025
DIDO1 N/A 0.025 0.025
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
SFRS9 SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9 0.025 0.025
WWTR1 WWTR1, TAZ: WW domain-containing transcription regulator protein 1 0.025 0.075
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
HNRPM HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M 0.025 0.025
SMN2 SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein 0.025 0.025
TCEA1 N/A 0.025 0.025
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.025 0.025
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.025 0.075
IWS1 IWS1, IWS1L: IWS1 homolog 0.025 0.025
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.025 0.025
MKI67IP MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein 0.025 0.025
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.025 0.025
2.15E-3
Total Score 1.37