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Evidence of Interaction Between MAPK1 and DUSP18

The interaction score between MAPK1 and DUSP18 is 10.90.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismMAPK1 OrthologueDUSP18 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YBL016W 1 YBR276C 0.668
bakers yeast YBL016W 1 YIL113W 0.668
bakers yeast YBL016W 1 YNL053W 0.668
  • Immunoprecipitation
  • CoLocalization

Get References From PubMed
bakers yeast YGR040W 0.096 YBR276C 0.668
bakers yeast YGR040W 0.096 YIL113W 0.668
bakers yeast YGR040W 0.096 YNL053W 0.668
worm P39745 1 Q9XVE7 0.2
fly P40417 1 Q9VAB0 0.28

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.119
Domains Domains present in MAPK1 and DUSP18:
Domains in MAPK1Domains in DUSP18
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase
IPR000340 Dual specificity protein phosphatase

The Chi square scores for co-occurrence of domains that are present in MAPK1 and DUSP18 are listed below.

Domain 1Domain 2Chi Square
IPR003527 MAP kinase IPR000340 Dual specificity protein phosphatase 575.549
IPR008349 ERK1/2 MAP kinase IPR000340 Dual specificity protein phosphatase 317.529
IPR003527 MAP kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 128.642
IPR002290 Serine/threonine protein kinase IPR000340 Dual specificity protein phosphatase 108.157
IPR008349 ERK1/2 MAP kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 89.8437
IPR008271 Serine/threonine protein kinase, active site IPR000340 Dual specificity protein phosphatase 76.5901
IPR000719 Protein kinase IPR000340 Dual specificity protein phosphatase 30.0934
IPR011009 Protein kinase-like IPR000340 Dual specificity protein phosphatase 15.3476
IPR000719 Protein kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 14.0817
IPR002290 Serine/threonine protein kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 10.8808
IPR011009 Protein kinase-like IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 6.38835
IPR008271 Serine/threonine protein kinase, active site IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 2.56073

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in DUSP18
  • Green Domain is present in both MAPK1 and DUSP18

 0.265
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: DUSP18

PTMResidueReference
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: DUSP18

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between MAPK1 and DUSP18 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andDUSP18. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and DUSP18 has 115 interactors of which there are 49 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for DUSP18-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 6.75
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.027
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.027
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.027
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.027
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.210 0.027
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.027
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.027
NF2 NF2, SCH: Merlin 0.165 0.027
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.027
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.027
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.155 0.027
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.127 0.027
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.027
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.027
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.127 0.027
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.127 0.027
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.027
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.027
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.096 0.027
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.096 0.027
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.027
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.096 0.027
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.217
MAPKAPK5 N/A 0.083 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.083 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.265
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.083 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.217
MAPK15 N/A 0.083 0.265
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.083 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.083 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.027
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.027
PRKAA1 N/A 0.077 0.027
STK16 N/A 0.077 0.027
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.077 0.027
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.077 0.027
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.062 0.027
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.062 0.027
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.056 0.195
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.027
TP73 TP73, P73: Tumor protein p73 0.055 0.027
CDKL5 N/A 0.049 0.027
DAPK2 DAPK2: Death-associated protein kinase 2 0.049 0.027
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.237
DOK5 DOK5, C20orf180: Docking protein 5 0.027 0.027
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.027
2.15E-3
Total Score 10.90