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Evidence of Interaction Between MAPK1 and SHC3

The interaction score between MAPK1 and SHC3 is 1.62.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and SHC3 = 0.03

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology
OrganismMAPK1 OrthologueSHC3 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm P39745 1 Q9TYT3 0.34
fly P40417 1 Q24080 0.171

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in MAPK1 and SHC3:
Domains in MAPK1Domains in SHC3
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR000980 SH2 motif
IPR006019 Phosphotyrosine interaction (PID or PI)
IPR006020 Phosphotyrosine interaction domain
IPR011993 PH_type.

The Chi square scores for co-occurrence of domains that are present in MAPK1 and SHC3 are listed below.

Domain 1Domain 2Chi Square
IPR000719 Protein kinase IPR000980 SH2 motif 82.1364
IPR011009 Protein kinase-like IPR000980 SH2 motif 59.6059
IPR008271 Serine/threonine protein kinase, active site IPR000980 SH2 motif 41.4368
IPR000719 Protein kinase IPR011993 PH_type. 37.108
IPR011009 Protein kinase-like IPR011993 PH_type. 21.3114
IPR002290 Serine/threonine protein kinase IPR000980 SH2 motif 18.5445
IPR003527 MAP kinase IPR000980 SH2 motif 3.65309
IPR003527 MAP kinase IPR006020 Phosphotyrosine interaction domain 1.95712
IPR008349 ERK1/2 MAP kinase IPR000980 SH2 motif 0.969135
IPR008271 Serine/threonine protein kinase, active site IPR011993 PH_type. 0.535834
IPR011009 Protein kinase-like IPR006020 Phosphotyrosine interaction domain 0.203907
IPR002290 Serine/threonine protein kinase IPR006020 Phosphotyrosine interaction domain 0.195004
IPR002290 Serine/threonine protein kinase IPR011993 PH_type. 0.0555974
IPR003527 MAP kinase IPR011993 PH_type. 0.0276008
IPR000719 Protein kinase IPR006020 Phosphotyrosine interaction domain 0.00379833
IPR008271 Serine/threonine protein kinase, active site IPR006020 Phosphotyrosine interaction domain 0.00100301

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in SHC3
  • Green Domain is present in both MAPK1 and SHC3

 0.027
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: SHC3

PTMResidueReference
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: SHC3

LocalisationReference
Cytoplasm HPRD
Transitive Score

The common interactors between MAPK1 and SHC3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andSHC3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and SHC3 has 346 interactors of which there are 151 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for SHC3-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 17.40
DUSP10 DUSP10, MKP5: Dual specificity protein phosphatase 10 12.60 0.027
DUSP8 DUSP8, VH5: Dual specificity protein phosphatase 8 11.60 0.074
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.975 0.032
CRKL CRKL: Crk-like protein 0.461 7.56
JAK1 0.461 0.141
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 7.67
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.141
DUSP7 DUSP7, PYST2: Dual specificity protein phosphatase 7 0.440 0.028
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 7.67
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.141
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 6.81
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.141
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.156
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 67.50
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 67.50
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.036
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.141
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.156
HCK N/A 0.275 67.50
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.141
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.157
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 16.30
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 6.81
SOS1 SOS1: Son of sevenless homolog 1 0.225 5.35
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 7.56
PSD TYL: TYL protein 0.171 0.060
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.047
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.027
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.027
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.027
PSCD2 N/A 0.165 0.027
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.265
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.027
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.265
MAP2K5 N/A 0.165 0.027
NF2 NF2, SCH: Merlin 0.165 0.027
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.027
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.027
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.0308
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.157
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.197
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 11.50
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.237
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 9.04
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 114.00
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.139 0.036
FYN N/A 0.137 0.174
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.060
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.074
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.028
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.036
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.114 0.028
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.028
CDK5 CDK5: Cell division protein kinase 5 0.114 0.060
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.028
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.114 0.028
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.156
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 74.90
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.197
BMX N/A 0.110 0.244
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.0308
MCF2 MCF2, DBL: Proto-oncogene DBL 0.109 0.0308
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.174
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.156
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.036
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 5.94
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.044
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.028
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.177
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.036
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.044
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.086 0.028
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.086 10.50
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.027
MAPKAPK5 N/A 0.083 0.027
AMPH AMPH, AMPH1: Amphiphysin 0.083 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.083 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.027
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.083 0.027
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.083 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.027
MAPK15 N/A 0.083 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.083 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.083 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.027
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.083 0.197
CNN2 CNN2: Calponin-2 0.075 0.027
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.237
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.075 0.027
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.069 0.036
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.069 0.060
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 55.50
COBL N/A 0.062 0.050
SPTAN1 N/A 0.062 0.067
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.056 0.044
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 173.00
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.056 0.044
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.056 0.028
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.217
PIP3-E N/A 0.044 0.036
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.044 0.028
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.028
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.043 0.029
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 69.80
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.128
TSC1 TSC1, KIAA0243, TSC: Hamartin 0.038 0.036
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.032 0.039
PHLPP PHLPP, KIAA0606, PLEKHE1, SCOP: PH domain leucine-rich repeat-containing protein 0.0308 0.050
WSB2 WSB2: WD repeat and SOCS box-containing protein 2 0.0308 0.032
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 61.50
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 61.50
OSBPL6 OSBPL6, ORP6: Oxysterol-binding protein-related protein 6 0.027 0.027
PLEKHA4 PLEKHA4, PEPP1: Pleckstrin homology domain-containing family A member 4 0.027 0.027
VEPH1 VEPH1, KIAA1692, VEPH: Ventricular zone-expressed PH domain-containing protein h 0.027 0.027
APBB1 APBB1, FE65, RIR: Amyloid beta A4 precursor protein-binding family B member 1 0.027 0.027
ASB10 ASB10: Ankyrin repeat and SOCS box protein 10 0.027 0.027
CADPS CADPS, CAPS, CAPS1, KIAA1121: Calcium-dependent secretion activator 1 0.027 0.027
DOK6 DOK6: Uncharacterized protein DOK6 0.027 0.027
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.027
FAM43A N/A 0.027 0.027
ARHGEF1 ARHGEF1: Rho guanine nucleotide exchange factor 1 0.027 0.027
SRA1 APBB3, FE65L2: Amyloid beta A4 precursor protein-binding family B member 3 0.027 0.027
CENTB5 KIAA1716, CENTB5: Centaurin-beta 5 0.027 0.027
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.027
ASB6 ASB6: Ankyrin repeat and SOCS box protein 6 0.027 0.027
OSBPL9 N/A 0.027 0.027
ASB17 ASB17: Ankyrin repeat and SOCS box protein 17 0.027 0.027
NOXA1 NOXA1, RP13-927H1.1-001: NADPH oxidase activator 1 0.027 0.027
PLEKHA3 PLEKHA3, FAPP1: Pleckstrin homology domain-containing family A member 3 0.027 0.027
ASB14 ASB14: Ankyrin repeat and SOCS box protein 14 0.027 0.027
ASB2 ASB2: Ankyrin repeat and SOCS box protein 2 0.027 0.027
ASB3 ASB3: ASB3 protein 0.027 0.027
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.265
ASB12 ASB12: Ankyrin repeat and SOCS box protein 12 0.027 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.027
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
ASB7 ASB7: Ankyrin repeat and SOCS box protein 7 0.027 0.027
CADPS2 CADPS2, CAPS2, KIAA1591: Calcium-dependent secretion activator 2 0.027 0.027
DOK5 DOK5, C20orf180: Docking protein 5 0.027 0.027
RASGRF1 RASGRF1, CDC25: Guanine nucleotide-releasing protein 0.027 0.027
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.027
PSD3 N/A 0.027 0.027
RASGRF2 RASGRF2: Ras protein-specific guanine nucleotide-releasing factor 2 (Fragment) 0.027 0.027
PTPN13 N/A 0.027 0.027
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.026 0.128
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.145
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.197
MT3 MT3: Metallothionein-3 0.026 0.083
0.228
Total Score 1.62