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Evidence of Interaction Between MAPK1 and STMN2

The interaction score between MAPK1 and STMN2 is 13.2.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and STMN2 = 0.04

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology
OrganismMAPK1 OrthologueSTMN2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
fly P40417 1 Q8IPK0 0.533

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 0.165
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: STMN2

PTMResidueReference
Palmitoylation 22 PubMed, HPRD
Palmitoylation 24 PubMed, HPRD
Phosphorylation 50 PubMed, HPRD
Phosphorylation 62 PubMed, HPRD
Phosphorylation 73 PubMed, HPRD
Phosphorylation 97 PubMed, HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: STMN2

LocalisationReference
Golgi HPRD
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between MAPK1 and STMN2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andSTMN2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and STMN2 has 548 interactors of which there are 418 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for STMN2-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 0.171
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.025
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.028
CDK2 CDK2: Cell division protein kinase 2 6.80 0.099
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 2.02 0.088
GNAZ GNAZ: Guanine nucleotide-binding protein G(z) subunit alpha 0.509 0.074
JAK1 0.461 0.088
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.088
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.385 0.097
STK10 STK10: Uncharacterized protein STK10 0.385 0.088
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.098
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.088
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.088
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.097
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.088
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.098
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.029
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.344 0.081
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.098
CDK3 CDK3: Cell division protein kinase 3 0.285 0.028
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.088
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.097
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.099
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.088
HCK N/A 0.275 0.098
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.088
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.097
GAB2 N/A 0.251 0.032
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.098
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.049
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.233 0.088
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.233 0.088
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.233 0.136
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.088
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.099
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.029
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.049
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.210 0.109
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.098
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.026
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.188 0.088
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.098
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.188 0.088
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.088
RPS6KB1 N/A 0.188 0.088
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.188 0.123
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.174 0.0333
RIN1 RIN1: Ras and Rab interactor 1 0.171 0.026
PSD TYL: TYL protein 0.171 0.063
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.171 0.136
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.032
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.028
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.028
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.028
PSCD2 N/A 0.165 0.028
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.165
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.028
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.165 0.028
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.165
MAP2K5 N/A 0.165 0.165
NF2 NF2, SCH: Merlin 0.165 0.028
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.028
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.028
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.152
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.110
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.155 0.109
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.098
SNCB SNCB: Beta-synuclein 0.152 0.070
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.098
CDC25C CDC25C: M-phase inducer phosphatase 3 0.148 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.148 0.025
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.148
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.083
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.025
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.025
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.148
STAT3 0.148 0.028
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.148
ELMO1 N/A 0.148 0.025
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.025
ARHGEF7 N/A 0.148 0.025
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.025
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.025
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 0.165
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.148 0.025
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.139 0.058
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.139 0.097
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.139 0.099
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.099
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.139 0.088
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.139 0.372
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.139 0.088
ATM ATM: Serine-protein kinase ATM 0.139 0.044
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.139 0.088
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.139 0.088
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.139 0.088
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.137 0.030
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.137 0.030
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.046
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.046
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.046
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.372
STMN1 STMN1, LAP18, OP18: Stathmin 0.136 0.046
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.127 0.098
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.098
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.098
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.127 0.098
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.127 0.123
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.114 0.088
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.114 0.038
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.114 0.032
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.111
CDK5 CDK5: Cell division protein kinase 5 0.114 0.275
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.069
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.114 0.099
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.114 0.109
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.114 0.136
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.114 0.136
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.109
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 0.111
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.109
BMX N/A 0.110 0.123
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.109 0.0425
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.026
MCF2 MCF2, DBL: Proto-oncogene DBL 0.109 0.032
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.109
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.111
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.225
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.063
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.096 0.191
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.096 0.072
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.062
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.096 0.098
PTPRZ1 N/A 0.090 0.141
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.097
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.087 0.026
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.086 0.097
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.225
CDK7 CDK7, MO15: Cell division protein kinase 7 0.086 0.088
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.086 0.225
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.086 0.097
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.086 0.088
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.086 0.099
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.086 0.152
PITPNM1 PITPNM1: Uncharacterized protein PITPNM1 0.086 0.038
CDK5R1 CDK5R1, CDK5R, NCK5A: Cyclin-dependent kinase 5 activator 1 precursor 0.086 0.066
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.086 0.136
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.086 0.097
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.165
MAPKAPK5 N/A 0.083 0.165
AMPH AMPH, AMPH1: Amphiphysin 0.083 0.028
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.083 0.165
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.165
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.083 0.028
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.083 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.083 0.165
CASP8 CASP8, MCH5: Caspase-8 precursor 0.083 0.028
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.165
MAPK15 N/A 0.083 0.165
CASP9 CASP9, MCH6: Caspase-9 precursor 0.083 0.028
CASP1 CASP1, IL1BC, IL1BCE: Caspase-1 precursor 0.083 0.028
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.083 0.165
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.083 0.165
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.165
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.083 0.028
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.111
AGTPBP1 AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein 0.078 0.032
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.123
PRKAA1 N/A 0.077 0.110
LIMK2 LIMK2: LIM domain kinase 2 0.077 0.098
STK16 N/A 0.077 0.098
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.077 0.123
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.077 0.098
ATP2B1 N/A 0.075 0.027
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.075 0.148
GIT2 N/A 0.075 0.025
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.075 0.025
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.075 0.098
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.098
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.075 0.025
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.148
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.028
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.165
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.075 0.148
SNX3 N/A 0.075 0.025
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.148
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.075 0.025
CNN2 CNN2: Calponin-2 0.075 0.028
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.075 0.148
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.075 0.098
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.075 0.028
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.165
TSC2 TSC2, TSC4: Tuberin 0.075 0.025
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.148
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.075 0.165
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.075 0.148
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.075 0.025
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.075 0.148
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.148
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.148
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.148
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.075 0.165
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 0.148
CDC2 CDC2: Cell division control protein 2 homolog 0.075 0.165
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.075 0.148
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.165
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.075 0.165
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.028
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.071 0.027
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.070 0.032
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.069 0.111
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.069 0.136
CDK6 CDK6: Cell division protein kinase 6 0.069 0.088
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.069 0.088
HIPK2 HIPK2: Homeodomain-interacting protein kinase 2 0.069 0.136
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.069 0.069
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.069 0.097
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.069 0.088
HIPK3 HIPK3, DYRK6, FIST3, PKY: Homeodomain-interacting protein kinase 3 0.069 0.088
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.069 0.098
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.099
CDK4 CDK4: Cell division protein kinase 4 0.069 0.099
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.088
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.069 0.097
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 0.072
CKAP1 TBCB, CG22, CKAP1: Tubulin folding cofactor B 0.063 0.046
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.063 0.046
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.063 0.038
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.063 0.097
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.063
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.038
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.062 0.052
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.062 0.109
COBL N/A 0.062 0.052
SPTAN1 N/A 0.062 0.087
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.062 0.072
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.056 0.041
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.056 1.62
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.056 0.099
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 0.275
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.056 0.416
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.056 0.110
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.056 0.191
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.056 0.088
WEE1 WEE1: Wee1-like protein kinase 0.056 0.099
PRKCB1 PRKCB1, PKCB, PRKCB: Protein kinase C beta type 0.055 0.059
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.109
YWHAQ YWHAQ: 14-3-3 protein theta 0.052 0.032
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.051 0.065
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.050 0.097
CDKL5 N/A 0.049 0.098
DAPK2 DAPK2: Death-associated protein kinase 2 0.049 0.098
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.109
DYRK3 N/A 0.049 0.088
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.109
TUBB3 TUBB3, TUBB4: Tubulin beta-3 chain 0.048 0.157
NEFL NEFL, NF68, NFL: Neurofilament light polypeptide 0.048 0.070
KCNAB2 KCNAB2, KCNA2B, KCNK2: Voltage-gated potassium channel subunit beta-2 0.047 0.025
RAB5B RAB5B: Ras-related protein Rab-5B 0.047 0.025
HSPH1 HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa 0.046 0.029
DLG1 N/A 0.046 0.029
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.046 0.038
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.046 0.088
MYO3A MYO3A: Myosin IIIA 0.044 0.111
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.044 0.088
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.111
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.044 0.123
PRKAA2 PRKAA2, AMPK, AMPK2: 5'-AMP-activated protein kinase catalytic subunit alpha-2 0.044 0.136
CTTN CTTN, EMS1: Src substrate cortactin 0.044 0.026
CNN3 CNN3: Calponin-3 0.044 0.026
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.136
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.044 0.111
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.098
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.043 0.141
PDE4A N/A 0.0425 0.0425
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 0.100
GLRB GLRB: Glycine receptor subunit beta precursor 0.041 0.032
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.072
GRM3 GRM3, GPRC1C, MGLUR3: Metabotropic glutamate receptor 3 precursor 0.041 0.040
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.040 0.111
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.040 0.097
NEF3 NEFM, NEF3, NFM: Neurofilament medium polypeptide 0.039 0.070
GFAP GFAP: Glial fibrillary acidic protein 0.039 0.0425
GMFB GMFB: Glia maturation factor beta 0.038 0.046
APC N/A 0.038 0.129
DYNC1I2 N/A 0.038 0.046
TSC1 TSC1, KIAA0243, TSC: Hamartin 0.038 0.029
NEFH NEFH, KIAA0845, NFH: Neurofilament heavy polypeptide 0.034 0.032
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.066
GRM1 GRM1, GPRC1A, MGLUR1: Metabotropic glutamate receptor 1 precursor 0.033 0.027
TGFBR1 TGFBR1: TGF-beta receptor type-1 precursor 0.033 0.058
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.032 0.036
CP110 N/A 0.032 0.052
MAP2K5 N/A 0.032 0.026
MAPK8IP3 MAPK8IP3, JIP3, KIAA1066: C-jun-amino-terminal kinase-interacting protein 3 0.032 0.027
YWHAH YWHAH, YWHA1: 14-3-3 protein eta 0.032 0.070
SOX11 SOX11: Transcription factor SOX-11 0.0308 0.141
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 0.081
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.029 0.064
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 0.058
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.029 0.113
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.029 0.046
PPP2CB PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.029 0.046
DPYSL2 DPYSL2, CRMP2: Dihydropyrimidinase-related protein 2 0.029 0.129
FXR2 FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2 0.029 0.029
AHCYL1 AHCYL1, DCAL, XPVKONA: Putative adenosylhomocysteinase 2 0.029 0.038
PMM1 PMM1, PMMH22: Phosphomannomutase 1 0.029 0.038
PDZD2 CDNA FLJ46853 fis, clone UTERU3009775, moderately similar to Rattus norvegicus P 0.028 0.028
RGS18 RGS18, RGS13: Regulator of G-protein signaling 18 0.028 0.028
DNAJC13 DNAJC13, KIAA0678, RME8: DnaJ homolog subfamily C member 13 0.028 0.028
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
SH2D3A SH2D3A, NSP1, UNQ175/PRO201: SH2 domain-containing protein 3A 0.028 0.028
AHSA2 AHSA2, DKFZp564C236, hCG_15158: Putative uncharacterized protein DKFZp564C236 0.028 0.028
CACNB2 N/A 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
HNRPK HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K 0.028 0.028
PTPN7 N/A 0.028 0.028
STAP2 Uncharacterized protein ENSP00000317912 0.028 0.028
CDC42 N/A 0.028 0.028
PDE5A PDE5A, PDE5: cGMP-specific 3',5'-cyclic phosphodiesterase 0.028 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.028
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.028 0.028
AXIN1 0.028 0.028
MATK 0.028 0.028
PHLDB2 N/A 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
YWHAG YWHAG: 14-3-3 protein gamma 0.028 0.028
ABLIM1 ABLIM1, RP11-317F20.1-001: Actin binding LIM protein 1 0.028 0.028
PPEF1 N/A 0.028 0.028
SIVA SIVA1, SIVA: Apoptosis regulatory protein Siva 0.028 0.028
LNX1 N/A 0.028 0.028
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.028 0.028
CASP14 CASP14: Caspase-14 precursor 0.028 0.028
C9orf88 N/A 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
NASP NASP: Nuclear autoantigenic sperm protein 0.028 0.028
CASP6 CASP6, MCH2: Caspase-6 precursor 0.028 0.028
NCF4 N/A 0.028 0.028
SLC9A3R2 SLC9A3R2: SLC9A3R2 protein (Fragment) 0.028 0.028
FASN FASN, FAS: Fatty acid synthase 0.028 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
PKP4 PKP4: Plakophilin-4 0.028 0.028
TRIM39 TRIM39, RNF23, TFP: Tripartite motif-containing protein 39 0.028 0.028
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.026 0.073
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.026 0.058
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.090
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.152
DBN1 DBN1, D0S117E: Drebrin 0.026 0.032
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.026 0.070
RGS4 RGS4: Regulator of G-protein signaling 4 0.026 0.0425
DCAMKL1 DCLK1, DCAMKL1, DCDC3A, KIAA0369: Serine/threonine-protein kinase DCLK1 0.026 0.307
CEP170 CEP170, FAM68A, KAB, KIAA0470: Centrosomal protein of 170 kDa 0.026 0.074
TNIK TNIK, KIAA0551: TRAF2 and NCK-interacting protein kinase 0.0253 0.059
LMO6 LMO6: LIM domain only protein 6 0.025 0.025
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.025 0.028
RAD50 RAD50: DNA repair protein RAD50 0.025 0.025
SCRIB N/A 0.025 0.028
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.025
UBE2R2 UBE2R2, CDC34B, UBC3B: Ubiquitin-conjugating enzyme E2 R2 0.025 0.025
NDNL2 NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1 0.025 0.025
WRNIP1 WRNIP1, WHIP: ATPase WRNIP1 0.025 0.028
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.025
BCR N/A 0.025 0.025
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.025 0.025
GSN GSN: Gelsolin precursor 0.025 0.025
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.025 0.025
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.025
MYO18A 0.025 0.025
COTL1 COTL1, CLP: Coactosin-like protein 0.025 0.025
EPN2 N/A 0.025 0.025
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.025
NCOA5 NCOA5, KIAA1637: Nuclear receptor coactivator 5 0.025 0.025
G3BP2 G3BP2, KIAA0660: Ras GTPase-activating protein-binding protein 2 0.025 0.025
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
SH3PX3 SH3PX3, DKFZp666B159, hCG_1731072: SH3 and PX domain-containing protein 3. 0.025 0.028
DPP8 DPP8, DPRP1, MSTP097, MSTP135, MSTP141: Dipeptidyl peptidase 8 0.025 0.025
SPAST SPAST, KIAA1083, SPG4: Spastin 0.025 0.025
ACTN4 ACTN4: Alpha-actinin-4 0.025 0.025
DCTN1 DCTN1: Dynactin subunit 1 0.025 0.025
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.025 0.025
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
BCOR N/A 0.025 0.028
MAP2K3 N/A 0.025 0.025
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.025 0.028
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.025 0.025
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
UBE2A UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A 0.025 0.025
GRK6 N/A 0.025 0.025
CASP7 N/A 0.025 0.025
RASD1 RASD1, AGS1, DEXRAS1: Dexamethasone-induced Ras-related protein 1 precursor 0.025 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.025 0.025
PRKCB1 N/A 0.025 0.025
HSPA8 HSPA8, HSC70, HSP73, HSPA10: Heat shock cognate 71 kDa protein 0.025 0.025
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.025
RAC1 N/A 0.025 0.025
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.025 0.028
NIPBL N/A 0.025 0.025
DBNL N/A 0.025 0.025
CAMK2A N/A 0.025 0.025
RSN CLIP1, CYLN1, RSN: CAP-Gly domain-containing linker protein 1 0.025 0.025
CFL2 CFL2: Cofilin-2 0.025 0.025
SVIL SVIL: Supervillin 0.025 0.025
USP16 USP16: Ubiquitin carboxyl-terminal hydrolase 16 0.025 0.025
DCP1B DCP1B: mRNA-decapping enzyme 1B 0.025 0.025
CAMKK1 N/A 0.025 0.028
ADK ADK: Adenosine kinase 0.025 0.025
KIAA0031 EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component 0.025 0.025
CHTF18 RUVBL, CHTF18: Protein CTF18 homolog. 0.025 0.025
PDE4B PDE4B, DPDE4: cAMP-specific 3',5'-cyclic phosphodiesterase 4B 0.025 0.025
0.299
Total Score 13.2