PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between MAPK1 and UBE2E3

The interaction score between MAPK1 and UBE2E3 is 9.32.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between MAPK1 and UBE2E3 = 0.62

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

7.78E-3

Orthology

Organism	MAPK1 Orthologue		UBE2E3 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
fly	P40417	1	P52485	0.491

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3

Domains

Domains present in MAPK1 and UBE2E3:

Domains in MAPK1

Domains in UBE2E3

IPR000719	Protein kinase
IPR002290	Serine/threonine protein kinase
IPR011009	Protein kinase-like
IPR008271	Serine/threonine protein kinase, active site
IPR003527	MAP kinase
IPR008349	ERK1/2 MAP kinase

IPR000608

Ubiquitin-conjugating enzymes

The Chi square scores for co-occurrence of domains that are present in MAPK1 and UBE2E3 are listed below.

Domain 1		Domain 2		Chi Square
IPR000719	Protein kinase	IPR000608	Ubiquitin-conjugating enzymes	14.0467
IPR008271	Serine/threonine protein kinase, active site	IPR000608	Ubiquitin-conjugating enzymes	3.90333
IPR002290	Serine/threonine protein kinase	IPR000608	Ubiquitin-conjugating enzymes	1.74898

The background colour of the table refers to:

Blue Domain is only present in MAPK1
Yellow Domain is only present in UBE2E3
Green Domain is present in both MAPK1 and UBE2E3

0.028

Post-translational Modifications

Protein: MAPK1

PTM	Residue	Reference
Acetylation	2	PubMed, HPRD
Dephosphorylation	187	PubMed, HPRD
N-acetylalanine	1	HPRD
Phosphorylation	29	PubMed, HPRD
Phosphorylation	41	PubMed, HPRD
Phosphorylation	181	PubMed, HPRD
Phosphorylation	185	PubMed, HPRD
Phosphorylation	187	PubMed, HPRD
Phosphorylation	202	PubMed, HPRD
Phosphothreonine	184	PubMed, HPRD
Phosphotyrosine	186	HPRD

Protein: UBE2E3

PTM	Residue	Reference
Phosphoserine	12	HPRD

Localisation

Protein: MAPK1

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD
Cytoskeleton	HPRD

Protein: UBE2E3

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between MAPK1 and UBE2E3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andUBE2E3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and UBE2E3 has 808 interactors of which there are 640 common interactors.

Common Interactor	Name of Common Interactor	Score for MAPK1-Interactor (?)	Score for UBE2E3-Interactor (?)
MAPK3	MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3	153.00	0.029
DUSP6	DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6	62.30	0.025
DUSP16	DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16	62.30	0.025
DIAPH1	Diaphanous 1	20.60	0.063
SKIIP	SNW1, SKIIP, SKIP: SNW domain-containing protein 1	11.60	2.08
CDK2	CDK2: Cell division protein kinase 2	6.80	0.038
HSPD1		6.11	0.029
PSMD4	PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4	4.15	0.112
HSP90AA1	Hsp89-alpha-delta-N	3.95	0.063
PSMD11	PSMD11: 26S proteasome non-ATPase regulatory subunit 11	3.35	0.063
PTEN	PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du	2.17	0.038
CCT2	CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta	2.02	0.046
PLEK	PLEK, P47: Pleckstrin	0.515	0.027
PTPN12	PTPN12: Tyrosine-protein phosphatase non-receptor type 12	0.461	0.046
CRKL	CRKL: Crk-like protein	0.461	0.063
JAK1		0.461	0.046
VAV1	VAV1, VAV: Proto-oncogene vav	0.461	0.046
MSN	MSN: Moesin	0.461	0.046
TYK2	TYK2: Non-receptor tyrosine-protein kinase TYK2	0.461	0.046
WAS	WAS, IMD2: Wiskott-Aldrich syndrome protein	0.461	0.046
ID2	ID2: DNA-binding protein inhibitor ID-2	0.430	0.036
SH3BP2	SH3BP2: Uncharacterized protein SH3BP2	0.416	0.0425
ELF1	ELF1: ETS-related transcription factor Elf-1	0.416	0.124
LCP2	LCP2: Lymphocyte cytosolic protein 2	0.416	0.061
TAOK3	TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3	0.385	0.063
STK10	STK10: Uncharacterized protein STK10	0.385	0.046
IQGAP1	IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1	0.385	0.046
CBLB	CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B	0.372	0.060
STAT6	STAT6: Signal transducer and activator of transcription 6	0.372	0.038
PSCD4	PSCD4, CYT4: Cytohesin-4	0.372	0.046
ATF1	ATF1: Cyclic AMP-dependent transcription factor ATF-1	0.372	0.040
ARHGEF6	ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6	0.372	0.046
LYN	LYN: Tyrosine-protein kinase Lyn	0.372	0.0425
NCK1	NCK1, NCK: Cytoplasmic protein NCK1	0.372	0.046
CSK	CSK: Tyrosine-protein kinase CSK	0.372	0.038
ACP1	ACP1: Low molecular weight phosphotyrosine protein phosphatase	0.372	0.078
JAK2	JAK2: Tyrosine-protein kinase JAK2	0.372	0.046
JUND	JUND: Transcription factor jun-D	0.372	0.032
RAF1	RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase	0.372	0.063
ZAP70	ZAP70: Uncharacterized protein ZAP70	0.372	0.038
FGR	FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR	0.372	0.029
IQSEC1	IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein	0.372	0.038
KHDRBS1	KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate	0.344	0.078
OSBPL11	OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11	0.307	0.032
ROCK1	ROCK1: Rho-associated protein kinase 1	0.307	0.032
VASP	VASP: Vasodilator-stimulated phosphoprotein	0.307	0.032
HMGN2	HMGN2, HMG17: Non-histone chromosomal protein HMG-17	0.307	0.036
DOK1	DOK1: Docking protein 1	0.275	0.038
BTK	BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK	0.275	0.038
AKT1	AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase	0.275	0.046
ADRBK1	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1	0.275	0.029
TXK	TXK, PTK4: Tyrosine-protein kinase TXK	0.275	0.029
HCK	N/A	0.275	0.029
MAFG	MAFG: Transcription factor MafG	0.275	0.032
ETS1	ETS1, EWSR2: Protein C-ets-1	0.275	0.051
PSMA3	PSMA3, PSC8: Proteasome subunit alpha type-3	0.275	0.046
SYK	SYK: Tyrosine-protein kinase SYK	0.275	0.046
BRAF	BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase	0.275	0.046
PSMA5	PSMA5: Proteasome subunit alpha type-5	0.275	0.046
PSTPIP1	PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1	0.260	0.0425
LCK	LCK: Proto-oncogene tyrosine-protein kinase LCK	0.251	0.032
HMGN1	HMGN1, HMG14: Non-histone chromosomal protein HMG-14	0.251	0.027
IRS2	IRS2: Insulin receptor substrate 2	0.251	0.026
IQGAP2	IQGAP2: Ras GTPase-activating-like protein IQGAP2	0.233	0.032
WASPIP	N/A	0.233	0.038
DOCK2	DOCK2, KIAA0209: Dedicator of cytokinesis protein 2	0.233	0.046
EIF4G2	EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2	0.233	0.040
PIK3CG	PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i	0.233	0.046
NMT1	NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1	0.233	0.063
OXSR1	OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1	0.233	0.063
STK38	STK38, NDR1: Serine/threonine-protein kinase 38	0.233	0.046
MAP2K1	MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1	0.233	0.046
RPS6KA1	RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1	0.233	0.046
HCLS1	HCLS1, HS1: Hematopoietic lineage cell-specific protein	0.233	0.038
SMAD2	SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2	0.233	15.50
SH3BP5	N/A	0.225	0.029
STAT5A	STAT5A, STAT5: Signal transducer and activator of transcription 5A	0.225	0.038
PRKD2	PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2	0.225	0.038
OSBP	OSBP, OSBP1: Oxysterol-binding protein 1	0.225	0.046
SOS1	SOS1: Son of sevenless homolog 1	0.225	0.067
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.210	0.251
NR3C1	NR3C1, GRL: Glucocorticoid receptor	0.210	0.027
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.208	0.034
APPL	APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha	0.191	0.0425
BLNK	BLNK, BASH, SLP65: B-cell linker protein	0.191	0.0425
CXorf9	N/A	0.188	0.054
SNX17	SNX17, KIAA0064: Sorting nexin-17	0.188	0.046
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	0.188	0.032
PRPF4B	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol	0.188	0.063
NEK7	NEK7: Serine/threonine-protein kinase Nek7	0.188	0.046
NACA	NACA, HSD48: Nascent polypeptide-associated complex subunit alpha	0.188	0.111
CSNK2A1	CSNK2A1: CSNK2A1 protein	0.188	0.078
RPS6KB1	N/A	0.188	0.046
FNBP1	N/A	0.188	0.046
GMIP	GMIP: GEM-interacting protein	0.188	0.038
SEC24B	SEC24B: Protein transport protein Sec24B	0.188	0.063
NCK2	NCK2: Cytoplasmic protein NCK2	0.171	0.038
HSF2	HSF2, HSTF2: Heat shock factor protein 2	0.171	0.037
PLCB3	PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3	0.171	0.038
PRKCI	PRKCI, DXS1179E: Protein kinase C iota type	0.171	0.038
PTPN6	PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6	0.165	0.028
PSCD1	PSCD1, D17S811E: Cytohesin-1	0.165	0.028
ITSN1	ITSN1, ITSN, SH3D1A: Intersectin-1	0.165	0.028
PSCD2	N/A	0.165	0.028
SNCA	SNCA, NACP, PARK1: Alpha-synuclein	0.165	0.028
NF2	NF2, SCH: Merlin	0.165	0.028
DNM3	DNM3: Uncharacterized protein DNM3	0.165	0.028
LNK	SH2B3, LNK: SH2B adapter protein 3	0.165	0.028
ARFGAP1	N/A	0.155	0.027
HD	HD, IT15: Huntingtin	0.155	0.0425
H1FX	H1FX: Histone H1x	0.155	0.0446
TRADD	TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein	0.155	0.127
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.155	0.096
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.155	0.032
IL2RB	IL2RB: Interleukin-2 receptor subunit beta precursor	0.153	0.027
ERF	ERF: ETS domain-containing transcription factor ERF	0.152	0.057
GAB1	GAB1: GRB2-associated-binding protein 1	0.152	0.026
ABL1	ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1	0.152	0.032
SRC	SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src	0.152	0.026
ETS2	ETS2: Protein C-ets-2	0.152	0.057
CDC25C	CDC25C: M-phase inducer phosphatase 3	0.148	0.025
CDC25A	CDC25A: M-phase inducer phosphatase 1	0.148	0.025
AKT3	AKT3: RAC-gamma serine/threonine-protein kinase	0.148	0.025
DGKD	DGKD, KIAA0145: Diacylglycerol kinase delta	0.148	0.047
EEF2K	EEF2K: Elongation factor 2 kinase	0.148	0.028
GRB2	GRB2, ASH: Growth factor receptor-bound protein 2	0.148	0.025
RASA1	RASA1, RASA: Ras GTPase-activating protein 1	0.148	0.025
ITK	ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK	0.148	0.025
PDPK1	PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1	0.148	0.025
ELMO1	N/A	0.148	0.025
ITSN2	ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2	0.148	0.025
ARHGEF7	N/A	0.148	0.025
SPTBN1	SPTBN1, SPTB2: Spectrin beta chain, brain 1	0.148	0.025
EPB41L1	EPB41L1, KIAA0338: Band 4.1-like protein 1	0.148	0.025
FYN	FYN: Proto-oncogene tyrosine-protein kinase Fyn	0.148	0.025
PARD6A	PARD6A, PAR6A: Partitioning defective 6 homolog alpha	0.148	0.025
PPP2R5A	PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha	0.146	0.046
RAP1A	RAP1A, KREV1: Ras-related protein Rap-1A precursor	0.146	0.063
RAP1B	RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor	0.146	0.063
IRAK1	IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1	0.139	0.188
CTDP1	CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase	0.139	0.032
STK24	STK24, MST3, STK3: Serine/threonine-protein kinase 24	0.139	0.063
STK11	STK11, LKB1, PJS: Serine/threonine-protein kinase 11	0.139	0.063
MAP2K4	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k	0.139	0.029
ATR	ATR, FRP1: Serine/threonine-protein kinase ATR	0.139	0.046
RPS6KB2	RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2	0.139	0.063
MAP2K2	MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki	0.139	0.063
RAPGEF6	RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6	0.139	0.029
PKN2	PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2	0.139	0.046
CNKSR2	CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2	0.136	0.035
RDX	RDX: Radixin	0.136	0.029
VIL2	N/A	0.136	0.029
STMN1	STMN1, LAP18, OP18: Stathmin	0.136	0.029
HSF1	HSF1, HSTF1: Heat shock factor protein 1	0.136	0.051
RHOA	RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor	0.132	0.070
TMEM1	TMEM1, EHOC1: Transmembrane protein 1	0.129	0.046
RBM8A	RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A	0.129	0.040
RB1	RB1: Retinoblastoma-associated protein	0.127	0.027
MAP3K8	MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8	0.127	0.032
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.127	0.032
TRAFD1	TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1	0.127	0.032
MAPKAPK2	MAPKAPK2: MAP kinase-activated protein kinase 2	0.127	0.052
MAPK6	MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6	0.127	0.032
HSP90AB1	HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta	0.127	0.0425
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.123	0.026
SQSTM1	SQSTM1: Uncharacterized protein SQSTM1	0.123	0.096
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.118	0.063
PPP1R8	N/A	0.118	0.137
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.118	0.040
NRAS	NRAS, HRAS1: GTPase NRas precursor	0.118	0.063
VRK1	VRK1: Serine/threonine-protein kinase VRK1	0.114	0.063
STAM	STAM, STAM1: Signal transducing adapter molecule 1	0.114	0.372
SIPA1L1	SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein	0.114	0.026
TAGLN2	TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein	0.114	0.038
CDK5	CDK5: Cell division protein kinase 5	0.114	0.038
PIK3CB	PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit	0.114	0.029
MAPKAPK3	MAPKAPK3: MAP kinase-activated protein kinase 3	0.114	0.038
RPS10	RPS10: 40S ribosomal protein S10	0.114	0.139
THOC1	THOC1, HPR1: THO complex subunit 1	0.114	0.139
CSNK1E	CSNK1E: Casein kinase I isoform epsilon	0.114	0.038
EDD1	EDD1, EDD, HYD, KIAA0896: E3 ubiquitin-protein ligase EDD1	0.113	0.090
MYCBP2	MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2	0.111	0.0735
YES1	YES1, YES: Proto-oncogene tyrosine-protein kinase Yes	0.111	0.026
ELK1	ELK1: ETS domain-containing protein Elk-1	0.111	0.029
ANKS1A	ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A	0.111	0.043
CBLC	CBLC, CBL3, RNF57: Signal transduction protein CBL-C	0.109	0.081
ETV1	ETV1, ER81: ETS translocation variant 1	0.098	0.033
PTPRF	PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor	0.098	0.044
CBL	CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL	0.097	0.073
PTMA	N/A	0.0971	0.036
NBN	NBN, NBS, NBS1, P95: Nibrin	0.0971	0.091
HUWE1	HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1	0.096	0.191
TRAF2	TRAF2, TRAP3: TNF receptor-associated factor 2	0.096	0.191
EIF4G1	EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1	0.096	0.027
CIITA	CIITA, MHC2TA: MHC class II transactivator	0.096	0.032
ICK	ICK, KIAA0936: Serine/threonine-protein kinase ICK	0.096	0.032
PRKDC	PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit	0.096	0.032
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.096	0.026
MAP3K14	MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14	0.096	0.026
SMAD7	SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7	0.096	0.057
TOP2A	TOP2A, TOP2: DNA topoisomerase 2-alpha	0.096	0.027
NCF1	Neutrophil cytosolic factor 1 variant (Fragment)	0.096	0.026
CDKN2D	CDKN2D: Cyclin-dependent kinase 4 inhibitor D	0.087	0.163
SH2BP1	CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog	0.087	0.087
MATR3	MATR3, KIAA0723: Matrin-3	0.087	0.036
IFI16	N/A	0.087	0.027
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.087	0.032
TUBA1	TUBA4A, TUBA1: Tubulin alpha-4A chain	0.087	0.067
CRKRS	CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7	0.086	0.029
CDK7	CDK7, MO15: Cell division protein kinase 7	0.086	0.029
GRK5	GRK5, GPRK5: G protein-coupled receptor kinase 5	0.086	0.029
CHEK1	CHEK1, CHK1: Serine/threonine-protein kinase Chk1	0.086	0.029
CTPS	CTPS: CTP synthase 1	0.086	0.038
SMAD3	SMAD3, MADH3: Mothers against decapentaplegic homolog 3	0.086	19.50
ILK	ILK, ILK1, ILK2: Integrin-linked protein kinase	0.086	0.071
DAPK1	DAPK1, DAPK: Death-associated protein kinase 1	0.086	0.096
MTA1	MTA1: Metastasis-associated protein MTA1	0.086	0.067
SMAD4	SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4	0.086	0.051
CAD	CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase	0.086	0.038
TP53	TP53, P53: Cellular tumor antigen p53	0.086	0.054
CDC7	CDC7, CDC7L1: Cell division cycle 7-related protein kinase	0.086	0.038
MAPK8	MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8	0.083	0.028
MAPKAPK5	N/A	0.083	0.028
AMPH	AMPH, AMPH1: Amphiphysin	0.083	0.028
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.083	0.028
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.083	0.028
KRT6E	KRT6C, KRT6E: Keratin, type II cytoskeletal 6C	0.083	0.028
ABI1	ABI1, SSH3BP1: Abl interactor 1	0.083	0.028
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.083	0.028
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.083	0.028
MAPK10	MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10	0.083	0.028
MAPK15	N/A	0.083	0.028
CASP9	CASP9, MCH6: Caspase-9 precursor	0.083	0.083
CASP1	CASP1, IL1BC, IL1BCE: Caspase-1 precursor	0.083	0.083
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.083	0.028
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.083	0.028
AKAP12	AKAP12, AKAP250: A-kinase anchor protein 12	0.083	0.028
IRF3	IRF3: Interferon regulatory factor 3	0.080	0.057
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.078	0.046
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.078	0.032
LCP1	LCP1, PLS2: Plastin-2	0.078	0.038
AGTPBP1	AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein	0.078	0.052
PPP1R12A	PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A	0.078	0.118
JARID1A	JARID1A, RBBP2, RBP2: Histone demethylase JARID1A	0.078	0.032
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.078	0.032
HNRPK	N/A	0.078	0.078
KIAA1012	KIAA1012: Protein TRS85 homolog	0.078	0.063
USP47	USP47: Ubiquitin carboxyl-terminal hydrolase 47	0.078	0.063
PPID	PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase	0.078	0.078
PIK4CB	PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic,	0.078	0.063
KLHDC4	N/A	0.078	0.063
YWHAB	YWHAB: 14-3-3 protein beta/alpha	0.078	0.063
KLF13	KLF13, BTEB3, NSLP1: Krueppel-like factor 13	0.078	0.032
GNB1	GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.078	0.040
YWHAZ	YWHAZ: 14-3-3 protein zeta/delta	0.078	0.046
PAPOLA	PAPOLA, PAP: Poly(A) polymerase alpha	0.078	0.040
MYB	MYB: Myb proto-oncogene protein	0.077	0.075
PRKAA1	N/A	0.077	0.026
MGMT	MGMT: Methylated-DNA--protein-cysteine methyltransferase	0.077	0.032
SPTA1	SPTA1, SPTA: Spectrin alpha chain, erythrocyte	0.077	0.032
FADD	FADD, MORT1: Protein FADD	0.075	0.091
MAP3K7	MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7	0.075	0.025
GIT2	N/A	0.075	0.047
NEDD9	NEDD9, CASL: Enhancer of filamentation 1	0.075	0.025
CHEK2	CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2	0.075	0.044
NEK6	NEK6: Serine/threonine-protein kinase Nek6	0.075	0.028
PHKG1	PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo	0.075	0.025
SNX3	N/A	0.075	0.025
LATS1	LATS1, WARTS: Serine/threonine-protein kinase LATS1	0.075	0.075
CNN2	CNN2: Calponin-2	0.075	0.028
MKNK1	MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1	0.075	0.025
SH3KBP1	SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1	0.075	0.025
CAMK4	CAMK4: Calcium/calmodulin-dependent protein kinase type IV	0.075	0.025
TSC2	TSC2, TSC4: Tuberin	0.075	0.025
PTK2B	PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta	0.075	0.025
DYRK1B	DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.075	0.028
MKNK2	MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2	0.075	0.025
BIN1	BIN1, AMPHL: Myc box-dependent-interacting protein 1	0.075	0.025
CAMK1D	CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D	0.075	0.025
LATS2	LATS2, KPM: Serine/threonine-protein kinase LATS2	0.075	0.075
CDC2L5	CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5	0.075	0.025
RPS6KA4	RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4	0.075	0.025
RPS6KA2	RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2	0.075	0.025
SMAD1	SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1	0.075	2.29
CDC2	CDC2: Cell division control protein 2 homolog	0.075	0.028
PRKACA	PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit	0.075	0.025
SGK2	SGK2: Serine/threonine-protein kinase Sgk2	0.075	0.028
RASGRP3	RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3	0.075	0.025
PTPN1	PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1	0.073	0.027
SLC4A1AP	SLC4A1AP: Uncharacterized protein SLC4A1AP	0.071	0.041
TXNL1	TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1	0.071	0.233
K-ALPHA-1	TUBA1B: Tubulin alpha-1B chain	0.071	0.111
ZNF148	ZNF148, ZBP89: Zinc finger protein 148	0.070	0.027
RBM3	RBM3, RNPL: Putative RNA-binding protein 3	0.070	0.0446
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.070	0.036
SLC9A3R1	SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50	0.070	0.0425
JMJD1A	JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr	0.070	0.027
KIAA0528	KIAA0528: Uncharacterized protein KIAA0528	0.070	0.087
GTF3C1	N/A	0.070	0.036
RFXDC2	RFXDC2: Regulatory factor X domain-containing protein 2.	0.070	0.027
KIAA0853	N/A	0.070	0.036
ABCF1	N/A	0.070	0.052
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	0.070	0.036
TOP2B	N/A	0.070	0.036
IFI35	N/A	0.070	0.0425
WDR1	N/A	0.070	0.036
MARK2	N/A	0.070	0.032
IKBKG	IKBKG, FIP3, NEMO: NF-kappa-B essential modulator	0.070	0.027
ITGB1BP1	ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1	0.070	0.070
GIT1	GIT1: ARF GTPase-activating protein GIT1	0.069	0.043
PBK	PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase	0.069	0.029
CDK4	CDK4: Cell division protein kinase 4	0.069	0.038
GSK3B	N/A	0.063	0.063
COPA	COPA: Coatomer subunit alpha	0.063	0.063
TDG	TDG: G/T mismatch-specific thymine DNA glycosylase	0.063	0.040
ACTG1	ACTB: Actin, cytoplasmic 1	0.063	0.046
PCBP1	PCBP1: Poly(rC)-binding protein 1	0.063	0.078
PTPN11	N/A	0.063	0.063
HGS	HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate	0.063	0.245
ANAPC5	ANAPC5, APC5: Anaphase-promoting complex subunit 5	0.063	0.078
DPF2	DPF2, REQ, UBID4: Zinc finger protein ubi-d4	0.063	0.372
NUP153	N/A	0.063	0.032
PPIA	PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A	0.063	0.063
EHD1	EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1	0.063	0.038
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.063	0.063
CKAP1	TBCB, CG22, CKAP1: Tubulin folding cofactor B	0.063	0.046
ME2	ME2: NAD-dependent malic enzyme, mitochondrial precursor	0.063	0.038
PSMC2	PSMC2, MSS1: 26S protease regulatory subunit 7	0.063	0.063
USP7	USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7	0.063	0.063
DYNC1LI1	DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1	0.063	0.063
SFRS2	SFRS2: Splicing factor, arginine/serine-rich 2	0.063	0.040
TBK1	TBK1, NAK: Serine/threonine-protein kinase TBK1	0.063	0.038
TOPBP1	TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1	0.063	0.032
CUL5	CUL5, VACM1: Cullin-5	0.063	0.181
CSPG6	SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3	0.063	0.032
SFRS10	SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10	0.063	0.040
H3F3A	H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3	0.063	0.137
SEC24C	SEC24C, KIAA0079: Protein transport protein Sec24C	0.063	0.046
CAPN2	CAPN2, CANPL2: Calpain-2 catalytic subunit precursor	0.063	0.038
PPP1CB	PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit	0.063	0.063
EXOC2	N/A	0.063	0.038
SUZ12	SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12	0.063	0.040
RBM15	RBM15, OTT: Putative RNA-binding protein 15	0.063	0.032
PABPN1	PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2	0.063	0.040
AKAP8	AKAP8, AKAP95: A-kinase anchor protein 8	0.063	0.032
NCOR1	NCOR1, KIAA1047: Nuclear receptor corepressor 1	0.063	0.067
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	0.063	0.032
CALM2	CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca	0.063	0.046
EP300	N/A	0.063	0.032
SAFB	SAFB, HAP, HET, SAFB1: Scaffold attachment factor B	0.063	0.0818
PPARBP	N/A	0.063	0.063
YY1	YY1: Transcriptional repressor protein YY1	0.063	0.066
EPS15	EPS15, AF1P: Epidermal growth factor receptor substrate 15	0.063	0.038
ZCCHC8	ZCCHC8: Zinc finger CCHC domain-containing protein 8	0.063	0.032
FRG1	FRG1: Protein FRG1	0.063	0.063
USP10	USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10	0.063	0.046
PEA15	PEA15: Astrocytic phosphoprotein PEA-15	0.062	0.062
MDM4	MDM4, MDMX: Mdm4 protein	0.062	0.072
CEBPA	CEBPA: CCAAT/enhancer-binding protein alpha	0.062	0.037
GRLF1	N/A	0.062	0.026
TNFRSF1A	TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre	0.057	0.057
RERE	RERE, ARG, ARP, ATN1L, KIAA0458: Arginine-glutamic acid dipeptide repeats protei	0.056	0.033
AURKA	AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6	0.056	0.038
PCTK1	PCTK1: Serine/threonine-protein kinase PCTAIRE-1	0.056	0.026
PKMYT1	PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito	0.056	0.029
STAM2	STAM2: Signal transducing adapter molecule 2	0.056	0.111
WEE1	WEE1: Wee1-like protein kinase	0.056	0.029
XRCC6	XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1	0.052	0.153
DNM2	N/A	0.052	0.052
TERF1	TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1	0.052	0.091
CHUK	N/A	0.052	0.052
VCPIP1	VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135	0.052	0.0425
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.052	0.082
RGS2	RGS2, G0S8: Regulator of G-protein signaling 2	0.052	0.032
TERF2	TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2	0.052	0.075
SET	SET: Protein SET	0.052	0.027
YWHAQ	YWHAQ: 14-3-3 protein theta	0.052	0.087
DEF6	DEF6, IBP: Differentially expressed in FDCP 6	0.052	0.032
RBM14	RBM14, SIP: RNA-binding protein 14	0.052	0.036
LIMS1	N/A	0.052	0.052
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.052	0.052
API5	N/A	0.052	0.052
RANGAP1	RANGAP1, SD: Ran GTPase-activating protein 1	0.052	0.070
AHNAK	AHNAK: AHNAK protein	0.052	0.0425
DDX21	DDX21: Nucleolar RNA helicase 2	0.052	0.027
TERF2IP	TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1	0.052	0.091
RNPS1	RNPS1, LDC2: RNA-binding protein with serine-rich domain 1	0.052	0.036
MAPK7	mitogen-activated protein kinase 7 isoform 1	0.052	0.052
FLNA	FLNA, FLN, FLN1: Filamin-A	0.052	0.0425
TRPV1	TRPV1: Vanilloid receptor variant TRPV1b	0.049	0.04
EDAR	EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor	0.049	0.049
TRPV4	TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb	0.049	0.04
TUBB3	TUBB3, TUBB4: Tubulin beta-3 chain	0.048	0.075
BIRC5	BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5	0.048	0.0425
MKI67	MKI67: Antigen KI-67	0.048	0.075
BIRC4	BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4	0.048	0.123
H2-ALPHA	TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain	0.047	0.044
RAB5B	RAB5B: Ras-related protein Rab-5B	0.047	0.025
HDAC3	HDAC3: Histone deacetylase 3	0.046	0.032
EVL	N/A	0.046	0.029
CDC23	CDC23: Cell division cycle protein 23 homolog	0.046	0.063
EIF5B	EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B	0.046	0.046
SP3	SP3: Transcription factor Sp3	0.046	0.032
HIST3H3	HIST3H3, H3FT: Histone H3.1t	0.046	0.051
HSPH1	HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa	0.046	0.046
EIF3S9	EIF3S9: Eukaryotic translation initiation factor 3 subunit 9	0.046	0.032
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	0.046	0.032
PCBP2	PCBP2: Poly(rC)-binding protein 2	0.046	0.063
EIF3S8	EIF3S8: Eukaryotic translation initiation factor 3 subunit 8	0.046	0.063
TBCE	TBCE: Tubulin-specific chaperone E	0.046	0.063
SSB	SSB: Lupus La protein	0.046	0.032
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.046	0.0818
BRPF1	BRPF1, BR140: Peregrin	0.046	0.046
COPS3	COPS3, CSN3: COP9 signalosome complex subunit 3	0.046	0.078
PPP2CA	PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	0.046	0.029
DLG1	N/A	0.046	0.038
RGS19	RGS19, GAIP, GNAI3IP: Regulator of G-protein signaling 19	0.046	0.032
BRD3	BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3	0.046	0.032
WARS	WARS, IFI53, WRS: Tryptophanyl-tRNA synthetase, cytoplasmic	0.046	0.029
NFKBIA	NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha	0.046	0.054
EIF2S3	EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3	0.046	0.038
XPO1	XPO1, CRM1: Exportin-1	0.046	0.063
FLII	FLII, FLIL: Protein flightless-1 homolog	0.046	0.046
SFRS6	SFRS6, SRP55: Splicing factor, arginine/serine-rich 6	0.046	0.032
USP34	USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34	0.046	0.038
SEC31L1	N/A	0.046	0.032
LPXN	LPXN, LDLP: Leupaxin	0.046	0.038
CLASP1	CLASP1, KIAA0622, MAST1: CLIP-associating protein 1	0.046	0.063
COPE	COPE: Coatomer subunit epsilon	0.046	0.063
CBX3	CBX3: Chromobox protein homolog 3	0.046	0.032
NRBP1	NRBP1, BCON3, NRBP: Nuclear receptor-binding protein	0.046	0.063
CLTC	CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1	0.046	0.032
RARS	RARS: Arginyl-tRNA synthetase, cytoplasmic	0.046	0.046
ANP32B	ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb	0.046	0.032
EPRS	EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes:	0.046	0.038
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.046	0.032
SAPS3	N/A	0.046	0.038
UTX	UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein	0.046	0.038
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.046	0.032
RPS3	RPS3, OK/SW-cl.26: 40S ribosomal protein S3	0.046	0.046
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.046	0.078
PSMC1	PSMC1: 26S protease regulatory subunit 4	0.046	0.063
GNB2	GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.046	0.032
CPSF1	CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1	0.046	0.032
ITGA4	ITGA4, CD49D: Integrin alpha-4 precursor	0.0446	0.036
CASKIN2	CASKIN2, KIAA1139: Caskin-2	0.044	0.0308
TRPV6	TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6	0.044	0.036
TUBB2A	TUBB2A, TUBB2: Tubulin beta-2A chain	0.043	0.051
AKR7A2	AKR7A2, AFAR, AFAR1, AKR7: Aflatoxin B1 aldehyde reductase member 2	0.043	0.038
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.0425	0.036
VAV2	VAV2, RP11-153P4.1-003: Vav 2 oncogene	0.0425	0.0425
SAT	SAT1, SAT: Diamine acetyltransferase 1	0.0425	0.0425
DAPP1	N/A	0.0425	0.026
MPG	N/A	0.0425	0.0425
SMARCC2	N/A	0.0425	0.027
AOF2	AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1	0.0425	0.036
S100A9	S100A9, CAGB, CFAG, MRP14: Protein S100-A9	0.0425	0.026
XRCC1	XRCC1: DNA-repair protein XRCC1	0.0425	0.091
MNAR	PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1	0.0425	0.0425
PDE4A	N/A	0.0425	0.026
FTH1	FTH1, FTH, OK/SW-cl.84, FTHL6, PIG15: Ferritin heavy chain	0.0425	0.052
ALOX5	ALOX5, LOG5: Arachidonate 5-lipoxygenase	0.0425	0.026
MYLIP	MYLIP, BZF1, BM-023, PP5242: E3 ubiquitin-protein ligase MYLIP	0.041	0.041
ITGB2	ITGB2, CD18, MFI7: Integrin beta-2 precursor	0.040	0.054
UNC84B	UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2	0.040	0.0818
ITGB7	ITGB7: Integrin beta-7 precursor	0.040	0.054
HDAC2	HDAC2: Histone deacetylase 2	0.038	0.032
TAF6	TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6	0.038	0.054
PHF10	N/A	0.038	0.032
RANBP9	RANBP9, RANBPM: Ran-binding protein 9	0.038	0.067
COPB2	COPB2: Coatomer subunit beta'	0.038	0.032
CDC34	CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1	0.038	0.087
CCT4	CCT4, CCTD, SRB: T-complex protein 1 subunit delta	0.038	0.038
APC	N/A	0.038	0.029
ELAVL1	ELAVL1, HUR: ELAV-like protein 1	0.038	0.032
EEF1A1	EEF1A1: Elongation factor 1-alpha	0.038	0.038
SENP6	SENP6, KIAA0797, FKSG6, SSP1, SUSP1: Sentrin-specific protease 6	0.038	0.032
ACIN1	ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus	0.038	0.067
RNF11	RNF11, CGI-123: RING finger protein 11	0.038	0.148
CFL1	CFL1, CFL: Cofilin-1	0.038	0.038
EEF1B2	EEF1B2, EEF1B, EF1B: Elongation factor 1-beta	0.038	0.046
CAT	CAT: Catalase	0.038	0.063
CCT6A	CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta	0.038	0.063
APEX1	APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase	0.038	0.032
UBA2	SAE2, UBA2, HRIHFB2115, UBLE1B: SUMO-activating enzyme subunit 2	0.038	0.032
STUB1	STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1	0.038	0.275
NOC2L	NOC2L: Nucleolar complex protein 2 homolog	0.038	0.038
PSMD1	PSMD1: 26S proteasome non-ATPase regulatory subunit 1	0.038	0.046
MDN1	MDN1, KIAA0301: Midasin	0.038	0.054
EEF2	EEF2, EF2: Elongation factor 2	0.038	0.038
HDGF	HDGF, HMG1L2: Hepatoma-derived growth factor	0.038	0.032
BAP1	BAP1, KIAA0272, hucep-6: Ubiquitin carboxyl-terminal hydrolase BAP1	0.038	0.063
TPT1	TPT1: Translationally-controlled tumor protein	0.038	0.038
G3BP	G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1	0.038	0.046
TSC1	TSC1, KIAA0243, TSC: Hamartin	0.038	0.029
VCP	VCP: Transitional endoplasmic reticulum ATPase	0.038	0.063
TLN1	TLN1: Uncharacterized protein TLN1	0.038	0.029
EEF1G	EEF1G, EF1G, PRO1608: Elongation factor 1-gamma	0.038	0.046
HLA-B	HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor	0.036	0.027
CP110	N/A	0.032	0.0425
S100A11	MLN70, S100A11, S100C: Protein S100-A11	0.032	0.026
ZYX	ZYX: Zyxin	0.032	0.026
SNAPC4	SNAPC4, SNAP190: snRNA-activating protein complex subunit 4	0.032	0.0453
MAP2K5	N/A	0.032	0.032
UBAP2	N/A	0.032	0.052
AFF1	N/A	0.032	0.027
IPO7	IPO7: Uncharacterized protein IPO7	0.032	0.0425
YWHAH	YWHAH, YWHA1: 14-3-3 protein eta	0.032	0.026
TRIM28	TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta	0.032	0.202
NME1	NME1, NDPKA, NM23: Nucleoside diphosphate kinase A	0.032	0.032
NAT1	NAT1, AAC1: Arylamine N-acetyltransferase 1	0.032	0.026
AP2M1	AP2M1, CLAPM1, KIAA0109: AP-2 complex subunit mu-1	0.032	0.040
CUL2	CUL2: Cullin-2	0.032	0.035
RYR2	RYR2: Ryanodine receptor 2	0.031	0.025
NGFR	NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor	0.029	0.032
KIAA0683	DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized	0.029	0.038
EHBP1	EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1	0.029	0.038
GSTP1	GSTP1, FAEES3, GST3: Glutathione S-transferase P	0.029	0.0425
WWOX	WWOX, FOR, WOX1: WW domain-containing oxidoreductase	0.029	0.029
FKBP5	FKBP5, AIG6, FKBP51: FK506-binding protein 5	0.029	0.029
BARD1	BARD1: BRCA1-associated RING domain protein 1	0.029	0.166
MYBL2	MYBL2, BMYB: Myb-related protein B	0.029	0.067
UNG	N/A	0.029	0.027
KPNA2	KPNA2, RCH1, SRP1: Importin subunit alpha-2	0.029	0.046
THOP1	THOP1: Thimet oligopeptidase	0.029	0.029
PRDX6	PRDX6, AOP2, KIAA0106: Peroxiredoxin-6	0.029	0.046
PPP2CB	PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	0.029	0.038
FKBP1A	FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A	0.029	0.029
SYMPK	SYMPK, SPK: Symplekin	0.029	0.038
CTNNB1	CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1	0.029	0.029
DPYSL2	DPYSL2, CRMP2: Dihydropyrimidinase-related protein 2	0.029	0.029
RRM2	RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2	0.029	0.038
GAPD	GAPDH, GAPD, CDABP0047, OK/SW-cl.12: Glyceraldehyde-3-phosphate dehydrogenase	0.029	0.029
SGTA	SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A	0.029	0.029
H2AFX	H2AFX, H2AX: Histone H2A.x	0.029	0.0818
TRIM25	TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25	0.029	0.046
NME2	NME2, NM23B: Nucleoside diphosphate kinase B	0.029	0.038
ENO1	ENO1, ENO1L1, MBPB1, MPB1: Alpha-enolase	0.029	0.029
PMM1	PMM1, PMMH22: Phosphomannomutase 1	0.029	0.038
FHOD1	FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1	0.029	0.029
HIST1H3A	HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD,	0.029	0.041
BCDO2	PTS: 6-pyruvoyl tetrahydrobiopterin synthase	0.029	0.038
CASP3	CASP3, CPP32: Caspase-3 precursor	0.029	0.046
RGS18	RGS18, RGS13: Regulator of G-protein signaling 18	0.028	0.028
C20orf18	N/A	0.028	0.109
UACA	UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats	0.028	0.028
SH2D3A	SH2D3A, NSP1, UNQ175/PRO201: SH2 domain-containing protein 3A	0.028	0.028
AHSA2	AHSA2, DKFZp564C236, hCG_15158: Putative uncharacterized protein DKFZp564C236	0.028	0.028
CACNB2	N/A	0.028	0.028
FBXO4	FBXO4, FBX4: F-box only protein 4	0.028	0.083
PTPN7	N/A	0.028	0.028
STAP2	Uncharacterized protein ENSP00000317912	0.028	0.028
CDC42	N/A	0.028	0.028
PDE5A	PDE5A, PDE5: cGMP-specific 3',5'-cyclic phosphodiesterase	0.028	0.028
S100A16	S100A16, AAG13: Protein S100-A16	0.028	0.028
AXIN1		0.028	0.028
MATK		0.028	0.028
UHRF1		0.028	0.044
PHLDB2	N/A	0.028	0.028
ZNF687	ZNF687, KIAA1441: Zinc finger protein 687	0.028	0.028
YWHAG	YWHAG: 14-3-3 protein gamma	0.028	0.028
ABLIM1	ABLIM1, RP11-317F20.1-001: Actin binding LIM protein 1	0.028	0.028
PPEF1	N/A	0.028	0.028
LNX1	N/A	0.028	0.028
SPAG6	SPAG6, PF16: Sperm-associated antigen 6	0.028	0.028
C9orf88	N/A	0.028	0.028
GPRASP2	GPRASP2: G-protein coupled receptor-associated sorting protein 2	0.028	0.028
SF1	SF1, ZFM1, ZNF162: Splicing factor 1	0.028	0.028
C14orf151	C14orf151: Uncharacterized protein C14orf151 (Fragment)	0.028	0.028
PPP1R12C	PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C	0.028	0.028
CASP6	CASP6, MCH2: Caspase-6 precursor	0.028	0.028
NCF4	N/A	0.028	0.028
SLC9A3R2	SLC9A3R2: SLC9A3R2 protein (Fragment)	0.028	0.028
MLL2	MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2	0.028	0.109
CCAR1	CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1	0.028	0.083
PKP4	PKP4: Plakophilin-4	0.028	0.028
TRIM39	TRIM39, RNF23, TFP: Tripartite motif-containing protein 39	0.028	0.165
TRRAP	N/A	0.026	0.032
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	0.026	0.032
AANAT	AANAT, SNAT: Serotonin N-acetyltransferase	0.026	0.026
AFAP	AFAP1, AFAP: Actin filament-associated protein 1	0.026	0.026
CENPA	CENPA: Histone H3-like centromeric protein A	0.026	0.057
TESK1	TESK1: Dual specificity testis-specific protein kinase 1	0.026	0.032
DCAMKL1	DCLK1, DCAMKL1, DCDC3A, KIAA0369: Serine/threonine-protein kinase DCLK1	0.026	0.026
FANCA	FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein	0.026	0.026
ESPL1	N/A	0.026	0.032
LMO6	LMO6: LIM domain only protein 6	0.025	0.025
RAD50	RAD50: DNA repair protein RAD50	0.025	0.025
SCRIB	N/A	0.025	0.025
UBE2R2	UBE2R2, CDC34B, UBC3B: Ubiquitin-conjugating enzyme E2 R2	0.025	0.025
NDNL2	NDNL2, HCA4, MAGEG1: Melanoma-associated antigen G1	0.025	0.025
WRNIP1	WRNIP1, WHIP: ATPase WRNIP1	0.025	0.028
BCR	N/A	0.025	0.025
LTA4H	LTA4H, LTA4: Leukotriene A-4 hydrolase	0.025	0.025
GSN	GSN: Gelsolin precursor	0.025	0.025
FBXL10	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio	0.025	0.075
MYO18A		0.025	0.025
RFFL	RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin	0.025	0.098
COTL1	COTL1, CLP: Coactosin-like protein	0.025	0.025
EPN2	N/A	0.025	0.025
LRRC7	LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7	0.025	0.025
NCOA5	NCOA5, KIAA1637: Nuclear receptor coactivator 5	0.025	0.025
G3BP2	G3BP2, KIAA0660: Ras GTPase-activating protein-binding protein 2	0.025	0.025
PDE8B	PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies	0.025	0.025
SH3PX3	SH3PX3, DKFZp666B159, hCG_1731072: SH3 and PX domain-containing protein 3.	0.025	0.028
DPP8	DPP8, DPRP1, MSTP097, MSTP135, MSTP141: Dipeptidyl peptidase 8	0.025	0.025
SPAST	SPAST, KIAA1083, SPG4: Spastin	0.025	0.025
DCTN1	DCTN1: Dynactin subunit 1	0.025	0.025
PPP1R9B	PPP1R9B, PPP1R6: Neurabin-2	0.025	0.025
RSU1	RSU1, RSP1: Ras suppressor protein 1	0.025	0.025
RAD51	RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1	0.025	0.025
BCOR	N/A	0.025	0.025
MAP2K3	N/A	0.025	0.025
GOPC	GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein	0.025	0.028
ARID1A	ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A	0.025	0.025
PHC2	PHC2, EDR2, PH2: Polyhomeotic-like protein 2	0.025	0.036
SMC4L1	SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4	0.025	0.025
UBE2A	UBE2A, RAD6A: Ubiquitin-conjugating enzyme E2 A	0.025	0.047
GRK6	N/A	0.025	0.025
CARHSP1	CARHSP1: Calcium-regulated heat stable protein 1	0.025	0.025
RNF20		0.025	0.098
TRERF1	TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1	0.025	0.044
PRKCB1	N/A	0.025	0.025
HIST2H2AC	HIST2H2AC, H2AFQ: Histone H2A type 2-C	0.025	0.044
HSPA8	HSPA8, HSC70, HSP73, HSPA10: Heat shock cognate 71 kDa protein	0.025	0.025
CPNE1	RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12	0.025	0.025
DLX3	DLX3: Homeobox protein DLX-3	0.025	0.036
RAC1	N/A	0.025	0.025
C14orf4	C14orf4, KIAA1865, My039: RING finger protein C14orf4	0.025	0.098
RNF113A	RNF113A, RNF113, ZNF183: RING finger protein 113A	0.025	0.098
DBNL	N/A	0.025	0.025
CAMK2A	N/A	0.025	0.025
RSN	CLIP1, CYLN1, RSN: CAP-Gly domain-containing linker protein 1	0.025	0.025
CFL2	CFL2: Cofilin-2	0.025	0.025
SVIL	SVIL: Supervillin	0.025	0.025
CAMKK1	N/A	0.025	0.025
KIAA0031	EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component	0.025	0.025
CHTF18	RUVBL, CHTF18: Protein CTF18 homolog.	0.025	0.025
PDE4B	PDE4B, DPDE4: cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0.025	0.025
MIER1	MIER1, KIAA1610: Mesoderm induction early response protein 1	0.025	0.044

0.299

Total Score

9.32