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Evidence of Interaction Between MAPK1 and DUSP10

The interaction score between MAPK1 and DUSP10 is 10.90.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismMAPK1 OrthologueDUSP10 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YBL016W 1 YBR276C 0.076
bakers yeast YGR040W 0.096 YBR276C 0.076
bakers yeast YBL016W 1 YIL113W 0.076
bakers yeast YGR040W 0.096 YIL113W 0.076
bakers yeast YBL016W 1 YNL053W 0.076
  • Immunoprecipitation
  • CoLocalization

Get References From PubMed
bakers yeast YGR040W 0.096 YNL053W 0.076

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.119
Domains Domains present in MAPK1 and DUSP10:
Domains in MAPK1Domains in DUSP10
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase
IPR001763 Rhodanese-like
IPR000340 Dual specificity protein phosphatase
IPR008343 MAP kinase phosphatase
IPR001762 Disintegrin

The Chi square scores for co-occurrence of domains that are present in MAPK1 and DUSP10 are listed below.

Domain 1Domain 2Chi Square
IPR003527 MAP kinase IPR008343 MAP kinase phosphatase 991.673
IPR003527 MAP kinase IPR000340 Dual specificity protein phosphatase 575.549
IPR008349 ERK1/2 MAP kinase IPR008343 MAP kinase phosphatase 440.473
IPR008349 ERK1/2 MAP kinase IPR000340 Dual specificity protein phosphatase 317.529
IPR003527 MAP kinase IPR001763 Rhodanese-like 312.614
IPR002290 Serine/threonine protein kinase IPR008343 MAP kinase phosphatase 147.067
IPR008349 ERK1/2 MAP kinase IPR001763 Rhodanese-like 137.552
IPR003527 MAP kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 128.642
IPR008271 Serine/threonine protein kinase, active site IPR008343 MAP kinase phosphatase 108.893
IPR002290 Serine/threonine protein kinase IPR000340 Dual specificity protein phosphatase 108.157
IPR008349 ERK1/2 MAP kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 89.8437
IPR002290 Serine/threonine protein kinase IPR001763 Rhodanese-like 87.68
IPR008271 Serine/threonine protein kinase, active site IPR000340 Dual specificity protein phosphatase 76.5901
IPR008271 Serine/threonine protein kinase, active site IPR001763 Rhodanese-like 75.5504
IPR000719 Protein kinase IPR008343 MAP kinase phosphatase 51.9861
IPR000719 Protein kinase IPR001763 Rhodanese-like 35.31
IPR000719 Protein kinase IPR000340 Dual specificity protein phosphatase 30.0934
IPR011009 Protein kinase-like IPR008343 MAP kinase phosphatase 21.8577
IPR003527 MAP kinase IPR001762 Disintegrin 18.6627
IPR011009 Protein kinase-like IPR000340 Dual specificity protein phosphatase 15.3476
IPR011009 Protein kinase-like IPR001763 Rhodanese-like 14.9678
IPR000719 Protein kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 14.0817
IPR002290 Serine/threonine protein kinase IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 10.8808
IPR011009 Protein kinase-like IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 6.38835
IPR000719 Protein kinase IPR001762 Disintegrin 6.30049
IPR008271 Serine/threonine protein kinase, active site IPR000387 Tyrosine specific protein phosphatase and dual specificity protein phosphatase 2.56073
IPR002290 Serine/threonine protein kinase IPR001762 Disintegrin 0.454007
IPR011009 Protein kinase-like IPR001762 Disintegrin 0.232125
IPR008271 Serine/threonine protein kinase, active site IPR001762 Disintegrin 0.0552247

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in DUSP10
  • Green Domain is present in both MAPK1 and DUSP10

 0.265
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: DUSP10

PTMResidueReference
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: DUSP10

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between MAPK1 and DUSP10 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andDUSP10. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and DUSP10 has 458 interactors of which there are 247 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for DUSP10-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 6.75
MSN MSN: Moesin 0.461 0.027
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.027
JAK1 0.461 0.027
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.027
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.027
STK10 STK10: Uncharacterized protein STK10 0.385 0.027
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.385 0.027
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.027
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.027
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.027
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 0.027
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.372 0.027
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.027
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.027
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.027
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.307 0.027
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 0.027
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.027
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.027
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.027
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.027
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.027
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.027
DOK1 DOK1: Docking protein 1 0.275 0.027
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.027
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 0.027
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.260 0.027
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.260 0.027
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.027
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.251 0.027
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.027
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.233 0.027
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.027
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.027
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.027
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.027
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 0.027
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.027
STAT4 STAT4: Signal transducer and activator of transcription 4 0.225 0.027
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.027
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.027
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.210 0.027
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.027
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.027
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.188 0.027
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.027
RPS6KB1 N/A 0.188 0.027
CXorf9 N/A 0.188 0.027
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.188 0.027
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.171 0.027
RIN1 RIN1: Ras and Rab interactor 1 0.171 0.027
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.027
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.027
MAP2K5 N/A 0.165 0.027
NF2 NF2, SCH: Merlin 0.165 0.027
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.027
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.027
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.027
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.027
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.027
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.027
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.155 0.027
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.027
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.027
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 0.027
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.148 0.027
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.027
STAT3 0.148 0.027
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.027
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.027
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.027
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.148 0.027
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.027
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.027
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.027
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.027
ATM ATM: Serine-protein kinase ATM 0.139 0.027
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.139 0.027
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.139 0.027
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.139 0.027
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.139 0.027
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.139 0.027
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.139 0.027
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.139 0.027
FYN N/A 0.137 0.027
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.027
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.027
RDX RDX: Radixin 0.136 0.027
VIL2 N/A 0.136 0.027
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.027
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.027
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.127 0.027
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.027
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.127 0.027
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.127 0.027
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.123 0.027
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.123 0.027
CDK5 CDK5: Cell division protein kinase 5 0.114 0.027
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.027
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.027
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.114 0.027
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.114 0.027
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.027
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.111 0.027
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.027
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.027
BMX N/A 0.110 0.027
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.027
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.099 0.027
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.027
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.027
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.027
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.027
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.027
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.027
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 0.027
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.027
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.096 0.027
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.096 0.027
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.096 0.027
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.096 0.027
CCND1 CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1 0.088 0.027
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.027
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.086 0.027
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.086 0.027
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.086 0.027
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.086 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.027
MAPK15 N/A 0.083 0.265
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.083 0.265
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.083 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.083 0.027
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.083 0.265
MAPKAPK5 N/A 0.083 0.027
AMPH AMPH, AMPH1: Amphiphysin 0.083 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.265
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.083 0.027
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.083 0.027
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.083 0.027
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.083 0.027
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.027
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.078 0.027
YWHAZ YWHAZ: 14-3-3 protein zeta/delta 0.078 0.027
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.077 0.027
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.077 0.027
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.077 0.027
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.077 0.027
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.027
PRKAA1 N/A 0.077 0.027
LIMK2 LIMK2: LIM domain kinase 2 0.077 0.027
STK16 N/A 0.077 0.027
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.075 0.027
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.027
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.075 0.027
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.027
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.075 0.027
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.075 0.027
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.027
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.027
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.075 0.027
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 0.027
CDC2 CDC2: Cell division control protein 2 homolog 0.075 0.027
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.027
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.027
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.075 0.027
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.027
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.075 0.027
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.075 0.027
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.027
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.075 0.027
RIN3 N/A 0.074 0.027
CCND3 CCND3: G1/S-specific cyclin-D3 0.074 0.027
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.071 0.027
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.069 0.027
MAP2K6 MAP2K6, MEK6, MKK6, PRKMK6: Dual specificity mitogen-activated protein kinase ki 0.069 0.027
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.069 0.027
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.027
CDK4 CDK4: Cell division protein kinase 4 0.069 0.027
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.027
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.069 0.027
CDK6 CDK6: Cell division protein kinase 6 0.069 0.027
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.069 0.027
SCAP2 SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP55R: Src kinase-associated phosphoprotein 2 0.067 0.027
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.063 0.027
SPTAN1 N/A 0.062 0.027
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.062 0.027
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.062 0.027
CCNI CCNI: Cyclin-I 0.060 0.027
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.056 0.027
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.056 0.027
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.056 0.237
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.056 0.027
WEE1 WEE1: Wee1-like protein kinase 0.056 0.027
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.056 0.027
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 0.027
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.027
TP73 TP73, P73: Tumor protein p73 0.055 0.027
YWHAQ YWHAQ: 14-3-3 protein theta 0.052 0.027
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.050 0.027
NCF2 NCF2: Neutrophil cytosol factor 2 0.050 0.027
DAPK2 DAPK2: Death-associated protein kinase 2 0.049 0.027
CDKL5 N/A 0.049 0.027
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.237
DYRK3 N/A 0.049 0.027
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.046 0.027
ARHGAP26 ARHGAP26, GRAF, KIAA0621, OPHN1L: Rho GTPase-activating protein 26 0.044 0.027
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.027
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.027
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.027
MYO3A MYO3A: Myosin IIIA 0.044 0.027
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.044 0.027
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.027
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.044 0.027
XRCC1 XRCC1: DNA-repair protein XRCC1 0.0425 0.027
MYLIP MYLIP, BZF1, BM-023, PP5242: E3 ubiquitin-protein ligase MYLIP 0.041 0.027
SH2D1A SH2D1A, DSHP, SAP: SH2 domain-containing protein 1A 0.041 0.027
CAMK2D CAMK2D, CAMKD: Calcium/calmodulin-dependent protein kinase type II delta chain 0.040 0.027
TLN1 TLN1: Uncharacterized protein TLN1 0.038 0.027
GMFB GMFB: Glia maturation factor beta 0.038 0.027
ARAF ARAF, ARAF1, PKS, PKS2: A-Raf proto-oncogene serine/threonine-protein kinase 0.036 0.027
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.036 0.027
CCND2 CCND2: G1/S-specific cyclin-D2 0.036 0.027
FOSB FOSB, G0S3: Protein fosB 0.036 0.027
YWHAH YWHAH, YWHA1: 14-3-3 protein eta 0.032 0.027
CCNF CCNF: G2/mitotic-specific cyclin-F 0.0308 0.027
YWHAG YWHAG: 14-3-3 protein gamma 0.028 0.027
CCNA2 CCNA2, CCN1, CCNA: Cyclin-A2 0.028 0.027
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.028 0.027
CCNG2 CCNG2: Cyclin-G2 0.028 0.027
CCNG1 CCNG1, CCNG, CYCG1: Cyclin-G1 0.028 0.027
CCNL2 CCNL2, SB138: Cyclin-L2 0.028 0.027
NOXA1 NOXA1, RP13-927H1.1-001: NADPH oxidase activator 1 0.027 0.027
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.027
DOK5 DOK5, C20orf180: Docking protein 5 0.027 0.027
PTPN13 N/A 0.027 0.027
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.027
DOK6 DOK6: Uncharacterized protein DOK6 0.027 0.027
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.027
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.027
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.027
DBN1 DBN1, D0S117E: Drebrin 0.026 0.027
OSTF1 N/A 0.0255 0.027
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.027
COTL1 COTL1, CLP: Coactosin-like protein 0.025 0.027
2.15E-3
Total Score 10.90