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Evidence of Interaction Between MAPK1 and GNAI2

The interaction score between MAPK1 and GNAI2 is 1.48.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and GNAI2 = 0.57

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 6.27E-3
Orthology
OrganismMAPK1 OrthologueGNAI2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YBL016W 1 YER020W 0.815
  • AffinityCaptureWestern

Get References From PubMed
bakers yeast YGR040W 0.096 YER020W 0.815
  • AffinityCaptureWestern

Get References From PubMed
bakers yeast YBL016W 1 YHR005C 0.815
  • AffinityChromatography
  • Immunoprecipitation
  • InVitro
  • pullDown
  • AffinityCaptureWestern
  • CoLocalization

Get References From PubMed
bakers yeast YGR040W 0.096 YHR005C 0.815
fly P40417 1 P20353 0.467

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.119
Domains Domains present in MAPK1 and GNAI2:
Domains in MAPK1Domains in GNAI2
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001408 G-protein alpha subunit, group I
IPR011025 Transducin, alpha subunit, insertion

The Chi square scores for co-occurrence of domains that are present in MAPK1 and GNAI2 are listed below.

Domain 1Domain 2Chi Square
IPR000719 Protein kinase IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit 21.2146
IPR000719 Protein kinase IPR011025 Transducin, alpha subunit, insertion 16.1737
IPR000719 Protein kinase IPR001408 G-protein alpha subunit, group I 15.1364
IPR008271 Serine/threonine protein kinase, active site IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit 14.3705
IPR008271 Serine/threonine protein kinase, active site IPR011025 Transducin, alpha subunit, insertion 10.7955
IPR011009 Protein kinase-like IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit 10.3672
IPR002290 Serine/threonine protein kinase IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit 9.32298
IPR011009 Protein kinase-like IPR001408 G-protein alpha subunit, group I 7.90245
IPR011009 Protein kinase-like IPR011025 Transducin, alpha subunit, insertion 7.70697
IPR002290 Serine/threonine protein kinase IPR011025 Transducin, alpha subunit, insertion 6.73349

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in GNAI2
  • Green Domain is present in both MAPK1 and GNAI2

 0.014
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: GNAI2

PTMResidueReference
ADP-ribosylarginine 178 PubMed, HPRD
ADP-ribosylcysteine 351 PubMed, HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: GNAI2

LocalisationReference
ER HPRD
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between MAPK1 and GNAI2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andGNAI2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and GNAI2 has 1186 interactors of which there are 316 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for GNAI2-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 0.422
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 10.50 6.86
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 4.15 0.066
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 3.35 0.026
GNAI1 GNAI1: Guanine nucleotide-binding protein G(i), alpha-1 subunit 2.53 0.877
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.185
GNAQ GNAQ, GAQ: Guanine nucleotide-binding protein G(q) subunit alpha 1.03 0.824
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.683 0.714
PLEK PLEK, P47: Pleckstrin 0.515 0.354
GNAZ GNAZ: Guanine nucleotide-binding protein G(z) subunit alpha 0.509 0.423
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.036
JAK1 0.461 0.032
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.227
MSN MSN: Moesin 0.461 0.066
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.066
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.141
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 0.456 0.476
GNAT1 GNAT1, GNATR: Guanine nucleotide-binding protein G(t), alpha-1 subunit 0.449 0.469
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.074
ELF1 ELF1: ETS-related transcription factor Elf-1 0.416 0.049
GNAT2 GNAT2, GNATC: Guanine nucleotide-binding protein G(t), alpha-2 subunit 0.405 0.423
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.385 0.066
STK10 STK10: Uncharacterized protein STK10 0.385 0.040
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.066
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 0.141
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.066
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.137
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.074
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 0.032
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.040
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.040
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.137
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.066
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.344 0.032
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.0446
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.036
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.0446
DOK1 DOK1: Docking protein 1 0.275 0.066
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.137
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.032
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 2.20
HCK N/A 0.275 0.066
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.275 0.032
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.066
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.0818
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.275 0.032
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.260 0.074
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.036
WASPIP N/A 0.233 0.040
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.141
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.125
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.233 0.040
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.233 0.040
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.233 0.040
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.233 0.040
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.066
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.233 0.141
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.032
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.046
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.0446
TGFB1 TGFB1, TGFB: Transforming growth factor beta-1 precursor 0.192 0.033
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.057
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.027
CXorf9 N/A 0.188 0.066
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.188 0.100
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.188 0.032
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.036
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.032
RPS6KB1 N/A 0.188 0.032
FNBP1 N/A 0.188 0.040
GMIP GMIP: GEM-interacting protein 0.188 0.066
SEC24B SEC24B: Protein transport protein Sec24B 0.188 0.032
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.090
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.049
HD HD, IT15: Huntingtin 0.155 0.036
H1FX H1FX: Histone H1x 0.155 0.039
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.155 0.027
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.032
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.049
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.044
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.044
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.148 0.036
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.146 0.032
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.146 0.040
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.146 0.066
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.139 0.040
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.032
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.139 0.0818
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.139 0.032
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.139 0.046
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.054
ELF4 ELF4, ELFR, MEF: ETS-related transcription factor Elf-4 0.137 0.025
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.132 0.157
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.129 0.111
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.036
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.127 0.036
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.127 0.027
TNFRSF1B TNFRSF1B, TNFBR, TNFR2: Tumor necrosis factor receptor superfamily member 1B pre 0.124 0.307
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.144
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.119 0.064
HSPCB 0.119 0.064
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.118 0.067
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.118 0.035
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.114 0.037
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.054
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.114 0.040
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.114 0.032
RPS10 RPS10: 40S ribosomal protein S10 0.114 0.040
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.041
BMX N/A 0.110 0.029
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.028
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.025
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.025
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.025
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.075
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.025
DAB1 DAB1: Disabled homolog 1 0.097 0.029
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.029
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.033
CIITA CIITA, MHC2TA: MHC class II transactivator 0.096 0.091
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.096 0.057
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.081
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.096 0.027
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.096 0.036
GNA14 GNA14: Guanine nucleotide-binding protein alpha-14 subunit 0.095 0.469
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.144
CD44 N/A 0.091 0.307
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.090 3.28
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.029
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.087 0.027
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.087 0.036
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.027
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.086 1.33
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.086 0.032
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.086 0.027
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.0818 0.063
IRF3 IRF3: Interferon regulatory factor 3 0.080 0.039
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.078 0.040
LCP1 LCP1, PLS2: Plastin-2 0.078 0.185
AGTPBP1 AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein 0.078 0.036
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.078 0.040
HNRPK N/A 0.078 0.066
KIAA1012 KIAA1012: Protein TRS85 homolog 0.078 0.137
USP47 USP47: Ubiquitin carboxyl-terminal hydrolase 47 0.078 0.032
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.078 0.100
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.078 0.040
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.078 0.066
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.078 2.05
YWHAZ YWHAZ: 14-3-3 protein zeta/delta 0.078 0.040
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.077 0.046
TNFSF12 TNFSF12, APO3L, UNQ181/PRO207, DR3LG: Tumor necrosis factor ligand superfamily m 0.075 0.025
ATP2B1 N/A 0.075 0.026
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.075 0.052
FADD FADD, MORT1: Protein FADD 0.075 0.070
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.036
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.025
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.036
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.038
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.070 0.101
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.101
ABCF1 N/A 0.070 0.027
MARK2 N/A 0.070 0.074
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.070 0.091
SEL1L SEL1L, TSA305, UNQ128/PRO1063: Protein sel-1 homolog 1 precursor 0.070 0.036
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.032
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 0.087
GSK3B N/A 0.063 0.040
COPA COPA: Coatomer subunit alpha 0.063 0.040
ACTG1 ACTB: Actin, cytoplasmic 1 0.063 0.033
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.063 0.066
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.063 0.245
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.063 0.040
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.063 0.090
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.063 0.046
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.063 0.040
PPP1CB PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0.063 0.032
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.054
PPARBP N/A 0.063 0.032
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.054
USP10 USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10 0.063 0.040
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.063 0.154
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.057 0.070
TNF TNF, TNFA, TNFSF2: Tumor necrosis factor precursor 0.057 0.0425
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.057 0.087
NOS1 NOS1: Nitric-oxide synthase, brain 0.056 0.027
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.644
DNM2 N/A 0.052 0.0446
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.052 0.027
RGS2 RGS2, G0S8: Regulator of G-protein signaling 2 0.052 5.04
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.052 0.036
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.052 0.036
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.052 0.075
AHNAK AHNAK: AHNAK protein 0.052 0.0446
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.052 0.0446
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.052 0.082
FLNA FLNA, FLN, FLN1: Filamin-A 0.052 0.0446
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.051 0.032
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.051 0.0425
NCF2 NCF2: Neutrophil cytosol factor 2 0.050 0.065
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.028
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.028
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.083
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.028
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.028
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.049 0.028
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.028
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.083
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.028
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.049 0.028
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.028
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.028
CDC23 CDC23: Cell division cycle protein 23 homolog 0.046 0.181
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.046 0.040
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 0.046 0.040
DLG1 N/A 0.046 0.029
RGS19 RGS19, GAIP, GNAI3IP: Regulator of G-protein signaling 19 0.046 3.05
GSR GSR, GLUR, GRD1: Glutathione reductase, mitochondrial precursor 0.046 0.032
WARS WARS, IFI53, WRS: Tryptophanyl-tRNA synthetase, cytoplasmic 0.046 0.040
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.046 0.040
FLII FLII, FLIL: Protein flightless-1 homolog 0.046 0.227
LPXN LPXN, LDLP: Leupaxin 0.046 0.0446
COPE COPE: Coatomer subunit epsilon 0.046 0.123
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.046 0.040
CLTC CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1 0.046 0.035
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.046 0.0818
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.046 0.148
RPS3 RPS3, OK/SW-cl.26: 40S ribosomal protein S3 0.046 0.032
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.046 0.032
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.046 1.25
CCR5 CCR5: CCR5 receptor (Fragment) 0.046 2.32
LTA LTA, TNFB, TNFSF1: Lymphotoxin-alpha precursor 0.0453 0.032
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.026
CD40LG CD40LG, CD40L, TNFSF5, TRAP: CD40 ligand 0.0453 0.026
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.0446 0.070
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.032
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.025
AQP4 AQP4: Aquaporin-4 0.044 0.025
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.025
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.025
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.075
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.044 0.025
VAV2 VAV2, RP11-153P4.1-003: Vav 2 oncogene 0.0425 0.036
SAT SAT1, SAT: Diamine acetyltransferase 1 0.0425 0.0446
DAPP1 N/A 0.0425 0.036
MPG N/A 0.0425 0.0446
GNB2L1 Lung cancer oncogene 7 0.0425 0.030
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0425 0.125
NUP214 N/A 0.0425 0.039
FTH1 FTH1, FTH, OK/SW-cl.84, FTHL6, PIG15: Ferritin heavy chain 0.0425 0.0446
ALOX5 ALOX5, LOG5: Arachidonate 5-lipoxygenase 0.0425 0.0446
SLC4A7 SLC4A7: Uncharacterized protein SLC4A7 0.041 0.038
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.032
GRM3 GRM3, GPRC1C, MGLUR3: Metabotropic glutamate receptor 3 precursor 0.041 0.0296
TBXA2R TBXA2R: Thromboxane A2 receptor 0.04 1.05
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.04 0.028
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.129
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.040 0.046
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.063
RP2 RP2: Protein XRP2 0.038 0.036
DNAJC7 DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7 0.038 0.060
EEF1A1 EEF1A1: Elongation factor 1-alpha 0.038 0.032
CFL1 CFL1, CFL: Cofilin-1 0.038 0.032
STUB1 STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1 0.038 0.148
TPT1 TPT1: Translationally-controlled tumor protein 0.038 0.040
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.037 0.032
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.037 0.026
GHR GHR: Growth hormone receptor precursor 0.037 0.026
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.026
RAP1GA1 N/A 0.037 0.041
KIAA0372 TTC37, KIAA0372: Tetratricopeptide repeat protein 37 0.036 0.029
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 0.144
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.070
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 0.144
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 0.144
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 0.144
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 0.144
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.036 0.025
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.050
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.033 0.044
GRM1 GRM1, GPRC1A, MGLUR1: Metabotropic glutamate receptor 1 precursor 0.033 0.110
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.033 0.044
RHO RHO, OPN2: Rhodopsin 0.033 0.775
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.033 0.775
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.032 0.098
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.101
ZYX ZYX: Zyxin 0.032 0.0446
PLSCR1 PLSCR1: Phospholipid scramblase 1 0.032 0.129
OPRM1 OPRM1, MOR1: Mu-type opioid receptor 0.030 0.540
RGS3 RGS3: Regulator of G-protein signaling 3 0.030 0.404
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.029 0.049
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.029 0.056
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.029 0.044
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.029 0.148
FKBP8 DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment) 0.029 0.030
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.029 0.148
AIP AIP, XAP2: AH receptor-interacting protein 0.029 0.181
RGS18 RGS18, RGS13: Regulator of G-protein signaling 18 0.028 0.543
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.04
AXIN1 0.028 0.980
NASP NASP: Nuclear autoantigenic sperm protein 0.028 0.044
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.028 0.490
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.027 2.17
LILRB1 N/A 0.027 0.025
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.027 0.087
LTB4R LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7: Leukotriene B4 receptor 1 0.027 3.28
CD69 CD69: Early activation antigen CD69 0.027 0.0425
CD59 CD59, MIC11, MIN1, MIN2, MIN3, MSK21: CD59 glycoprotein precursor 0.0263 0.026
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.026 0.049
RGS4 RGS4: Regulator of G-protein signaling 4 0.026 0.644
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.044
MYO18A 0.025 0.036
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.044
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.025 0.04
HSPA8 HSPA8, HSC70, HSP73, HSPA10: Heat shock cognate 71 kDa protein 0.025 0.683
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.036
2.15E-3
Total Score 1.48