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Evidence of Interaction Between MAPK1 and INSR

The interaction score between MAPK1 and INSR is 1.05.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and INSR = -0.17

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.48E-3
Orthology
OrganismMAPK1 OrthologueINSR OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm P39745 1 Q968Y9 0.438
fly P40417 1 P09208 0.377

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in MAPK1 and INSR:
Domains in MAPK1Domains in INSR
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR000494 Epidermal growth-factor receptor (EGFR), L domain
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR006211 Furin-like cysteine rich region
IPR006212 Furin-like repeat
IPR008266 Tyrosine protein kinase, active site
IPR003961 Fibronectin, type III
IPR002011 Receptor tyrosine kinase, class II

The Chi square scores for co-occurrence of domains that are present in MAPK1 and INSR are listed below.

Domain 1Domain 2Chi Square
IPR008271 Serine/threonine protein kinase, active site IPR008266 Tyrosine protein kinase, active site 41.8291
IPR000719 Protein kinase IPR000719 Protein kinase 30.6895
IPR008271 Serine/threonine protein kinase, active site IPR003961 Fibronectin, type III 30.5883
IPR002290 Serine/threonine protein kinase IPR008266 Tyrosine protein kinase, active site 25.0766
IPR002290 Serine/threonine protein kinase IPR003961 Fibronectin, type III 13.198
IPR008271 Serine/threonine protein kinase, active site IPR001245 Tyrosine protein kinase 8.08585
IPR000719 Protein kinase IPR008266 Tyrosine protein kinase, active site 6.98997
IPR008271 Serine/threonine protein kinase, active site IPR000719 Protein kinase 6.25263
IPR002290 Serine/threonine protein kinase IPR001245 Tyrosine protein kinase 5.09618
IPR008271 Serine/threonine protein kinase, active site IPR006212 Furin-like repeat 5.08741
IPR008271 Serine/threonine protein kinase, active site IPR006211 Furin-like cysteine rich region 4.65446
IPR008271 Serine/threonine protein kinase, active site IPR000494 Epidermal growth-factor receptor (EGFR), L domain 4.65446
IPR008349 ERK1/2 MAP kinase IPR000719 Protein kinase 4.26499
IPR002290 Serine/threonine protein kinase IPR006212 Furin-like repeat 4.10189
IPR002290 Serine/threonine protein kinase IPR006211 Furin-like cysteine rich region 3.77
IPR002290 Serine/threonine protein kinase IPR000494 Epidermal growth-factor receptor (EGFR), L domain 3.77
IPR011009 Protein kinase-like IPR000719 Protein kinase 2.94434
IPR003527 MAP kinase IPR000719 Protein kinase 2.81413
IPR000719 Protein kinase IPR001245 Tyrosine protein kinase 2.31134
IPR000719 Protein kinase IPR006212 Furin-like repeat 1.94477
IPR008349 ERK1/2 MAP kinase IPR003961 Fibronectin, type III 1.72177
IPR003527 MAP kinase IPR001245 Tyrosine protein kinase 1.50703
IPR000719 Protein kinase IPR006211 Furin-like cysteine rich region 1.5062
IPR000719 Protein kinase IPR000494 Epidermal growth-factor receptor (EGFR), L domain 1.5062
IPR000719 Protein kinase IPR002011 Receptor tyrosine kinase, class II 1.16654
IPR002290 Serine/threonine protein kinase IPR000719 Protein kinase 0.986464
IPR000719 Protein kinase IPR003961 Fibronectin, type III 0.712801
IPR011009 Protein kinase-like IPR003961 Fibronectin, type III 0.616354
IPR011009 Protein kinase-like IPR002011 Receptor tyrosine kinase, class II 0.315004
IPR003527 MAP kinase IPR003961 Fibronectin, type III 0.246402
IPR011009 Protein kinase-like IPR006212 Furin-like repeat 0.180255
IPR011009 Protein kinase-like IPR001245 Tyrosine protein kinase 0.178275
IPR011009 Protein kinase-like IPR000494 Epidermal growth-factor receptor (EGFR), L domain 0.0778402
IPR011009 Protein kinase-like IPR006211 Furin-like cysteine rich region 0.0778402
IPR011009 Protein kinase-like IPR008266 Tyrosine protein kinase, active site 0.00724826
IPR008349 ERK1/2 MAP kinase IPR001245 Tyrosine protein kinase 0.0000302204

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in INSR
  • Green Domain is present in both MAPK1 and INSR

 0.014
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: INSR

PTMResidueReference
Dephosphorylation 999 PubMed, HPRD
Dephosphorylation 1185 PubMed, HPRD
Dephosphorylation 1189 PubMed, HPRD
Dephosphorylation 1190 PubMed, HPRD
Glycosylation 43 PubMed, HPRD
Glycosylation 52 PubMed, HPRD
Glycosylation 105 PubMed, HPRD
Glycosylation 138 PubMed, HPRD
Glycosylation 424 PubMed, HPRD
Glycosylation 445 PubMed, HPRD
Glycosylation 769 PubMed, HPRD
Glycosylation 782 PubMed, HPRD
Glycosylation 920 PubMed, HPRD
Glycosylation 933 PubMed, HPRD
N-linked 541 PubMed, HPRD
Phosphorylation 992 PubMed, HPRD
Phosphorylation 999 PubMed, HPRD
Phosphorylation 1062 PubMed, HPRD
Phosphorylation 1064 PubMed, HPRD
Phosphorylation 1185 PubMed, HPRD
Phosphorylation 1189 PubMed, HPRD
Phosphorylation 1190 PubMed, HPRD
Phosphorylation 1314 PubMed, HPRD
Phosphorylation 1332 PubMed, HPRD
Phosphorylation 1333 PubMed, HPRD
Phosphorylation 1348 PubMed, HPRD
Phosphorylation 1354 PubMed, HPRD
Phosphorylation 1355 PubMed, HPRD
Phosphorylation 1361 PubMed, HPRD
Phosphorylation 1362 PubMed, HPRD
Phosphorylation 1375 PubMed, HPRD
Phosphotyrosine 992 PubMed, HPRD
Phosphotyrosine 999 PubMed, HPRD
Phosphotyrosine 1011 PubMed, HPRD
Phosphotyrosine 1185 PubMed, HPRD
Phosphotyrosine 1189 PubMed, HPRD
Phosphotyrosine 1190 PubMed, HPRD
Phosphotyrosine 1355 PubMed, HPRD
Phosphotyrosine 1361 PubMed, HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: INSR

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Transitive Score

The common interactors between MAPK1 and INSR that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andINSR. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and INSR has 1177 interactors of which there are 575 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for INSR-Interactor (?)
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 115.00 0.046
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 94.70 0.041
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.098
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.098
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 62.30 0.062
GNAI3 GNAI3: Guanine nucleotide-binding protein G(k) subunit alpha 10.50 56.70
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 4.15 0.026
HSP90AA1 Hsp89-alpha-delta-N 3.95 0.064
GNAI1 GNAI1: Guanine nucleotide-binding protein G(i), alpha-1 subunit 2.53 23.60
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.064
GNAI2 Galphai2 protein 1.71 0.049
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 1.42 0.073
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.975 0.063
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.683 35.90
PLEK PLEK, P47: Pleckstrin 0.515 0.045
GNAZ GNAZ: Guanine nucleotide-binding protein G(z) subunit alpha 0.509 23.60
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.064
CRKL CRKL: Crk-like protein 0.461 277.00
JAK1 0.461 0.520
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.461 0.058
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.461 0.058
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.520
MSN MSN: Moesin 0.461 0.058
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.577
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.064
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 0.456 8.99
GNAT1 GNAT1, GNATR: Guanine nucleotide-binding protein G(t), alpha-1 subunit 0.449 26.80
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.644
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.416 0.320
GNAT2 GNAT2, GNATC: Guanine nucleotide-binding protein G(t), alpha-2 subunit 0.405 23.60
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.064
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.372 0.318
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 0.577
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.064
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.058
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.577
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 0.586
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.520
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.372 0.064
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 277.00
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.372 0.029
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.029
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.372 0.520
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.577
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.372 0.058
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.344 0.902
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.072
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.065
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.307 0.644
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.307 0.581
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.072
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.307 0.045
DOK1 DOK1: Docking protein 1 0.275 0.058
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.577
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.275 173.00
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.058
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.064
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.275 0.577
HCK N/A 0.275 0.577
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.275 0.029
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.577
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.058
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.275 0.029
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.260 0.072
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.260 0.072
GAB2 N/A 0.251 0.081
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.251 0.581
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.251 0.041
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.251 0.072
IRS2 IRS2: Insulin receptor substrate 2 0.251 0.100
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.233 0.046
WASPIP N/A 0.233 0.026
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.064
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.064
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.233 0.029
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.058
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.233 0.064
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.225 0.026
SH3BP5 N/A 0.225 0.090
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 277.00
STAT4 STAT4: Signal transducer and activator of transcription 4 0.225 0.286
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.058
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.090
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.225 0.520
RASA3 RASA3: Ras GTPase-activating protein 3 0.225 0.058
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.037
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.210 0.065
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.210 0.032
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.072
TGFB1 TGFB1, TGFB: Transforming growth factor beta-1 precursor 0.192 0.064
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.065
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.644
STAT2 STAT2: Signal transducer and activator of transcription 2 0.191 0.403
CXorf9 N/A 0.188 0.058
SNX17 SNX17, KIAA0064: Sorting nexin-17 0.188 0.064
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.188 0.058
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.064
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.188 0.041
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.064
RPS6KB1 N/A 0.188 0.064
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.188 0.064
FNBP1 N/A 0.188 0.064
GMIP GMIP: GEM-interacting protein 0.188 0.064
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.174 0.096
RIN1 RIN1: Ras and Rab interactor 1 0.171 0.577
NCK2 NCK2: Cytoplasmic protein NCK2 0.171 0.520
PSD TYL: TYL protein 0.171 0.058
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.171 0.065
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.064
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 0.064
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.171 0.029
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.171 0.037
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.980
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.109
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.109
PSCD2 N/A 0.165 0.109
NSBP1 NSBP1: Nucleosome-binding protein 1 0.165 0.0688
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.165 0.980
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.165 0.980
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.165 0.109
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.165 0.980
MAP2K5 N/A 0.165 0.049
NF2 NF2, SCH: Merlin 0.165 0.109
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.109
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.980
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.155 0.065
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.081
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.109
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.152 0.581
GAB1 GAB1: GRB2-associated-binding protein 1 0.152 0.081
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.152 0.644
SNCB SNCB: Beta-synuclein 0.152 0.065
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.152 0.731
ETS2 ETS2: Protein C-ets-2 0.152 0.025
CREB1 CREB1: cAMP response element-binding protein 0.148 0.030
CDC25C CDC25C: M-phase inducer phosphatase 3 0.148 0.098
CDC25A CDC25A: M-phase inducer phosphatase 1 0.148 0.098
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.148 0.098
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.148 0.098
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.098
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.148 0.878
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.148 0.878
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.878
STAT3 0.148 0.878
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.148 0.098
ELMO1 N/A 0.148 0.098
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.098
ARHGEF7 N/A 0.148 0.098
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.098
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.098
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.148 0.483
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.148 0.878
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.148 0.044
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.139 0.058
MLH1 MLH1, COCA2: DNA mismatch repair protein Mlh1 0.139 0.026
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.064
ATM ATM: Serine-protein kinase ATM 0.139 0.026
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.139 0.026
CD2AP CD2AP: CD2-associated protein 0.139 0.064
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.064
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.139 0.026
FYN N/A 0.137 0.129
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.136 0.058
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 0.058
RDX RDX: Radixin 0.136 0.073
VIL2 N/A 0.136 0.090
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.064
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.136 0.064
STMN1 STMN1, LAP18, OP18: Stathmin 0.136 0.058
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.136 0.041
CENTA1 CENTA1: Centaurin-alpha 1 0.128 0.041
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.072
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.032
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.127 0.072
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.098
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.123 0.731
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.123 0.072
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.123 0.081
CDC37 CDC37: Hsp90 co-chaperone Cdc37 0.116 0.0273
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.114 0.058
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.114 0.026
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.114 0.064
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.073
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.114 0.065
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.111 0.073
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.111 0.577
APS SH2B2, APS: SH2B adapter protein 2 0.111 0.577
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.073
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.111 0.058
STMN2 STMN2, SCG10, SCGN10: Stathmin-2 0.111 0.064
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.111 0.655
PLD2 PLD2: Phospholipase D2 0.111 0.073
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.644
BMX N/A 0.110 0.902
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.165
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.165
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.109 0.072
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.109 0.081
MCF2 MCF2, DBL: Proto-oncogene DBL 0.109 0.072
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.109 0.063
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.109 0.355
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.099 388.00
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.098 0.644
IRS1 IRS1: Insulin receptor substrate 1 0.098 0.081
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 71.20
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.165
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.165
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.148
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.148
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.097 0.577
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.097 0.064
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 0.318
PLD1 PLD1: Phospholipase D1 0.097 0.090
DAB1 DAB1: Disabled homolog 1 0.097 0.073
TST TST: Thiosulfate sulfurtransferase 0.097 0.064
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.097 0.064
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.181
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.058
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.096 0.081
CIITA CIITA, MHC2TA: MHC class II transactivator 0.096 0.0263
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.096 0.032
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.032
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.096 0.065
GNA14 GNA14: Guanine nucleotide-binding protein alpha-14 subunit 0.095 1.38
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.109
CD44 N/A 0.091 0.055
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.090 0.044
PTPRZ1 N/A 0.090 0.088
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 0.577
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.088 0.058
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.087 0.037
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.086 0.058
CTPS CTPS: CTP synthase 1 0.086 0.029
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.086 0.064
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.086 0.054
PITPNM1 PITPNM1: Uncharacterized protein PITPNM1 0.086 0.033
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.086 0.029
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.086 0.029
AMPH AMPH, AMPH1: Amphiphysin 0.083 0.109
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.083 0.049
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.083 0.109
CASP8 CASP8, MCH5: Caspase-8 precursor 0.083 0.049
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.049
MAPK15 N/A 0.083 0.109
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.049
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.083 0.049
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.083 0.129
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.0818 0.049
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.078 0.097
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.078 0.029
LCP1 LCP1, PLS2: Plastin-2 0.078 0.064
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.078 12.50
YWHAZ YWHAZ: 14-3-3 protein zeta/delta 0.078 0.026
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.072
STK16 N/A 0.077 0.065
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.077 0.109
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.077 0.029
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.077 0.081
ATP2B1 N/A 0.075 0.049
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.075 0.123
FADD FADD, MORT1: Protein FADD 0.075 0.055
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.075 0.098
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.062
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.075 0.098
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.098
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.098
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.098
SNX3 N/A 0.075 0.098
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.098
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.075 0.044
CNN2 CNN2: Calponin-2 0.075 0.109
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.075 0.098
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.025
TSC2 TSC2, TSC4: Tuberin 0.075 0.044
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.098
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.075 0.098
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.098
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.098
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.098
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.098
RIN3 N/A 0.074 0.128
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.097
GABRB1 GABRB1: Gamma-aminobutyric acid receptor subunit beta-1 precursor 0.073 0.049
GABRR1 N/A 0.0727 0.062
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.072 0.123
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.071 0.037
TXNL1 TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1 0.071 0.029
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.071 0.037
CAPNS1 CAPNS1, CAPN4, CAPNS: Calpain small subunit 1 0.070 0.065
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.032
SEL1L SEL1L, TSA305, UNQ128/PRO1063: Protein sel-1 homolog 1 precursor 0.070 0.053
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.069 0.064
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.069 0.058
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.069 0.064
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.064
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.069 0.033
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.113
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.069 0.044
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 0.171
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.136
IL1B IL1B, IL1F2: Interleukin-1 beta precursor 0.063 0.072
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.063 0.027
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.063 0.058
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.063 0.029
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.063 0.026
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.063 0.064
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.058
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.065
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.062 0.032
COBL N/A 0.062 0.032
SPTAN1 N/A 0.062 0.065
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.062 0.109
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.062 0.051
GRLF1 N/A 0.062 0.065
CHAT CHAT: Choline O-acetyltransferase 0.062 0.030
VIM VIM: Vimentin 0.060 0.025
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.058 0.111
GLRA1 N/A 0.058 0.056
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.058 0.097
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.057 0.109
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.057 0.062
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.057 0.123
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.056 0.064
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.056 0.064
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.056 0.029
TRAP1 TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor 0.056 0.029
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 0.064
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.056 0.029
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.056 0.029
STAM2 STAM2: Signal transducing adapter molecule 2 0.056 0.073
CDKN1A CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1: Cyclin-dependent kinase inhi 0.055 0.025
TP73 TP73, P73: Tumor protein p73 0.055 0.063
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.054 0.041
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.053 0.030
FUBP1 N/A 0.052 0.032
YWHAQ YWHAQ: 14-3-3 protein theta 0.052 0.029
FLNA FLNA, FLN, FLN1: Filamin-A 0.052 0.032
MT1H N/A 0.051 0.051
PPP1R14C PPP1R14C, KEPI: Protein phosphatase 1 regulatory subunit 14C 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
GRB10 N/A 0.051 0.617
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
PTPRA N/A 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.617
RAPH1 N/A 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
PPP1R1B PPP1R1B, DARPP32: Protein phosphatase 1 regulatory subunit 1B 0.051 0.051
EVL EVL, RNB6: Ena/VASP-like protein 0.051 0.051
C9orf88 N/A 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.617
CRK CRK: Proto-oncogene C-crk 0.051 0.617
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
FGF23 FGF23, HYPF, UNQ3027/PRO9828: Fibroblast growth factor 23 precursor 0.051 0.072
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.051 0.056
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.050 0.040
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.050 0.073
KRT1 KRT1, KRTA: Keratin, type II cytoskeletal 1 0.049 0.032
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.049 0.165
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.049 0.083
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.049 0.083
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.165
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.165
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.165
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.049 0.028
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.052
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.165
EDA N/A 0.049 0.083
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.049 0.028
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.165
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.165
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.083
ATP2A3 ATP2A3: Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 0.049 0.083
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.049 0.083
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.165
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.049 0.028
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.165
AQP1 AQP1, CHIP28: Aquaporin-1 0.049 0.027
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.049 0.026
AQP2 AQP2: Aquaporin-2 0.049 0.027
SORBS3 SORBS3, SCAM1: Vinexin 0.049 0.064
TUBB3 TUBB3, TUBB4: Tubulin beta-3 chain 0.048 0.041
NEFL NEFL, NF68, NFL: Neurofilament light polypeptide 0.048 0.029
KCNAB2 KCNAB2, KCNA2B, KCNK2: Voltage-gated potassium channel subunit beta-2 0.047 0.044
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.047 0.062
FLII FLII, FLIL: Protein flightless-1 homolog 0.046 0.026
CCR5 CCR5: CCR5 receptor (Fragment) 0.046 0.049
TBC1D4 TBC1D4: TBC1D4 protein 0.046 0.046
PPP1R14A PPP1R14A, CPI17, PPP1INL: Protein phosphatase 1 regulatory subunit 14A 0.046 0.046
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.046 0.046
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.553
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.553
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.046
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.046 0.046
EPB41 EPB41, E41P: Protein 4.1 0.046 0.046
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.046 0.060
EFNB1 EFNB1, EFL-3, EPLG2, LERK2: Ephrin-B1 precursor 0.046 0.073
MT1X MT1X: Metallothionein-1X 0.046 0.126
MT2A MT2A, CES1, MT2: Metallothionein-2 0.046 0.100
EPOR EPOR: Erythropoietin receptor precursor 0.0453 0.123
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.0453 0.055
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.098
GDF15 GDF15, MIC1, PDF, PLAB, PTGFB: Growth/differentiation factor 15 precursor 0.045 0.202
CGA CGA: Glycoprotein hormones alpha chain precursor 0.045 0.126
TSHB TSHB: Thyrotropin subunit beta precursor 0.045 0.081
FSHB FSHB: Follitropin subunit beta precursor 0.045 0.081
LHB LHB: Lutropin subunit beta precursor 0.045 0.081
CGB CGB, CGB3, CGB5, CGB7, CGB8: Choriogonadotropin subunit beta precursor 0.045 0.202
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.0446 0.049
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.044 0.033
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.044 0.064
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.044 0.041
CTTN CTTN, EMS1: Src substrate cortactin 0.044 0.100
CNN3 CNN3: Calponin-3 0.044 0.126
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.044 0.064
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.073
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.044 0.073
ESR1 ESR1, ESR, NR3A1: Estrogen receptor 0.044 0.025
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.075
AQP4 AQP4: Aquaporin-4 0.044 0.047
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.075
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.044 0.047
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.025
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.075
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.044 0.025
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.148
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.043 0.041
AKR7A2 AKR7A2, AFAR, AFAR1, AKR7: Aflatoxin B1 aldehyde reductase member 2 0.043 0.029
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0425 0.072
TBC1D1 TBC1D1, KIAA1108: TBC1 domain family member 1 0.042 0.034
SLC4A7 SLC4A7: Uncharacterized protein SLC4A7 0.041 0.028
EFNB2 EFNB2, EPLG5, HTKL, LERK5: Ephrin-B2 precursor 0.041 0.073
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.090
MT1F MT1F, PRO0376: Metallothionein-1F 0.041 0.100
INHA INHA: Inhibin alpha chain precursor 0.041 0.100
KRT8 KRT8, CYK8: Keratin, type II cytoskeletal 8 0.041 0.025
FGF5 FGF5: Fibroblast growth factor 5 precursor 0.041 0.081
NDP NDP: Norrin precursor 0.041 0.081
PDGFA PDGFA, PDGF1: Platelet-derived growth factor A chain precursor 0.041 0.100
LOC645745 MT1H: Metallothionein-1H 0.041 0.100
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 0.111
GLRB GLRB: Glycine receptor subunit beta precursor 0.041 0.028
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.111
SH2D1A SH2D1A, DSHP, SAP: SH2 domain-containing protein 1A 0.041 0.129
FGF9 FGF9: Glia-activating factor precursor 0.041 0.073
BMP7 BMP7, OP1: Bone morphogenetic protein 7 precursor 0.041 0.073
TBXA2R TBXA2R: Thromboxane A2 receptor 0.04 0.028
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.04 0.052
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.049
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.040 0.044
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.049
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.040 15.80
NEF3 NEFM, NEF3, NFM: Neurofilament medium polypeptide 0.039 0.029
GFAP GFAP: Glial fibrillary acidic protein 0.039 0.032
CHP CHP: Calcium-binding protein p22 0.038 0.064
MDN1 MDN1, KIAA0301: Midasin 0.038 0.026
TLN1 TLN1: Uncharacterized protein TLN1 0.038 0.073
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.037 0.049
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.037 0.098
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.037 0.098
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.037 0.109
GHR GHR: Growth hormone receptor precursor 0.037 0.123
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.123
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.037 0.049
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.123
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.037 0.098
RAP1GA1 N/A 0.037 0.025
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.036 6.81
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 0.098
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.036 0.109
CRLF3 N/A 0.036 0.098
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.098
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 0.098
CD7 CD7: T-cell antigen CD7 precursor 0.036 0.098
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 0.098
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.036 0.098
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 0.098
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 0.109
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.036 0.109
KRT20 KRT20: Keratin, type I cytoskeletal 20 0.034 0.031
NEFH NEFH, KIAA0845, NFH: Neurofilament heavy polypeptide 0.034 0.029
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.034 0.034
MT1E MT1E: Metallothionein-1E 0.034 0.038
GJA1 GJA1, GJAL: Gap junction alpha-1 protein 0.0338 0.0338
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.034 0.109
SLC4A1 SLC4A1, AE1, DI, EPB3: Band 3 anion transport protein 0.033 0.035
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.0308
SCARB2 SCARB2, CD36L2, LIMPII: Lysosome membrane protein 2 0.033 0.056
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.033 0.0308
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.033 0.0308
RHO RHO, OPN2: Rhodopsin 0.033 0.062
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.033 0.127
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.033 0.191
PRLR PRLR: Prolactin receptor precursor 0.033 0.152
F3 F3: Tissue factor precursor 0.032 0.123
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.032 0.123
IL9R IL9R: Interleukin-9 receptor precursor 0.032 0.098
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.098
ITGB4 N/A 0.032 0.123
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.032 0.098
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.072
YWHAH YWHAH, YWHA1: 14-3-3 protein eta 0.032 0.029
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.032 0.029
SORL1 SORL1: Sortilin-related receptor precursor 0.032 0.098
RYR2 RYR2: Ryanodine receptor 2 0.031 0.041
KRT18 KRT18: Uncharacterized protein KRT18 0.031 0.031
DES DES: Desmin 0.031 0.032
PPP1R14D PPP1R14D, GBPI: Protein phosphatase 1 regulatory subunit 14D 0.031 0.030
GJB1 GJB1, CX32: Gap junction beta-1 protein 0.030 0.038
PPP1R1A PPP1R1A, IPP1: Protein phosphatase 1 regulatory subunit 1A 0.030 0.0338
GJA5 GJA5: Gap junction alpha-5 protein 0.030 0.0782
PEBP1 PEBP1, PBP, PEBP: Phosphatidylethanolamine-binding protein 1 0.030 0.034
C1QBP C1QBP, GC1QBP, HABP1, SF2P32: Complement component 1 Q subcomponent-binding prot 0.030 0.030
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 0.171
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.029 0.136
NEO1 NEO1, NGN: Neogenin precursor 0.029 0.088
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.029 0.077
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.123
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.029 0.049
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.029 0.062
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.029 0.055
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 0.136
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.029 0.026
HPCAL1 HPCAL1, BDR1: Hippocalcin-like protein 1 0.029 0.064
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
HNRPK HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K 0.028 0.04
SYTL4 Endocrine transmitter regulatory protein 0.028 0.034
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.109
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.028 0.109
YWHAG YWHAG: 14-3-3 protein gamma 0.028 0.049
PPEF1 N/A 0.028 0.109
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.04
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.028 0.058
PRPH PRPH, NEF4, PRPH1: Peripherin 0.0277 0.032
VAV3 VAV3: Protein vav-3 0.028 0.179
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.217
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.217
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.027 0.265
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.217
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.217
LILRB1 N/A 0.027 0.109
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.027 0.123
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.027 0.098
CD69 CD69: Early activation antigen CD69 0.027 0.049
ITGAE ITGAE: Integrin alpha-E precursor 0.027 0.056
CD59 CD59, MIC11, MIN1, MIN2, MIN3, MSK21: CD59 glycoprotein precursor 0.0263 0.096
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.026 0.035
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.026 0.097
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.097
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.026 0.035
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.026 0.072
DBN1 DBN1, D0S117E: Drebrin 0.026 0.027
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.026 0.072
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.026 0.065
MT3 MT3: Metallothionein-3 0.026 0.049
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.025 0.072
IL18 IL18, IGIF, IL1F4: Interleukin-18 precursor 0.025 0.072
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.025 0.081
F5 F5: Coagulation factor V precursor 0.025 0.100
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.025 0.098
GSN GSN: Gelsolin precursor 0.025 0.036
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.025 46.90
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.036
COTL1 COTL1, CLP: Coactosin-like protein 0.025 0.036
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.044
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.062
ACTN4 ACTN4: Alpha-actinin-4 0.025 0.098
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.025 0.044
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.030
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.025 0.030
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.098
CFL2 CFL2: Cofilin-2 0.025 0.036
SVIL SVIL: Supervillin 0.025 0.036
0.347
Total Score 1.05