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Evidence of Interaction Between MAPK1 and ASGR2

The interaction score between MAPK1 and ASGR2 is 1.12.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and ASGR2 = -0.03

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology N/A N/A
Domains No domains were used in calculating likelihood of interaction 0.014
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: ASGR2

PTMResidueReference
N-linked 102 PubMed, HPRD
N-linked 170 PubMed, HPRD
N-linked 305 PubMed, HPRD
Palmitoylation 54 PubMed, HPRD
Palmitoylation 58 PubMed, HPRD
Phosphorylation 12 PubMed, HPRD
Phosphoserine 12 HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: ASGR2

LocalisationReference
ER HPRD
Golgi HPRD
Plasma membrane HPRD
Secreted HPRD
Transitive Score

The common interactors between MAPK1 and ASGR2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andASGR2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and ASGR2 has 804 interactors of which there are 196 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for ASGR2-Interactor (?)
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 115.00 0.039
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 94.70 0.031
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 62.30 0.049
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 62.30 0.049
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 62.30 0.034
HSP90AA1 Hsp89-alpha-delta-N 3.95 0.032
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.037
GNAI2 Galphai2 protein 1.71 0.026
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.975 0.031
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.683 0.028
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.037
JAK1 0.461 0.032
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.037
MSN MSN: Moesin 0.461 0.037
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.037
GNAT1 GNAT1, GNATR: Guanine nucleotide-binding protein G(t), alpha-1 subunit 0.449 0.032
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.037
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.037
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.037
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.233 0.031
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.049
NF2 NF2, SCH: Merlin 0.165 0.049
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.055
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.148 0.049
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.148 0.049
RDX RDX: Radixin 0.136 0.032
VIL2 N/A 0.136 0.032
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.136 0.032
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.127 0.032
TNFRSF1B TNFRSF1B, TNFBR, TNFR2: Tumor necrosis factor receptor superfamily member 1B pre 0.124 0.026
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.077
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.114 0.072
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.114 0.037
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.110 0.037
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.083
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.165
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.083
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.083
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.083
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.028
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.165
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.097 0.031
TST TST: Thiosulfate sulfurtransferase 0.097 0.472
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.097 0.029
CIITA CIITA, MHC2TA: MHC class II transactivator 0.096 0.032
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.081
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.062
CD44 N/A 0.091 0.123
PTPRZ1 N/A 0.090 0.055
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.083 0.049
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.0818 0.123
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.078 0.032
LCP1 LCP1, PLS2: Plastin-2 0.078 0.037
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.077 0.0446
TNFSF12 TNFSF12, APO3L, UNQ181/PRO207, DR3LG: Tumor necrosis factor ligand superfamily m 0.075 0.032
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.075 0.062
FADD FADD, MORT1: Protein FADD 0.075 0.026
CNN2 CNN2: Calponin-2 0.075 0.049
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.028
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.075 0.049
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.062
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.072 0.055
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.069 0.027
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 0.191
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.064 0.055
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.063 0.029
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.062 0.126
VIM VIM: Vimentin 0.060 0.025
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.058 0.055
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.058 0.098
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.057 0.152
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.057 0.096
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.057 0.055
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.056 0.032
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.056 0.037
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.056 0.029
FUBP1 N/A 0.052 0.072
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.052 0.032
FLNA FLNA, FLN, FLN1: Filamin-A 0.052 0.037
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.051 0.026
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.050 0.032
KRT1 KRT1, KRTA: Keratin, type II cytoskeletal 1 0.049 0.032
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.049 0.165
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.049 0.028
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.049 0.165
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.083
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.083
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.028
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.049 0.028
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.028
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.165
EDA N/A 0.049 0.165
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.049 0.028
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.028
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.028
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.028
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.049 0.028
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.165
TNFSF12 TNFSF13, APRIL, UNQ383/PRO715, TALL2, ZTNF2: Tumor necrosis factor ligand superf 0.049 0.028
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.165
NEFL NEFL, NF68, NFL: Neurofilament light polypeptide 0.048 0.032
LMNA LMNA, LMN1: Lamin-A/C 0.047 0.034
TBCE TBCE: Tubulin-specific chaperone E 0.046 0.032
FLII FLII, FLIL: Protein flightless-1 homolog 0.046 0.0453
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.046 0.032
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.046 0.032
CCR5 CCR5: CCR5 receptor (Fragment) 0.046 0.026
EPOR EPOR: Erythropoietin receptor precursor 0.0453 0.062
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.109
CNN3 CNN3: Calponin-3 0.044 0.029
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.028
AQP4 AQP4: Aquaporin-4 0.044 0.028
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.028
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.044 0.028
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.028
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.028
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.044 0.028
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.165
AKR7A2 AKR7A2, AFAR, AFAR1, AKR7: Aflatoxin B1 aldehyde reductase member 2 0.043 0.036
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.032
KRT8 KRT8, CYK8: Keratin, type II cytoskeletal 8 0.041 0.025
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 0.109
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.123
TBXA2R TBXA2R: Thromboxane A2 receptor 0.04 0.028
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.04 0.028
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.152
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.109
NEF3 NEFM, NEF3, NFM: Neurofilament medium polypeptide 0.039 0.032
GFAP GFAP: Glial fibrillary acidic protein 0.039 0.032
TLN1 TLN1: Uncharacterized protein TLN1 0.038 0.037
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.037 0.109
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.037 0.152
GHR GHR: Growth hormone receptor precursor 0.037 0.096
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.055
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.055
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.037 0.109
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 0.123
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.036 0.123
CRLF3 N/A 0.036 0.062
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.109
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 0.152
CD7 CD7: T-cell antigen CD7 precursor 0.036 0.109
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 0.123
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.036 0.123
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 0.123
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 0.152
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.036 0.152
NEFH NEFH, KIAA0845, NFH: Neurofilament heavy polypeptide 0.034 0.032
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.034 0.109
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.033 0.032
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.033 0.055
PRLR PRLR: Prolactin receptor precursor 0.033 0.055
F3 F3: Tissue factor precursor 0.032 0.055
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.032 0.109
IL9R IL9R: Interleukin-9 receptor precursor 0.032 0.055
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.109
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.032 0.026
ITGB4 N/A 0.032 0.109
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.032 0.098
IPO7 IPO7: Uncharacterized protein IPO7 0.032 0.072
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.032 0.0453
PLSCR1 PLSCR1: Phospholipid scramblase 1 0.032 0.026
NCSTN NCSTN, KIAA0253, UNQ1874/PRO4317: Nicastrin precursor 0.032 0.026
SORL1 SORL1: Sortilin-related receptor precursor 0.032 0.152
KRT18 KRT18: Uncharacterized protein KRT18 0.031 0.039
DES DES: Desmin 0.031 0.032
GJB1 GJB1, CX32: Gap junction beta-1 protein 0.030 0.053
PPP1R1A PPP1R1A, IPP1: Protein phosphatase 1 regulatory subunit 1A 0.030 0.025
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 0.109
NEO1 NEO1, NGN: Neogenin precursor 0.029 0.098
EGF EGF: Pro-epidermal growth factor precursor 0.029 0.109
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.029 0.123
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.029 0.055
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.029 0.123
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.029 0.029
THOP1 THOP1: Thimet oligopeptidase 0.029 0.166
COL1A2 COL1A2: Collagen alpha-2(I) chain precursor 0.029 0.027
COL5A2 COL5A2: Collagen alpha-2(V) chain precursor 0.029 0.027
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.028 0.029
PRPH PRPH, NEF4, PRPH1: Peripherin 0.0277 0.037
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.027 0.026
LILRB1 N/A 0.027 0.152
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.027 0.191
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.027 0.123
CD69 CD69: Early activation antigen CD69 0.027 0.109
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.026 0.251
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.026 0.123
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.025 0.072
F5 F5: Coagulation factor V precursor 0.025 0.074
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.025 0.109
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.049
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.049
ACTN4 ACTN4: Alpha-actinin-4 0.025 0.049
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.025 0.049
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.025 0.109
0.299
Total Score 1.12