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Evidence of Interaction Between MAPK1 and GNAI3

The interaction score between MAPK1 and GNAI3 is 9.16.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MAPK1 and GNAI3 = 0.65

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 7.78E-3
Orthology
OrganismMAPK1 OrthologueGNAI3 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YBL016W 1 YER020W 1
  • AffinityCaptureWestern

Get References From PubMed
bakers yeast YBL016W 1 YHR005C 1
  • AffinityChromatography
  • Immunoprecipitation
  • InVitro
  • pullDown
  • AffinityCaptureWestern
  • CoLocalization

Get References From PubMed
bakers yeast YGR040W 0.096 YER020W 1
  • AffinityCaptureWestern

Get References From PubMed
bakers yeast YGR040W 0.096 YHR005C 1
fly P40417 1 P20353 0.767

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in MAPK1 and GNAI3:
Domains in MAPK1Domains in GNAI3
IPR000719 Protein kinase
IPR002290 Serine/threonine protein kinase
IPR011009 Protein kinase-like
IPR008271 Serine/threonine protein kinase, active site
IPR003527 MAP kinase
IPR008349 ERK1/2 MAP kinase
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001408 G-protein alpha subunit, group I
IPR011025 Transducin, alpha subunit, insertion

The Chi square scores for co-occurrence of domains that are present in MAPK1 and GNAI3 are listed below.

Domain 1Domain 2Chi Square
IPR000719 Protein kinase IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit 21.2146
IPR000719 Protein kinase IPR011025 Transducin, alpha subunit, insertion 16.1737
IPR000719 Protein kinase IPR001408 G-protein alpha subunit, group I 15.1364
IPR008271 Serine/threonine protein kinase, active site IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit 14.3705
IPR008271 Serine/threonine protein kinase, active site IPR011025 Transducin, alpha subunit, insertion 10.7955
IPR011009 Protein kinase-like IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit 10.3672
IPR002290 Serine/threonine protein kinase IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit 9.32298
IPR011009 Protein kinase-like IPR001408 G-protein alpha subunit, group I 7.90245
IPR011009 Protein kinase-like IPR011025 Transducin, alpha subunit, insertion 7.70697
IPR002290 Serine/threonine protein kinase IPR011025 Transducin, alpha subunit, insertion 6.73349

The background colour of the table refers to:

  • Blue Domain is only present in MAPK1
  • Yellow Domain is only present in GNAI3
  • Green Domain is present in both MAPK1 and GNAI3

 0.014
Post-translational Modifications

Protein: MAPK1

PTMResidueReference
Acetylation 2 PubMed, HPRD
Dephosphorylation 187 PubMed, HPRD
N-acetylalanine 1 HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 181 PubMed, HPRD
Phosphorylation 185 PubMed, HPRD
Phosphorylation 187 PubMed, HPRD
Phosphorylation 202 PubMed, HPRD
Phosphothreonine 184 PubMed, HPRD
Phosphotyrosine 186 HPRD

Protein: GNAI3

PTMResidueReference
ADP-ribosylarginine 177 PubMed, HPRD
ADP-ribosylcysteine 350 PubMed, HPRD
Localisation

Protein: MAPK1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: GNAI3

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between MAPK1 and GNAI3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MAPK1 andGNAI3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MAPK1 has 1694 interactors and GNAI3 has 1307 interactors of which there are 394 common interactors.

Common InteractorName of Common InteractorScore for MAPK1-Interactor (?)Score for GNAI3-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 153.00 0.509
SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 11.60 0.038
CDK2 CDK2: Cell division protein kinase 2 6.80 0.032
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 4.15 0.141
HSP90AA1 Hsp89-alpha-delta-N 3.95 0.040
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 3.35 0.0525
GNAI1 GNAI1: Guanine nucleotide-binding protein G(i), alpha-1 subunit 2.53 19.90
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 2.17 0.185
GNAI2 Galphai2 protein 1.71 6.86
GNAQ GNAQ, GAQ: Guanine nucleotide-binding protein G(q) subunit alpha 1.03 1.53
GNAO1 GNAO1: Guanine nucleotide-binding protein G(o) subunit alpha 1 0.683 33.70
MRCL3 MRLC2, MLCB, RLC: Myosin regulatory light chain 2, nonsarcomeric 0.622 0.042
PLEK PLEK, P47: Pleckstrin 0.515 0.354
GNAZ GNAZ: Guanine nucleotide-binding protein G(z) subunit alpha 0.509 19.90
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.461 0.141
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.461 0.066
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.461 0.032
CRKL CRKL: Crk-like protein 0.461 0.040
JAK1 0.461 0.040
VAV1 VAV1, VAV: Proto-oncogene vav 0.461 0.137
MSN MSN: Moesin 0.461 0.066
GNA11 GNA11, GA11: Guanine nucleotide-binding protein subunit alpha-11 0.456 17.80
GNAT1 GNAT1, GNATR: Guanine nucleotide-binding protein G(t), alpha-1 subunit 0.449 22.10
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.416 0.036
ELF1 ELF1: ETS-related transcription factor Elf-1 0.416 0.081
GNAT2 GNAT2, GNATC: Guanine nucleotide-binding protein G(t), alpha-2 subunit 0.405 22.50
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.385 0.066
STK10 STK10: Uncharacterized protein STK10 0.385 0.040
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.385 0.066
STAT6 STAT6: Signal transducer and activator of transcription 6 0.372 0.066
PSCD4 PSCD4, CYT4: Cytohesin-4 0.372 0.040
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.372 0.111
LYN LYN: Tyrosine-protein kinase Lyn 0.372 0.0446
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.372 0.066
CSK CSK: Tyrosine-protein kinase CSK 0.372 0.066
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.372 0.040
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.372 0.040
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 0.372 0.033
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.227
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.372 0.040
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.344 0.141
VASP VASP: Vasodilator-stimulated phosphoprotein 0.307 0.036
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.307 0.036
ROCK1 ROCK1: Rho-associated protein kinase 1 0.307 0.0446
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 0.275 0.066
SYK SYK: Tyrosine-protein kinase SYK 0.275 0.040
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.275 0.067
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.275 0.066
DOK1 DOK1: Docking protein 1 0.275 0.040
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.275 0.137
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 2.20
HCK N/A 0.275 0.032
ETS1 ETS1, EWSR2: Protein C-ets-1 0.275 0.026
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.260 0.0446
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.233 0.066
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.233 0.038
WASPIP N/A 0.233 0.040
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.233 0.066
EIF4G2 EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2 0.233 0.038
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.233 0.112
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.233 0.141
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.233 0.141
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.233 0.066
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.233 0.032
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.233 0.066
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.225 0.032
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.225 0.032
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.225 0.032
SOS1 SOS1: Son of sevenless homolog 1 0.225 0.056
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.210 0.0446
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.191 0.075
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.191 0.027
FNBP1 N/A 0.188 0.040
GMIP GMIP: GEM-interacting protein 0.188 0.040
SEC24B SEC24B: Protein transport protein Sec24B 0.188 0.066
CXorf9 N/A 0.188 0.040
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.188 0.204
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.188 0.066
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.188 0.040
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.188 0.038
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.188 0.066
RPS6KB1 N/A 0.188 0.066
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.171 0.148
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.171 11.40
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.049
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.155 0.027
HD HD, IT15: Huntingtin 0.155 0.036
H1FX H1FX: Histone H1x 0.155 0.039
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.155 0.027
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.153 0.052
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.148 0.036
EEF2K EEF2K: Elongation factor 2 kinase 0.148 0.049
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.148 0.044
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.148 0.044
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.146 0.141
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.146 0.040
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.146 0.066
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.139 0.067
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.139 0.040
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.139 0.066
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.139 0.040
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.139 0.137
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.139 0.040
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.139 0.063
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.139 0.035
ELF4 ELF4, ELFR, MEF: ETS-related transcription factor Elf-4 0.137 0.025
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.136 3.26
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.132 0.157
ACTR3 ACTR3, ARP3: Actin-related protein 3 0.129 0.099
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.129 0.137
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.127 0.0446
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.127 0.027
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.036
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.127 0.036
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.127 0.027
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.127 0.0446
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.124 0.087
TNFRSF1B TNFRSF1B, TNFBR, TNFR2: Tumor necrosis factor receptor superfamily member 1B pre 0.124 0.087
HSPCB 0.119 0.119
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.119 0.119
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.118 0.072
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.118 0.090
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.114 0.032
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.114 0.030
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.114 0.026
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.114 0.054
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.114 0.032
RPS10 RPS10: 40S ribosomal protein S10 0.114 0.066
THOC1 THOC1, HPR1: THO complex subunit 1 0.114 0.032
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.111 0.029
BMX N/A 0.110 0.033
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.028
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.098 0.075
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.025
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.098 0.025
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.098 0.025
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.098 0.025
DAB1 DAB1: Disabled homolog 1 0.097 0.026
DAB2 DAB2, DOC2: Disabled homolog 2 0.097 0.033
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.096 0.027
CIITA CIITA, MHC2TA: MHC class II transactivator 0.096 0.091
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.096 0.124
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.100
GNA14 GNA14: Guanine nucleotide-binding protein alpha-14 subunit 0.095 19.90
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.091 0.087
CD44 N/A 0.091 0.144
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.090 2.17
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.088 13.90
IFI16 N/A 0.087 0.042
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.087 0.027
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.087 0.157
CDK7 CDK7, MO15: Cell division protein kinase 7 0.086 0.040
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.086 1.33
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.086 0.032
CTPS CTPS: CTP synthase 1 0.086 0.032
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.086 0.032
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.0818 0.129
IRF3 IRF3: Interferon regulatory factor 3 0.080 0.039
KLHDC4 N/A 0.078 0.040
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.078 0.040
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.078 2.32
YWHAZ YWHAZ: 14-3-3 protein zeta/delta 0.078 0.066
PAPOLA PAPOLA, PAP: Poly(A) polymerase alpha 0.078 0.038
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.078 0.066
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.078 0.033
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.078 0.038
LCP1 LCP1, PLS2: Plastin-2 0.078 0.185
AGTPBP1 AGTPBP1, RP11-30C23.1-005, hCG_1743691: AGTPBP1 protein 0.078 0.036
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.078 0.066
HNRPK N/A 0.078 0.141
KIAA1012 KIAA1012: Protein TRS85 homolog 0.078 0.227
USP47 USP47: Ubiquitin carboxyl-terminal hydrolase 47 0.078 0.066
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.078 0.204
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.078 0.040
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.077 0.046
STK16 N/A 0.077 0.027
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.075 0.052
FADD FADD, MORT1: Protein FADD 0.075 0.087
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.075 0.036
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.075 0.036
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.075 0.025
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.029
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.071 1.44
MARK2 N/A 0.070 0.036
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.070 0.153
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.070 0.042
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.070 0.042
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.070 0.101
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.070 0.125
ABCF1 N/A 0.070 0.0446
SEL1L SEL1L, TSA305, UNQ128/PRO1063: Protein sel-1 homolog 1 precursor 0.070 0.049
CDK4 CDK4: Cell division protein kinase 4 0.069 0.032
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.069 0.032
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.067 18.30
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.063 0.038
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.063 0.041
PPARBP N/A 0.063 0.066
YY1 YY1: Transcriptional repressor protein YY1 0.063 0.038
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.063 0.067
USP10 USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10 0.063 0.066
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.063 0.072
GSK3B N/A 0.063 0.066
COPA COPA: Coatomer subunit alpha 0.063 0.066
ACTG1 ACTB: Actin, cytoplasmic 1 0.063 0.033
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.063 0.066
PTPN11 N/A 0.063 0.040
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.063 0.503
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.063 0.040
PPIA PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A 0.063 0.033
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.063 0.185
USP7 USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7 0.063 0.032
DYNC1LI1 DYNC1LI1, DNCLI1: Cytoplasmic dynein 1 light intermediate chain 1 0.063 0.032
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.063 0.078
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.063 0.038
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.063 0.066
PPP1CB PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0.063 0.066
EXOC2 N/A 0.063 0.032
SPTAN1 N/A 0.062 0.027
GTF2F2 N/A 0.060 0.039
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.057 0.052
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.057 0.052
TNF TNF, TNFA, TNFSF2: Tumor necrosis factor precursor 0.057 0.0425
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.056 0.032
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.055 0.644
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.052 0.036
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.052 0.138
FLNA FLNA, FLN, FLN1: Filamin-A 0.052 0.036
DNM2 N/A 0.052 0.036
CHUK N/A 0.052 0.0446
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.052 0.027
RGS2 RGS2, G0S8: Regulator of G-protein signaling 2 0.052 2.46
YWHAQ YWHAQ: 14-3-3 protein theta 0.052 0.0446
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.052 0.036
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.052 0.074
API5 N/A 0.052 0.0446
RANGAP1 RANGAP1, SD: Ran GTPase-activating protein 1 0.052 0.091
AHNAK AHNAK: AHNAK protein 0.052 0.0446
DDX21 DDX21: Nucleolar RNA helicase 2 0.052 0.042
TGFBR2 TGFBR2: TGF-beta receptor type-2 precursor 0.051 0.0425
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.051 0.038
NCF2 NCF2: Neutrophil cytosol factor 2 0.050 0.039
LAT LAT: Linker for activation of T-cells family member 1 0.049 0.028
LSP1 LSP1, WP34: Lymphocyte-specific protein 1 0.049 0.028
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.028
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.028
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.049 0.028
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.049 0.028
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.049 0.083
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.049 0.028
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.028
TNFSF13B TNFSF13B, BAFF, UNQ401/PRO738, BLYS, TALL1, TNFSF20, ZTNF4: Tumor necrosis facto 0.049 0.028
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.049 0.028
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.049 0.083
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.046 0.040
CLTC CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1 0.046 0.056
RARS RARS: Arginyl-tRNA synthetase, cytoplasmic 0.046 0.033
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.046 0.137
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.046 0.066
SAPS3 N/A 0.046 0.040
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.046 0.304
RPS3 RPS3, OK/SW-cl.26: 40S ribosomal protein S3 0.046 0.066
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.046 0.141
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.046 1.42
CDC23 CDC23: Cell division cycle protein 23 homolog 0.046 0.503
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.046 0.066
QARS QARS: Glutaminyl-tRNA synthetase 0.046 0.033
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.046 0.040
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 0.046 0.040
TBCE TBCE: Tubulin-specific chaperone E 0.046 0.026
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.046 0.032
DLG1 N/A 0.046 0.038
FLII FLII, FLIL: Protein flightless-1 homolog 0.046 0.137
RGS19 RGS19, GAIP, GNAI3IP: Regulator of G-protein signaling 19 0.046 2.46
GSR GSR, GLUR, GRD1: Glutathione reductase, mitochondrial precursor 0.046 0.040
WARS WARS, IFI53, WRS: Tryptophanyl-tRNA synthetase, cytoplasmic 0.046 0.032
NAPG NAPG, SNAPG: Gamma-soluble NSF attachment protein 0.046 0.026
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.046 0.032
XPO1 XPO1, CRM1: Exportin-1 0.046 0.066
USP34 USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34 0.046 0.032
LPXN LPXN, LDLP: Leupaxin 0.046 0.040
COPE COPE: Coatomer subunit epsilon 0.046 0.100
CCR5 CCR5: CCR5 receptor (Fragment) 0.046 1.76
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.0438
CD40LG CD40LG, CD40L, TNFSF5, TRAP: CD40 ligand 0.0453 0.026
LTA LTA, TNFB, TNFSF1: Lymphotoxin-alpha precursor 0.0453 0.0425
EPOR EPOR: Erythropoietin receptor precursor 0.0453 0.026
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.0453 0.026
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.0446 0.144
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.044 0.041
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.044 0.025
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.044 0.075
ABCC1 ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1 0.044 0.025
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.044 0.025
AQP4 AQP4: Aquaporin-4 0.044 0.025
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.044 0.025
TXN TXN, TRDX, TRX, TRX1: Thioredoxin 0.043 0.032
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.043 0.026
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.0425 0.027
NUP214 N/A 0.0425 0.029
FTH1 FTH1, FTH, OK/SW-cl.84, FTHL6, PIG15: Ferritin heavy chain 0.0425 0.027
ALOX5 ALOX5, LOG5: Arachidonate 5-lipoxygenase 0.0425 0.027
VAV2 VAV2, RP11-153P4.1-003: Vav 2 oncogene 0.0425 0.036
SAT SAT1, SAT: Diamine acetyltransferase 1 0.0425 0.0446
DAPP1 N/A 0.0425 0.036
MPG N/A 0.0425 0.036
GNB2L1 Lung cancer oncogene 7 0.0425 0.049
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.0425 0.074
SLC4A7 SLC4A7: Uncharacterized protein SLC4A7 0.041 0.046
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.041 0.0425
GRM3 GRM3, GPRC1C, MGLUR3: Metabotropic glutamate receptor 3 precursor 0.041 12.70
KIT KIT: Mast/stem cell growth factor receptor precursor 0.041 11.10
TBXA2R TBXA2R: Thromboxane A2 receptor 0.04 1.05
SLC4A3 SLC4A3, AE3: Anion exchange protein 3 0.04 0.028
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.078
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.040 0.046
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.078
CST7 CST7: Cystatin-F precursor 0.039 0.027
EEF2 EEF2, EF2: Elongation factor 2 0.038 0.040
TPT1 TPT1: Translationally-controlled tumor protein 0.038 0.066
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.038 0.066
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.038 0.027
RP2 RP2: Protein XRP2 0.038 0.0446
DNAJC7 DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7 0.038 0.0735
EEF1A1 EEF1A1: Elongation factor 1-alpha 0.038 0.066
SENP6 SENP6, KIAA0797, FKSG6, SSP1, SUSP1: Sentrin-specific protease 6 0.038 0.036
EEF1B2 EEF1B2, EEF1B, EF1B: Elongation factor 1-beta 0.038 0.066
STUB1 STUB1, CHIP, PP1131: STIP1 homology and U box-containing protein 1 0.038 0.113
NOC2L NOC2L: Nucleolar complex protein 2 homolog 0.038 0.032
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.038 0.032
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.026
RAP1GA1 N/A 0.037 0.036
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.037 0.0425
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.037 0.032
GHR GHR: Growth hormone receptor precursor 0.037 0.032
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.037 0.026
KIAA0372 TTC37, KIAA0372: Tetratricopeptide repeat protein 37 0.036 0.047
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.036 0.087
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.036 0.025
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.036 0.087
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.036 0.087
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.036 0.087
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.036 0.087
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.036 0.144
TXNDC TXNDC1, TMX, PSEC0085, TXNDC, UNQ235/PRO268: Thioredoxin domain-containing prote 0.035 0.038
GRIK2 GRIK2, GLUR6: Glutamate receptor, ionotropic kainate 2 precursor 0.033 0.044
GRIA1 GRIA1, GLUH1, GLUR1: Glutamate receptor 1 precursor 0.033 0.050
GRIN1 GRIN1, NMDAR1: Glutamate [NMDA] receptor subunit zeta-1 precursor 0.033 0.044
GRM1 GRM1, GPRC1A, MGLUR1: Metabotropic glutamate receptor 1 precursor 0.033 0.098
RHO RHO, OPN2: Rhodopsin 0.033 0.775
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.033 0.775
F3 F3: Tissue factor precursor 0.032 0.026
CASR CASR, GPRC2A, PCAR1: Extracellular calcium-sensing receptor precursor 0.032 0.109
NME1 NME1, NDPKA, NM23: Nucleoside diphosphate kinase A 0.032 0.027
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.032 0.074
ZYX ZYX: Zyxin 0.032 0.027
UBAP2 N/A 0.032 0.027
PLSCR1 PLSCR1: Phospholipid scramblase 1 0.032 0.129
VDP DKFZp451D234: Putative uncharacterized protein DKFZp451D234 0.032 0.038
OPRM1 OPRM1, MOR1: Mu-type opioid receptor 0.030 0.540
RGS3 RGS3: Regulator of G-protein signaling 3 0.030 0.404
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.029 7.92
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.029 0.044
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.029 0.049
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.029 0.044
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.029 0.026
CASP3 CASP3, CPP32: Caspase-3 precursor 0.029 0.032
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.029 0.032
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.029 0.181
FKBP8 DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment) 0.029 0.026
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.029 0.040
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.029 0.148
NME2 NME2, NM23B: Nucleoside diphosphate kinase B 0.029 0.040
ENO1 ENO1, ENO1L1, MBPB1, MPB1: Alpha-enolase 0.029 0.032
AIP AIP, XAP2: AH receptor-interacting protein 0.029 0.113
RGS18 RGS18, RGS13: Regulator of G-protein signaling 18 0.028 0.543
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.04
AXIN1 0.028 0.980
NASP NASP: Nuclear autoantigenic sperm protein 0.028 0.044
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.028 0.361
PTGIR PTGIR, PRIPR: Prostacyclin receptor 0.027 1.35
CD69 CD69: Early activation antigen CD69 0.027 0.052
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.027 0.070
LTB4R LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7: Leukotriene B4 receptor 1 0.027 2.42
CD59 CD59, MIC11, MIN1, MIN2, MIN3, MSK21: CD59 glycoprotein precursor 0.0263 0.026
GRIA4 GRIA4, GLUR4: Glutamate receptor 4 precursor 0.026 0.049
FANCA FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein 0.026 0.027
RGS4 RGS4: Regulator of G-protein signaling 4 0.026 0.581
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.044
MYO18A 0.025 0.036
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.025 0.044
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.025 0.04
HSPA8 HSPA8, HSC70, HSP73, HSPA10: Heat shock cognate 71 kDa protein 0.025 3.39
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.036
2.15E-3
Total Score 9.16